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Fusion gene ID: 36132 |
FusionGeneSummary for SSBP3_SLC27A4 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SSBP3_SLC27A4 | Fusion gene ID: 36132 | Hgene | Tgene | Gene symbol | SSBP3 | SLC27A4 | Gene ID | 23648 | 10999 |
Gene name | single stranded DNA binding protein 3 | solute carrier family 27 member 4 | |
Synonyms | CSDP|SSDP|SSDP1 | ACSVL4|FATP4|IPS | |
Cytomap | 1p32.3 | 9q34.11 | |
Type of gene | protein-coding | protein-coding | |
Description | single-stranded DNA-binding protein 3sequence-specific single-stranded-DNA-binding protein | long-chain fatty acid transport protein 4solute carrier family 27 (fatty acid transporter), member 4 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9BWW4 | Q6P1M0 | |
Ensembl transtripts involved in fusion gene | ENST00000326956, ENST00000417664, ENST00000371320, ENST00000371319, ENST00000357475, | ENST00000372870, ENST00000300456, | |
Fusion gene scores | * DoF score | 7 X 5 X 3=105 | 3 X 3 X 3=27 |
# samples | 7 | 3 | |
** MAII score | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SSBP3 [Title/Abstract] AND SLC27A4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SLC27A4 | GO:0001676 | long-chain fatty acid metabolic process | 22022213 |
Tgene | SLC27A4 | GO:0044539 | long-chain fatty acid import | 22022213 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU623643 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000326956 | ENST00000372870 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
intron-3UTR | ENST00000326956 | ENST00000300456 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
intron-3UTR | ENST00000417664 | ENST00000372870 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
intron-3UTR | ENST00000417664 | ENST00000300456 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
intron-3UTR | ENST00000371320 | ENST00000372870 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
intron-3UTR | ENST00000371320 | ENST00000300456 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
intron-3UTR | ENST00000371319 | ENST00000372870 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
intron-3UTR | ENST00000371319 | ENST00000300456 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
intron-3UTR | ENST00000357475 | ENST00000372870 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
intron-3UTR | ENST00000357475 | ENST00000300456 | SSBP3 | chr1 | 54692389 | + | SLC27A4 | chr9 | 131123242 | - |
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FusionProtFeatures for SSBP3_SLC27A4 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SSBP3 | SLC27A4 |
May be involved in transcription regulation of the alpha2(I) collagen gene where it binds to the single-strandedpolypyrimidine sequences in the promoter region. {ECO:0000250}. | Involved in translocation of long-chain fatty acids(LFCA) across the plasma membrane. Appears to be the principalfatty acid transporter in small intestinal enterocytes. Plays arole in the formation of the epidermal barrier. Required for fatabsorption in early embryogenesis. Has acyl-CoA ligase activityfor long-chain and very-long-chain fatty acids (VLCFAs).Indirectly inhibits RPE65 via substrate competition and viaproduction of VLCFA derivatives like lignoceroyl-CoA. Preventslight-induced degeneration of rods and cones (By similarity).{ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SSBP3_SLC27A4 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SSBP3_SLC27A4 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SSBP3_SLC27A4 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SSBP3_SLC27A4 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SLC27A4 | C1837610 | ICHTHYOSIS PREMATURITY SYNDROME | 2 | CTD_human;ORPHANET;UNIPROT |