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Fusion gene ID: 35904 |
FusionGeneSummary for SRBD1_C2orf91 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SRBD1_C2orf91 | Fusion gene ID: 35904 | Hgene | Tgene | Gene symbol | SRBD1 | C2orf91 | Gene ID | 55133 | 400950 |
| Gene name | S1 RNA binding domain 1 | chromosome 2 open reading frame 91 | |
| Synonyms | - | - | |
| Cytomap | 2p21 | 2p21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | S1 RNA-binding domain-containing protein 1H_NH0576F01.1WUGSC:H_NH0576F01.1 | uncharacterized protein C2orf91 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q8N5C6 | Q6ZV80 | |
| Ensembl transtripts involved in fusion gene | ENST00000263736, ENST00000535761, ENST00000490133, | ENST00000378711, ENST00000403980, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SRBD1 [Title/Abstract] AND C2orf91 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-EB-A6L9-06A | SRBD1 | chr2 | 45789792 | - | C2orf91 | chr2 | 42165753 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263736 | ENST00000378711 | SRBD1 | chr2 | 45789792 | - | C2orf91 | chr2 | 42165753 | - |
| 5CDS-intron | ENST00000263736 | ENST00000403980 | SRBD1 | chr2 | 45789792 | - | C2orf91 | chr2 | 42165753 | - |
| 5UTR-3CDS | ENST00000535761 | ENST00000378711 | SRBD1 | chr2 | 45789792 | - | C2orf91 | chr2 | 42165753 | - |
| 5UTR-intron | ENST00000535761 | ENST00000403980 | SRBD1 | chr2 | 45789792 | - | C2orf91 | chr2 | 42165753 | - |
| intron-3CDS | ENST00000490133 | ENST00000378711 | SRBD1 | chr2 | 45789792 | - | C2orf91 | chr2 | 42165753 | - |
| intron-intron | ENST00000490133 | ENST00000403980 | SRBD1 | chr2 | 45789792 | - | C2orf91 | chr2 | 42165753 | - |
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FusionProtFeatures for SRBD1_C2orf91 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SRBD1 | C2orf91 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SRBD1 | chr2:45789792 | chr2:42165753 | ENST00000263736 | - | 10 | 21 | 258_288 | 469 | 996 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SRBD1 | chr2:45789792 | chr2:42165753 | ENST00000263736 | - | 10 | 21 | 80_83 | 469 | 996 | Compositional bias | Note=Poly-Val |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SRBD1 | chr2:45789792 | chr2:42165753 | ENST00000263736 | - | 10 | 21 | 919_992 | 469 | 996 | Domain | S1 motif |
