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Fusion gene ID: 35988 |
FusionGeneSummary for SRGAP3_ATP2B2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SRGAP3_ATP2B2 | Fusion gene ID: 35988 | Hgene | Tgene | Gene symbol | SRGAP3 | ATP2B2 | Gene ID | 23380 | 493 |
| Gene name | SLIT-ROBO Rho GTPase activating protein 2 | ATPase plasma membrane Ca2+ transporting 4 | |
| Synonyms | ARHGAP34|FNBP2|SRGAP2A|SRGAP3 | ATP2B2|MXRA1|PMCA4|PMCA4b|PMCA4x | |
| Cytomap | 1q32.1 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SLIT-ROBO Rho GTPase-activating protein 2SLIT-ROBO GAP2formin-binding protein 2rho GTPase-activating protein 34 | plasma membrane calcium-transporting ATPase 4ATPase, Ca++ transporting, plasma membrane 4matrix-remodeling-associated protein 1sarcolemmal calcium pump | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43295 | Q01814 | |
| Ensembl transtripts involved in fusion gene | ENST00000383836, ENST00000360413, ENST00000433332, | ENST00000352432, ENST00000343816, ENST00000360273, ENST00000383800, ENST00000397077, ENST00000467702, | |
| Fusion gene scores | * DoF score | 9 X 5 X 7=315 | 4 X 6 X 4=96 |
| # samples | 13 | 6 | |
| ** MAII score | log2(13/315*10)=-1.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SRGAP3 [Title/Abstract] AND ATP2B2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SRGAP3 | GO:0043547 | positive regulation of GTPase activity | 21148482 |
| Hgene | SRGAP3 | GO:0046847 | filopodium assembly | 22559944 |
| Hgene | SRGAP3 | GO:0051014 | actin filament severing | 21148482 |
| Hgene | SRGAP3 | GO:0060996 | dendritic spine development | 22559944 |
| Hgene | SRGAP3 | GO:2001223 | negative regulation of neuron migration | 22559944 |
| Tgene | ATP2B2 | GO:0006874 | cellular calcium ion homeostasis | 19278978 |
| Tgene | ATP2B2 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction | 19278978 |
| Tgene | ATP2B2 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19278978 |
| Tgene | ATP2B2 | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 11591728|19278978 |
| Tgene | ATP2B2 | GO:0051001 | negative regulation of nitric-oxide synthase activity | 11591728|17242280|19278978|19287093 |
| Tgene | ATP2B2 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 19287093 |
| Tgene | ATP2B2 | GO:0071872 | cellular response to epinephrine stimulus | 19278978 |
| Tgene | ATP2B2 | GO:0098736 | negative regulation of the force of heart contraction | 17242280 |
| Tgene | ATP2B2 | GO:0140199 | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process | 17242280 |
| Tgene | ATP2B2 | GO:1900082 | negative regulation of arginine catabolic process | 19278978 |
| Tgene | ATP2B2 | GO:1903249 | negative regulation of citrulline biosynthetic process | 19278978 |
| Tgene | ATP2B2 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity | 19278978 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CV-7418-01A | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| TCGA | LD | OV | TCGA-24-1417-01A | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000383836 | ENST00000352432 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-5UTR | ENST00000383836 | ENST00000343816 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-5UTR | ENST00000383836 | ENST00000360273 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-5UTR | ENST00000383836 | ENST00000383800 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-5UTR | ENST00000383836 | ENST00000397077 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-intron | ENST00000383836 | ENST00000467702 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-intron | ENST00000360413 | ENST00000352432 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-5UTR | ENST00000360413 | ENST00000343816 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-5UTR | ENST00000360413 | ENST00000360273 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-5UTR | ENST00000360413 | ENST00000383800 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-5UTR | ENST00000360413 | ENST00000397077 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-intron | ENST00000360413 | ENST00000467702 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| intron-intron | ENST00000433332 | ENST00000352432 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| intron-5UTR | ENST00000433332 | ENST00000343816 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| intron-5UTR | ENST00000433332 | ENST00000360273 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| intron-5UTR | ENST00000433332 | ENST00000383800 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| intron-5UTR | ENST00000433332 | ENST00000397077 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| intron-intron | ENST00000433332 | ENST00000467702 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10491546 | - |
