|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 36043 |
FusionGeneSummary for SRPK2_PRKAR2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SRPK2_PRKAR2B | Fusion gene ID: 36043 | Hgene | Tgene | Gene symbol | SRPK2 | PRKAR2B | Gene ID | 6733 | 5577 |
| Gene name | SRSF protein kinase 2 | protein kinase cAMP-dependent type II regulatory subunit beta | |
| Synonyms | SFRSK2 | PRKAR2|RII-BETA | |
| Cytomap | 7q22.3 | 7q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2 | cAMP-dependent protein kinase type II-beta regulatory subunitH_RG363E19.2WUGSC:H_RG363E19.2cAMP-dependent protein kinase type II-beta regulatory chainprotein kinase, cAMP-dependent, regulatory subunit type II betaprotein kinase, cAMP-dependent, regul | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P78362 | P31323 | |
| Ensembl transtripts involved in fusion gene | ENST00000393651, ENST00000357311, ENST00000489828, ENST00000493638, | ENST00000265717, ENST00000393613, | |
| Fusion gene scores | * DoF score | 11 X 6 X 10=660 | 5 X 3 X 5=75 |
| # samples | 19 | 5 | |
| ** MAII score | log2(19/660*10)=-1.79646660591487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SRPK2 [Title/Abstract] AND PRKAR2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SRPK2 | GO:0000245 | spliceosomal complex assembly | 9472028 |
| Hgene | SRPK2 | GO:0006468 | protein phosphorylation | 9472028 |
| Hgene | SRPK2 | GO:0008284 | positive regulation of cell proliferation | 18559500 |
| Hgene | SRPK2 | GO:0008380 | RNA splicing | 9472028 |
| Hgene | SRPK2 | GO:0035556 | intracellular signal transduction | 9472028 |
| Hgene | SRPK2 | GO:0045070 | positive regulation of viral genome replication | 20498328 |
| Hgene | SRPK2 | GO:0045071 | negative regulation of viral genome replication | 12417631 |
| Tgene | PRKAR2B | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 21812984 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-5P-A9JZ-01A | SRPK2 | chr7 | 104800954 | - | PRKAR2B | chr7 | 106791367 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393651 | ENST00000265717 | SRPK2 | chr7 | 104800954 | - | PRKAR2B | chr7 | 106791367 | + |
| 5CDS-intron | ENST00000393651 | ENST00000393613 | SRPK2 | chr7 | 104800954 | - | PRKAR2B | chr7 | 106791367 | + |
| In-frame | ENST00000357311 | ENST00000265717 | SRPK2 | chr7 | 104800954 | - | PRKAR2B | chr7 | 106791367 | + |
| 5CDS-intron | ENST00000357311 | ENST00000393613 | SRPK2 | chr7 | 104800954 | - | PRKAR2B | chr7 | 106791367 | + |
| Frame-shift | ENST00000489828 | ENST00000265717 | SRPK2 | chr7 | 104800954 | - | PRKAR2B | chr7 | 106791367 | + |
| 5CDS-intron | ENST00000489828 | ENST00000393613 | SRPK2 | chr7 | 104800954 | - | PRKAR2B | chr7 | 106791367 | + |
| intron-3CDS | ENST00000493638 | ENST00000265717 | SRPK2 | chr7 | 104800954 | - | PRKAR2B | chr7 | 106791367 | + |
| intron-intron | ENST00000493638 | ENST00000393613 | SRPK2 | chr7 | 104800954 | - | PRKAR2B | chr7 | 106791367 | + |
Top |
FusionProtFeatures for SRPK2_PRKAR2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SRPK2 | PRKAR2B |
| Serine/arginine-rich protein-specific kinase whichspecifically phosphorylates its substrates at serine residueslocated in regions rich in arginine/serine dipeptides, known as RSdomains and is involved in the phosphorylation of SR splicingfactors and the regulation of splicing. Promotes neuronalapoptosis by up-regulating cyclin-D1 (CCND1) expression. This isdone by the phosphorylation of SRSF2, leading to the suppressionof p53/TP53 phosphorylation thereby relieving the repressiveeffect of p53/TP53 on cyclin-D1 (CCND1) expression. PhosphorylatesACIN1, and redistributes it from the nuclear speckles to thenucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complexformation via the phosphorylation of DDX23/PRP28. Can mediatehepatitis B virus (HBV) core protein phosphorylation. Plays anegative role in the regulation of HBV replication through amechanism not involving the phosphorylation of the core proteinbut by reducing the packaging efficiency of the pregenomic RNA(pgRNA) without affecting the formation of the viral coreparticles. {ECO:0000269|PubMed:12134018,ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142,ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491,ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21157427,ECO:0000269|PubMed:9472028}. | Regulatory subunit of the cAMP-dependent protein kinasesinvolved in cAMP signaling in cells. Type II regulatory chainsmediate membrane association by binding to anchoring proteins,including the MAP2 kinase. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SRPK2 | chr7:104800954 | chr7:106791367 | ENST00000357311 | - | 6 | 15 | 87_95 | 196 | 689 | Nucleotide binding | ATP |
| Hgene | SRPK2 | chr7:104800954 | chr7:106791367 | ENST00000393651 | - | 7 | 16 | 87_95 | 207 | 700 | Nucleotide binding | ATP |
| Hgene | SRPK2 | chr7:104800954 | chr7:106791367 | ENST00000489828 | - | 8 | 17 | 87_95 | 196 | 689 | Nucleotide binding | ATP |
| Tgene | >PRKAR2B | chr7:104800954 | chr7:106791367 | ENST00000265717 | + | 5 | 11 | 276_418 | 247 | 419 | Nucleotide binding | Note=cAMP 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SRPK2 | chr7:104800954 | chr7:106791367 | ENST00000357311 | - | 6 | 15 | 81_684 | 196 | 689 | Domain | Protein kinase |
| Hgene | >SRPK2 | chr7:104800954 | chr7:106791367 | ENST00000393651 | - | 7 | 16 | 81_684 | 207 | 700 | Domain | Protein kinase |
| Hgene | >SRPK2 | chr7:104800954 | chr7:106791367 | ENST00000489828 | - | 8 | 17 | 81_684 | 196 | 689 | Domain | Protein kinase |
| Tgene | PRKAR2B | chr7:104800954 | chr7:106791367 | ENST00000265717 | + | 5 | 11 | 154_275 | 247 | 419 | Nucleotide binding | Note=cAMP 1 |
| Tgene | PRKAR2B | chr7:104800954 | chr7:106791367 | ENST00000265717 | + | 5 | 11 | 2_153 | 247 | 419 | Region | Note=Dimerization and phosphorylation |
Top |
FusionGeneSequence for SRPK2_PRKAR2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SRPK2_ENST00000393651_chr7_104800954_-_PRKAR2B_ENST00000265717_chr7_106791367_+_379aa MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNG RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL GHHLLKWIIKSNYQGLPVRCVKSIIRQDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSA DSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYE >In-frame_SRPK2_ENST00000357311_chr7_104800954_-_PRKAR2B_ENST00000265717_chr7_106791367_+_368aa MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWG HFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS NYQGLPVRCVKSIIRQDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEV KITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SRPK2_ENST00000393651_chr7_104800954_-_PRKAR2B_ENST00000265717_chr7_106791367_+_1137nt ATGAGCTCCCGGAAAGTGCTGGCCATTCAGGCCCGAAAGCGGAGGCCGAAAAGAGAGAAACATCCGAAAAAGCCGGAGCCTCAACAGAAA GCTCCTTTAGTTCCTCCTCCTCCACCGCCACCACCACCACCACCGCCACCTTTGCCAGACCCCACACCCCCGGAGCCAGAGGAGGAGATC CTGGGATCAGATGATGAGGAGCAAGAGGACCCTGCGGACTACTGCAAAGGTGGATATCATCCAGTGAAAATTGGAGACCTCTTCAATGGC CGGTATCATGTTATTAGAAAGCTTGGATGGGGGCACTTCTCTACTGTCTGGCTGTGCTGGGATATGCAGGGGAAAAGATTTGTTGCAATG AAAGTTGTAAAAAGTGCCCAGCATTATACGGAGACAGCCTTGGATGAAATAAAATTGCTCAAATGTGTTCGAGAAAGTGATCCCAGTGAC CCAAACAAAGACATGGTGGTCCAGCTCATTGACGACTTCAAGATTTCAGGCATGAATGGGATACATGTCTGCATGGTCTTCGAAGTACTT GGCCACCATCTCCTCAAGTGGATCATCAAATCCAACTATCAAGGCCTCCCAGTACGTTGTGTGAAGAGTATCATTCGACAGGACAGGGTA ACCTTCAGGAGAATAATTGTGAAAAACAATGCCAAAAAGAGAAAAATGTATGAAAGCTTTATTGAGTCACTGCCATTCCTTAAATCTTTG GAGTTTTCTGAACGCCTGAAAGTAGTAGATGTGATAGGCACCAAAGTATACAACGATGGAGAACAAATCATTGCTCAGGGAGATTCGGCT GATTCTTTTTTCATTGTAGAATCTGGAGAAGTGAAAATTACTATGAAAAGAAAGGGTAAATCAGAAGTGGAAGAGAATGGTGCAGTAGAA ATCGCTCGATGCTCGCGGGGACAGTACTTTGGAGAGCTTGCCCTGGTAACTAACAAACCTCGAGCAGCTTCTGCCCACGCCATTGGGACT GTCAAATGTTTAGCAATGGATGTGCAAGCATTTGAAAGGCTTCTGGGACCTTGCATGGAAATTATGAAAAGGAACATCGCTACCTATGAA >In-frame_SRPK2_ENST00000357311_chr7_104800954_-_PRKAR2B_ENST00000265717_chr7_106791367_+_1104nt ATGTCAGTTAACTCTGAGAAGTCGTCCTCTTCAGAAAGGCCGGAGCCTCAACAGAAAGCTCCTTTAGTTCCTCCTCCTCCACCGCCACCA CCACCACCACCGCCACCTTTGCCAGACCCCACACCCCCGGAGCCAGAGGAGGAGATCCTGGGATCAGATGATGAGGAGCAAGAGGACCCT GCGGACTACTGCAAAGGTGGATATCATCCAGTGAAAATTGGAGACCTCTTCAATGGCCGGTATCATGTTATTAGAAAGCTTGGATGGGGG CACTTCTCTACTGTCTGGCTGTGCTGGGATATGCAGGGGAAAAGATTTGTTGCAATGAAAGTTGTAAAAAGTGCCCAGCATTATACGGAG ACAGCCTTGGATGAAATAAAATTGCTCAAATGTGTTCGAGAAAGTGATCCCAGTGACCCAAACAAAGACATGGTGGTCCAGCTCATTGAC GACTTCAAGATTTCAGGCATGAATGGGATACATGTCTGCATGGTCTTCGAAGTACTTGGCCACCATCTCCTCAAGTGGATCATCAAATCC AACTATCAAGGCCTCCCAGTACGTTGTGTGAAGAGTATCATTCGACAGGACAGGGTAACCTTCAGGAGAATAATTGTGAAAAACAATGCC AAAAAGAGAAAAATGTATGAAAGCTTTATTGAGTCACTGCCATTCCTTAAATCTTTGGAGTTTTCTGAACGCCTGAAAGTAGTAGATGTG ATAGGCACCAAAGTATACAACGATGGAGAACAAATCATTGCTCAGGGAGATTCGGCTGATTCTTTTTTCATTGTAGAATCTGGAGAAGTG AAAATTACTATGAAAAGAAAGGGTAAATCAGAAGTGGAAGAGAATGGTGCAGTAGAAATCGCTCGATGCTCGCGGGGACAGTACTTTGGA GAGCTTGCCCTGGTAACTAACAAACCTCGAGCAGCTTCTGCCCACGCCATTGGGACTGTCAAATGTTTAGCAATGGATGTGCAAGCATTT GAAAGGCTTCTGGGACCTTGCATGGAAATTATGAAAAGGAACATCGCTACCTATGAAGAACAGTTAGTTGCCCTGTTTGGAACGAACATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SRPK2_ENST00000393651_chr7_104800954_-_PRKAR2B_ENST00000265717_chr7_106791367_+_3454nt GGCGGAGCGAGTGGAGGCTGCAGCCCAGCTCGTCTCGGCGCCCGCGTCGCCGTCGCGAAGCCCCCCGCCCCGCTTCCGCCGCGTCGGAAT GAGCTCCCGGAAAGTGCTGGCCATTCAGGCCCGAAAGCGGAGGCCGAAAAGAGAGAAACATCCGAAAAAGCCGGAGCCTCAACAGAAAGC TCCTTTAGTTCCTCCTCCTCCACCGCCACCACCACCACCACCGCCACCTTTGCCAGACCCCACACCCCCGGAGCCAGAGGAGGAGATCCT GGGATCAGATGATGAGGAGCAAGAGGACCCTGCGGACTACTGCAAAGGTGGATATCATCCAGTGAAAATTGGAGACCTCTTCAATGGCCG GTATCATGTTATTAGAAAGCTTGGATGGGGGCACTTCTCTACTGTCTGGCTGTGCTGGGATATGCAGGGGAAAAGATTTGTTGCAATGAA AGTTGTAAAAAGTGCCCAGCATTATACGGAGACAGCCTTGGATGAAATAAAATTGCTCAAATGTGTTCGAGAAAGTGATCCCAGTGACCC AAACAAAGACATGGTGGTCCAGCTCATTGACGACTTCAAGATTTCAGGCATGAATGGGATACATGTCTGCATGGTCTTCGAAGTACTTGG CCACCATCTCCTCAAGTGGATCATCAAATCCAACTATCAAGGCCTCCCAGTACGTTGTGTGAAGAGTATCATTCGACAGGACAGGGTAAC CTTCAGGAGAATAATTGTGAAAAACAATGCCAAAAAGAGAAAAATGTATGAAAGCTTTATTGAGTCACTGCCATTCCTTAAATCTTTGGA GTTTTCTGAACGCCTGAAAGTAGTAGATGTGATAGGCACCAAAGTATACAACGATGGAGAACAAATCATTGCTCAGGGAGATTCGGCTGA TTCTTTTTTCATTGTAGAATCTGGAGAAGTGAAAATTACTATGAAAAGAAAGGGTAAATCAGAAGTGGAAGAGAATGGTGCAGTAGAAAT CGCTCGATGCTCGCGGGGACAGTACTTTGGAGAGCTTGCCCTGGTAACTAACAAACCTCGAGCAGCTTCTGCCCACGCCATTGGGACTGT CAAATGTTTAGCAATGGATGTGCAAGCATTTGAAAGGCTTCTGGGACCTTGCATGGAAATTATGAAAAGGAACATCGCTACCTATGAAGA ACAGTTAGTTGCCCTGTTTGGAACGAACATGGATATTGTTGAACCCACTGCATGAAGCAAAAGTATGGAGCAAGACCTGTAGTGACAAAA TTACACAGTAGTGGTTAGTCCACTGAGAATGTGTTTGTGTAGATGCCAAGCATTTTCTGTGATTTCAGGTTTTTTCCTTTTTTTACATTT ACAACGTATCAATAAACAGTAGTGATTTAATAGTCAATAGGCTTTAACATCACTTTCTAAAGAGTAGTTCATAAAAAAATCAACATACTG ATAAAATGACTTTGTACTCCACAAAATTATGACTGAAAGGTTTATTAAAATGATTGTAATATATAGAAAGTATCTGTGTTTAAGAAGATA ATTAAAGGATGTTATCATAGGCTATATGTGTTTTACTTATTCAGACTGATAATCATATTAGTGACTATCCCCATGTAAGAGGGCACTTGG CAATTAAACATGCTACACAGCATGGCATCACTTTTTTTTATAACTCATTAAACACAGTAAAATTTTAATCATTTTTGTTTTAAAGTTTTC TAGCTTGATAAGTTATGTGCTGGCCTTGGCCTATTGGTGAAATGGTATAAAATATCATATGCAGTTTTAAAACTTTTTATATTTTTGCAA TAAAGTACATTTTGACTTTGTTGGCATAATGTCAGTAACATACATATTCCAGTGGTTTTATGGACAGGCAATTTAGTCATTATGATAATA AGGAAAACAGTGTTTTAGATGAGAGATCATTAATGCATTTTTCCCTCATCAAGCATATATCTGCTTTTTTTTATTTTGCAATTCTCTGTA TTCTATGTCTTTAAAAATTTGATCTTGACATTTAATGTCACAAAGTTTTGTTTTTTTAAAAAGTGATTTAAACTTAAGATCCGACATTTT TTGTATTCTTTAAGATTTTACACCTAAAAAATCTCTCCTATCCCAAAAATAATGTGGGATCCTTATCAGCATGCCCACAGTTTATTTCTT TGTTCTTCACTAGGCCTGCATAATACAGTCCTATGTAGACATCTGTTCCCTTGGGTTTCCGTTCTTTCTTAGGATGGTTGCCAACCCACA ATCTCATTGATCAGCAGCCAATATGGGTTTGTTTGGTTTTTTTAATTCTTAAAAACATCCTCTAGAGGAATAGAAACAAATTTTTATGAG CATAACCCTATATAAAGACAAAATGAATTTCTGACCTTACCATATATACCATTAGGCCTTGCCATTGCTTTAATGTAGACTCATAGTTGA AATTAGTGCAGAAAGAACTCAGATGTACTAGATTTTCATTGTTCATTGATATGCTCAGTATGCTGCCACATAAGATGAATTTAATTATAT TCAACCAAAGCAATATACTCTTACATGATTTCTAGGCCCCATGACCCAGTGTCTAGAGACATTAATTCTAACCAGTTGTTTGCTTTTAAA TGAGTGATTTCATTTTGGGAAACAGGTTTCAAATGAATATATATACATGGGTAAAATTACTCTGTGCTAGTGTAGTCTTACTAGAGAATG TTTATGGTCCCACTTGTATATGAAAATGTGGTTAGAATGTTAATTGGATAATGTATATATAAGAAGTTAAAGTATGTAAAGTATAACTTC AGCCACATTTTTAGAACACTGTTTAACATTTTTGCAAAACCTTCTTGTAGGAAAAGAGAGCTCTCTACATGAAGATGACTTGTTTTATAT TTCAGATTTTATTTTAAAAGCCATGTCTGTTAAACAAGAAAAAACACAAAAGAACTCCAGATTCCTGGTTCATCATTCTGTATTCTTACT CACTTTTTCAAGTTATCTATTTTGTTGCATAAACTAATTGTTAACTATTCATGGAACAGCAAACGCCTGTTTAATAAAGAACTTTGACCA AGGCTATAAATGCCACGTACATTATTTTCAGTATTGTTGGTTATATTTAAATTTTCCTTACAATAAAGCACACTTTTATAATAAAATACA TGAATTATTGTTTTTCATACTTTTTTGCTTGTTTCTTTAAAGTTTTCTGACGTGCATAATGCATAATTCATTGAAAAGCATGATAGCAAT GTGGCATGTGGAAGCGAACCCCCAGGGCATAACATAGTAAGAAAGTATGGTTCTGTATGGCAATAGGTTTTTAAAATTATTAGCTATTCA TCATGTGTGGGAGAAATAATTGTGGTGTGTTGCAGATTTATTTGGCCATTTAGAATAACCAAATCAATCTGGCTAACTAGGAATTTATGT >In-frame_SRPK2_ENST00000357311_chr7_104800954_-_PRKAR2B_ENST00000265717_chr7_106791367_+_3505nt