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FusionGeneSequence for SRBD1_C2orf91 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SRBD1_ENST00000263736_chr2_45789792_-_C2orf91_ENST00000378711_chr2_42165753_-_473aa MSSLPRRAKVQVQDVVLKDEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMPRVKKNAPQISDGSEVVVVKEELNSS VAIADTALEDRKNKLDTVQTLKTAKTKQKCAAQPHTVRRTKKLKVEEETSKASNLEGESNSSETPSTSTVWGGTCKKEENDDDFTFGQSA LKKIKTETYPQGQPVKFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNTIPFIIRYRKELINNLDADSLREVQQTLEE LRAVAKKVHSTIQKIKKEGKMSECLLKAMLNCKTFEELEHVSAPYKTGSKGTKAQRARQLGLEGAARALLEKPGELSLLSYIRPDVKGLS TLQDIEIGVQHILADMIAKDKDTLDFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQHFSCNIRNIHHHQILAINRGENLKVLTV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SRBD1_ENST00000263736_chr2_45789792_-_C2orf91_ENST00000378711_chr2_42165753_-_1420nt ATGTCATCATTGCCAAGAAGAGCGAAAGTACAGGTCCAGGATGTGGTACTGAAAGATGAATTTTCTTCATTCTCTGAGTTATCATCTGCC TCTGAAGAAGATGACAAGGAAGATAGTGCCTGGGAGCCCCAAAAGAAAGTTCCCAGAAGCCGTAAACAGCCCCCTCCCAAGGAATCCAAA CCAAAGAGGATGCCTCGGGTGAAGAAGAATGCCCCACAGATCAGTGATGGCTCAGAAGTCGTTGTTGTTAAGGAGGAGCTGAATAGCTCT GTGGCTATTGCTGATACTGCTTTAGAAGACAGAAAAAATAAATTGGATACTGTACAGACTCTGAAAACAGCCAAGACAAAACAGAAATGT GCAGCGCAGCCACATACAGTTCGAAGGACTAAAAAGCTGAAAGTTGAAGAAGAAACCAGCAAAGCCAGCAACTTAGAGGGTGAGAGTAAT AGTTCAGAGACACCATCCACAAGCACTGTGTGGGGAGGTACATGCAAGAAGGAAGAGAATGACGATGACTTTACATTTGGTCAGTCCGCT TTAAAGAAAATCAAGACTGAGACATATCCTCAGGGGCAGCCTGTCAAGTTTCCAGCAAATGCCAATAGTACTAAAGAGGAGGTGGAAATG AATTGGGACATGGTACAGGTTTTATCTGAGAGAACTAATATTGAACCTTGGGTTTGTGCCAACATCATTCGTCTCTTTAATGATGATAAC ACAATTCCCTTCATTATACGTTATAGAAAAGAGCTCATTAATAACCTTGATGCTGATTCCTTGAGAGAAGTTCAGCAAACCCTAGAAGAG CTACGGGCTGTTGCAAAGAAAGTTCATAGTACAATCCAGAAAATTAAGAAGGAAGGGAAGATGTCTGAGTGCTTGTTAAAAGCCATGCTG AATTGTAAAACTTTTGAAGAACTAGAACACGTGTCTGCTCCATATAAAACTGGAAGCAAAGGGACTAAAGCCCAGAGAGCAAGACAGTTG GGCTTAGAAGGAGCAGCCAGGGCACTGCTTGAGAAACCAGGGGAGCTCAGTCTGCTATCGTACATTAGGCCTGACGTTAAAGGGCTTTCA ACGCTTCAGGATATTGAAATAGGAGTGCAGCATATTTTAGCAGATATGATTGCTAAAGACAAAGACACGCTTGACTTCATTCGGAACTTG TGCCAGAAGAGACATGTTTGTATCCAGTCATCTCTGGCAAAAGTATCCTCAAAAAAGGTAAATGAGAAAGATGTTGATAAGTTTCTGCTC TACCAGCATTTTTCCTGCAACATAAGAAACATTCACCATCATCAGATTCTGGCAATTAACCGTGGAGAAAATTTGAAGGTACTGACGGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SRBD1_ENST00000263736_chr2_45789792_-_C2orf91_ENST00000378711_chr2_42165753_-_4718nt GGGAACCGGAAGGTGCGGTGGCACTCACGGAATCTCGGGTCTTCTGACGTGCCGGGCGGGAAGATGTCATCATTGCCAAGAAGAGCGAAA GTACAGGTCCAGGATGTGGTACTGAAAGATGAATTTTCTTCATTCTCTGAGTTATCATCTGCCTCTGAAGAAGATGACAAGGAAGATAGT GCCTGGGAGCCCCAAAAGAAAGTTCCCAGAAGCCGTAAACAGCCCCCTCCCAAGGAATCCAAACCAAAGAGGATGCCTCGGGTGAAGAAG AATGCCCCACAGATCAGTGATGGCTCAGAAGTCGTTGTTGTTAAGGAGGAGCTGAATAGCTCTGTGGCTATTGCTGATACTGCTTTAGAA