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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35865

FusionGeneSummary for SPTBN4_RAD51B

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTBN4_RAD51B
Fusion gene ID: 35865
HgeneTgene
Gene symbol

SPTBN4

RAD51B

Gene ID

57731

5890

Gene namespectrin beta, non-erythrocytic 4RAD51 paralog B
SynonymsCMND|QV|SPNB4|SPTBN3R51H2|RAD51L1|REC2
Cytomap

19q13.2

14q24.1

Type of geneprotein-codingprotein-coding
Descriptionspectrin beta chain, non-erythrocytic 4beta-IV spectrinspectrin beta chain, brain 3spectrin, non-erythroid beta chain 3DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
Modification date2018051920180523
UniProtAcc

Q9H254

O15315

Ensembl transtripts involved in fusion geneENST00000595535, ENST00000352632, 
ENST00000344104, ENST00000338932, 
ENST00000598249, ENST00000392025, 
ENST00000392023, ENST00000593816, 
ENST00000487861, ENST00000471583, 
ENST00000487270, ENST00000488612, 
ENST00000390683, ENST00000469165, 
Fusion gene scores* DoF score5 X 3 X 5=7525 X 15 X 8=3000
# samples 533
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/3000*10)=-3.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPTBN4 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-DD-AACV-01ASPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000595535ENST00000487861SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000595535ENST00000471583SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000595535ENST00000487270SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000595535ENST00000488612SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000595535ENST00000390683SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3UTRENST00000595535ENST00000469165SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000352632ENST00000487861SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000352632ENST00000471583SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000352632ENST00000487270SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000352632ENST00000488612SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000352632ENST00000390683SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3UTRENST00000352632ENST00000469165SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000344104ENST00000487861SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000344104ENST00000471583SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000344104ENST00000487270SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000344104ENST00000488612SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000344104ENST00000390683SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3UTRENST00000344104ENST00000469165SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000338932ENST00000487861SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000338932ENST00000471583SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000338932ENST00000487270SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000338932ENST00000488612SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000338932ENST00000390683SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3UTRENST00000338932ENST00000469165SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000598249ENST00000487861SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000598249ENST00000471583SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000598249ENST00000487270SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000598249ENST00000488612SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3CDSENST00000598249ENST00000390683SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
5UTR-3UTRENST00000598249ENST00000469165SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392025ENST00000487861SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392025ENST00000471583SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392025ENST00000487270SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392025ENST00000488612SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392025ENST00000390683SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3UTRENST00000392025ENST00000469165SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392023ENST00000487861SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392023ENST00000471583SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392023ENST00000487270SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392023ENST00000488612SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000392023ENST00000390683SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3UTRENST00000392023ENST00000469165SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000593816ENST00000487861SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000593816ENST00000471583SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000593816ENST00000487270SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000593816ENST00000488612SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3CDSENST00000593816ENST00000390683SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+
intron-3UTRENST00000593816ENST00000469165SPTBN4chr19

40973212

+RAD51Bchr14

68758601

+

Top

FusionProtFeatures for SPTBN4_RAD51B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPTBN4

Q9H254

RAD51B

O15315


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPTBN4_RAD51B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPTBN4_RAD51B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPTBN4DISC1, ANK3, PTPRN, PTPRN2, GSK3B, NEK2, CENPU, CDC37, RPS6KA6, PFDN1, GADD45A, HOMER1, CLK1, ESRRB, RSBN1, PCDHGC3, SPTAN1, SPTA1RAD51BRAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SPTBN4_RAD51B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPTBN4_RAD51B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPTBN4C0007134Renal Cell Carcinoma1CTD_human
HgeneSPTBN4C0032460Polycystic Ovary Syndrome1CTD_human
TgeneRAD51BC0236969Substance-Related Disorders1CTD_human
TgeneRAD51BC0242788Breast Neoplasms, Male1CTD_human
TgeneRAD51BC1458155Mammary Neoplasms1CTD_human