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Fusion gene ID: 36130 |
FusionGeneSummary for SSBP3_EIF4EBP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SSBP3_EIF4EBP2 | Fusion gene ID: 36130 | Hgene | Tgene | Gene symbol | SSBP3 | EIF4EBP2 | Gene ID | 23648 | 1979 |
| Gene name | single stranded DNA binding protein 3 | eukaryotic translation initiation factor 4E binding protein 2 | |
| Synonyms | CSDP|SSDP|SSDP1 | 4EBP2|PHASII | |
| Cytomap | 1p32.3 | 10q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | single-stranded DNA-binding protein 3sequence-specific single-stranded-DNA-binding protein | eukaryotic translation initiation factor 4E-binding protein 24E-BP2eIF4E-binding protein 2phosphorylated, heat and acid stable regulated by insulin protein II | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BWW4 | Q13542 | |
| Ensembl transtripts involved in fusion gene | ENST00000326956, ENST00000417664, ENST00000371320, ENST00000371319, ENST00000357475, | ENST00000373218, | |
| Fusion gene scores | * DoF score | 7 X 5 X 3=105 | 5 X 5 X 1=25 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SSBP3 [Title/Abstract] AND EIF4EBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI738781 | SSBP3 | chr1 | 54692683 | + | EIF4EBP2 | chr10 | 72183278 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000326956 | ENST00000373218 | SSBP3 | chr1 | 54692683 | + | EIF4EBP2 | chr10 | 72183278 | - |
| intron-3UTR | ENST00000417664 | ENST00000373218 | SSBP3 | chr1 | 54692683 | + | EIF4EBP2 | chr10 | 72183278 | - |
| intron-3UTR | ENST00000371320 | ENST00000373218 | SSBP3 | chr1 | 54692683 | + | EIF4EBP2 | chr10 | 72183278 | - |
| intron-3UTR | ENST00000371319 | ENST00000373218 | SSBP3 | chr1 | 54692683 | + | EIF4EBP2 | chr10 | 72183278 | - |
| intron-3UTR | ENST00000357475 | ENST00000373218 | SSBP3 | chr1 | 54692683 | + | EIF4EBP2 | chr10 | 72183278 | - |
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FusionProtFeatures for SSBP3_EIF4EBP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SSBP3 | EIF4EBP2 |
| May be involved in transcription regulation of the alpha2(I) collagen gene where it binds to the single-strandedpolypyrimidine sequences in the promoter region. {ECO:0000250}. | Repressor of translation initiation involved in synapticplasticity, learning and memory formation (By similarity).Regulates EIF4E activity by preventing its assembly into the eIF4Fcomplex: hypophosphorylated form of EIF4EBP2 competes withEIF4G1/EIF4G3 and strongly binds to EIF4E, leading to represstranslation. In contrast, hyperphosphorylated form dissociatesfrom EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E,leading to initiation of translation (PubMed:25533957). EIF4EBP2is enriched in brain and acts as a regulator of synapse activityand neuronal stem cell renewal via its ability to represstranslation initiation (By similarity). Mediates the regulation ofprotein translation by hormones, growth factors and other stimulithat signal through the MAP kinase and mTORC1 pathways (Bysimilarity). {ECO:0000250|UniProtKB:P70445,ECO:0000269|PubMed:25533957}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SSBP3_EIF4EBP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SSBP3_EIF4EBP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SSBP3_EIF4EBP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SSBP3_EIF4EBP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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