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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35969

FusionGeneSummary for SRGAP1_GAB2

check button Fusion gene summary
Fusion gene informationFusion gene name: SRGAP1_GAB2
Fusion gene ID: 35969
HgeneTgene
Gene symbol

SRGAP1

GAB2

Gene ID

57522

9846

Gene nameSLIT-ROBO Rho GTPase activating protein 1GRB2 associated binding protein 2
SynonymsARHGAP13|NMTC2-
Cytomap

12q14.2

11q14.1

Type of geneprotein-codingprotein-coding
DescriptionSLIT-ROBO Rho GTPase-activating protein 1rho GTPase-activating protein 13GRB2-associated-binding protein 2Grb2-associated binder 2growth factor receptor bound protein 2-associated protein 2pp100
Modification date2018052320180527
UniProtAcc

Q7Z6B7

Q9UQC2

Ensembl transtripts involved in fusion geneENST00000355086, ENST00000357825, 
ENST00000543397, 
ENST00000340149, 
ENST00000361507, ENST00000526030, 
Fusion gene scores* DoF score13 X 6 X 9=70211 X 6 X 3=198
# samples 1314
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/198*10)=-0.500073603134643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRGAP1 [Title/Abstract] AND GAB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGAB2

GO:0008284

positive regulation of cell proliferation

19172738


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A0A9-01ASRGAP1chr12

64480806

+GAB2chr11

77991947

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355086ENST00000340149SRGAP1chr12

64480806

+GAB2chr11

77991947

-
5CDS-5UTRENST00000355086ENST00000361507SRGAP1chr12

64480806

+GAB2chr11

77991947

-
5CDS-5UTRENST00000355086ENST00000526030SRGAP1chr12

64480806

+GAB2chr11

77991947

-
5CDS-5UTRENST00000357825ENST00000340149SRGAP1chr12

64480806

+GAB2chr11

77991947

-
5CDS-5UTRENST00000357825ENST00000361507SRGAP1chr12

64480806

+GAB2chr11

77991947

-
5CDS-5UTRENST00000357825ENST00000526030SRGAP1chr12

64480806

+GAB2chr11

77991947

-
5CDS-5UTRENST00000543397ENST00000340149SRGAP1chr12

64480806

+GAB2chr11

77991947

-
5CDS-5UTRENST00000543397ENST00000361507SRGAP1chr12

64480806

+GAB2chr11

77991947

-
5CDS-5UTRENST00000543397ENST00000526030SRGAP1chr12

64480806

+GAB2chr11

77991947

-

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FusionProtFeatures for SRGAP1_GAB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRGAP1

Q7Z6B7

GAB2

Q9UQC2

GTPase-activating protein for RhoA and Cdc42 smallGTPases. Together with CDC42 seems to be involved in the pathwaymediating the repulsive signaling of Robo and Slit proteins inneuronal migration. SLIT2, probably through interaction withROBO1, increases the interaction of SRGAP1 with ROBO1 andinactivates CDC42. {ECO:0000269|PubMed:11672528}. Adapter protein which acts downstream of severalmembrane receptors including cytokine, antigen, hormone, cellmatrix and growth factor receptors to regulate multiple signalingpathways. Regulates osteoclast differentiation mediating theTNFRSF11A/RANK signaling. In allergic response, it plays a role inmast cells activation and degranulation through PI-3-kinaseregulation. Also involved in the regulation of cell proliferationand hematopoiesis. {ECO:0000269|PubMed:15750601,ECO:0000269|PubMed:19172738}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SRGAP1_GAB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SRGAP1_GAB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SRGAP1RHOA, ELAVL1, SH3KBP1, FASLG, CDK8, RAD18, SKA1, TRIM25GAB2BCR, GRB2, ETV6, ARHGAP32, LYN, PLCG2, PTPN11, SHC1, ZAP70, CD247, LAT, PTPN6, PIK3R1, AKT1, GRAP, SRC, NCK1, PLCG1, CRKL, MET, GRAP2, LRRK1, PIK3R2, CRK, PIK3CB, MAPK1, MAPK3, MARK2, GAB1, GAB2, YWHAE, NTRK1, XPO1, FRS2, TGM4, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, RTKN, MAST3, SYDE1, PPM1H, AGAP1, CDC25B, CDK16, FAM110B, USP21, ANKRD34A, FAM53C, CGN, FAM110A, DENND4C, HDAC4, MAPKAP1, TBC1D25, NF1, NADK, CBY1, RAB3IP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRGAP1_GAB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRGAP1_GAB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRGAP1C4225426THYROID CANCER, NONMEDULLARY, 21UNIPROT
TgeneGAB2C0025202melanoma1CTD_human
TgeneGAB2C0027626Neoplasm Invasiveness1CTD_human
TgeneGAB2C0027627Neoplasm Metastasis1CTD_human