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Fusion gene ID: 36135 |
FusionGeneSummary for SSBP4_SLC5A5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SSBP4_SLC5A5 | Fusion gene ID: 36135 | Hgene | Tgene | Gene symbol | SSBP4 | SLC5A5 | Gene ID | 170463 | 6528 |
| Gene name | single stranded DNA binding protein 4 | solute carrier family 5 member 5 | |
| Synonyms | - | NIS|TDH1 | |
| Cytomap | 19p13.11 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | single-stranded DNA-binding protein 4 | sodium/iodide cotransporterNa(+)/I(-) cotransporterNa(+)/I(-) symportersolute carrier family 5 (sodium iodide symporter), member 5solute carrier family 5 (sodium/iodide cotransporter), member 5 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BWG4 | Q92911 | |
| Ensembl transtripts involved in fusion gene | ENST00000348495, ENST00000270061, ENST00000598159, ENST00000599699, | ENST00000222248, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SSBP4 [Title/Abstract] AND SLC5A5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-AJ-A3QS-01A | SSBP4 | chr19 | 18544627 | + | SLC5A5 | chr19 | 17994659 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000348495 | ENST00000222248 | SSBP4 | chr19 | 18544627 | + | SLC5A5 | chr19 | 17994659 | + |
| In-frame | ENST00000270061 | ENST00000222248 | SSBP4 | chr19 | 18544627 | + | SLC5A5 | chr19 | 17994659 | + |
| intron-3CDS | ENST00000598159 | ENST00000222248 | SSBP4 | chr19 | 18544627 | + | SLC5A5 | chr19 | 17994659 | + |
| In-frame | ENST00000599699 | ENST00000222248 | SSBP4 | chr19 | 18544627 | + | SLC5A5 | chr19 | 17994659 | + |
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FusionProtFeatures for SSBP4_SLC5A5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SSBP4 | SLC5A5 |
| Mediates iodide uptake in the thyroid gland. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SSBP4 | chr19:18544627 | chr19:17994659 | ENST00000270061 | + | 17 | 18 | 125_279 | 376 | 386 | Compositional bias | Note=Pro-rich |
| Hgene | SSBP4 | chr19:18544627 | chr19:17994659 | ENST00000270061 | + | 17 | 18 | 17_49 | 376 | 386 | Domain | LisH |
| Tgene | >SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 466_525 | 443 | 644 | Topological domain | Extracellular |
| Tgene | >SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 547_643 | 443 | 644 | Topological domain | Cytoplasmic |
| Tgene | >SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 445_465 | 443 | 644 | Transmembrane | Helical |
