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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35929

FusionGeneSummary for SRD5A1_ADAMTS16

check button Fusion gene summary
Fusion gene informationFusion gene name: SRD5A1_ADAMTS16
Fusion gene ID: 35929
HgeneTgene
Gene symbol

SRD5A1

ADAMTS16

Gene ID

6715

170690

Gene namesteroid 5 alpha-reductase 1ADAM metallopeptidase with thrombospondin type 1 motif 16
SynonymsS5AR 1ADAMTS16s
Cytomap

5p15.31

5p15.32

Type of geneprotein-codingprotein-coding
Description3-oxo-5-alpha-steroid 4-dehydrogenase 1SR type 1steroid 5-alpha-reductase type Isteroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)A disintegrin and metalloproteinase with thrombospondin motifs 16ADAM-TS 16ADAM-TS16ADAMTS-16a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16
Modification date2018052320180522
UniProtAcc

P18405

Q8TE57

Ensembl transtripts involved in fusion geneENST00000274192, ENST00000537411, 
ENST00000504286, ENST00000538824, 
ENST00000274181, ENST00000511368, 
ENST00000513709, 
Fusion gene scores* DoF score4 X 1 X 3=124 X 5 X 3=60
# samples 44
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRD5A1 [Title/Abstract] AND ADAMTS16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-75-5122-01ASRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
TCGALDLUADTCGA-75-5122-01ASRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000274192ENST00000274181SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
5CDS-intronENST00000274192ENST00000511368SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
5CDS-intronENST00000274192ENST00000513709SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
Frame-shiftENST00000537411ENST00000274181SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
5CDS-intronENST00000537411ENST00000511368SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
5CDS-intronENST00000537411ENST00000513709SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
3UTR-3CDSENST00000504286ENST00000274181SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
3UTR-intronENST00000504286ENST00000511368SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
3UTR-intronENST00000504286ENST00000513709SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
Frame-shiftENST00000538824ENST00000274181SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
5CDS-intronENST00000538824ENST00000511368SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
5CDS-intronENST00000538824ENST00000513709SRD5A1chr5

6633982

+ADAMTS16chr5

5303381

+
Frame-shiftENST00000274192ENST00000274181SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
5CDS-intronENST00000274192ENST00000511368SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
5CDS-intronENST00000274192ENST00000513709SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
Frame-shiftENST00000537411ENST00000274181SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
5CDS-intronENST00000537411ENST00000511368SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
5CDS-intronENST00000537411ENST00000513709SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
3UTR-3CDSENST00000504286ENST00000274181SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
3UTR-intronENST00000504286ENST00000511368SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
3UTR-intronENST00000504286ENST00000513709SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
Frame-shiftENST00000538824ENST00000274181SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
5CDS-intronENST00000538824ENST00000511368SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+
5CDS-intronENST00000538824ENST00000513709SRD5A1chr5

6633982

+ADAMTS16chr5

5303685

+

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FusionProtFeatures for SRD5A1_ADAMTS16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRD5A1

P18405

ADAMTS16

Q8TE57

Converts testosterone into 5-alpha-dihydrotestosteroneand progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexualdifferentiation and androgen physiology.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRD5A1chr5:6633982chr5:5303381ENST00000274192+1512_2997260TransmembraneHelical
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+17231051_11159291225DomainTSP type-1 5
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+17231127_11819291225DomainTSP type-1 6
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+17231186_12239291225DomainPLAC
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+1723927_9879291225DomainTSP type-1 3
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+1723988_10489291225DomainTSP type-1 4

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRD5A1chr5:6633982chr5:5303381ENST00000274192+15111_13197260TransmembraneHelical
HgeneSRD5A1chr5:6633982chr5:5303381ENST00000274192+15151_17197260TransmembraneHelical
HgeneSRD5A1chr5:6633982chr5:5303381ENST00000274192+15209_22997260TransmembraneHelical
HgeneSRD5A1chr5:6633982chr5:5303381ENST00000274192+1586_10697260TransmembraneHelical
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+1723642_7469291225Compositional biasNote=Cys-rich
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+1723290_4959291225DomainPeptidase M12B
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+1723496_5859291225DomainNote=Disintegrin
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+1723586_6419291225DomainTSP type-1 1
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+1723874_9229291225DomainTSP type-1 2
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+1723247_2549291225MotifCysteine switch
TgeneADAMTS16chr5:6633982chr5:5303381ENST00000274181+1723747_8739291225RegionNote=Spacer


