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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35975

FusionGeneSummary for SRGAP1_PTPRR

check button Fusion gene summary
Fusion gene informationFusion gene name: SRGAP1_PTPRR
Fusion gene ID: 35975
HgeneTgene
Gene symbol

SRGAP1

PTPRR

Gene ID

57522

5801

Gene nameSLIT-ROBO Rho GTPase activating protein 1protein tyrosine phosphatase, receptor type R
SynonymsARHGAP13|NMTC2EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ
Cytomap

12q14.2

12q15

Type of geneprotein-codingprotein-coding
DescriptionSLIT-ROBO Rho GTPase-activating protein 1rho GTPase-activating protein 13receptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1
Modification date2018052320180519
UniProtAcc

Q7Z6B7

Q15256

Ensembl transtripts involved in fusion geneENST00000355086, ENST00000357825, 
ENST00000543397, 
ENST00000283228, 
ENST00000440835, ENST00000537619, 
ENST00000378778, ENST00000342084, 
ENST00000549308, 
Fusion gene scores* DoF score13 X 6 X 9=70233 X 13 X 10=4290
# samples 1331
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/4290*10)=-3.79063752711267
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRGAP1 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A23Z-01ASRGAP1chr12

64238663

+PTPRRchr12

71158558

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000355086ENST00000283228SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000355086ENST00000440835SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000355086ENST00000537619SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000355086ENST00000378778SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000355086ENST00000342084SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000355086ENST00000549308SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
Frame-shitENST00000357825ENST00000283228SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000357825ENST00000440835SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000357825ENST00000537619SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000357825ENST00000378778SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000357825ENST00000342084SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
5CDS-intronENST00000357825ENST00000549308SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
intron-3CDSENST00000543397ENST00000283228SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
intron-intronENST00000543397ENST00000440835SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
intron-intronENST00000543397ENST00000537619SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
intron-intronENST00000543397ENST00000378778SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
intron-intronENST00000543397ENST00000342084SRGAP1chr12

64238663

+PTPRRchr12

71158558

-
intron-intronENST00000543397ENST00000549308SRGAP1chr12

64238663

+PTPRRchr12

71158558

-

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FusionProtFeatures for SRGAP1_PTPRR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRGAP1

Q7Z6B7

PTPRR

Q15256

GTPase-activating protein for RhoA and Cdc42 smallGTPases. Together with CDC42 seems to be involved in the pathwaymediating the repulsive signaling of Robo and Slit proteins inneuronal migration. SLIT2, probably through interaction withROBO1, increases the interaction of SRGAP1 with ROBO1 andinactivates CDC42. {ECO:0000269|PubMed:11672528}. Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SRGAP1_PTPRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SRGAP1_PTPRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SRGAP1RHOA, ELAVL1, SH3KBP1, FASLG, CDK8, RAD18, SKA1, TRIM25PTPRRMAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRGAP1_PTPRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRGAP1_PTPRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRGAP1C4225426THYROID CANCER, NONMEDULLARY, 21UNIPROT
TgenePTPRRC0041696Unipolar Depression1PSYGENET
TgenePTPRRC1269683Major Depressive Disorder1PSYGENET