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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36102

FusionGeneSummary for SRXN1_SRXN1

check button Fusion gene summary
Fusion gene informationFusion gene name: SRXN1_SRXN1
Fusion gene ID: 36102
HgeneTgene
Gene symbol

SRXN1

SRXN1

Gene ID

140809

140809

Gene namesulfiredoxin 1sulfiredoxin 1
SynonymsC20orf139|Npn3|SRX|SRX1C20orf139|Npn3|SRX|SRX1
Cytomap

20p13

20p13

Type of geneprotein-codingprotein-coding
Descriptionsulfiredoxin-1sulfiredoxin-1
Modification date2018052320180523
UniProtAcc

Q9BYN0

Q9BYN0

Ensembl transtripts involved in fusion geneENST00000381962, ENST00000381962, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: SRXN1 [Title/Abstract] AND SRXN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRXN1

GO:0006979

response to oxidative stress

15448164

TgeneSRXN1

GO:0006979

response to oxidative stress

15448164


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU608361SRXN1chr20

627566

+SRXN1chr20

627636

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000381962ENST00000381962SRXN1chr20

627566

+SRXN1chr20

627636

-

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FusionProtFeatures for SRXN1_SRXN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRXN1

Q9BYN0

SRXN1

Q9BYN0

Contributes to oxidative stress resistance by reducingcysteine-sulfinic acid formed under exposure to oxidants in theperoxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act onPRDX5 or PRDX6. May catalyze the reduction in a multi-step processby acting both as a specific phosphotransferase and athioltransferase. {ECO:0000269|PubMed:15448164,ECO:0000269|PubMed:15590625}. Contributes to oxidative stress resistance by reducingcysteine-sulfinic acid formed under exposure to oxidants in theperoxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act onPRDX5 or PRDX6. May catalyze the reduction in a multi-step processby acting both as a specific phosphotransferase and athioltransferase. {ECO:0000269|PubMed:15448164,ECO:0000269|PubMed:15590625}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SRXN1_SRXN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SRXN1_SRXN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRXN1_SRXN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRXN1_SRXN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource