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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35833

FusionGeneSummary for SPTAN1_FPGS

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTAN1_FPGS
Fusion gene ID: 35833
HgeneTgene
Gene symbol

SPTAN1

FPGS

Gene ID

6709

2356

Gene namespectrin alpha, non-erythrocytic 1folylpolyglutamate synthase
SynonymsEIEE5|NEAS|SPTA2-
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionspectrin alpha chain, non-erythrocytic 1alpha-II spectrinalpha-fodrinfodrin alpha chainspectrin, non-erythroid alpha chainspectrin, non-erythroid alpha subunitfolylpolyglutamate synthase, mitochondrialfolylpoly-gamma-glutamate synthetasetetrahydrofolate synthasetetrahydrofolylpolyglutamate synthase
Modification date2018052920180523
UniProtAcc

Q13813

Q05932

Ensembl transtripts involved in fusion geneENST00000358161, ENST00000372739, 
ENST00000372731, ENST00000475367, 
ENST00000373247, ENST00000373245, 
ENST00000393706, ENST00000460181, 
ENST00000373225, 
Fusion gene scores* DoF score17 X 15 X 10=25503 X 4 X 2=24
# samples 214
** MAII scorelog2(21/2550*10)=-3.6020360140801
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SPTAN1 [Title/Abstract] AND FPGS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFPGS

GO:0006536

glutamate metabolic process

3619447

TgeneFPGS

GO:0006760

folic acid-containing compound metabolic process

3619447

TgeneFPGS

GO:0046901

tetrahydrofolylpolyglutamate biosynthetic process

3619447


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-IN-A6RN-01ASPTAN1chr9

131314975

+FPGSchr9

130566564

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000358161ENST00000373247SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3CDSENST00000358161ENST00000373245SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3CDSENST00000358161ENST00000393706SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3UTRENST00000358161ENST00000460181SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-5UTRENST00000358161ENST00000373225SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3CDSENST00000372739ENST00000373247SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3CDSENST00000372739ENST00000373245SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3CDSENST00000372739ENST00000393706SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3UTRENST00000372739ENST00000460181SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-5UTRENST00000372739ENST00000373225SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3CDSENST00000372731ENST00000373247SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3CDSENST00000372731ENST00000373245SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3CDSENST00000372731ENST00000393706SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-3UTRENST00000372731ENST00000460181SPTAN1chr9

131314975

+FPGSchr9

130566564

+
5UTR-5UTRENST00000372731ENST00000373225SPTAN1chr9

131314975

+FPGSchr9

130566564

+
intron-3CDSENST00000475367ENST00000373247SPTAN1chr9

131314975

+FPGSchr9

130566564

+
intron-3CDSENST00000475367ENST00000373245SPTAN1chr9

131314975

+FPGSchr9

130566564

+
intron-3CDSENST00000475367ENST00000393706SPTAN1chr9

131314975

+FPGSchr9

130566564

+
intron-3UTRENST00000475367ENST00000460181SPTAN1chr9

131314975

+FPGSchr9

130566564

+
intron-5UTRENST00000475367ENST00000373225SPTAN1chr9

131314975

+FPGSchr9

130566564

+

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FusionProtFeatures for SPTAN1_FPGS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPTAN1

Q13813

FPGS

Q05932

Catalyzes conversion of folates to polyglutamatederivatives allowing concentration of folate compounds in the celland the intracellular retention of these cofactors, which areimportant substrates for most of the folate-dependent enzymes thatare involved in one-carbon transfer reactions involved in purine,pyrimidine and amino acid synthesis. Unsubstituted reduced folatesare the preferred substrates. Metabolizes methotrexate (MTX) topolyglutamates. {ECO:0000269|PubMed:8408018,ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021,ECO:0000269|PubMed:8662720}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPTAN1_FPGS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPTAN1_FPGS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPTAN1FANCA, FANCC, FANCG, ERCC4, PTOV1, PIN4, DDX24, TSSC4, DES, ABL1, NEFL, SHANK3, SHANK1, EPB41, SPTB, GRIA2, EPB42, PLEC, VIM, LMNB1, ACTA1, MSN, TAF10, SOS1, STAT1, PLEKHA5, EMD, FANCF, HES1, TERF1, POT1, AGO3, TJP1, DISC1, CEP63, EXOC1, MAPK6, ARRB1, ARRB2, SIRT7, ERG, CUL3, CDK2, CUL1, COPS5, NEDD8, GRK5, CBL, UBASH3B, SHC1, SPTBN1, MYH9, SPTBN2, SARS2, PRKCDBP, PPT2, ILF2, GSPT1, RABL2A, HNRNPR, STRIP1, SFXN3, KIAA0368, MCAT, DNAJA1, HSPA5, HNRNPK, CLPTM1L, MAPRE1, DBN1, ACTA2, NENF, DDX19A, ESR1, EIF4A3, MAGOH, SMURF1, EVL, TES, HSP90AA1, HSP90AB1, MLH1, GRIN1, GRIN2A, GRIN2B, UBL4A, SVIL, PAN2, CAPN1, CASP3, CASP7, MAPK9, SAV1, CRYZ, EHBP1L1, NUP188, PLS1, PPFIA1, PPP4R1, RPS24, FAU, GPHN, PTBP1, RPA3, RPA2, RPA1, ZBTB1, STAU1, CEP57, CEP76, VCP, CANX, DHX9, NCAPD3, NUCB2, PXDN, PXDNL, RPN2, SF3B3, SPTBN5, NTRK1, PDE4D, PTEN, MED4, MED20, EWSR1, HIST1H3E, ADD1, CAPZA2, CENPE, FLNA, GAK, MYH7, MYO1C, PPP1CB, VCL, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZSCAN26, GAN, SNW1, CDC5L, U2AF2, CDH1, PDP1, PPM1B, PTP4A2, STYXL1, SPTBN4, KALRN, KARS, AKIP1, TAF1, ZNF333, FANCD2, CYLD, LASP1, TRIM25, BRCA1FPGSHMGCL, PALM2, LIPH, THEM4, LAMP2, TOR1AIP2, NIT1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPTAN1_FPGS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFPGSQ05932DB00293RaltitrexedFolylpolyglutamate synthase, mitochondrialsmall moleculeapproved|investigational
TgeneFPGSQ05932DB00142Glutamic AcidFolylpolyglutamate synthase, mitochondrialsmall moleculeapproved|nutraceutical

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RelatedDiseases for SPTAN1_FPGS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPTAN1C0524851Neurodegenerative Disorders1CTD_human
TgeneFPGSC0003873Rheumatoid Arthritis1CTD_human
TgeneFPGSC0009404Colorectal Neoplasms1CTD_human
TgeneFPGSC0024305Lymphoma, Non-Hodgkin1CTD_human
TgeneFPGSC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human