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FusionGeneSequence for SRD5A1_ADAMTS16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SRD5A1_ENST00000274192_chr5_6633982_+_ADAMTS16_ENST00000274181_chr5_5303381_+_393aa
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAM
FLVHYGHRWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVA
CKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS
LELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SRD5A1_ENST00000274192_chr5_6633982_+_ADAMTS16_ENST00000274181_chr5_5303381_+_1179nt
ATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGGCTGCGCGGTCTTCGCGCGC
AATCGTCAGACGAACTCAGTGTACGGCCGCCACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAG
CTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAACTGCATCCTCCTGGCCATG
TTCCTCGTCCACTACGGGCATCGCTGGTCCGTGGGGAACTGGAGTGCCTGCAGTCGGACGTGTGGCGGGGGTGCCCAGAGCCGCCCCGTG
CAGTGCACACGGCGGGTGCACTATGACTCGGAGCCAGTCCCGGCCAGCCTGTGCCCTCAGCCTGCTCCCTCCAGCAGGCAGGCCTGCAAC
TCTCAGAGCTGCCCACCTGCATGGAGCGCCGGGCCCTGGGCAGAGTGCTCACACACCTGTGGGAAGGGGTGGAGGAAGCGGGCAGTGGCC
TGTAAGAGCACCAACCCCTCGGCCAGAGCGCAGCTGCTGCCCGACGCTGTCTGCACCTCCGAGCCCAAGCCCAGGATGCATGAAGCCTGT
CTGCTTCAGCGCTGCCACAAGCCCAAGAAGCTGCAGTGGCTGGTGTCCGCCTGGTCCCAGTGCTCTGTGACATGTGAAAGAGGAACACAG
AAAAGATTCTTAAAATGTGCTGAAAAGTATGTTTCTGGAAAGTATCGAGAGCTGGCCTCAAAGAAGTGCTCACATTTGCCGAAGCCCAGC
CTGGAGCTGGAACGTGCCTGCGCCCCGCTTCCATGCCCCAGGCACCCCCCATTTGCTGCTGCGGGACCCTCGAGGGGCAGCTGGTTTGCC
TCACCCTGGTCTCAGTGCACGGCCAGCTGTGGGGGAGGCGTTCAGACGAGGTCCGTGCAGTGCCTGGCTGGGGGCCGGCCGGCCTCAGGC
TGCCTCCTGCACCAGAAGCCTTCGGCCTCCCTGGCCTGCAACACTCACTTCTGCCCCATTGCAGAGAAGAAAGATGCCTTCTGCAAAGAC
TACTTCCACTGGTGCTACCTGGTACCCCAGCACGGGATGTGCAGCCACAAGTTCTACGGCAAGCAGTGCTGCAAGACTTGCTCTAAGTCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SRD5A1_ENST00000274192_chr5_6633982_+_ADAMTS16_ENST00000274181_chr5_5303381_+_2579nt
TGGGGCGCTTGCAGGTCCCTCCCCGCGCAAGTGCTCGCCCCGCCCCCGGGGCCGCACCCACAGCCCCGGCTACCCCGGAGAAGCCTGACT
TGAGAACCCTTTCTGCAGAGTCCCGGCAGTGCGGGACTCCGGTAGCCGCCCCTCCGGTAGCCGCCCCTCCTGCCCCCGCGCCGCCGCCCT
ATATGTTGCCCGCCGCGGCCTCTGGGGCATGGAGCACGCTGCCCAGCCCTGGCGATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTG
CTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGGCTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGCCACGCG
CTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAGCTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCC
AGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGCTGGTCCGTGGGG
AACTGGAGTGCCTGCAGTCGGACGTGTGGCGGGGGTGCCCAGAGCCGCCCCGTGCAGTGCACACGGCGGGTGCACTATGACTCGGAGCCA
GTCCCGGCCAGCCTGTGCCCTCAGCCTGCTCCCTCCAGCAGGCAGGCCTGCAACTCTCAGAGCTGCCCACCTGCATGGAGCGCCGGGCCC
TGGGCAGAGTGCTCACACACCTGTGGGAAGGGGTGGAGGAAGCGGGCAGTGGCCTGTAAGAGCACCAACCCCTCGGCCAGAGCGCAGCTG
CTGCCCGACGCTGTCTGCACCTCCGAGCCCAAGCCCAGGATGCATGAAGCCTGTCTGCTTCAGCGCTGCCACAAGCCCAAGAAGCTGCAG
TGGCTGGTGTCCGCCTGGTCCCAGTGCTCTGTGACATGTGAAAGAGGAACACAGAAAAGATTCTTAAAATGTGCTGAAAAGTATGTTTCT
GGAAAGTATCGAGAGCTGGCCTCAAAGAAGTGCTCACATTTGCCGAAGCCCAGCCTGGAGCTGGAACGTGCCTGCGCCCCGCTTCCATGC
CCCAGGCACCCCCCATTTGCTGCTGCGGGACCCTCGAGGGGCAGCTGGTTTGCCTCACCCTGGTCTCAGTGCACGGCCAGCTGTGGGGGA
GGCGTTCAGACGAGGTCCGTGCAGTGCCTGGCTGGGGGCCGGCCGGCCTCAGGCTGCCTCCTGCACCAGAAGCCTTCGGCCTCCCTGGCC
TGCAACACTCACTTCTGCCCCATTGCAGAGAAGAAAGATGCCTTCTGCAAAGACTACTTCCACTGGTGCTACCTGGTACCCCAGCACGGG
ATGTGCAGCCACAAGTTCTACGGCAAGCAGTGCTGCAAGACTTGCTCTAAGTCCAACTTGTGAGTTGGGACCGCTCTCCGTAGCAGAGAA
AGTGCCTGCGTGGCACAGAAATTTCCCACAAATGAGCTGTGCAATCTACGTCGGAATACATCCAAGGAAGAGCAAAGCCAAAAGAAGAAA
ACCGTGTTAGGCTCTTTGACCAGGAGTGTATGTATGTGTTTCACTGTGAGCCTGGGTGCAGACCTGTGTCCCCATGCACACAGTGTCTCC
TGTCAGGCTGAAATGTGGCACCCTGGCAGACAGAGCTGTGGCTCGTGAGGCAGAAGGCAGGCACCACAACGGGAGAGGCAGCACTCACCC
CTGCCTGTTGCAGCTAAATCAAGTCAAAAAGACAGGCGAGGCTGAACTTGCTAAATGTCTGGTGCCTTAGAAAAAGAAGGAAAGGCCATG
AAATAAGGAAAACATACAAAATATGTACCCCCTAGTTCACCAGCCTCCCCTCCCACTAGGAGGGCCCCTCGAGCCATCAGGAGTGACCAA
CTTCCTGGGTGGAGGTCAGGGGAGCTCCAGGAGGCTGCCCAGGCTCCTCCTCCTCCTCCCCAGCGGCCGAGCATCTCTTACCAGGAACCT
GGAGCCACCGCCGGAGCCAGCGTCATCTCTAGGGTCACTGGCCAGGGGACTGCATTCTGGTTTGGGACTTTGCCTATGGAAATGGGAAAA
ATGAAATTCCTGCTAAGGTGCTTCTATCTCTTTCAGATTCATGCATTGAAGGAGAGATTTTTTATACTTTATGTTTTATCTTTCTCAGTT
ATTTGCAAGTGAGTGTCCTTTTAAAAACACACTTCTTCATGCTTTTCTTTGTAAATGACAGATCGAAGTATAGGTTACATCAAAACCCTA
CCATCCTGAGAAGAGTTATGGTTCTATTATAGCAGACGTCAGCCACACAGCCTATGTGACAATAACCTTAGAGTCCTGTGTTTTGTTTTT
GTGTGTTGTGAGATTTTAATCTTTTTTTTTTCGGTGAGTCTGGCCATTTCTATAATGCCAGGTGGGAAGCCAGGCTGCGGGTGTTAGGGT
GGGAATCTGCCCGGCGTCTCTGGCACCCTCCCTGCCATCCTCAGTGCGGCTGCTGTTCTCCTGTCCGGTGCTGTGGCTCCATTCCAAAGG


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FusionGenePPI for SRD5A1_ADAMTS16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SRD5A1ELAVL1, ACTBL2, TRIM25ADAMTS16


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRD5A1_ADAMTS16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSRD5A1P18405DB00421Spironolactone3-oxo-5-alpha-steroid 4-dehydrogenase 1small moleculeapproved
HgeneSRD5A1P18405DB01216Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1small moleculeapproved
HgeneSRD5A1P18405DB09389Norgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1small moleculeapproved
HgeneSRD5A1P18405DB00367Levonorgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1small moleculeapproved|investigational
HgeneSRD5A1P18405DB01126Dutasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1small moleculeapproved|investigational

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RelatedDiseases for SRD5A1_ADAMTS16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRD5A1C0001973Alcoholic Intoxication, Chronic2PSYGENET
HgeneSRD5A1C0014175Endometriosis2CTD_human
HgeneSRD5A1C0032460Polycystic Ovary Syndrome2CTD_human
HgeneSRD5A1C0033578Prostatic Neoplasms2CTD_human
HgeneSRD5A1C0005586Bipolar Disorder1PSYGENET
HgeneSRD5A1C0011570Mental Depression1PSYGENET
HgeneSRD5A1C0011581Depressive disorder1PSYGENET
HgeneSRD5A1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSRD5A1C0338831Manic1PSYGENET
HgeneSRD5A1C0564408Manic mood1PSYGENET