| Tgene | >SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 526_546 | 443 | 644 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 110_136 | 443 | 644 | Topological domain | Cytoplasmic |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 158_163 | 443 | 644 | Topological domain | Extracellular |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 185_186 | 443 | 644 | Topological domain | Cytoplasmic |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 1_16 | 443 | 644 | Topological domain | Extracellular |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 208_241 | 443 | 644 | Topological domain | Extracellular |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 263_286 | 443 | 644 | Topological domain | Cytoplasmic |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 308_326 | 443 | 644 | Topological domain | Extracellular |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 348_391 | 443 | 644 | Topological domain | Cytoplasmic |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 38_53 | 443 | 644 | Topological domain | Cytoplasmic |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 413_416 | 443 | 644 | Topological domain | Extracellular |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 438_444 | 443 | 644 | Topological domain | Cytoplasmic |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 75_88 | 443 | 644 | Topological domain | Extracellular |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 137_157 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 164_184 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 17_37 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 187_207 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 242_262 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 287_307 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 327_347 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 392_412 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 417_437 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 54_74 | 443 | 644 | Transmembrane | Helical |
| Tgene | SLC5A5 | chr19:18544627 | chr19:17994659 | ENST00000222248 | + | 10 | 15 | 89_109 | 443 | 644 | Transmembrane | Helical |
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FusionGeneSequence for SSBP4_SLC5A5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SSBP4_ENST00000348495_chr19_18544627_+_SLC5A5_ENST00000222248_chr19_17994659_+_555aa MYAKGGKGSAVPSDSQAREKLALYVYEYLLHIGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPDRREACEHSGEAKAF QDYSAAAAPSPVMGSMAPGDTMAAGSMAAGFFQPFMSPRFPGGPRPTLRMPSQPPAGLPGSQPLLPGAMEPSPRAQGHPSMGGPMQRVTP PRGMASVGPQSYGGGMRPPPNSLAGPGLPAMNMGPGVRGPWASPSGNSIPYSSSSPGSYTGPPGGGGPPGTPIMPSPGDSTNSSENMYTI MNPIGQGAGRANFPLGPGPEGPMAAMSAMEPHHVNGSLGSGDMDGLPKSSPGAVAGLSNAPGTPRDDGEMAAAGTFLHPFPSESGVLAGL GAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTT VLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTPC >In-frame_SSBP4_ENST00000270061_chr19_18544627_+_SLC5A5_ENST00000222248_chr19_17994659_+_577aa MYAKGGKGSAVPSDSQAREKLALYVYEYLLHIGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPDRREACEHSGEAKAF QDYSAAAAPSPVMGSMAPGDTMAAGSMAAGFFQGPPGSQPSPHNPNAPMMGPHGQPFMSPRFPGGPRPTLRMPSQPPAGLPGSQPLLPGA MEPSPRAQGHPSMGGPMQRVTPPRGMASVGPQSYGGGMRPPPNSLAGPGLPAMNMGPGVRGPWASPSGNSIPYSSSSPGSYTGPPGGGGP PGTPIMPSPGDSTNSSENMYTIMNPIGQGAGRANFPLGPGPEGPMAAMSAMEPHHVNGSLGSGDMDGLPKSSPGAVAGLSNAPGTPRDDG EMAAAGTFLHPFPSESGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRP ALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPT >In-frame_SSBP4_ENST00000599699_chr19_18544627_+_SLC5A5_ENST00000222248_chr19_17994659_+_263aa MAPARLSRCPCLSVSVGSGDMDGLPKSSPGAVAGLSNAPGTPRDDGEMAAAGTFLHPFPSESGVLAGLGAGLALSLWVALGATLYPPSEQ TMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAPG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SSBP4_ENST00000348495_chr19_18544627_+_SLC5A5_ENST00000222248_chr19_17994659_+_1665nt ATGTACGCCAAGGGGGGCAAGGGTTCGGCCGTGCCCTCCGACAGCCAGGCCCGCGAGAAGTTGGCGCTGTACGTTTATGAGTACCTGCTG CACATCGGTGCCCAGAAGTCAGCCCAGACCTTCCTGTCTGAGATCCGATGGGAGAAGAACATCACGCTGGGGGAGCCCCCTGGGTTCCTG CACTCCTGGTGGTGCGTCTTCTGGGACCTGTACTGCGCGGCGCCTGACAGAAGAGAGGCCTGCGAGCACTCCGGCGAGGCCAAGGCCTTC CAGGACTATAGTGCTGCAGCCGCCCCCAGCCCCGTTATGGGGAGTATGGCCCCAGGTGACACAATGGCCGCAGGCTCCATGGCGGCTGGC TTCTTCCAGCCCTTCATGTCACCGCGCTTCCCAGGGGGCCCCCGGCCCACCCTGCGGATGCCGAGTCAGCCTCCCGCAGGCCTCCCTGGC TCCCAGCCCCTCCTCCCTGGCGCCATGGAGCCCTCCCCACGAGCCCAGGGGCATCCGAGCATGGGCGGCCCAATGCAGAGGGTGACGCCT CCTCGTGGCATGGCCAGCGTGGGGCCCCAGAGCTATGGAGGTGGCATGCGACCCCCACCCAACTCCCTCGCCGGCCCAGGCCTGCCTGCC ATGAACATGGGCCCAGGAGTTCGTGGCCCGTGGGCCAGCCCCAGTGGAAACTCGATCCCCTACTCCTCCTCATCCCCCGGCAGCTACACC GGACCCCCAGGAGGAGGTGGGCCCCCTGGAACACCCATCATGCCTAGCCCTGGAGATTCCACCAACTCCAGCGAAAACATGTACACTATC ATGAACCCCATCGGGCAGGGCGCCGGCAGGGCTAATTTCCCGCTCGGCCCTGGCCCGGAGGGCCCCATGGCCGCCATGAGCGCGATGGAG CCTCACCACGTGAACGGATCCCTGGGCTCGGGCGACATGGACGGGTTGCCGAAGAGTTCCCCCGGCGCCGTGGCCGGCCTGAGCAACGCC CCGGGCACCCCGCGGGACGACGGCGAGATGGCGGCCGCCGGGACCTTCCTGCACCCGTTCCCGAGCGAAAGCGGCGTCCTCGCGGGACTA GGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCTGTACCCACCCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCG GCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGACCCGGCTCTCCTCCCTGCTAACGACTCCAGCAGGGCCCCCAGC TCAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGCCCTGGGCACGCTGACCACT GTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGCCCCACCAAGCGCAGCACCCTGGCCCCGGGATTGTTGTGGTGGGACCTCGCACGG CAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGACAACTTGGTCAAGGGTCCTGAAGAACTCCCCACTGGAAACAAG AAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGGGCAGAAGGAGCTGGAGGGGGCTGGCTCTTGGACCCCCTGT >In-frame_SSBP4_ENST00000270061_chr19_18544627_+_SLC5A5_ENST00000222248_chr19_17994659_+_1731nt ATGTACGCCAAGGGGGGCAAGGGTTCGGCCGTGCCCTCCGACAGCCAGGCCCGCGAGAAGTTGGCGCTGTACGTTTATGAGTACCTGCTG CACATCGGTGCCCAGAAGTCAGCCCAGACCTTCCTGTCTGAGATCCGATGGGAGAAGAACATCACGCTGGGGGAGCCCCCTGGGTTCCTG CACTCCTGGTGGTGCGTCTTCTGGGACCTGTACTGCGCGGCGCCTGACAGAAGAGAGGCCTGCGAGCACTCCGGCGAGGCCAAGGCCTTC CAGGACTATAGTGCTGCAGCCGCCCCCAGCCCCGTTATGGGGAGTATGGCCCCAGGTGACACAATGGCCGCAGGCTCCATGGCGGCTGGC TTCTTCCAGGGCCCCCCCGGCTCCCAGCCGTCCCCCCACAACCCCAACGCCCCCATGATGGGGCCTCACGGTCAGCCCTTCATGTCACCG CGCTTCCCAGGGGGCCCCCGGCCCACCCTGCGGATGCCGAGTCAGCCTCCCGCAGGCCTCCCTGGCTCCCAGCCCCTCCTCCCTGGCGCC ATGGAGCCCTCCCCACGAGCCCAGGGGCATCCGAGCATGGGCGGCCCAATGCAGAGGGTGACGCCTCCTCGTGGCATGGCCAGCGTGGGG CCCCAGAGCTATGGAGGTGGCATGCGACCCCCACCCAACTCCCTCGCCGGCCCAGGCCTGCCTGCCATGAACATGGGCCCAGGAGTTCGT GGCCCGTGGGCCAGCCCCAGTGGAAACTCGATCCCCTACTCCTCCTCATCCCCCGGCAGCTACACCGGACCCCCAGGAGGAGGTGGGCCC CCTGGAACACCCATCATGCCTAGCCCTGGAGATTCCACCAACTCCAGCGAAAACATGTACACTATCATGAACCCCATCGGGCAGGGCGCC GGCAGGGCTAATTTCCCGCTCGGCCCTGGCCCGGAGGGCCCCATGGCCGCCATGAGCGCGATGGAGCCTCACCACGTGAACGGATCCCTG GGCTCGGGCGACATGGACGGGTTGCCGAAGAGTTCCCCCGGCGCCGTGGCCGGCCTGAGCAACGCCCCGGGCACCCCGCGGGACGACGGC GAGATGGCGGCCGCCGGGACCTTCCTGCACCCGTTCCCGAGCGAAAGCGGCGTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTG TGGGTGGCCTTGGGCGCCACGCTGTACCCACCCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCGGCTGCCCGCTGCGTGGCTCTCTCA GTCAACGCCTCTGGCCTCCTGGACCCGGCTCTCCTCCCTGCTAACGACTCCAGCAGGGCCCCCAGCTCAGGAATGGACGCCAGCCGACCC GCCTTAGCTGACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGCCCTGGGCACGCTGACCACTGTGCTGTGCGGAGCCCTCATCAGC TGCCTGACAGGCCCCACCAAGCGCAGCACCCTGGCCCCGGGATTGTTGTGGTGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAG GAAGAAGTGGCCATCCTGGATGACAACTTGGTCAAGGGTCCTGAAGAACTCCCCACTGGAAACAAGAAGCCCCCTGGCTTCCTGCCCACC AATGAGGATCGTCTGTTTTTCTTGGGGCAGAAGGAGCTGGAGGGGGCTGGCTCTTGGACCCCCTGTGTTGGACATGATGGTGGTCGAGAC >In-frame_SSBP4_ENST00000599699_chr19_18544627_+_SLC5A5_ENST00000222248_chr19_17994659_+_789nt ATGGCGCCAGCACGTCTGAGCCGGTGCCCGTGTCTGTCCGTGTCTGTAGGCTCGGGCGACATGGACGGGTTGCCGAAGAGTTCCCCCGGC GCCGTGGCCGGCCTGAGCAACGCCCCGGGCACCCCGCGGGACGACGGCGAGATGGCGGCCGCCGGGACCTTCCTGCACCCGTTCCCGAGC GAAAGCGGCGTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCTGTACCCACCCAGCGAGCAG ACCATGAGGGTCCTGCCATCGTCGGCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGACCCGGCTCTCCTCCCTGCT AACGACTCCAGCAGGGCCCCCAGCTCAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGCCATCTCCTATCTCTATTAC GGTGCCCTGGGCACGCTGACCACTGTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGCCCCACCAAGCGCAGCACCCTGGCCCCGGGA TTGTTGTGGTGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGACAACTTGGTCAAGGGTCCT GAAGAACTCCCCACTGGAAACAAGAAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGGGCAGAAGGAGCTGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SSBP4_ENST00000348495_chr19_18544627_+_SLC5A5_ENST00000222248_chr19_17994659_+_3275nt CGCCCGCGGGCGGCGTAGAGGCAGCGGGCGGGGGCGCGCGCGGCGGGAGGAGGGGAGCGCGCGTTTCCCGGAACAGCCCGCGCGGAGGAA AGGGAGGAAAAAAAGCCACCCTGCGGCCGGGGCCGGAGCTGGAGCCGCCGCTGCCGCCGCCGCCGCGGCCGTCTGGAGCTCCCCCGCGCG GACGATGCCTGCCGTGCCCGCCTGGGGCTCGGGGCGGTGAGGCCCGGGGCGCGGGGTAGCTATGGCGACGGCAAGCGCGGCCCGCGGCGC CGCCTGACAGGTGTGGGCCCCGGCGGCGGCGGCGTGGAGCAGCATGTACGCCAAGGGGGGCAAGGGTTCGGCCGTGCCCTCCGACAGCCA GGCCCGCGAGAAGTTGGCGCTGTACGTTTATGAGTACCTGCTGCACATCGGTGCCCAGAAGTCAGCCCAGACCTTCCTGTCTGAGATCCG ATGGGAGAAGAACATCACGCTGGGGGAGCCCCCTGGGTTCCTGCACTCCTGGTGGTGCGTCTTCTGGGACCTGTACTGCGCGGCGCCTGA CAGAAGAGAGGCCTGCGAGCACTCCGGCGAGGCCAAGGCCTTCCAGGACTATAGTGCTGCAGCCGCCCCCAGCCCCGTTATGGGGAGTAT GGCCCCAGGTGACACAATGGCCGCAGGCTCCATGGCGGCTGGCTTCTTCCAGCCCTTCATGTCACCGCGCTTCCCAGGGGGCCCCCGGCC CACCCTGCGGATGCCGAGTCAGCCTCCCGCAGGCCTCCCTGGCTCCCAGCCCCTCCTCCCTGGCGCCATGGAGCCCTCCCCACGAGCCCA GGGGCATCCGAGCATGGGCGGCCCAATGCAGAGGGTGACGCCTCCTCGTGGCATGGCCAGCGTGGGGCCCCAGAGCTATGGAGGTGGCAT GCGACCCCCACCCAACTCCCTCGCCGGCCCAGGCCTGCCTGCCATGAACATGGGCCCAGGAGTTCGTGGCCCGTGGGCCAGCCCCAGTGG AAACTCGATCCCCTACTCCTCCTCATCCCCCGGCAGCTACACCGGACCCCCAGGAGGAGGTGGGCCCCCTGGAACACCCATCATGCCTAG CCCTGGAGATTCCACCAACTCCAGCGAAAACATGTACACTATCATGAACCCCATCGGGCAGGGCGCCGGCAGGGCTAATTTCCCGCTCGG CCCTGGCCCGGAGGGCCCCATGGCCGCCATGAGCGCGATGGAGCCTCACCACGTGAACGGATCCCTGGGCTCGGGCGACATGGACGGGTT GCCGAAGAGTTCCCCCGGCGCCGTGGCCGGCCTGAGCAACGCCCCGGGCACCCCGCGGGACGACGGCGAGATGGCGGCCGCCGGGACCTT CCTGCACCCGTTCCCGAGCGAAAGCGGCGTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCT GTACCCACCCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCGGCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGA CCCGGCTCTCCTCCCTGCTAACGACTCCAGCAGGGCCCCCAGCTCAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGC CATCTCCTATCTCTATTACGGTGCCCTGGGCACGCTGACCACTGTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGCCCCACCAAGCG CAGCACCCTGGCCCCGGGATTGTTGTGGTGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGA CAACTTGGTCAAGGGTCCTGAAGAACTCCCCACTGGAAACAAGAAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTT GGGGCAGAAGGAGCTGGAGGGGGCTGGCTCTTGGACCCCCTGTGTTGGACATGATGGTGGTCGAGACCAGCAGGAGACAAACCTCTGAGG ACAGGGCCAGCCGCGGGACTGACACCCTGGGATGGAACCTCAGGATGGGCCAAACCCAGACAACGGGCCCATGGCCTTGGGCTCTGATTG GCTGGATTGCCTTGTATGCAAATGAGTTCAGGACTACAATACCCTACCCTATGGGGAGGCCCTGCCTCCGGGAGGTCATTTTTTAAATCC AGCCCCTTGCTTCAACCGTCCCCAGTATTAGACGCTGCAGCCCTGACGGCTCCCCCCAAATAAGGCTGGGTTTTTCTCTCTCTCTTTTTT TTTTTTTTTTTTTTTTGAGACAGGGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCC CAGGCTCAAGTGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGGGATTGTAGGTGCCCACCACCATGCCCAGCCAACTTTTTGTATTTTTA GTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGG TTACAGGCGTAAGCTACCATGCCCAGCCTACCGTTTTTCTCAATCTATAATAGAAAGCCACCACGCCCAGGTAATTTTTGTAATTTTGTA TTTTTGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATCCTCCTGCCTTGGCCTCCCAAAGGG CTGGGATTACAGGGGTGAGCCACCGCGCCCCACCTCTTTCTTATTTTCTTCCTGGGATTGGGGAGGGGATGATTCAGACCCCACATGGCC TCCAACCTTGGCCCACACACCTGCCATGGCTCCCATCATCCTGAGCATGCTAGCGTCCCCTCCTCACCTGACAATGGAGGCTCTCGAATT GGGTTGTGTCCCCCCAAAATTTATGTCTACCCAGAACCTCAGAACATGAGCTTACTTGGAAATAGGGTCTTTGCAGGTGTAACTGGTTAA ATTAAAAGAGGTATTACTGGAGGAGGATGGATGAATCCAGTGACTGGTTCCTCATATGAAGTAGAGAAGAGATGCAGAGAAACACATGGG GAAGATGCCACGTGAAGACAGAGGCAGTGGTTGGATCAATGCATCTACGAGTCGGAGAACCCAAGGATTGCCAGCAACAACCAGAAATCA GGAGGGGGGCATGAGATGCATTATTTCTTAGAGCCTTTAGAGGGAACATGGCCCTACTGACACCTTGATGTCAGACTTCTGGCTGCTAGA >In-frame_SSBP4_ENST00000270061_chr19_18544627_+_SLC5A5_ENST00000222248_chr19_17994659_+_3322nt GGCAGCGGGCGGGGGCGCGCGCGGCGGGAGGAGGGGAGCGCGCGTTTCCCGGAACAGCCCGCGCGGAGGAAAGGGAGGAAAAAAAGCCAC CCTGCGGCCGGGGCCGGAGCTGGAGCCGCCGCTGCCGCCGCCGCCGCGGCCGTCTGGAGCTCCCCCGCGCGGACGATGCCTGCCGTGCCC GCCTGGGGCTCGGGGCGGTGAGGCCCGGGGCGCGGGGTAGCTATGGCGACGGCAAGCGCGGCCCGCGGCGCCGCCTGACAGGTGTGGGCC CCGGCGGCGGCGGCGTGGAGCAGCATGTACGCCAAGGGGGGCAAGGGTTCGGCCGTGCCCTCCGACAGCCAGGCCCGCGAGAAGTTGGCG CTGTACGTTTATGAGTACCTGCTGCACATCGGTGCCCAGAAGTCAGCCCAGACCTTCCTGTCTGAGATCCGATGGGAGAAGAACATCACG CTGGGGGAGCCCCCTGGGTTCCTGCACTCCTGGTGGTGCGTCTTCTGGGACCTGTACTGCGCGGCGCCTGACAGAAGAGAGGCCTGCGAG CACTCCGGCGAGGCCAAGGCCTTCCAGGACTATAGTGCTGCAGCCGCCCCCAGCCCCGTTATGGGGAGTATGGCCCCAGGTGACACAATG GCCGCAGGCTCCATGGCGGCTGGCTTCTTCCAGGGCCCCCCCGGCTCCCAGCCGTCCCCCCACAACCCCAACGCCCCCATGATGGGGCCT CACGGTCAGCCCTTCATGTCACCGCGCTTCCCAGGGGGCCCCCGGCCCACCCTGCGGATGCCGAGTCAGCCTCCCGCAGGCCTCCCTGGC TCCCAGCCCCTCCTCCCTGGCGCCATGGAGCCCTCCCCACGAGCCCAGGGGCATCCGAGCATGGGCGGCCCAATGCAGAGGGTGACGCCT CCTCGTGGCATGGCCAGCGTGGGGCCCCAGAGCTATGGAGGTGGCATGCGACCCCCACCCAACTCCCTCGCCGGCCCAGGCCTGCCTGCC ATGAACATGGGCCCAGGAGTTCGTGGCCCGTGGGCCAGCCCCAGTGGAAACTCGATCCCCTACTCCTCCTCATCCCCCGGCAGCTACACC GGACCCCCAGGAGGAGGTGGGCCCCCTGGAACACCCATCATGCCTAGCCCTGGAGATTCCACCAACTCCAGCGAAAACATGTACACTATC ATGAACCCCATCGGGCAGGGCGCCGGCAGGGCTAATTTCCCGCTCGGCCCTGGCCCGGAGGGCCCCATGGCCGCCATGAGCGCGATGGAG CCTCACCACGTGAACGGATCCCTGGGCTCGGGCGACATGGACGGGTTGCCGAAGAGTTCCCCCGGCGCCGTGGCCGGCCTGAGCAACGCC CCGGGCACCCCGCGGGACGACGGCGAGATGGCGGCCGCCGGGACCTTCCTGCACCCGTTCCCGAGCGAAAGCGGCGTCCTCGCGGGACTA GGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCTGTACCCACCCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCG GCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGACCCGGCTCTCCTCCCTGCTAACGACTCCAGCAGGGCCCCCAGC TCAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGCCCTGGGCACGCTGACCACT GTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGCCCCACCAAGCGCAGCACCCTGGCCCCGGGATTGTTGTGGTGGGACCTCGCACGG CAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGACAACTTGGTCAAGGGTCCTGAAGAACTCCCCACTGGAAACAAG AAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGGGCAGAAGGAGCTGGAGGGGGCTGGCTCTTGGACCCCCTGT GTTGGACATGATGGTGGTCGAGACCAGCAGGAGACAAACCTCTGAGGACAGGGCCAGCCGCGGGACTGACACCCTGGGATGGAACCTCAG GATGGGCCAAACCCAGACAACGGGCCCATGGCCTTGGGCTCTGATTGGCTGGATTGCCTTGTATGCAAATGAGTTCAGGACTACAATACC CTACCCTATGGGGAGGCCCTGCCTCCGGGAGGTCATTTTTTAAATCCAGCCCCTTGCTTCAACCGTCCCCAGTATTAGACGCTGCAGCCC TGACGGCTCCCCCCAAATAAGGCTGGGTTTTTCTCTCTCTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCATGCTCTGTCACCCAG GCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGCTCAAGTGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGG GATTGTAGGTGCCCACCACCATGCCCAGCCAACTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAAC TCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGTTACAGGCGTAAGCTACCATGCCCAGCCTACCGTTTTTCTCAA TCTATAATAGAAAGCCACCACGCCCAGGTAATTTTTGTAATTTTGTATTTTTGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCT CAAACTCCTGATCTCAGGTGATCCTCCTGCCTTGGCCTCCCAAAGGGCTGGGATTACAGGGGTGAGCCACCGCGCCCCACCTCTTTCTTA TTTTCTTCCTGGGATTGGGGAGGGGATGATTCAGACCCCACATGGCCTCCAACCTTGGCCCACACACCTGCCATGGCTCCCATCATCCTG AGCATGCTAGCGTCCCCTCCTCACCTGACAATGGAGGCTCTCGAATTGGGTTGTGTCCCCCCAAAATTTATGTCTACCCAGAACCTCAGA ACATGAGCTTACTTGGAAATAGGGTCTTTGCAGGTGTAACTGGTTAAATTAAAAGAGGTATTACTGGAGGAGGATGGATGAATCCAGTGA CTGGTTCCTCATATGAAGTAGAGAAGAGATGCAGAGAAACACATGGGGAAGATGCCACGTGAAGACAGAGGCAGTGGTTGGATCAATGCA TCTACGAGTCGGAGAACCCAAGGATTGCCAGCAACAACCAGAAATCAGGAGGGGGGCATGAGATGCATTATTTCTTAGAGCCTTTAGAGG >In-frame_SSBP4_ENST00000599699_chr19_18544627_+_SLC5A5_ENST00000222248_chr19_17994659_+_2347nt TTCCCCCTGCCGTCAGCCCGCCTGCCGGGTGGAGGCGTCTAGTGGCGTCCTGAGCCCCCCGGGGGCCGCTCAGTGACAGGGGCTGCCCCG AGCTGGAGGGGGATCCAGCGACCAAACCAGAGGATGCACTGACCGCCCCTCCCCCCCAGGCCCAACCCTCCACCTGGCCTCAGTCCCGGG GTTCCTGGCGGGCTGTGCGGGGCGGGGGCGCGTCGGCGGGGGCAGCTTGCGAGGGTCGTTGGCCCCTGGAGGCCGAGGGGCATGGCGCCA GCACGTCTGAGCCGGTGCCCGTGTCTGTCCGTGTCTGTAGGCTCGGGCGACATGGACGGGTTGCCGAAGAGTTCCCCCGGCGCCGTGGCC GGCCTGAGCAACGCCCCGGGCACCCCGCGGGACGACGGCGAGATGGCGGCCGCCGGGACCTTCCTGCACCCGTTCCCGAGCGAAAGCGGC GTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCTGTACCCACCCAGCGAGCAGACCATGAGG GTCCTGCCATCGTCGGCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGACCCGGCTCTCCTCCCTGCTAACGACTCC AGCAGGGCCCCCAGCTCAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGCCCTG GGCACGCTGACCACTGTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGCCCCACCAAGCGCAGCACCCTGGCCCCGGGATTGTTGTGG TGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGACAACTTGGTCAAGGGTCCTGAAGAACTC CCCACTGGAAACAAGAAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGGGCAGAAGGAGCTGGAGGGGGCTGGC