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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35962

FusionGeneSummary for SREK1_ST6GAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SREK1_ST6GAL1
Fusion gene ID: 35962
HgeneTgene
Gene symbol

SREK1

ST6GAL1

Gene ID

140890

6480

Gene namesplicing regulatory glutamic acid and lysine rich protein 1ST6 beta-galactoside alpha-2,6-sialyltransferase 1
SynonymsSFRS12|SRrp508|SRrp86SIAT1|ST6GalI|ST6N
Cytomap

5q12.3

3q27.3

Type of geneprotein-codingprotein-coding
Descriptionsplicing regulatory glutamine/lysine-rich protein 1serine-arginine-rich splicing regulatory protein 508serine/arginine-rich-splicing regulatory protein 86splicing factor, arginine/serine-rich 12splicing regulatory glutamic acid/lysine-rich protein 1beta-galactoside alpha-2,6-sialyltransferase 1B-cell antigen CD75CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferaseCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1ST6 N-acetylgalactosaminide alpha-2,6-sialyl
Modification date2018052320180523
UniProtAcc

Q8WXA9

P15907

Ensembl transtripts involved in fusion geneENST00000334121, ENST00000380918, 
ENST00000284041, 
ENST00000169298, 
ENST00000457772, ENST00000448044, 
ENST00000487031, 
Fusion gene scores* DoF score3 X 6 X 2=3610 X 8 X 3=240
# samples 611
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/240*10)=-1.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SREK1 [Title/Abstract] AND ST6GAL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneST6GAL1

GO:0006054

N-acetylneuraminate metabolic process

23999306

TgeneST6GAL1

GO:0018279

protein N-linked glycosylation via asparagine

23999306

TgeneST6GAL1

GO:0097503

sialylation

23999306


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-79-5596-01ASREK1chr5

65449424

+ST6GAL1chr3

186756530

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334121ENST00000169298SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
5CDS-5UTRENST00000334121ENST00000457772SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
5CDS-5UTRENST00000334121ENST00000448044SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
5CDS-intronENST00000334121ENST00000487031SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
5UTR-5UTRENST00000380918ENST00000169298SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
5UTR-5UTRENST00000380918ENST00000457772SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
5UTR-5UTRENST00000380918ENST00000448044SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
5UTR-intronENST00000380918ENST00000487031SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
intron-5UTRENST00000284041ENST00000169298SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
intron-5UTRENST00000284041ENST00000457772SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
intron-5UTRENST00000284041ENST00000448044SREK1chr5

65449424

+ST6GAL1chr3

186756530

+
intron-intronENST00000284041ENST00000487031SREK1chr5

65449424

+ST6GAL1chr3

186756530

+

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FusionProtFeatures for SREK1_ST6GAL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SREK1

Q8WXA9

ST6GAL1

P15907

Participates in the regulation of alternative splicingby modulating the activity of other splice facors. Inhibits thesplicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicingactivity of SFRS3 (By similarity). {ECO:0000250}. Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. {ECO:0000269|PubMed:21081508,ECO:0000269|PubMed:23999306}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SREK1_ST6GAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SREK1_ST6GAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SREK1RNPS1, SRSF3, SRSF2, SRSF8, SRSF7, DGKD, TARBP1, SH3GLB2, SNRPD1, SNRPD3, SF3A3, SF3B3, EFTUD2, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPD, RBMX, HNRNPK, HNRNPU, HNRNPH1, SRSF1, SRSF4, SRSF5, SRSF6, SRSF9, TRA2B, DDX39B, DDX17, DDX3X, SRSF10, C1QBP, PABPC1, PABPC4, PARP1, SAFB, SFPQ, ELAVL1, ZRANB2, RBM10, NPM1, NCL, SUPT16H, SSRP1, YBX1, THRAP3, SRPK1, GNB2L1, SRPK3, HNRNPCL1, CUL1, VPS33A, MDM2, SRPK2, LIN28A, SRSF11, SREK1, HIST1H1A, NIFK, LUC7L2, PNN, JMJD6, PUF60, RBM25, RBM39, SNRNP40, NTRK1, MUS81, ILF2, CSNK2A1, CEP135, CEP290, SSX2IP, CDC5L, SPATA1, HIST1H1T, CDX1, RPL37A, RRS1, CHCHD10, PAIP1, INO80BST6GAL1ST6GAL1, KIAA1244, ATRIP, WAPAL, ZYG11B, GLMN, HOOK2, SAAL1, USP28, PRMT9, TNPO3, INTS3, INTS12, PIP4K2A, ERGIC2, HLA-C, HEATR3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SREK1_ST6GAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SREK1_ST6GAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneST6GAL1C0001969Alcoholic Intoxication1PSYGENET
TgeneST6GAL1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneST6GAL1C0162820Dermatitis, Allergic Contact1CTD_human
TgeneST6GAL1C0337677Moderate drinker1PSYGENET