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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 35875

FusionGeneSummary for SPTLC2_DIAPH3

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTLC2_DIAPH3
Fusion gene ID: 35875
HgeneTgene
Gene symbol

SPTLC2

DIAPH3

Gene ID

9517

81624

Gene nameserine palmitoyltransferase long chain base subunit 2diaphanous related formin 3
SynonymsHSN1C|LCB2|LCB2A|NSAN1C|SPT2|hLCB2aAN|AUNA1|DIA2|DRF3|NSDAN|diap3|mDia2
Cytomap

14q24.3

13q21.2

Type of geneprotein-codingprotein-coding
Descriptionserine palmitoyltransferase 2LCB 2SPT 2long chain base biosynthesis protein 2aserine palmitoyltransferase, subunit IIserine-palmitoyl-CoA transferase 2protein diaphanous homolog 3diaphanous homolog 3
Modification date2018051920180527
UniProtAcc

O15270

Q9NSV4

Ensembl transtripts involved in fusion geneENST00000216484, ENST00000556264, 
ENST00000400324, ENST00000400330, 
ENST00000400319, ENST00000400320, 
ENST00000377908, ENST00000267215, 
ENST00000465066, 
Fusion gene scores* DoF score6 X 6 X 4=14410 X 10 X 7=700
# samples 713
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/700*10)=-2.42884329880387
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPTLC2 [Title/Abstract] AND DIAPH3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPTLC2

GO:0030148

sphingolipid biosynthetic process

25332431

HgeneSPTLC2

GO:0046513

ceramide biosynthetic process

25691431

HgeneSPTLC2

GO:1904504

positive regulation of lipophagy

25332431


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-IN-AB1X-01ASPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000216484ENST00000400324SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
In-frameENST00000216484ENST00000400330SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
In-frameENST00000216484ENST00000400319SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
In-frameENST00000216484ENST00000400320SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
In-frameENST00000216484ENST00000377908SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
In-frameENST00000216484ENST00000267215SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
5CDS-5UTRENST00000216484ENST00000465066SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
intron-3CDSENST00000556264ENST00000400324SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
intron-3CDSENST00000556264ENST00000400330SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
intron-3CDSENST00000556264ENST00000400319SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
intron-3CDSENST00000556264ENST00000400320SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
intron-3CDSENST00000556264ENST00000377908SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
intron-3CDSENST00000556264ENST00000267215SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-
intron-5UTRENST00000556264ENST00000465066SPTLC2chr14

78043110

-DIAPH3chr13

60348957

-

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FusionProtFeatures for SPTLC2_DIAPH3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPTLC2

O15270

DIAPH3

Q9NSV4

Serine palmitoyltransferase (SPT). The heterodimerformed with LCB1/SPTLC1 constitutes the catalytic core. Thecomposition of the serine palmitoyltransferase (SPT) complexdetermines the substrate preference. The SPTLC1-SPTLC2-SPTSSAcomplex shows a strong preference for C16-CoA substrate, while theSPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoAsubstrate. {ECO:0000269|PubMed:19416851,ECO:0000269|PubMed:20920666}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTLC2chr14:78043110chr13:60348957ENST00000216484-41267_87210563TransmembraneHelical
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400319-22261013_10569841124Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400320-22261013_105610081148Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000267215-24271057_108710541113DomainDAD
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000377908-23271057_108710431183DomainDAD
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400319-22261057_10879841124DomainDAD
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400320-22261057_108710081148DomainDAD
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400324-24281057_108710541194DomainDAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000267215-24271013_105610541113Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000267215-2427497_55410541113Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000377908-23271013_105610431183Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000377908-2327497_55410431183Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400319-2226497_5549841124Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400320-2226497_55410081148Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400324-24281013_105610541194Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400324-2428497_55410541194Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000267215-2427561_63610541113Compositional biasNote=Pro-rich
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000377908-2327561_63610431183Compositional biasNote=Pro-rich
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400319-2226561_6369841124Compositional biasNote=Pro-rich
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400320-2226561_63610081148Compositional biasNote=Pro-rich
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400324-2428561_63610541194Compositional biasNote=Pro-rich
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000267215-2427114_47610541113DomainGBD/FH3
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000267215-2427561_63110541113DomainNote=FH1
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000267215-2427636_103410541113DomainFH2
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000377908-2327114_47610431183DomainGBD/FH3
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000377908-2327561_63110431183DomainNote=FH1
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000377908-2327636_103410431183DomainFH2
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400319-2226114_4769841124DomainGBD/FH3
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400319-2226561_6319841124DomainNote=FH1
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400319-2226636_10349841124DomainFH2
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400320-2226114_47610081148DomainGBD/FH3
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400320-2226561_63110081148DomainNote=FH1
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400320-2226636_103410081148DomainFH2
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400324-2428114_47610541194DomainGBD/FH3
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400324-2428561_63110541194DomainNote=FH1
TgeneDIAPH3chr14:78043110chr13:60348957ENST00000400324-2428636_103410541194DomainFH2


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FusionGeneSequence for SPTLC2_DIAPH3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400324_chr13_60348957_-_350aa
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDF
LRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400330_chr13_60348957_-_350aa
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDF
LRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400319_chr13_60348957_-_350aa
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDF
LRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400320_chr13_60348957_-_350aa
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDF
LRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000377908_chr13_60348957_-_350aa
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDF
LRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000267215_chr13_60348957_-_269aa
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDF
LRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400324_chr13_60348957_-_1050nt
ATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTACGGAACGGGTACGTG
AGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATAAAAGACCGTTTAAT
GAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGATATCTTCGAGATTTC
TTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATCAAGATTTTGAAAAC
TTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGGTGGACATCATGGAG
AGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCTACAACTATCTTGGA
TTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTACTCGGCAGGAAATT
GAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATG
CCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACA
GAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACG
TCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400330_chr13_60348957_-_1050nt
ATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTACGGAACGGGTACGTG
AGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATAAAAGACCGTTTAAT
GAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGATATCTTCGAGATTTC
TTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATCAAGATTTTGAAAAC
TTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGGTGGACATCATGGAG
AGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCTACAACTATCTTGGA
TTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTACTCGGCAGGAAATT
GAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATG
CCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACA
GAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACG
TCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400319_chr13_60348957_-_1050nt
ATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTACGGAACGGGTACGTG
AGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATAAAAGACCGTTTAAT
GAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGATATCTTCGAGATTTC
TTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATCAAGATTTTGAAAAC
TTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGGTGGACATCATGGAG
AGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCTACAACTATCTTGGA
TTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTACTCGGCAGGAAATT
GAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATG
CCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACA
GAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACG
TCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400320_chr13_60348957_-_1050nt
ATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTACGGAACGGGTACGTG
AGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATAAAAGACCGTTTAAT
GAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGATATCTTCGAGATTTC
TTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATCAAGATTTTGAAAAC
TTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGGTGGACATCATGGAG
AGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCTACAACTATCTTGGA
TTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTACTCGGCAGGAAATT
GAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATG
CCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACA
GAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACG
TCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000377908_chr13_60348957_-_1050nt
ATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTACGGAACGGGTACGTG
AGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATAAAAGACCGTTTAAT
GAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGATATCTTCGAGATTTC
TTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATCAAGATTTTGAAAAC
TTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGGTGGACATCATGGAG
AGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCTACAACTATCTTGGA
TTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTACTCGGCAGGAAATT
GAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATG
CCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACA
GAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACG
TCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTT

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000267215_chr13_60348957_-_807nt
ATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTACGGAACGGGTACGTG
AGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATAAAAGACCGTTTAAT
GAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGATATCTTCGAGATTTC
TTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATCAAGATTTTGAAAAC
TTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGGTGGACATCATGGAG
AGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCTACAACTATCTTGGA
TTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTACTCGGCAGGAAATT
GAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400324_chr13_60348957_-_2245nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC
TTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTA
AAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTA
AATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTA
CCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGA
GCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACA
TTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAA
TTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCAT
TATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGT
ATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAG
AGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAA
ACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATG

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400330_chr13_60348957_-_2237nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC
TTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTA
AAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTA
AATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTA
CCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGA
GCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACA
TTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAA
TTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCAT
TATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGT
ATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAG
AGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAA
ACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATG

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400319_chr13_60348957_-_1244nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000400320_chr13_60348957_-_1244nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000377908_chr13_60348957_-_1244nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC

>In-frame_SPTLC2_ENST00000216484_chr14_78043110_-_DIAPH3_ENST00000267215_chr13_60348957_-_1111nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGGTAATAAAC
CGTATTTATAAATTGCACATTCTTCTTATCTACTTTTATCCTATTGATCTGTGATTTTAGTAGACTGCTGTGAAATTCTCAAGTTCCAAT


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FusionGenePPI for SPTLC2_DIAPH3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPTLC2BCL6, NOTCH3, SPINT2, NRG1, P2RX4, FAM189A2, WBP1, EVA1C, NTRK1, HERC2, PTAR1, LRRTM1, ROM1, PTPRN, TRIM25DIAPH3NCKIPSD, HDAC6, SIRT1, VCP, SMAD9, CDC42, RHOA, RAC1, CENPA, WWOX, ENO1, NXF1, HS2ST1, CCDC183, COMTD1, PNKD, ENPP6, SCN2B, CCNB1, CCNB2, OFD1, PCM1, SPICE1, NINL, NIN, XPO1, SNW1, CDH1, EPHA1, TPTE2, BCHE, VASN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPTLC2_DIAPH3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSPTLC2O15270DB00114Pyridoxal PhosphateSerine palmitoyltransferase 2small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for SPTLC2_DIAPH3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPTLC2C3150896NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IC2CTD_human;UNIPROT