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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36055

FusionGeneSummary for SRRM1_FAU

check button Fusion gene summary
Fusion gene informationFusion gene name: SRRM1_FAU
Fusion gene ID: 36055
HgeneTgene
Gene symbol

SRRM1

FAU

Gene ID

10250

2197

Gene nameserine and arginine repetitive matrix 1FAU, ubiquitin like and ribosomal protein S30 fusion
Synonyms160-KD|POP101|SRM160FAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1
Cytomap

1p36.11

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionserine/arginine repetitive matrix protein 1SR-related nuclear matrix protein of 160 kDaSer/Arg-related nuclear matrix proteinserine/arginine repetitive matrix 1ubiquitin-like protein fubi and ribosomal protein S3040S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monoclo
Modification date2018052220180522
UniProtAcc

Q8IYB3

P62861

Ensembl transtripts involved in fusion geneENST00000323848, ENST00000447431, 
ENST00000374389, ENST00000479034, 
ENST00000537199, 
ENST00000529639, 
ENST00000531743, ENST00000525297, 
ENST00000527548, ENST00000279259, 
ENST00000529259, ENST00000434372, 
Fusion gene scores* DoF score8 X 10 X 3=2407 X 6 X 2=84
# samples 107
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRRM1 [Title/Abstract] AND FAU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A6E1-01ASRRM1chr1

24974293

+FAUchr11

64888246

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000323848ENST00000529639SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000323848ENST00000531743SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000323848ENST00000525297SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000323848ENST00000527548SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000323848ENST00000279259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3UTRENST00000323848ENST00000529259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-intronENST00000323848ENST00000434372SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000447431ENST00000529639SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000447431ENST00000531743SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000447431ENST00000525297SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000447431ENST00000527548SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000447431ENST00000279259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3UTRENST00000447431ENST00000529259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-intronENST00000447431ENST00000434372SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000374389ENST00000529639SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000374389ENST00000531743SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000374389ENST00000525297SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000374389ENST00000527548SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000374389ENST00000279259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3UTRENST00000374389ENST00000529259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-intronENST00000374389ENST00000434372SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000479034ENST00000529639SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000479034ENST00000531743SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000479034ENST00000525297SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000479034ENST00000527548SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000479034ENST00000279259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3UTRENST00000479034ENST00000529259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-intronENST00000479034ENST00000434372SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000537199ENST00000529639SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000537199ENST00000531743SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000537199ENST00000525297SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000537199ENST00000527548SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3CDSENST00000537199ENST00000279259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-3UTRENST00000537199ENST00000529259SRRM1chr1

24974293

+FAUchr11

64888246

-
intron-intronENST00000537199ENST00000434372SRRM1chr1

24974293

+FAUchr11

64888246

-

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FusionProtFeatures for SRRM1_FAU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRRM1

Q8IYB3

FAU

P62861

Part of pre- and post-splicing multiprotein mRNPcomplexes. Involved in numerous pre-mRNA processing events.Promotes constitutive and exonic splicing enhancer (ESE)-dependentsplicing activation by bridging together sequence-specific (SRfamily proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP(SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA3'-end cleavage independently of the formation of an exon junctioncomplex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream ofexon-exon junctions. Binds RNA and DNA with low sequencespecificity and has similar preference for either double- orsingle-stranded nucleic acid substrates.{ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804,ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940,ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SRRM1_FAU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SRRM1_FAU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SRRM1RNPS1, FUS, DEK, SRRM2, SRSF4, SRSF5, CDC5L, SMC1A, RAD21, SMC3, SRSF6, GTF2F1, SNRPB, RBMX, PTBP1, HNRNPM, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPC, RBM25, SF3B2, SNRPA1, SNRPB2, SF3B3, SF3B4, EFTUD2, PRPF8, SNRNP200, SNRNP40, PRPF3, PNN, PRPF19, RBM8A, PLRG1, SRSF3, RBM23, SRSF2, SRSF7, DDX5, DHX16, NONO, SFPQ, DNAJC8, SNW1, KHDRBS1, PRPF40A, PCF11, CSTF2, ZC3H14, FUBP1, PUF60, BCLAF1, PAXIP1, GTF2I, OLIG2, KMT2D, ASH2L, NCOA5, CNOT3, RBM39, STAG2, WAPAL, SAP18, HIST2H2AA3, SMARCC2, CHD4, CBX3, SAFB, EIF3H, EIF4A3, EEF1A1, RPS5, RPS7, RPS19, DDX21, YBX3, ACIN1, NRP1, OGFR, LMNA, DNAJA1, CSNK2B, CRYBB3, CCT5, NES, TOP2B, SOS1, CNGB1, DPY30, ASB7, ISY1, PPIL1, PDS5A, ZNF638, TADA2A, YWHAG, ELAVL1, SF3A2, SIRT7, SH3KBP1, CUL3, CAND1, ALYREF, UPF3A, GRK5, HTATSF1, RBM14, ESR1, BARD1, MAGOH, CSNK2A1, ABI1, SPOP, SRPK2, SRPK3, PIN1, CSNK2A2, LIN28A, CLK2, OBSL1, RPL14, ZNF22, TRA2A, NIFK, LUC7L, ILF2, EPB41L3, ZMYND11, DHX15, GTF2E1, NOLC1, NUMA1, RANBP2, EIF3I, PAF1, SUPT16H, NTRK1, IFI16, MED4, MED23, EWSR1, CLK1, SNCA, VPS18, MYH7B, U2AF2, EGFR, P4HA3, HIST1H1T, RBM34, ZC3H18, CDX1, PDGFB, RPL18A, C11orf57, NCL, CD2BP2FAUCOPS6, CUL3, CUL1, COPS5, CAND1, RPS16, RPS23, RPS17, RPS26, RPS2, RPS6, RPL5, RPS13, RPL23A, RPS9, RPL27A, RPL13, FN1, GRB2, IL7R, CD81, IGSF8, ICAM1, TAF7, BYSL, DYNLL1, HDLBP, RPL18, RPS29, WIBG, G3BP1, RPSA, PA2G4, PNO1, PTBP1, RPS15A, RPS18, RPS19, RPS20, RPS24, RPS25, RPS27, RPS27L, RPS28, RPS3, RPS4X, RPS7, SPTAN1, TSR1, TP53, RPL11, RPS12, SERBP1, RPL12, RPS15, AHSA1, NPM1, RC3H1, EIF2S2, EIF3A, RPL32, PRPF3, PRPF4, ALYREF, CYLD, TRIM25, HEY1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRRM1_FAU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRRM1_FAU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource