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Fusion gene ID: 3616 |
FusionGeneSummary for AURKA_PCK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AURKA_PCK1 | Fusion gene ID: 3616 | Hgene | Tgene | Gene symbol | AURKA | PCK1 | Gene ID | 6790 | 5105 |
| Gene name | aurora kinase A | phosphoenolpyruvate carboxykinase 1 | |
| Synonyms | AIK|ARK1|AURA|BTAK|PPP1R47|STK15|STK6|STK7 | PCKDC|PEPCK-C|PEPCK1|PEPCKC | |
| Cytomap | 20q13.2 | 20q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | aurora kinase Aaurora 2aurora/IPL1-like kinaseaurora/IPL1-related kinase 1breast tumor-amplified kinaseprotein phosphatase 1, regulatory subunit 47serine/threonine protein kinase 15serine/threonine-protein kinase 6serine/threonine-protein kinase a | phosphoenolpyruvate carboxykinase, cytosolic [GTP]PEP carboxykinasephosphoenolpyruvate carboxykinase 1 (soluble)phosphoenolpyruvate carboxykinase, cytosolicphosphoenolpyruvate carboxylasephosphopyruvate carboxylase | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | O14965 | P35558 | |
| Ensembl transtripts involved in fusion gene | ENST00000395914, ENST00000395909, ENST00000371356, ENST00000347343, ENST00000395911, ENST00000312783, ENST00000395915, ENST00000395913, ENST00000395907, | ENST00000319441, ENST00000543666, ENST00000535860, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 2 X 3=18 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AURKA [Title/Abstract] AND PCK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AURKA | GO:0006468 | protein phosphorylation | 21600873|21820309 |
| Hgene | AURKA | GO:0009611 | response to wounding | 19435814 |
| Hgene | AURKA | GO:0032091 | negative regulation of protein binding | 21820309 |
| Hgene | AURKA | GO:0097421 | liver regeneration | 19435814 |
| Tgene | PCK1 | GO:0006475 | internal protein amino acid acetylation | 20167786 |
| Tgene | PCK1 | GO:0032868 | response to insulin | 14764811 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AR-A24R-01A | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000395914 | ENST00000319441 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395914 | ENST00000543666 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-intron | ENST00000395914 | ENST00000535860 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395909 | ENST00000319441 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395909 | ENST00000543666 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-intron | ENST00000395909 | ENST00000535860 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000371356 | ENST00000319441 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000371356 | ENST00000543666 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-intron | ENST00000371356 | ENST00000535860 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000347343 | ENST00000319441 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000347343 | ENST00000543666 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-intron | ENST00000347343 | ENST00000535860 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395911 | ENST00000319441 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395911 | ENST00000543666 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-intron | ENST00000395911 | ENST00000535860 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000312783 | ENST00000319441 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000312783 | ENST00000543666 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-intron | ENST00000312783 | ENST00000535860 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395915 | ENST00000319441 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395915 | ENST00000543666 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-intron | ENST00000395915 | ENST00000535860 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395913 | ENST00000319441 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395913 | ENST00000543666 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-intron | ENST00000395913 | ENST00000535860 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395907 | ENST00000319441 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-5UTR | ENST00000395907 | ENST00000543666 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
| 5CDS-intron | ENST00000395907 | ENST00000535860 | AURKA | chr20 | 54963212 | - | PCK1 | chr20 | 56136428 | + |
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FusionProtFeatures for AURKA_PCK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AURKA | PCK1 |
| Mitotic serine/threonine kinase that contributes to theregulation of cell cycle progression. Associates with thecentrosome and the spindle microtubules during mitosis and plays acritical role in various mitotic events including theestablishment of mitotic spindle, centrosome duplication,centrosome separation as well as maturation, chromosomalalignment, spindle assembly checkpoint, and cytokinesis. Requiredfor initial activation of CDK1 at centrosomes. Phosphorylatesnumerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B,DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1,TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymeraseactivity. Required for normal axon formation. Plays a role inmicrotubule remodeling during neurite extension. Important formicrotubule formation and/or stabilization. Also acts as a keyregulatory component of the p53/TP53 