CCATTGAATCCCAGTCCTAACAGAAGTACTGCGAATCTTGTGGCCTCATTCTGAACAAAAGGGATTAGAGAAGAAAAATCTCTTGATATA AGGCTTGAAAGCAAGGGCAGGCAATCTTGGTTGTGAATATTTTCTGATTTTTCCAGAAATCAAGCAGAAGATTGAGCTGCTGATGTCAGT TAACTCTGAGAAGTCGTCCTCTTCAGAAAGGCCGGAGCCTCAACAGAAAGCTCCTTTAGTTCCTCCTCCTCCACCGCCACCACCACCACC ACCGCCACCTTTGCCAGACCCCACACCCCCGGAGCCAGAGGAGGAGATCCTGGGATCAGATGATGAGGAGCAAGAGGACCCTGCGGACTA CTGCAAAGGTGGATATCATCCAGTGAAAATTGGAGACCTCTTCAATGGCCGGTATCATGTTATTAGAAAGCTTGGATGGGGGCACTTCTC TACTGTCTGGCTGTGCTGGGATATGCAGGGGAAAAGATTTGTTGCAATGAAAGTTGTAAAAAGTGCCCAGCATTATACGGAGACAGCCTT GGATGAAATAAAATTGCTCAAATGTGTTCGAGAAAGTGATCCCAGTGACCCAAACAAAGACATGGTGGTCCAGCTCATTGACGACTTCAA GATTTCAGGCATGAATGGGATACATGTCTGCATGGTCTTCGAAGTACTTGGCCACCATCTCCTCAAGTGGATCATCAAATCCAACTATCA AGGCCTCCCAGTACGTTGTGTGAAGAGTATCATTCGACAGGACAGGGTAACCTTCAGGAGAATAATTGTGAAAAACAATGCCAAAAAGAG AAAAATGTATGAAAGCTTTATTGAGTCACTGCCATTCCTTAAATCTTTGGAGTTTTCTGAACGCCTGAAAGTAGTAGATGTGATAGGCAC CAAAGTATACAACGATGGAGAACAAATCATTGCTCAGGGAGATTCGGCTGATTCTTTTTTCATTGTAGAATCTGGAGAAGTGAAAATTAC TATGAAAAGAAAGGGTAAATCAGAAGTGGAAGAGAATGGTGCAGTAGAAATCGCTCGATGCTCGCGGGGACAGTACTTTGGAGAGCTTGC CCTGGTAACTAACAAACCTCGAGCAGCTTCTGCCCACGCCATTGGGACTGTCAAATGTTTAGCAATGGATGTGCAAGCATTTGAAAGGCT TCTGGGACCTTGCATGGAAATTATGAAAAGGAACATCGCTACCTATGAAGAACAGTTAGTTGCCCTGTTTGGAACGAACATGGATATTGT TGAACCCACTGCATGAAGCAAAAGTATGGAGCAAGACCTGTAGTGACAAAATTACACAGTAGTGGTTAGTCCACTGAGAATGTGTTTGTG TAGATGCCAAGCATTTTCTGTGATTTCAGGTTTTTTCCTTTTTTTACATTTACAACGTATCAATAAACAGTAGTGATTTAATAGTCAATA GGCTTTAACATCACTTTCTAAAGAGTAGTTCATAAAAAAATCAACATACTGATAAAATGACTTTGTACTCCACAAAATTATGACTGAAAG GTTTATTAAAATGATTGTAATATATAGAAAGTATCTGTGTTTAAGAAGATAATTAAAGGATGTTATCATAGGCTATATGTGTTTTACTTA TTCAGACTGATAATCATATTAGTGACTATCCCCATGTAAGAGGGCACTTGGCAATTAAACATGCTACACAGCATGGCATCACTTTTTTTT ATAACTCATTAAACACAGTAAAATTTTAATCATTTTTGTTTTAAAGTTTTCTAGCTTGATAAGTTATGTGCTGGCCTTGGCCTATTGGTG AAATGGTATAAAATATCATATGCAGTTTTAAAACTTTTTATATTTTTGCAATAAAGTACATTTTGACTTTGTTGGCATAATGTCAGTAAC ATACATATTCCAGTGGTTTTATGGACAGGCAATTTAGTCATTATGATAATAAGGAAAACAGTGTTTTAGATGAGAGATCATTAATGCATT TTTCCCTCATCAAGCATATATCTGCTTTTTTTTATTTTGCAATTCTCTGTATTCTATGTCTTTAAAAATTTGATCTTGACATTTAATGTC ACAAAGTTTTGTTTTTTTAAAAAGTGATTTAAACTTAAGATCCGACATTTTTTGTATTCTTTAAGATTTTACACCTAAAAAATCTCTCCT ATCCCAAAAATAATGTGGGATCCTTATCAGCATGCCCACAGTTTATTTCTTTGTTCTTCACTAGGCCTGCATAATACAGTCCTATGTAGA CATCTGTTCCCTTGGGTTTCCGTTCTTTCTTAGGATGGTTGCCAACCCACAATCTCATTGATCAGCAGCCAATATGGGTTTGTTTGGTTT TTTTAATTCTTAAAAACATCCTCTAGAGGAATAGAAACAAATTTTTATGAGCATAACCCTATATAAAGACAAAATGAATTTCTGACCTTA CCATATATACCATTAGGCCTTGCCATTGCTTTAATGTAGACTCATAGTTGAAATTAGTGCAGAAAGAACTCAGATGTACTAGATTTTCAT