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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35807

FusionGeneSummary for SPRR1B_ARL13B

check button Fusion gene summary
Fusion gene informationFusion gene name: SPRR1B_ARL13B
Fusion gene ID: 35807
HgeneTgene
Gene symbol

SPRR1B

ARL13B

Gene ID

6699

200894

Gene namesmall proline rich protein 1BADP ribosylation factor like GTPase 13B
SynonymsCORNIFIN|GADD33|SPR-IB|SPRR1ARL2L1|JBTS8
Cytomap

1q21.3

3q11.1-q11.2

Type of geneprotein-codingprotein-coding
Descriptioncornifin-B14.9 kDa pancornulinsmall proline-rich protein IBADP-ribosylation factor-like protein 13BADP-ribosylation factor-like 13BADP-ribosylation factor-like 2-like 1ARL2-like protein 1
Modification date2018052320180523
UniProtAcc

P22528

Q3SXY8

Ensembl transtripts involved in fusion geneENST00000307098, ENST00000392661, 
ENST00000535334, ENST00000303097, 
ENST00000394222, ENST00000539730, 
ENST00000471138, ENST00000486562, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 3 X 2=18
# samples 44
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SPRR1B [Title/Abstract] AND ARL13B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPRR1B

GO:0018149

peptide cross-linking

10908733

HgeneSPRR1B

GO:0030216

keratinocyte differentiation

10908733


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE181429SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
ChiTaRS3.1BE181426SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000307098ENST00000535334SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
3UTR-intronENST00000307098ENST00000303097SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
3UTR-intronENST00000307098ENST00000394222SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
3UTR-intronENST00000307098ENST00000539730SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
3UTR-intronENST00000307098ENST00000471138SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
3UTR-intronENST00000307098ENST00000486562SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
intron-intronENST00000392661ENST00000535334SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
intron-intronENST00000392661ENST00000303097SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
intron-intronENST00000392661ENST00000394222SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
intron-intronENST00000392661ENST00000539730SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
intron-intronENST00000392661ENST00000471138SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-
intron-intronENST00000392661ENST00000486562SPRR1Bchr1

153005181

-ARL13Bchr3

93722769

-

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FusionProtFeatures for SPRR1B_ARL13B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPRR1B

P22528

ARL13B

Q3SXY8

Cross-linked envelope protein of keratinocytes. It is akeratinocyte protein that first appears in the cell cytosol, butultimately becomes cross-linked to membrane proteins bytransglutaminase. All that results in the formation of aninsoluble envelope beneath the plasma membrane. Can function asboth amine donor and acceptor in transglutaminase-mediated cross-linkage. Cilium-specific protein required to control themicrotubule-based, ciliary axoneme structure. May act bymaintaining the association between IFT subcomplexes A and B.Binds GTP but is not able to hydrolyze it; the GTPase activityremains unclear. Required to pattern the neural tube. Involved incerebral cortex development: required for the initial formation ofa polarized radial glial scaffold, the first step in theconstruction of the cerebral cortex, by regulating ciliarysignaling. Regulates the migration and placement of postmitoticinterneurons in the developing cerebral cortex. May regulateendocytic recycling traffic; however, additional evidences arerequired to confirm these data. {ECO:0000269|PubMed:23150559}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPRR1B_ARL13B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPRR1B_ARL13B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPRR1B_ARL13B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPRR1B_ARL13B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARL13BC2676771JOUBERT SYNDROME 8 (disorder)2CTD_human;UNIPROT