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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36121

FusionGeneSummary for SSBP2_ANKRD36C

check button Fusion gene summary
Fusion gene informationFusion gene name: SSBP2_ANKRD36C
Fusion gene ID: 36121
HgeneTgene
Gene symbol

SSBP2

ANKRD36C

Gene ID

23635

400986

Gene namesingle stranded DNA binding protein 2ankyrin repeat domain 36C
SynonymsHSPC116|SOSS-B2-
Cytomap

5q14.1

2q11.1

Type of geneprotein-codingprotein-coding
Descriptionsingle-stranded DNA-binding protein 2sequence-specific single-stranded-DNA-binding protein 2ankyrin repeat domain-containing protein 36Cprotein immuno-reactive with anti-PTH polyclonal antibodies
Modification date2018052320180403
UniProtAcc

P81877

Q5JPF3

Ensembl transtripts involved in fusion geneENST00000320672, ENST00000509053, 
ENST00000514493, ENST00000510060, 
ENST00000505980, ENST00000515395, 
ENST00000456556, ENST00000420871, 
ENST00000419039, ENST00000295246, 
Fusion gene scores* DoF score7 X 6 X 5=2101 X 1 X 1=1
# samples 71
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: SSBP2 [Title/Abstract] AND ANKRD36C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DR000829SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000320672ENST00000456556SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000320672ENST00000420871SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000320672ENST00000419039SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000320672ENST00000295246SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
Frame-shiftENST00000509053ENST00000456556SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000509053ENST00000420871SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000509053ENST00000419039SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000509053ENST00000295246SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
Frame-shiftENST00000514493ENST00000456556SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000514493ENST00000420871SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000514493ENST00000419039SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000514493ENST00000295246SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
intron-3CDSENST00000510060ENST00000456556SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
intron-intronENST00000510060ENST00000420871SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
intron-intronENST00000510060ENST00000419039SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
intron-intronENST00000510060ENST00000295246SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
Frame-shiftENST00000505980ENST00000456556SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000505980ENST00000420871SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000505980ENST00000419039SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000505980ENST00000295246SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
Frame-shiftENST00000515395ENST00000456556SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000515395ENST00000420871SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000515395ENST00000419039SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-
5CDS-intronENST00000515395ENST00000295246SSBP2chr5

80911292

-ANKRD36Cchr2

96628295

-

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FusionProtFeatures for SSBP2_ANKRD36C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSBP2

P81877

ANKRD36C

Q5JPF3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SSBP2_ANKRD36C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSBP2_ANKRD36C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SSBP2EWSR1, LDB1, IL36RN, TAL1, LMO2, TRIM33, DYRK2, CDK6, BAG3, TOM1, LDB2, LMX1B, IDI2, ISL2, ISL1, SSBP4, SSBP3, CLEC18A, LMO4, LHX4, LHX6, PIN1, ARHGAP22, ARHGEF10, CAMK2AANKRD36C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SSBP2_ANKRD36C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SSBP2_ANKRD36C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSSBP2C0033578Prostatic Neoplasms1CTD_human