TGTTCATTGATATGCTCAGTATGCTGCCACATAAGATGAATTTAATTATATTCAACCAAAGCAATATACTCTTACATGATTTCTAGGCCC CATGACCCAGTGTCTAGAGACATTAATTCTAACCAGTTGTTTGCTTTTAAATGAGTGATTTCATTTTGGGAAACAGGTTTCAAATGAATA TATATACATGGGTAAAATTACTCTGTGCTAGTGTAGTCTTACTAGAGAATGTTTATGGTCCCACTTGTATATGAAAATGTGGTTAGAATG TTAATTGGATAATGTATATATAAGAAGTTAAAGTATGTAAAGTATAACTTCAGCCACATTTTTAGAACACTGTTTAACATTTTTGCAAAA CCTTCTTGTAGGAAAAGAGAGCTCTCTACATGAAGATGACTTGTTTTATATTTCAGATTTTATTTTAAAAGCCATGTCTGTTAAACAAGA AAAAACACAAAAGAACTCCAGATTCCTGGTTCATCATTCTGTATTCTTACTCACTTTTTCAAGTTATCTATTTTGTTGCATAAACTAATT GTTAACTATTCATGGAACAGCAAACGCCTGTTTAATAAAGAACTTTGACCAAGGCTATAAATGCCACGTACATTATTTTCAGTATTGTTG GTTATATTTAAATTTTCCTTACAATAAAGCACACTTTTATAATAAAATACATGAATTATTGTTTTTCATACTTTTTTGCTTGTTTCTTTA AAGTTTTCTGACGTGCATAATGCATAATTCATTGAAAAGCATGATAGCAATGTGGCATGTGGAAGCGAACCCCCAGGGCATAACATAGTA AGAAAGTATGGTTCTGTATGGCAATAGGTTTTTAAAATTATTAGCTATTCATCATGTGTGGGAGAAATAATTGTGGTGTGTTGCAGATTT |
Top |
FusionGenePPI for SRPK2_PRKAR2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SRPK2 | U2AF2, RNPS1, SRSF1, SRSF3, SRSF2, SRSF5, SRSF6, SNRNP70, LUC7L3, SRPK1, VAV2, ARRB2, CUL3, APP, ESR1, BARD1, U2AF1, DDX46, RBM23, RBM39, PRPF38A, CTNNBL1, SNIP1, ACIN1, ARGLU1, SNRNP27, YTHDC1, DDX21, LUC7L, SRRM1, PABPC4, PRPF4B, SRRM2, PNN, SRPK2, SNRPD1, EIF4A3, HNRNPM, NOP2, DHX15, SNRPA, SNRPC, PCBP1, BCLAF1, RBBP6, PABPC1, C1orf35, DROSHA, LUC7L2, SRSF8, HNRNPC, RBM8A, MAGOH, SRSF7, TJP2, ALMS1, HNRNPCL1, CLASRP, DIDO1, DDX50, SNRPB, DGCR8, THRAP3, HNRNPH2, DDX39A, DDX39B, CPSF6, SON, NUDT21, NSG1, CHTOP, CDK13, FOXN3, EIF1AY, CHD2, TNFRSF10C, CASK, AURKA, CHUK, ARPC1B, UBD, NCK2, AHCYL1, TLE4, ERN1, DNAJC8, GABARAP, ZRANB2, TDP2, PAK4, ABL1, POLB, NELFE, ERCC3, MDK, PSMA3, DDX6, PTBP1, APEX1, GTF2E1, SRI, YWHAB, RPL22, MAGEB1, CBX5, CLK1, CLK3, CDK7, ADPRH, TPD52, RWDD2B, YPEL3, FGF12, WDR5, PPIA, RPL41, TRA2B, RNF4, MRPS6, PRKAA1, SRSF9, IFIT5, MPP3, TCOF1, TRA2A, DHX8, DRAP1, BRD3, SEC23B, HMGN3, ZRSR2, ENOX2, SNRNP35, C4orf46, C17orf85, TAF7L, FAM76B, ATAT1, ARL6IP4, AMMECR1L, CSAG1, RSRC2, NPM2, CAND1, LCA5, FAM90A1, MAPKAPK5, CCDC28A, ARHGAP12, CHERP, GPR114, DAW1, CLDN19, MARCH10, LRRN4CL, DBF4B, TNIP2, MCOLN3, EPS8L3, C16orf78, SDR42E1, TRIM41, SREK1, SRSF12, TTN, RTF1, RIT1, C18orf25, EVI5L, RPL39L, CCDC97, PELI1, NGLY1, RSRC1, EGLN2, UBE2E2, ALKBH3, YPEL2, RBM15, RIT2, VRK1, VIMP, CCM2, RSRP1, HIRIP3, LCE3D, NSRP1, GABARAPL1, KCNN2, CDC42EP4, EPB41L1, OCEL1, ZMAT4, EPB41L4A, PDE7B, NXT2, APOBEC3C, HOMER3, CBLN4, NSMCE4A, SLAIN2, NUP50, BAIAP2, DRG1, NOP16, PPIL1, HBS1L, MAB21L2, SUPT16H, SNURF, CACNG2, STON1, AES, CLK2, ZSCAN9, FXR2, LUZP4, BMI1, PPM1G, PRPF8, NTRK1, C5orf42, ACTB, ACTG1, ADAMTS18, AKAP13, ALDOA, ALPL, ANK3, ANKFY1, ANKRD35, AP1M1, KIAA1244, ARSG, ASL, BAG3, BAZ1A, BCL9L, BUD13, EFCAB12, ELP6, CADPS2, CALCOCO1, CAMSAP1, CARD11, CARHSP1, MTCL1, CCDC86, CCDC88B, CDK12, CEP170, CHD1L, CHEK2, CLASP1, CLASP2, CLCNKA, CLU, CPSF7, CRTC1, YBX3, DCAF10, DDX3X, DNAH6, DNAH9, DOCK3, ECT2, EED, EIF3A, EIF4B, EIF4G1, ELAVL3, ENSA, EPB41L4B, EPM2A, EPS8L1, ERBB3, ERC1, F5, AMER1, FAM179B, FAM43A, NXPE4, FBXO24, FCHO1, FGFR3, FIP1L1, FMNL1, GBF1, GCC2, GGCX, GHR, GLRA4, GLTSCR2, GNGT2, GSE1, GTPBP4, GXYLT2, HERC3, HIST1H2BK, HIVEP1, HMCN2, HMGA1, HMGN2, HMGXB4, HNRNPA1, HNRNPA3, HNRNPK, HTATSF1, IRS2, ISLR, JMJD1C, KANK2, KHDRBS1, KIF11, KRT78, LBR, LDHC, LINC00322, LMNA, LMNB1, LMO7, LRRC34, LRRC52, MACF1, MAP1S, MAP4, MAP7, MAP7D1, MAPKAPK3, MAPRE1, MAST2, MATR3, MDC1, MFSD10, MIB2, MIPOL1, ZAK, MMP23B, MYCBP2, MYLIP, MYO18B, MYO1E, MZT2B, NADK, NAGK, NCL, NGDN, NKAP, NOLC1, NSUN5P2, NTHL1, NXF1, OTOF, PALLD, PCF11, PDCL3, PHF6, PHLDB1, PKD1L2, PLEKHA5, PNMAL2, POLDIP3, PPHLN1, PPP1R13L, PRPF38B, PRRC2A, PRRC2B, PRRC2C, PSMD13, PTPN22, RABEP1, RASGRF1, RBM15B, RBM19, RBMX, RIPK3, RNF219, RPL13, RPL34, RPL37, RPLP2, RPS26, RRM2B, RRP1, RRP1B, RSL1D1, RXFP1, S100A4, SAFB, SART1, SBK1, SCAF1, SDK2, SEC16B, SERPING1, PNISR, SGPL1, SIPA1L3, SLC13A2, SLC17A6, SLFN5, SLTM, SMCHD1, SPDEF, SPEN, SRC, SRSF11, SRXN1, SYCP2, TCEANC2, TMEM57, TMPO, TMPRSS11A, TMSB10, TNFAIP8L2, TNS3, TOP1, TRIP12, TUBA1B, TXN, UBR4, UPF3B, USP36, USP39, VAC14, VSTM2L, WDR24, WDR70, XRCC5, YRDC, YTHDC2, ZC3H13, ZC3H18, ZCCHC17, ZDHHC5, ZFC3H1, ZFHX4, ZFP91, ZMYM4, ZNF140, ZNF234, ZNF529, ZNF592, ZNF593, ZNF616, FOXK2, FOXL2, FOXQ1, YBX1, AKT1, INO80B, TRIM25 | PRKAR2B | RYR2, AKAP5, MAATS1, AKAP11, GNAI3, USO1, GCH1, SOX2, PRKACA, PRKACB, KIF5B, TAF12, AKAP7, SPA17, AKAP1, PRKAR2A, AKAP9, AKAP13, PDE4DIP, CDK5RAP2, PRKACG, AKAP2, PALM2-AKAP2, MAP2, ZG16B, AMY1C, PRKX, CRYBG3, PRKAR1B, NAA25, VAPB, ZNF707, AKAP14, HERC2, CSNK1D, DYNC1I2, PCM1, SURF4, VAV2, OFD1, CEP170, SEC16A, CEP131, CEP68, HBP1, BABAM1, COPS7A, CEP72, MIB1, CCDC77, SSX2, ALX3, ROPN1, KIAA1683, GJB7, CSNK1E, PRKAR1A, MAPRE1, NUFIP1, HAX1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SRPK2_PRKAR2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SRPK2_PRKAR2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PRKAR2B | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | PRKAR2B | C0028754 | Obesity | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|