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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36108

FusionGeneSummary for SS18_NRAS

check button Fusion gene summary
Fusion gene informationFusion gene name: SS18_NRAS
Fusion gene ID: 36108
HgeneTgene
Gene symbol

SS18

NRAS

Gene ID

6760

4893

Gene nameSS18, nBAF chromatin remodeling complex subunitNRAS proto-oncogene, GTPase
SynonymsSSXT|SYTALPS4|CMNS|N-ras|NCMS|NRAS1|NS6
Cytomap

18q11.2

1p13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein SSXTsynovial sarcoma translocated to X chromosome proteinsynovial sarcoma translocation, chromosome 18synovial sarcoma, translocated to X chromosomeGTPase NRasN-ras protein part 4neuroblastoma RAS viral (v-ras) oncogene homologneuroblastoma RAS viral oncogene homologtransforming protein N-Rasv-ras neuroblastoma RAS viral oncogene homolog
Modification date2018052320180527
UniProtAcc

Q15532

P01111

Ensembl transtripts involved in fusion geneENST00000415083, ENST00000542420, 
ENST00000542743, ENST00000539849, 
ENST00000269137, ENST00000545952, 
ENST00000585241, 
ENST00000369535, 
Fusion gene scores* DoF score13 X 16 X 6=12481 X 1 X 1=1
# samples 371
** MAII scorelog2(37/1248*10)=-1.75402075834594
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: SS18 [Title/Abstract] AND NRAS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSS18

GO:0045944

positive regulation of transcription by RNA polymerase II

15919756


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG896663SS18chr18

23597748

-NRASchr1

115247345

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000415083ENST00000369535SS18chr18

23597748

-NRASchr1

115247345

-
intron-3UTRENST00000542420ENST00000369535SS18chr18

23597748

-NRASchr1

115247345

-
intron-3UTRENST00000542743ENST00000369535SS18chr18

23597748

-NRASchr1

115247345

-
intron-3UTRENST00000539849ENST00000369535SS18chr18

23597748

-NRASchr1

115247345

-
intron-3UTRENST00000269137ENST00000369535SS18chr18

23597748

-NRASchr1

115247345

-
intron-3UTRENST00000545952ENST00000369535SS18chr18

23597748

-NRASchr1

115247345

-
intron-3UTRENST00000585241ENST00000369535SS18chr18

23597748

-NRASchr1

115247345

-

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FusionProtFeatures for SS18_NRAS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SS18

Q15532

NRAS

P01111

Appears to function synergistically with RBM14 as atranscriptional coactivator. Isoform 1 and isoform 2 function innuclear receptor coactivation. Isoform 1 and isoform 2 function ingeneral transcriptional coactivation.{ECO:0000269|PubMed:15919756}. Ras proteins bind GDP/GTP and possess intrinsic GTPaseactivity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SS18_NRAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SS18_NRAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SS18_NRAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SS18_NRAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSS18C0039101synovial sarcoma1CTD_human;ORPHANET
TgeneNRASC1842036GIANT PIGMENTED HAIRY NEVUS6HPO;ORPHANET;UNIPROT
TgeneNRASC0025202melanoma5CTD_human;HPO
TgeneNRASC0334082NEVUS, EPIDERMAL (disorder)2UNIPROT
TgeneNRASC0349639Juvenile Myelomonocytic Leukemia2CTD_human;ORPHANET;UNIPROT
TgeneNRASC2674723RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER2ORPHANET;UNIPROT
TgeneNRASC0023487Acute Promyelocytic Leukemia1CTD_human
TgeneNRASC0024299Lymphoma1CTD_human;HPO
TgeneNRASC0027659Neoplasms, Experimental1CTD_human
TgeneNRASC0027819Neuroblastoma1CTD_human
TgeneNRASC0028326Noonan Syndrome1CTD_human;ORPHANET
TgeneNRASC0034885Rectal Neoplasms1CTD_human
TgeneNRASC0079731B-Cell Lymphomas1CTD_human
TgeneNRASC0206729Neurofibrosarcoma1CTD_human
TgeneNRASC1328840Autoimmune Lymphoproliferative Syndrome1CTD_human
TgeneNRASC1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human
TgeneNRASC2750732Noonan Syndrome 61CTD_human;UNIPROT
TgeneNRASC2931367Thyroid cancer, follicular1CTD_human