| 5CDS-intron | ENST00000383836 | ENST00000352432 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-intron | ENST00000383836 | ENST00000343816 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-intron | ENST00000383836 | ENST00000360273 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-intron | ENST00000383836 | ENST00000383800 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-5UTR | ENST00000383836 | ENST00000397077 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-intron | ENST00000383836 | ENST00000467702 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-intron | ENST00000360413 | ENST00000352432 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-intron | ENST00000360413 | ENST00000343816 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-intron | ENST00000360413 | ENST00000360273 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-intron | ENST00000360413 | ENST00000383800 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-5UTR | ENST00000360413 | ENST00000397077 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| 5CDS-intron | ENST00000360413 | ENST00000467702 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| intron-intron | ENST00000433332 | ENST00000352432 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| intron-intron | ENST00000433332 | ENST00000343816 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| intron-intron | ENST00000433332 | ENST00000360273 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| intron-intron | ENST00000433332 | ENST00000383800 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| intron-5UTR | ENST00000433332 | ENST00000397077 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
| intron-intron | ENST00000433332 | ENST00000467702 | SRGAP3 | chr3 | 9290569 | - | ATP2B2 | chr3 | 10575817 | - |
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FusionProtFeatures for SRGAP3_ATP2B2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SRGAP3 | ATP2B2 |
| GTPase-activating protein for RAC1 and perhaps Cdc42,but not for RhoA small GTPase. May attenuate RAC1 signaling inneurons. {ECO:0000269|PubMed:12195014,ECO:0000269|PubMed:12447388}. | This magnesium-dependent enzyme catalyzes the hydrolysisof ATP coupled with the transport of calcium out of the cell. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SRGAP3_ATP2B2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SRGAP3_ATP2B2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SRGAP3 | DISC1, DTNBP1, TNIK, FASLG, KDM1A, PRMT6, SUV39H1, SRGAP2, ACAD8, CLOCK, SPAG5, CCDC85C, PPP1R13B, TP53BP2, CCDC22, PGGT1B, TGM2, KIF2C, RAD18 | ATP2B2 | DLG1, DLG3, DLG2, ERBB2IP, SNTA1, LGR4, HLA-DQA1, HLA-DRA, EFNB2, DPH6, SRPRB, NUFIP1, DGUOK, DNAAF2, SPACA1, LGALS8, TAS2R7, GGH, HSD17B6, TRABD, GINM1, PTGFR, SDF4, SLAMF1, DHRS9, VSIG4, SCARA3, MYH15, UBXN8, MAOB, ATP2B3, GPAM, NRM, FAM174A, ABCD1, TMEM168, ATP2B4, DGAT1, APOD, GOLM1, LEMD2, CLU, DHRS7, SLC4A2, PIGN, MPC2, STEAP3, OSTC, CERS6, GOLIM4, ARL6IP1, FZD7, ERMP1, CYP2B6, TOR1A, SLC38A9, CHSY1, PIGO, C4A, FAR2, TMEM63A, ABCC10, TMEM5, ENTPD7, CD83, ABCC4, GHDC, GALNT6, LILRB4, TMEM63B, HTR2C, CD79B, MUCL1, FPR2, FZD10, SQLE, ATG9A, IL1R2, BCAP31, AZGP1, ALG10, ABCD4, PCNXL3, SLC2A5, ALG8, ST3GAL1, TNPO3, SLC22A16, SLC47A1, ADAMTS4, PCDHGB1, IFNL1, PTGIR, LPAR4, GLB1L2, ABCB9, SLC26A6, SLC15A4, HTR3A, BTBD9, GOLGA5, GPR161, TIMM23, ATP9A, VAC14, SLC45A2, EDNRB, C12orf49, RHOT2, GPR89A, LCLAT1, VAV1, UXS1, SLC4A7, RAPGEF5, PTPRQ, PIBF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SRGAP3_ATP2B2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SRGAP3_ATP2B2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SRGAP3 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | SRGAP3 | C2931337 | Chromosome 3, monosomy 3p25 | 1 | CTD_human |
| Hgene | SRGAP3 | C3714756 | Intellectual Disability | 1 | CTD_human |
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