FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36096

FusionGeneSummary for SRSF5_SLITRK2

check button Fusion gene summary
Fusion gene informationFusion gene name: SRSF5_SLITRK2
Fusion gene ID: 36096
HgeneTgene
Gene symbol

SRSF5

SLITRK2

Gene ID

6430

84631

Gene nameserine and arginine rich splicing factor 5SLIT and NTRK like family member 2
SynonymsHRS|SFRS5|SRP40CXorf1|CXorf2|SLITL1|TMEM257
Cytomap

14q24.1

Xq27.3

Type of geneprotein-codingprotein-coding
Descriptionserine/arginine-rich splicing factor 5SR splicing factor 5delayed-early protein HRSpre-mRNA-splicing factor SRP40splicing factor, arginine/serine-rich 5SLIT and NTRK-like protein 2slit and trk like gene 2slit-like 1transmembrane protein 257
Modification date2018052320180523
UniProtAcc

Q13243

Q9H156

Ensembl transtripts involved in fusion geneENST00000553521, ENST00000394366, 
ENST00000553548, ENST00000557154, 
ENST00000451983, ENST00000553635, 
ENST00000556587, ENST00000555349, 
ENST00000554021, 
ENST00000447897, 
ENST00000370490, ENST00000434188, 
ENST00000428560, ENST00000413937, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: SRSF5 [Title/Abstract] AND SLITRK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA497174SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000553521ENST00000447897SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553521ENST00000370490SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553521ENST00000434188SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553521ENST00000428560SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553521ENST00000413937SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000394366ENST00000447897SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000394366ENST00000370490SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000394366ENST00000434188SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000394366ENST00000428560SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000394366ENST00000413937SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553548ENST00000447897SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553548ENST00000370490SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553548ENST00000434188SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553548ENST00000428560SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553548ENST00000413937SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000557154ENST00000447897SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000557154ENST00000370490SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000557154ENST00000434188SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000557154ENST00000428560SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000557154ENST00000413937SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000451983ENST00000447897SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000451983ENST00000370490SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000451983ENST00000434188SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000451983ENST00000428560SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000451983ENST00000413937SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553635ENST00000447897SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553635ENST00000370490SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553635ENST00000434188SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553635ENST00000428560SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000553635ENST00000413937SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
3UTR-5UTRENST00000556587ENST00000447897SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
3UTR-5UTRENST00000556587ENST00000370490SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
3UTR-5UTRENST00000556587ENST00000434188SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
3UTR-5UTRENST00000556587ENST00000428560SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
3UTR-5UTRENST00000556587ENST00000413937SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000555349ENST00000447897SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000555349ENST00000370490SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000555349ENST00000434188SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000555349ENST00000428560SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000555349ENST00000413937SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000554021ENST00000447897SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000554021ENST00000370490SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000554021ENST00000434188SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000554021ENST00000428560SRSF5chr14

70234945

+SLITRK2chrX

144903210

+
5CDS-5UTRENST00000554021ENST00000413937SRSF5chr14

70234945

+SLITRK2chrX

144903210

+

Top

FusionProtFeatures for SRSF5_SLITRK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRSF5

Q13243

SLITRK2

Q9H156

Plays a role in constitutive splicing and can modulatethe selection of alternative splice sites. It is involved in synaptogenesis and promotes excitatorysynapse differentiation (PubMed:27273464, PubMed:27812321).Suppresses neurite outgrowth (By similarity).{ECO:0000250|UniProtKB:Q810C0, ECO:0000269|PubMed:27273464,ECO:0000269|PubMed:27812321}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SRSF5_SLITRK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SRSF5_SLITRK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SRSF5_SLITRK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SRSF5_SLITRK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRSF5C0023895Liver diseases1CTD_human
HgeneSRSF5C0235032Neurotoxicity Syndromes1CTD_human
TgeneSLITRK2C0015923Fetal Alcohol Syndrome1PSYGENET
TgeneSLITRK2C2985290Fetal Alcohol Spectrum Disorders1PSYGENET