pathway, and particularly thecheckpoint-response pathways critical for oncogenic transformationof cells, by phosphorylating and stabilizing p53/TP53.Phosphorylates its own inhibitors, the protein phosphatase type 1(PP1) isoforms, to inhibit their activity. Necessary for propercilia disassembly prior to mitosis. {ECO:0000269|PubMed:11039908,ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251,ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000,ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:14990569,ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269,ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279,ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723,ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013,ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19357306,ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038,ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:9606188}. | Catalyzes the conversion of oxaloacetate (OAA) tophosphoenolpyruvate (PEP), the rate-limiting step in the metabolicpathway that produces glucose from lactate and other precursorsderived from the citric acid cycle. {ECO:0000269|PubMed:24863970,ECO:0000269|PubMed:26971250, ECO:0000269|PubMed:28216384}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AURKA_PCK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AURKA_PCK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AURKA | RAB10, CDKN2A, SOD2, UBE2L3, BRCA1, TACC1, NIN, UBE2N, MBD3, NME1, CDC20, TP53, TPX2, CHFR, KIF2C, NFKBIA, INCENP, PLK1, TLK1, TLK2, HDAC6, HDAC2, RASSF1, FBXW7, MYCN, PUM2, AURKA, CALU, CEP192, HIST3H3, LATS2, USP2, TFAP2A, CEP131, AURKAIP1, GSK3B, HMMR, BARD1, PML, MAPRE1, MAPRE2, MAPRE3, PLK3, PTTG1, ARPC1B, ARPC2, TUBG1, PPP1CA, PPP1CB, PPP1CC, CSN2, APP, DLGAP5, SSSCA1, RANBP3, PSRC1, PTPN23, TARS, TP73, DAB2, TACC3, NDC80, NUF2, IKBKB, CHUK, IKBKG, BTRC, BIRC5, GMNN, CBX3, BCL2L11, SRPK2, SRPK1, PPP6R3, MDM2, VHL, HSPA5, PPP6C, TCEAL4, HSP90AB1, SORL1, TUBB, RPS19, HNRNPA1, RPS3, RPLP0, HSPD1, PRRC2C, RPS14, NPM1, RPS16, TUBA1C, HSPA2, DHX9, TUBB4B, FTH1, RPS4X, MFAP4, RPL30, DICER1, EPRS, EEF1A2, RPS3A, USP9X, ILF3, RPL22, MRPS22, RPS5, PSMA1, HNRNPU, RPL38, RPL23, LYZ, HSPA8, CEP55, FTL, UBB, NCL, CSNK2A1, TRIM28, HSPA9, LRPPRC, DGCR14, PSMB5, PPP6R2, IARS, LARP1, RPS10, SRP9, DDX5, HNRNPA2B1, SKP1, RPL12, RPL27, PSMA5, PSMA6, CTPS1, IGF2BP1, IGF2BP3, YBX1, MATR3, EEF1A1, ZSWIM8, PDCD6, IRS4, RPS27, DDB1, RPS7P4, MAPK6, PCMT1, RPL11, HSPA1A, PSMB7, UQCC2, CDC37, ILF2, MRPL24, HSP90AA1, CTNND1, DCAF7, ATAD3B, NCOR2, TCEAL2, RPS11, SEC61G, RPLP2, AURKB, GADD45A, UBE2I, NEDD9, RIC3, CELA2B, KIRREL2, PRKCSH, AMER1, REL, SNX9, TNRC6C, SCYL1, CALCOCO1, HEATR5B, TTC4, SH3GL1, WDR62, SETD2, TNKS1BP1, PASK, WAPAL, NFKB1, LIMD1, MTMR4, MTMR3, RPIA, SNX18, CNOT8, CNOT7, CNOT2, OSBPL3, ITPKC, PEAK1, RQCD1, FBN2, TARBP2, OSBPL6, AUNIP, SDCCAG3, EPS15, USP47, ARFGAP1, GAPVD1, FBXO30, SYNRG, EEF2, EZR, FUS, HNRNPD, PFKM, SMC2, UBA1, ANGPTL4, BEX2, BLID, CDH13, DKK3, EPSTI1, ERRFI1, KLK5, LYPD3, MTA3, NAT2, PDLIM2, PSMC3IP, S100A14, SCGB3A1, THRSP, WIF1, CNTROB, CEP128, XPO1, CTNNB1, GTF3C2, LIG1, TAF9, KLF4, MED16, MRPL28, HARS2, ASCC1, MECR, CHMP5, SIRT7, LARP7, MRPL16, KIF16B, WDR35, MRPS35, ZMYM1, ELOF1, PARK2, USP21, OTUD7B, OTUB1, SNW1, FOXP1, MYT1, SOX30, SUPT20H, UBTF, CTCFL, BTK, SSRP1, STAT2, PAX4, SOX18, YY1, TBX10, AATF, SWT1, IFI16, ZFHX3, REST, ATRX, MYT1L, TCERG1, SREBF2, POU4F3, HNRNPK, TRRAP, MED26, SIN3B, GTF3C4, NFXL1, FOXF1, TFAP2B, ZKSCAN2, NKX1-1, HNRNPF, CUL3, KLHL18, MTMR7, PLA2G10, LBHD1, FEZ1, FAM131B, PAK7, COPRS, RAPGEF6, EPS15L1, KLRG2, MYCL, KHDRBS2, C16orf71, PTPN5, FANCA, BCL2L1 | PCK1 | IKBKG, PSMC4, HLA-C, YWHAQ, ABCB7, ACTB, ATP2A1, BSG, BAG6, CALM1, CALM2, CALM3, HSPD1, CPT1A, DNAJA1, GNAI1, HSPA1L, LDHA, MAGED2, PSMC1, PSMC2, PSMC5, PSMA2, PSMA5, PSMB1, PSMB4, PSMD12, RPL4, RPL10L, RPL14, RPL23, RPLP0, RPS3A, RPS6, RPS15A, SKP1, TCP1, CCT2, CCT4, CCT5, C1QBP, TSC22D3, USP11, TCEB1, HLA-B, GNA12, GNAS, GPHN, HSP90AB2P, DDX21, MAGED1, DDX3X, MYLK2, NUP62, PSMB7, GIGYF2, SQSTM1, FASN, PSMD2, IRS4, SRPRB, LPCAT1, FAF2, PSMD6, RPS3, UBC, PSMD14, UBR5, SIRT2, EP300, CUL5, APP, FBXO25, C1R, NDUFA11, PCK2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AURKA_PCK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AURKA_PCK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AURKA | C0002938 | Aneuploidy | 1 | CTD_human |
| Hgene | AURKA | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | AURKA | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Hgene | AURKA | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | AURKA | C0025202 | melanoma | 1 | CTD_human |
| Hgene | AURKA | C0027819 | Neuroblastoma | 1 | CTD_human |
| Hgene | AURKA | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| Hgene | AURKA | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | AURKA | C1257806 | Chromosomal Instability | 1 | CTD_human |
| Hgene | AURKA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | PCK1 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Tgene | PCK1 | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | PCK1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | PCK1 | C0028754 | Obesity | 1 | CTD_human |
| Tgene | PCK1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | PCK1 | C2239176 | Liver carcinoma | 1 | CTD_human |
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