GACAGAAAAAATAAATTGGATACTGTACAGACTCTGAAAACAGCCAAGACAAAACAGAAATGTGCAGCGCAGCCACATACAGTTCGAAGG ACTAAAAAGCTGAAAGTTGAAGAAGAAACCAGCAAAGCCAGCAACTTAGAGGGTGAGAGTAATAGTTCAGAGACACCATCCACAAGCACT GTGTGGGGAGGTACATGCAAGAAGGAAGAGAATGACGATGACTTTACATTTGGTCAGTCCGCTTTAAAGAAAATCAAGACTGAGACATAT CCTCAGGGGCAGCCTGTCAAGTTTCCAGCAAATGCCAATAGTACTAAAGAGGAGGTGGAAATGAATTGGGACATGGTACAGGTTTTATCT GAGAGAACTAATATTGAACCTTGGGTTTGTGCCAACATCATTCGTCTCTTTAATGATGATAACACAATTCCCTTCATTATACGTTATAGA AAAGAGCTCATTAATAACCTTGATGCTGATTCCTTGAGAGAAGTTCAGCAAACCCTAGAAGAGCTACGGGCTGTTGCAAAGAAAGTTCAT AGTACAATCCAGAAAATTAAGAAGGAAGGGAAGATGTCTGAGTGCTTGTTAAAAGCCATGCTGAATTGTAAAACTTTTGAAGAACTAGAA CACGTGTCTGCTCCATATAAAACTGGAAGCAAAGGGACTAAAGCCCAGAGAGCAAGACAGTTGGGCTTAGAAGGAGCAGCCAGGGCACTG CTTGAGAAACCAGGGGAGCTCAGTCTGCTATCGTACATTAGGCCTGACGTTAAAGGGCTTTCAACGCTTCAGGATATTGAAATAGGAGTG CAGCATATTTTAGCAGATATGATTGCTAAAGACAAAGACACGCTTGACTTCATTCGGAACTTGTGCCAGAAGAGACATGTTTGTATCCAG TCATCTCTGGCAAAAGTATCCTCAAAAAAGGTAAATGAGAAAGATGTTGATAAGTTTCTGCTCTACCAGCATTTTTCCTGCAACATAAGA AACATTCACCATCATCAGATTCTGGCAATTAACCGTGGAGAAAATTTGAAGGTACTGACGGTTAAGGTCAATATTTCTGATGGAGTGAAG GATGAATTCTGTAGGTGGTGCATCCAAAACAGGTTCCACCTGAATTCCTTCCATGCTTTTCAGCGACTGAACCATTTGGGTGGCCTGGAA GAGCCTGTGAGCTCCCTGGAGAAAGGAGACAGTGTGGATGGAGAAGAATCTGGAGTAGAGAGGAGTCTGGGGACCCTGCCTTTCAAGTCG TTTGTGTGAGGGCTGCGTTGGTGGCCCAACTAGCCAGGGAAGGGCTATGGTATGCGGGGTCAGGCGGGAATAGGCAGGAAATGTTTGTGA TAAGAGGCTTCGCCTCTTGCAAGCTCCTCTGGTTTCCAGACCCAGCTGCAGGATAAGGGCCCAGGAGCTGAGCAGGGAGCCTCAGAGGAG GCTGCTGCAAGAGCCAGCTCTTGGGATTTCAGCAGGCAGAGTTGCAATCAGAGGCCCCTGGGGTCCCTGAAGACCATGCCTGGGGATAGA AACGACCCTGGGAACCCAGCCAGGGCTGCCTTCCTTTGGGATCAGGGATTTTCAATCATACTTCAGAGGGCCAAATCAATCCCTTAAGAA AAATAAAACAAAACAAACCCCAGCTTTGTTAATCCAAGTTGCTGAGAGGGTGGGAAGTACAGACTTGACCCCCCAGGGGATTTCATGCGC TGGATTGGTCCCAGTTGGAGCCATTCATTAATGTTAACCAGTAGAAATGGAAAATGGAAGGGTGCACTGACAAAAGACCAGGCTGGAAGC TCTGAGAAGGAATCTATCCCAAAGGGATCATCTGCTGGGGATAAATAGAGTCATCGAACAGTGTGTCATGCAGGCATTTGCAAAGCTTGG TGCTCCTTAGATTTCCAGTGTCGCCTCTTTGCCCAAGGCCCAGTGACTCCACCATCTGTGGTTGACTTGGCCAGCTCACAAAGGAGCAAG ATGTGCTTCACAGGAACACCCCATGAGCGGGGATGAGGCTACAGGCCACTTGCTATTGTACCAGCTCCCCTTCTTAAGGATTAGCAGCTT CTATCTATCCCTGGAGGCTGCACTGTAAATGCCTGTGTAATGCTAATTTGTGGTTGGCAGGAGATTGATTGGGAAGGAGCAGGACAATGG CAAGAGGAGGCTGAGCTCCCTCCTCCTCCTGGTGTAATGGTGTGCTTGCATGCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTACGT GTGTGTACGTGTGTGTCTTCTGGGAGAAATGTAGCAACAAGCCCACAGAAGAGATGATTATTCAAAGAGAGGAAGAAGATTTACTCACCG ATGCCCAGAATCTGAAAGGCATGTCTGGAGTGGAGAGATGGGAGTCTATGAAGCACAAATCCAGGGAGATTTTTTGATGGGAATAAGTGA