TCTTGGACCCCCTGTGTTGGACATGATGGTGGTCGAGACCAGCAGGAGACAAACCTCTGAGGACAGGGCCAGCCGCGGGACTGACACCCT GGGATGGAACCTCAGGATGGGCCAAACCCAGACAACGGGCCCATGGCCTTGGGCTCTGATTGGCTGGATTGCCTTGTATGCAAATGAGTT CAGGACTACAATACCCTACCCTATGGGGAGGCCCTGCCTCCGGGAGGTCATTTTTTAAATCCAGCCCCTTGCTTCAACCGTCCCCAGTAT TAGACGCTGCAGCCCTGACGGCTCCCCCCAAATAAGGCTGGGTTTTTCTCTCTCTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCA TGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGCTCAAGTGATTCTCCTGCCTCAGC CTCTTGAGTAGCTGGGATTGTAGGTGCCCACCACCATGCCCAGCCAACTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTC AGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGTTACAGGCGTAAGCTACCATGCCCAGCC TACCGTTTTTCTCAATCTATAATAGAAAGCCACCACGCCCAGGTAATTTTTGTAATTTTGTATTTTTGTAGAGACGGGGTTTTGCCATGT TGGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATCCTCCTGCCTTGGCCTCCCAAAGGGCTGGGATTACAGGGGTGAGCCACCGCGC CCCACCTCTTTCTTATTTTCTTCCTGGGATTGGGGAGGGGATGATTCAGACCCCACATGGCCTCCAACCTTGGCCCACACACCTGCCATG GCTCCCATCATCCTGAGCATGCTAGCGTCCCCTCCTCACCTGACAATGGAGGCTCTCGAATTGGGTTGTGTCCCCCCAAAATTTATGTCT ACCCAGAACCTCAGAACATGAGCTTACTTGGAAATAGGGTCTTTGCAGGTGTAACTGGTTAAATTAAAAGAGGTATTACTGGAGGAGGAT GGATGAATCCAGTGACTGGTTCCTCATATGAAGTAGAGAAGAGATGCAGAGAAACACATGGGGAAGATGCCACGTGAAGACAGAGGCAGT GGTTGGATCAATGCATCTACGAGTCGGAGAACCCAAGGATTGCCAGCAACAACCAGAAATCAGGAGGGGGGCATGAGATGCATTATTTCT TAGAGCCTTTAGAGGGAACATGGCCCTACTGACACCTTGATGTCAGACTTCTGGCTGCTAGAACTGTCAGAGAATAAATTTCTGTTGTTT |
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FusionGenePPI for SSBP4_SLC5A5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SSBP4 | LDB1, IL36RN, ISL1, TFAP2B, LDB2, TRIM33, MOV10, LMX1B, IDI2, SSBP2, LHX1, MBNL1, ISL2, SSBP3, LHX8, LMO4, GM2A, LHX4, LHX9, LHX6, PIN1, LMO2 | SLC5A5 | SLC5A5, ERBB2IP, ORMDL2, SFXN5, SLC19A2, VSIG8, TUBB3, ATL3, CTU2, ARL5B, YIPF3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SSBP4_SLC5A5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SSBP4_SLC5A5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SLC5A5 | C1848805 | Thyroid Dyshormonogenesis 1 | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | SLC5A5 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | SLC5A5 | C0040136 | Thyroid Neoplasm | 2 | CTD_human |
| Tgene | SLC5A5 | C2239176 | Liver carcinoma | 2 | CTD_human |
| Tgene | SLC5A5 | C0017638 | Glioma | 1 | CTD_human |
| Tgene | SLC5A5 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | SLC5A5 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | SLC5A5 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
| Tgene | SLC5A5 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | SLC5A5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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