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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35909

FusionGeneSummary for SRCAP_GNB1L

check button Fusion gene summary
Fusion gene informationFusion gene name: SRCAP_GNB1L
Fusion gene ID: 35909
HgeneTgene
Gene symbol

SRCAP

GNB1L

Gene ID

10847

54584

Gene nameSnf2 related CREBBP activator proteinG protein subunit beta 1 like
SynonymsDOMO1|EAF1|FLHS|SWR1DGCRK3|FKSG1|GY2|WDR14|WDVCF
Cytomap

16p11.2

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionhelicase SRCAPSnf2-related CBP activator proteinSwi2/Snf2-related ATPase homolog, domino homolog 1domino homolog 2guanine nucleotide-binding protein subunit beta-like protein 1G-protein beta subunit-like proteinWD repeat-containing protein 14WD40 repeat-containing protein deleted in VCFSg protein subunit beta-like protein 1guanine nucleotide binding protein (G p
Modification date2018052320180519
UniProtAcc

Q6ZRS2

Q9BYB4

Ensembl transtripts involved in fusion geneENST00000344771, ENST00000395059, 
ENST00000262518, 		ENST00000329517, 
ENST00000403325, ENST00000405009, 
ENST00000460402, 
Fusion gene scores* DoF score7 X 9 X 4=2525 X 5 X 5=125
# samples 95
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRCAP [Title/Abstract] AND GNB1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-AP-A3K1-01ASRCAPchr16

30752028

+GNB1Lchr22

19799970

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000344771ENST00000329517SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-3CDSENST00000344771ENST00000403325SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-3CDSENST00000344771ENST00000405009SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-5UTRENST00000344771ENST00000460402SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-3CDSENST00000395059ENST00000329517SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-3CDSENST00000395059ENST00000403325SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-3CDSENST00000395059ENST00000405009SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-5UTRENST00000395059ENST00000460402SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-3CDSENST00000262518ENST00000329517SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-3CDSENST00000262518ENST00000403325SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-3CDSENST00000262518ENST00000405009SRCAPchr16

30752028

+GNB1Lchr22

19799970

-
intron-5UTRENST00000262518ENST00000460402SRCAPchr16

30752028

+GNB1Lchr22

19799970

-

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FusionProtFeatures for SRCAP_GNB1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRCAP

Q6ZRS2

GNB1L

Q9BYB4

Catalytic component of the SRCAP complex which mediatesthe ATP-dependent exchange of histone H2AZ/H2B dimers fornucleosomal H2A/H2B, leading to transcriptional regulation ofselected genes by chromatin remodeling. Acts as a coactivator forCREB-mediated transcription, steroid receptor-mediatedtranscription, and Notch-mediated transcription.{ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779,ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792,ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SRCAP_GNB1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SRCAP_GNB1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SRCAPNCOR1, RUVBL2, CARM1, EP300, CREBBP, MORF4L1, MORF4L2, MRGBP, AR, DMAP1, KAT5, H2AFZ, VPS72, RUVBL1, IK, SARNP, CFDP1, CDK9, SAFB2, MSN, HECW2, OBSL1, QPRT, CARD8, ACTR6, HIST1H2BA, YEATS4, HIST1H2BG, PDK1, MAU2, NUF2, DIS3L, RNF168, P4HA3, NFATC2IP, ACTBL2, ZNHIT1GNB1LGAS2L1, RABGGTB, RCN1, TEAD4, TEKT2, GSTM3, TMEM132A, MTMR14, ASPRV1, CNPY2, KCNJ5, CCT7, CCT3, PDDC1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRCAP_GNB1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRCAP_GNB1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRCAPC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneGNB1LC0036341Schizophrenia4PSYGENET
TgeneGNB1LC0033975Psychotic Disorders2PSYGENET
TgeneGNB1LC0005586Bipolar Disorder1PSYGENET
TgeneGNB1LC0041696Unipolar Depression1PSYGENET
TgeneGNB1LC0349204Nonorganic psychosis1PSYGENET
TgeneGNB1LC1269683Major Depressive Disorder1PSYGENET