CAACCCATCACTCTTAACATATTCTATTCATTAGAACCAAGTCCCTAAGTCCAGCCCACGCTTAGAGGAAGGGATTACATGGGAGGCAAG AATCACTGAGAGCCATTTCGGAAACTGCCTACACTTAGAAAAACACTTCAAGAGCTCCCGGCCAAGGGCCTGGCACATAGCAAGTGCTCA AGGAATTGTTACTTGGACCAGTGACTCTTCTAGGATGTGATCTAGGTTTTCCCATAGTGGCCTGGGTCTCTGCTGTCCCATCTTTATTCC TGTTGGCACTGCTGGGTTTTCAGCAAAGGCTTTTTCCTCTGACACTGGGAGGTTTGTGACTAGGCTCTCTGGGTGTGGGCCAGCAGACAG GATAGACGCTAACTTACACTCTTGCTGTCTTCCGAACAGCCTCTTCATGACCATGTGTGGTCTTACTTTGTGGTCAGTGTACAGATATTT TAATTTCCTGCTCACCTGCTCAGAGGAGGATCTGATTTCTTCTTGCATTTATTTTTCTCTCCGGCAGCCTGTGGACAGGTATTTCTGTCT GACCATCTGGTAGCCATTCACCTTTATGGTGGCTTGAGAAAGGAATCAATTTCACTTGTTTCTTTAGTAATATCTGCCTCTTTTGACAGC AAGTTACCTTTATCACCTCTTAAAATTCTTACTATGTTGCACCTTCTGTTACCTTGGGGGCTCTTTCAATCCCCTAACTTTGTGCAACTG CATCTCCCTCTTTGGTTTAGCTTCTCAGGCCTTTCTTTTTGCACCACGGTTTAATACATTCCATATATACTTCTAAGTCTGCTGGTACCT CTCCCCACCCACTGCCTGCTGAGAGTGACGGATTCTTCCTGGCTGGACCAAGTCTAAAGTAATCAGAAAACAACTGAAAGAGGAAAGCTG ACCCCTGCCCTCATCCTGCCCCTCTGCAGACTTCTTGAGGCCTTTTGTCTAATTGTGGTGGGTAATGTGGGCAGGGTAAAAAATGGGGAA GATAGAGCAAATTTTCTGGGCAAGAATGAGGGGAGAGGTGAGTGGAGCGTCTTCATCTCGCTCTGGTTTTGTATCATGGGTGTCTCCAGG GCCTACTGTCTCCTCTGAGACTCCTAGAAAGTGAGGAGCCATGGATTGGTATCCTACTAACAGATGGAACATCAGAGGCCCGTGGTAAGG AGTATAATAAGCTCAGCTCGCCATGCTCTGTTTTGTTTTTGTTGGAAGAAGTGTTGAAAAAAGGAGTGGTTATACACTGGCCTATCTAGC TATAGAATACAAACACTTAGGGTGAGCAGCAGGGAATGCCTTTTCTGAAAATGATGCTGCATGGAATGGATGATTAATTCCCTGGTTAAA ATGAAGCCAGACTATCTTTCAGAGTCTTAAGCCTCCTCCCAATACCCTCCACATACTAGTTTCTAATTGGTTAATGAATATGGTCACTAT TTCTAGGGCCTGTTGCTCCAGTGTAGTGGTCAAGAGTGTACACTCCTATTTACAATAGCAAAGACATGGAACCAACCCAAATGCCCATCA ATGATAGACTGGATGAAGAAAATATTGTACATATATACCATGGAATACTATGCAGCCCTAAGAAGGAATGAGATCGTGTCCTTTGCAGGG ACATGGATGAAGCTGGAAGCCATCATCCTCAGCAAACTAACACAGGAACAGAAAACCAAATACCACACGTTCTCACTCATAAGTGGGAGC TGAACAGTGAGAACACATGGACACAGGGAGGGGAACATCACACACCAAGGCCTGTCTGGTGTGGGGAGGGGAGGGAGAGCATCAGGACAA ATAGCTAATGCATGTGGGGCTTAAACCTAGATGACGGGTTGATAGGTGCAGCAATCCACTATGGCACACATATACCTATGTAACAAACCA |
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FusionGenePPI for SRBD1_C2orf91 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SRBD1 | USP45, SART3, ELAVL1, TAOK1, CBX7, TARDBP, HECW2, RPA3, RPA2, RPA1, NXF1, NTRK1, HIST1H2BG, HIST1H3A, CEP89, HNRNPU, FBXW7, RCAN1, GSK3A, TRIM44, ARHGAP22, MECP2, CROCC, PPP3CC, RRP8, ZC3HC1, RPL18A, PPP3R1, ARIH1, ZBTB48, CCDC59 | C2orf91 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SRBD1_C2orf91 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SRBD1_C2orf91 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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