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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36037

FusionGeneSummary for SRPK2_C16orf70

check button Fusion gene summary
Fusion gene informationFusion gene name: SRPK2_C16orf70
Fusion gene ID: 36037
HgeneTgene
Gene symbol

SRPK2

C16orf70

Gene ID

6733

80262

Gene nameSRSF protein kinase 2chromosome 16 open reading frame 70
SynonymsSFRSK2C16orf6|LIN10|lin-10
Cytomap

7q22.3

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionSRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2UPF0183 protein C16orf70lin-10 homolog
Modification date2018052320180523
UniProtAcc

P78362

Q9BSU1

Ensembl transtripts involved in fusion geneENST00000393651, ENST00000357311, 
ENST00000489828, ENST00000493638, 
ENST00000569600, ENST00000219139, 
ENST00000569683, 
Fusion gene scores* DoF score11 X 6 X 10=6606 X 5 X 6=180
# samples 196
** MAII scorelog2(19/660*10)=-1.79646660591487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRPK2 [Title/Abstract] AND C16orf70 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRPK2

GO:0000245

spliceosomal complex assembly

9472028

HgeneSRPK2

GO:0006468

protein phosphorylation

9472028

HgeneSRPK2

GO:0008284

positive regulation of cell proliferation

18559500

HgeneSRPK2

GO:0008380

RNA splicing

9472028

HgeneSRPK2

GO:0035556

intracellular signal transduction

9472028

HgeneSRPK2

GO:0045070

positive regulation of viral genome replication

20498328

HgeneSRPK2

GO:0045071

negative regulation of viral genome replication

12417631


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE066992SRPK2chr7

104914747

+C16orf70chr16

67151365

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000393651ENST00000569600SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000393651ENST00000219139SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000393651ENST00000569683SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000357311ENST00000569600SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000357311ENST00000219139SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000357311ENST00000569683SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000489828ENST00000569600SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000489828ENST00000219139SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000489828ENST00000569683SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000493638ENST00000569600SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000493638ENST00000219139SRPK2chr7

104914747

+C16orf70chr16

67151365

-
intron-intronENST00000493638ENST00000569683SRPK2chr7

104914747

+C16orf70chr16

67151365

-

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FusionProtFeatures for SRPK2_C16orf70


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRPK2

P78362

C16orf70

Q9BSU1

Serine/arginine-rich protein-specific kinase whichspecifically phosphorylates its substrates at serine residueslocated in regions rich in arginine/serine dipeptides, known as RSdomains and is involved in the phosphorylation of SR splicingfactors and the regulation of splicing. Promotes neuronalapoptosis by up-regulating cyclin-D1 (CCND1) expression. This isdone by the phosphorylation of SRSF2, leading to the suppressionof p53/TP53 phosphorylation thereby relieving the repressiveeffect of p53/TP53 on cyclin-D1 (CCND1) expression. PhosphorylatesACIN1, and redistributes it from the nuclear speckles to thenucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complexformation via the phosphorylation of DDX23/PRP28. Can mediatehepatitis B virus (HBV) core protein phosphorylation. Plays anegative role in the regulation of HBV replication through amechanism not involving the phosphorylation of the core proteinbut by reducing the packaging efficiency of the pregenomic RNA(pgRNA) without affecting the formation of the viral coreparticles. {ECO:0000269|PubMed:12134018,ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142,ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491,ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21157427,ECO:0000269|PubMed:9472028}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SRPK2_C16orf70


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SRPK2_C16orf70


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRPK2_C16orf70


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRPK2_C16orf70


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource