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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 35965

FusionGeneSummary for SRF_F5

check button Fusion gene summary
Fusion gene informationFusion gene name: SRF_F5
Fusion gene ID: 35965
HgeneTgene
Gene symbol

SRF

F5

Gene ID

6722

2153

Gene nameserum response factorcoagulation factor V
SynonymsMCM1FVL|PCCF|RPRGL1|THPH2
Cytomap

6p21.1

1q24.2

Type of geneprotein-codingprotein-coding
Descriptionserum response factorc-fos serum response element-binding transcription factorminichromosome maintenance 1 homologcoagulation factor Vactivated protein c cofactorcoagulation factor V (proaccelerin, labile factor)coagulation factor V jinjiang A2 domainfactor V Leiden
Modification date2018052320180527
UniProtAcc

P11831

P12259

Ensembl transtripts involved in fusion geneENST00000265354, ENST00000457278, 
ENST00000367796, ENST00000367797, 
ENST00000546081, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/32*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRF [Title/Abstract] AND F5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRF

GO:0001829

trophectodermal cell differentiation

17576768

HgeneSRF

GO:0006366

transcription by RNA polymerase II

3203386

HgeneSRF

GO:0009725

response to hormone

17975004

HgeneSRF

GO:0010735

positive regulation of transcription via serum response element binding

3203386|8887666

HgeneSRF

GO:0045597

positive regulation of cell differentiation

17576768

HgeneSRF

GO:0045944

positive regulation of transcription by RNA polymerase II

17576768|19578358

HgeneSRF

GO:0045987

positive regulation of smooth muscle contraction

17215356

HgeneSRF

GO:0051091

positive regulation of DNA binding transcription factor activity

19098903

HgeneSRF

GO:0060261

positive regulation of transcription initiation from RNA polymerase II promoter

8887666


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A1-A0SK-01ASRFchr6

43141851

+F5chr1

169483697

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265354ENST00000367796SRFchr6

43141851

+F5chr1

169483697

-
In-frameENST00000265354ENST00000367797SRFchr6

43141851

+F5chr1

169483697

-
5CDS-intronENST00000265354ENST00000546081SRFchr6

43141851

+F5chr1

169483697

-
In-frameENST00000457278ENST00000367796SRFchr6

43141851

+F5chr1

169483697

-
In-frameENST00000457278ENST00000367797SRFchr6

43141851

+F5chr1

169483697

-
5CDS-intronENST00000457278ENST00000546081SRFchr6

43141851

+F5chr1

169483697

-

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FusionProtFeatures for SRF_F5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRF

P11831

F5

P12259

SRF is a transcription factor that binds to the serumresponse element (SRE), a short sequence of dyad symmetry located300 bp to the 5' of the site of transcription initiation of somegenes (such as FOS). Required for cardiac differentiation andmaturation. Central regulator of hemostasis. It serves as a criticalcofactor for the prothrombinase activity of factor Xa that resultsin the activation of prothrombin to thrombin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRFchr6:43141851chr1:169483697ENST00000265354+2713_142260509Compositional biasNote=Gly-rich
HgeneSRFchr6:43141851chr1:169483697ENST00000265354+27242_258260509Compositional biasNote=Asp/Glu-rich (acidic)
HgeneSRFchr6:43141851chr1:169483697ENST00000265354+2780_90260509Compositional biasNote=Asp/Glu-rich (acidic)
HgeneSRFchr6:43141851chr1:169483697ENST00000265354+27133_222260509DNA binding.
HgeneSRFchr6:43141851chr1:169483697ENST00000265354+27141_201260509DomainMADS-box
HgeneSRFchr6:43141851chr1:169483697ENST00000265354+27168_222260509RegionNote=Involved in dimerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251578_175121812230DomainNote=Plastocyanin-like 5
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251578_190721812230DomainNote=F5/8 type A 3
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251761_190721812230DomainNote=Plastocyanin-like 6
TgeneF5chr6:43141851chr1:169483697ENST00000367796-2325203_32921812230DomainNote=Plastocyanin-like 2
TgeneF5chr6:43141851chr1:169483697ENST00000367796-232530_19321812230DomainNote=Plastocyanin-like 1
TgeneF5chr6:43141851chr1:169483697ENST00000367796-232530_32921812230DomainNote=F5/8 type A 1
TgeneF5chr6:43141851chr1:169483697ENST00000367796-2325348_52621812230DomainNote=Plastocyanin-like 3
TgeneF5chr6:43141851chr1:169483697ENST00000367796-2325348_68421812230DomainNote=F5/8 type A 2
TgeneF5chr6:43141851chr1:169483697ENST00000367796-2325536_68421812230DomainNote=Plastocyanin-like 4
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251578_175121762225DomainNote=Plastocyanin-like 5
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251578_190721762225DomainNote=F5/8 type A 3
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251761_190721762225DomainNote=Plastocyanin-like 6
TgeneF5chr6:43141851chr1:169483697ENST00000367797-2325203_32921762225DomainNote=Plastocyanin-like 2
TgeneF5chr6:43141851chr1:169483697ENST00000367797-232530_19321762225DomainNote=Plastocyanin-like 1
TgeneF5chr6:43141851chr1:169483697ENST00000367797-232530_32921762225DomainNote=F5/8 type A 1
TgeneF5chr6:43141851chr1:169483697ENST00000367797-2325348_52621762225DomainNote=Plastocyanin-like 3
TgeneF5chr6:43141851chr1:169483697ENST00000367797-2325348_68421762225DomainNote=F5/8 type A 2
TgeneF5chr6:43141851chr1:169483697ENST00000367797-2325536_68421762225DomainNote=Plastocyanin-like 4
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251185_150121812230RegionNote=35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T
TgeneF5chr6:43141851chr1:169483697ENST00000367796-2325692_157321812230RegionNote=B
TgeneF5chr6:43141851chr1:169483697ENST00000367796-2325895_92821812230RegionNote=2 X 17 AA tandem repeats
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251185_150121762225RegionNote=35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T
TgeneF5chr6:43141851chr1:169483697ENST00000367797-2325692_157321762225RegionNote=B
TgeneF5chr6:43141851chr1:169483697ENST00000367797-2325895_92821762225RegionNote=2 X 17 AA tandem repeats
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251185_119321812230RepeatNote=2-1
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251194_120221812230RepeatNote=2-2
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251203_121121812230RepeatNote=2-3
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251212_122021812230RepeatNote=2-4
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251221_122921812230RepeatNote=2-5
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251230_123821812230RepeatNote=2-6
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251239_124721812230RepeatNote=2-7
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251248_125621812230RepeatNote=2-8
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251257_126521812230RepeatNote=2-9
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251266_127421812230RepeatNote=2-10
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251275_128321812230RepeatNote=2-11
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251284_129221812230RepeatNote=2-12
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251293_130121812230RepeatNote=2-13
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251302_131021812230RepeatNote=2-14
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251311_131921812230RepeatNote=2-15
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251320_132821812230RepeatNote=2-16
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251329_133721812230RepeatNote=2-17
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251338_134621812230RepeatNote=2-18
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251347_135521812230RepeatNote=2-19
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251356_136421812230RepeatNote=2-20
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251365_137321812230RepeatNote=2-21
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251374_138221812230RepeatNote=2-22
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251383_139121812230RepeatNote=2-23
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251392_140021812230RepeatNote=2-24
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251401_140921812230RepeatNote=2-25
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251410_141821812230RepeatNote=2-26
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251419_142721812230RepeatNote=2-27
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251428_143621812230RepeatNote=2-28
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251437_144521812230RepeatNote=2-29
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251446_145421812230RepeatNote=2-30
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251455_146321812230RepeatNote=2-31
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251464_147221812230RepeatNote=2-32
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251473_148121812230RepeatNote=2-33
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251482_149021812230RepeatNote=2-34
TgeneF5chr6:43141851chr1:169483697ENST00000367796-23251493_150121812230RepeatNote=2-35
TgeneF5chr6:43141851chr1:169483697ENST00000367796-2325895_91121812230RepeatNote=1-1
TgeneF5chr6:43141851chr1:169483697ENST00000367796-2325912_92821812230RepeatNote=1-2
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251185_119321762225RepeatNote=2-1
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251194_120221762225RepeatNote=2-2
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251203_121121762225RepeatNote=2-3
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251212_122021762225RepeatNote=2-4
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251221_122921762225RepeatNote=2-5
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251230_123821762225RepeatNote=2-6
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251239_124721762225RepeatNote=2-7
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251248_125621762225RepeatNote=2-8
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251257_126521762225RepeatNote=2-9
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251266_127421762225RepeatNote=2-10
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251275_128321762225RepeatNote=2-11
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251284_129221762225RepeatNote=2-12
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251293_130121762225RepeatNote=2-13
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251302_131021762225RepeatNote=2-14
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251311_131921762225RepeatNote=2-15
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251320_132821762225RepeatNote=2-16
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251329_133721762225RepeatNote=2-17
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251338_134621762225RepeatNote=2-18
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251347_135521762225RepeatNote=2-19
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251356_136421762225RepeatNote=2-20
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251365_137321762225RepeatNote=2-21
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251374_138221762225RepeatNote=2-22
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251383_139121762225RepeatNote=2-23
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251392_140021762225RepeatNote=2-24
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251401_140921762225RepeatNote=2-25
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251410_141821762225RepeatNote=2-26
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251419_142721762225RepeatNote=2-27
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251428_143621762225RepeatNote=2-28
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251437_144521762225RepeatNote=2-29
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251446_145421762225RepeatNote=2-30
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251455_146321762225RepeatNote=2-31
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251464_147221762225RepeatNote=2-32
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251473_148121762225RepeatNote=2-33
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251482_149021762225RepeatNote=2-34
TgeneF5chr6:43141851chr1:169483697ENST00000367797-23251493_150121762225RepeatNote=2-35
TgeneF5chr6:43141851chr1:169483697ENST00000367797-2325895_91121762225RepeatNote=1-1
TgeneF5chr6:43141851chr1:169483697ENST00000367797-2325912_92821762225RepeatNote=1-2


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FusionGeneSequence for SRF_F5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SRF_ENST00000265354_chr6_43141851_+_F5_ENST00000367796_chr1_169483697_-_309aa
MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGPGRLEREAAAAAATTPAPTAGALYSGSEGDSESGEEEE
LGAERRGLKRSLSEMEIGMVVGGPEASAAATGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTG
TQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSSGETKIFEGNTNTKG

>In-frame_SRF_ENST00000265354_chr6_43141851_+_F5_ENST00000367797_chr1_169483697_-_309aa
MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGPGRLEREAAAAAATTPAPTAGALYSGSEGDSESGEEEE
LGAERRGLKRSLSEMEIGMVVGGPEASAAATGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTG
TQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSSGETKIFEGNTNTKG

>In-frame_SRF_ENST00000457278_chr6_43141851_+_F5_ENST00000367796_chr1_169483697_-_105aa
MITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSSGETKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQ

>In-frame_SRF_ENST00000457278_chr6_43141851_+_F5_ENST00000367797_chr1_169483697_-_105aa
MITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSSGETKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SRF_ENST00000265354_chr6_43141851_+_F5_ENST00000367796_chr1_169483697_-_927nt
ATGTTACCGACCCAAGCTGGGGCCGCGGCGGCTCTGGGCCGGGGCTCGGCCCTGGGGGGCAGCCTGAACCGGACCCCGACGGGGCGGCCG
GGCGGCGGCGGCGGGACACGCGGGGCTAACGGGGGCCGGGTCCCCGGGAATGGCGCGGGGCTCGGGCCCGGCCGCCTGGAGCGGGAGGCT
GCGGCAGCGGCGGCAACCACCCCGGCGCCCACCGCGGGGGCCCTCTACAGCGGCAGCGAGGGCGACTCGGAGTCGGGCGAGGAGGAGGAG
CTGGGCGCCGAGCGGCGCGGCCTGAAGCGGAGCCTGAGCGAGATGGAGATCGGTATGGTGGTCGGTGGGCCCGAGGCGTCGGCAGCGGCC
ACCGGGGGCTACGGGCCGGTGAGCGGCGCGGTGAGCGGGGCCAAGCCGGGTAAGAAGACCCGGGGCCGCGTGAAGATCAAGATGGAGTTC
ATCGACAACAAGCTGCGGCGCTACACGACCTTCAGCAAGAGGAAGACGGGCATCATGAAGAAGGCCTATGAGCTGTCCACGCTGACAGGG
ACACAGGTGCTGTTGCTGGTGGCCAGTGAGACAGGCCATGTGTATACCTTTGCCACCCGAAAACTGCAGCCCATGATCACCAGTGAGACC
GGCAAGGCACTGATTCAGACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACCAGAGAATGAGTGCCACTGGC
TTTGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAGCAGTGGGGAGACCAAGATTTTTGAAGGAAATACTAATACCAAAGGA
CATGTGAAGAACTTTTTCAACCCCCCAATCATTTCCAGGTTTATCCGTGTCATTCCTAAAACATGGAATCAAAGTATTGCACTTCGCCTG

>In-frame_SRF_ENST00000265354_chr6_43141851_+_F5_ENST00000367797_chr1_169483697_-_927nt
ATGTTACCGACCCAAGCTGGGGCCGCGGCGGCTCTGGGCCGGGGCTCGGCCCTGGGGGGCAGCCTGAACCGGACCCCGACGGGGCGGCCG
GGCGGCGGCGGCGGGACACGCGGGGCTAACGGGGGCCGGGTCCCCGGGAATGGCGCGGGGCTCGGGCCCGGCCGCCTGGAGCGGGAGGCT
GCGGCAGCGGCGGCAACCACCCCGGCGCCCACCGCGGGGGCCCTCTACAGCGGCAGCGAGGGCGACTCGGAGTCGGGCGAGGAGGAGGAG
CTGGGCGCCGAGCGGCGCGGCCTGAAGCGGAGCCTGAGCGAGATGGAGATCGGTATGGTGGTCGGTGGGCCCGAGGCGTCGGCAGCGGCC
ACCGGGGGCTACGGGCCGGTGAGCGGCGCGGTGAGCGGGGCCAAGCCGGGTAAGAAGACCCGGGGCCGCGTGAAGATCAAGATGGAGTTC
ATCGACAACAAGCTGCGGCGCTACACGACCTTCAGCAAGAGGAAGACGGGCATCATGAAGAAGGCCTATGAGCTGTCCACGCTGACAGGG
ACACAGGTGCTGTTGCTGGTGGCCAGTGAGACAGGCCATGTGTATACCTTTGCCACCCGAAAACTGCAGCCCATGATCACCAGTGAGACC
GGCAAGGCACTGATTCAGACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACCAGAGAATGAGTGCCACTGGC
TTTGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAGCAGTGGGGAGACCAAGATTTTTGAAGGAAATACTAATACCAAAGGA
CATGTGAAGAACTTTTTCAACCCCCCAATCATTTCCAGGTTTATCCGTGTCATTCCTAAAACATGGAATCAAAGTATTGCACTTCGCCTG

>In-frame_SRF_ENST00000457278_chr6_43141851_+_F5_ENST00000367796_chr1_169483697_-_315nt
ATGATCACCAGTGAGACCGGCAAGGCACTGATTCAGACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACCAG
AGAATGAGTGCCACTGGCTTTGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAGCAGTGGGGAGACCAAGATTTTTGAAGGA
AATACTAATACCAAAGGACATGTGAAGAACTTTTTCAACCCCCCAATCATTTCCAGGTTTATCCGTGTCATTCCTAAAACATGGAATCAA

>In-frame_SRF_ENST00000457278_chr6_43141851_+_F5_ENST00000367797_chr1_169483697_-_315nt
ATGATCACCAGTGAGACCGGCAAGGCACTGATTCAGACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACCAG
AGAATGAGTGCCACTGGCTTTGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAGCAGTGGGGAGACCAAGATTTTTGAAGGA
AATACTAATACCAAAGGACATGTGAAGAACTTTTTCAACCCCCCAATCATTTCCAGGTTTATCCGTGTCATTCCTAAAACATGGAATCAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SRF_ENST00000265354_chr6_43141851_+_F5_ENST00000367796_chr1_169483697_-_1432nt
GGTCGGGGGATCCCTCCGCCGCCAGCGCGTGGTCCCGGCCCCCTCCACCCGCCGTCTCGGCCGCGGCCAGCAGCCCCTGCCCCCCGGGGG
ACGCTGACGGCCGCCCGGCGCGCCGCCCTAGCAGACGGACAGGGGGCGCTGCGCGCGGCCTGGGGCAACCCGGGCCACAGGGGCAGGAAA
GTGAGGGCCCAGGTCGGCCCGGGCGTGCAGGGGCCCCGGGTTCGCAGCGGCGGCCGCGGCAGCGATAGCGGCACTAGCAGCAGCGGGAGT
GCCGGGTTGAGCCGGGAAGCCGATGGCGGCGGCTGCGGCGGCTCCGATTCCTCGCTGACTGCCCGTCCGCCCTCCTGCATCGAGCGCCAT
GTTACCGACCCAAGCTGGGGCCGCGGCGGCTCTGGGCCGGGGCTCGGCCCTGGGGGGCAGCCTGAACCGGACCCCGACGGGGCGGCCGGG
CGGCGGCGGCGGGACACGCGGGGCTAACGGGGGCCGGGTCCCCGGGAATGGCGCGGGGCTCGGGCCCGGCCGCCTGGAGCGGGAGGCTGC
GGCAGCGGCGGCAACCACCCCGGCGCCCACCGCGGGGGCCCTCTACAGCGGCAGCGAGGGCGACTCGGAGTCGGGCGAGGAGGAGGAGCT
GGGCGCCGAGCGGCGCGGCCTGAAGCGGAGCCTGAGCGAGATGGAGATCGGTATGGTGGTCGGTGGGCCCGAGGCGTCGGCAGCGGCCAC
CGGGGGCTACGGGCCGGTGAGCGGCGCGGTGAGCGGGGCCAAGCCGGGTAAGAAGACCCGGGGCCGCGTGAAGATCAAGATGGAGTTCAT
CGACAACAAGCTGCGGCGCTACACGACCTTCAGCAAGAGGAAGACGGGCATCATGAAGAAGGCCTATGAGCTGTCCACGCTGACAGGGAC
ACAGGTGCTGTTGCTGGTGGCCAGTGAGACAGGCCATGTGTATACCTTTGCCACCCGAAAACTGCAGCCCATGATCACCAGTGAGACCGG
CAAGGCACTGATTCAGACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACCAGAGAATGAGTGCCACTGGCTT
TGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAGCAGTGGGGAGACCAAGATTTTTGAAGGAAATACTAATACCAAAGGACA
TGTGAAGAACTTTTTCAACCCCCCAATCATTTCCAGGTTTATCCGTGTCATTCCTAAAACATGGAATCAAAGTATTGCACTTCGCCTGGA
ACTCTTTGGCTGTGATATTTACTAGAATTGAACATTCAAAAACCCCTGGAAGAGACTCTTTAAGACCTCAAACCATTTAGAATGGGCAAT

>In-frame_SRF_ENST00000265354_chr6_43141851_+_F5_ENST00000367797_chr1_169483697_-_1432nt
GGTCGGGGGATCCCTCCGCCGCCAGCGCGTGGTCCCGGCCCCCTCCACCCGCCGTCTCGGCCGCGGCCAGCAGCCCCTGCCCCCCGGGGG
ACGCTGACGGCCGCCCGGCGCGCCGCCCTAGCAGACGGACAGGGGGCGCTGCGCGCGGCCTGGGGCAACCCGGGCCACAGGGGCAGGAAA
GTGAGGGCCCAGGTCGGCCCGGGCGTGCAGGGGCCCCGGGTTCGCAGCGGCGGCCGCGGCAGCGATAGCGGCACTAGCAGCAGCGGGAGT
GCCGGGTTGAGCCGGGAAGCCGATGGCGGCGGCTGCGGCGGCTCCGATTCCTCGCTGACTGCCCGTCCGCCCTCCTGCATCGAGCGCCAT
GTTACCGACCCAAGCTGGGGCCGCGGCGGCTCTGGGCCGGGGCTCGGCCCTGGGGGGCAGCCTGAACCGGACCCCGACGGGGCGGCCGGG
CGGCGGCGGCGGGACACGCGGGGCTAACGGGGGCCGGGTCCCCGGGAATGGCGCGGGGCTCGGGCCCGGCCGCCTGGAGCGGGAGGCTGC
GGCAGCGGCGGCAACCACCCCGGCGCCCACCGCGGGGGCCCTCTACAGCGGCAGCGAGGGCGACTCGGAGTCGGGCGAGGAGGAGGAGCT
GGGCGCCGAGCGGCGCGGCCTGAAGCGGAGCCTGAGCGAGATGGAGATCGGTATGGTGGTCGGTGGGCCCGAGGCGTCGGCAGCGGCCAC
CGGGGGCTACGGGCCGGTGAGCGGCGCGGTGAGCGGGGCCAAGCCGGGTAAGAAGACCCGGGGCCGCGTGAAGATCAAGATGGAGTTCAT
CGACAACAAGCTGCGGCGCTACACGACCTTCAGCAAGAGGAAGACGGGCATCATGAAGAAGGCCTATGAGCTGTCCACGCTGACAGGGAC
ACAGGTGCTGTTGCTGGTGGCCAGTGAGACAGGCCATGTGTATACCTTTGCCACCCGAAAACTGCAGCCCATGATCACCAGTGAGACCGG
CAAGGCACTGATTCAGACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACCAGAGAATGAGTGCCACTGGCTT
TGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAGCAGTGGGGAGACCAAGATTTTTGAAGGAAATACTAATACCAAAGGACA
TGTGAAGAACTTTTTCAACCCCCCAATCATTTCCAGGTTTATCCGTGTCATTCCTAAAACATGGAATCAAAGTATTGCACTTCGCCTGGA
ACTCTTTGGCTGTGATATTTACTAGAATTGAACATTCAAAAACCCCTGGAAGAGACTCTTTAAGACCTCAAACCATTTAGAATGGGCAAT

>In-frame_SRF_ENST00000457278_chr6_43141851_+_F5_ENST00000367796_chr1_169483697_-_623nt
AAAGGCGCAGAGGTGGGAGTGACCGGCGCCAGAGAGGAAGAGGGCCCTTGCTGAGTGAAGGGGCCTATGAGCTGTCCACGCTGACAGGGA
CACAGGTGCTGTTGCTGGTGGCCAGTGAGACAGGCCATGTGTATACCTTTGCCACCCGAAAACTGCAGCCCATGATCACCAGTGAGACCG
GCAAGGCACTGATTCAGACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACCAGAGAATGAGTGCCACTGGCT
TTGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAGCAGTGGGGAGACCAAGATTTTTGAAGGAAATACTAATACCAAAGGAC
ATGTGAAGAACTTTTTCAACCCCCCAATCATTTCCAGGTTTATCCGTGTCATTCCTAAAACATGGAATCAAAGTATTGCACTTCGCCTGG
AACTCTTTGGCTGTGATATTTACTAGAATTGAACATTCAAAAACCCCTGGAAGAGACTCTTTAAGACCTCAAACCATTTAGAATGGGCAA

>In-frame_SRF_ENST00000457278_chr6_43141851_+_F5_ENST00000367797_chr1_169483697_-_623nt
AAAGGCGCAGAGGTGGGAGTGACCGGCGCCAGAGAGGAAGAGGGCCCTTGCTGAGTGAAGGGGCCTATGAGCTGTCCACGCTGACAGGGA
CACAGGTGCTGTTGCTGGTGGCCAGTGAGACAGGCCATGTGTATACCTTTGCCACCCGAAAACTGCAGCCCATGATCACCAGTGAGACCG
GCAAGGCACTGATTCAGACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACCAGAGAATGAGTGCCACTGGCT
TTGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAGCAGTGGGGAGACCAAGATTTTTGAAGGAAATACTAATACCAAAGGAC
ATGTGAAGAACTTTTTCAACCCCCCAATCATTTCCAGGTTTATCCGTGTCATTCCTAAAACATGGAATCAAAGTATTGCACTTCGCCTGG
AACTCTTTGGCTGTGATATTTACTAGAATTGAACATTCAAAAACCCCTGGAAGAGACTCTTTAAGACCTCAAACCATTTAGAATGGGCAA


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FusionGenePPI for SRF_F5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SRFNCOA6, MYOCD, MKL1, MKL2, PML, CREBBP, SSRP1, RXRG, GATA4, REL, RELA, NFYA, GTF2F1, NKX3-1, MYOG, FLI1, ELK1, TEAD1, SP1, NCOR2, GTF2I, ELK4, CD63, ATF6, CEBPB, SMARCA4, HDAC3, SMAD7, EPC1, HDAC4, KAT5, PELP1, CSNK2A1, SRF, KDM6A, TRIM63, UBE2I, SHBG, PRKDC, NFKB1, SRFBP1, ALDH3A1, CIRBP, ZIC3, FHL1, FHL2, TRIP4, NCOA1, RARA, RXRAF5F10, CALR, PROS1, F2, F5, POT1, CCDC8, MMRN1, MED4, SRPK2, OLR1, KLRG2, TNFSF8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRF_F5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneF5P12259DB13151Anti-inhibitor coagulant complexCoagulation factor Vbiotechapproved|investigational
TgeneF5P12259DB00055Drotrecogin alfaCoagulation factor Vbiotechapproved|investigational|withdrawn

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RelatedDiseases for SRF_F5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRFC0015923Fetal Alcohol Syndrome2PSYGENET
HgeneSRFC2985290Fetal Alcohol Spectrum Disorders2PSYGENET
HgeneSRFC0019693HIV Infections1CTD_human
TgeneF5C0042487Venous Thrombosis5CTD_human
TgeneF5C1861171THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder)5CTD_human;UNIPROT
TgeneF5C0015499Factor V Deficiency3CTD_human;HPO;ORPHANET;UNIPROT
TgeneF5C0040038Thromboembolism2CTD_human
TgeneF5C0040053Thrombosis2CTD_human
TgeneF5C1861172Venous Thromboembolism2CTD_human
TgeneF5C0005779Blood Coagulation Disorders1CTD_human
TgeneF5C0007786Brain Ischemia1CTD_human
TgeneF5C0009375Colonic Neoplasms1CTD_human
TgeneF5C0023890Liver Cirrhosis1CTD_human;HPO
TgeneF5C0027051Myocardial Infarction1CTD_human
TgeneF5C0032580Adenomatous Polyposis Coli1CTD_human
TgeneF5C0035328Retinal Vein Occlusion1CTD_human
TgeneF5C0038454Cerebrovascular accident1CTD_human
TgeneF5C0338575Sagittal Sinus Thrombosis1CTD_human
TgeneF5C1412000Mesenteric vascular insufficiency1CTD_human
TgeneF5C2584620Thrombophilia, hereditary1CTD_human