FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 35804

FusionGeneSummary for SPRED2_SYNE2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPRED2_SYNE2
Fusion gene ID: 35804
HgeneTgene
Gene symbol

SPRED2

SYNE2

Gene ID

200734

23224

Gene namesprouty related EVH1 domain containing 2spectrin repeat containing nuclear envelope protein 2
SynonymsSpred-2EDMD5|KASH2|NUA|NUANCE|Nesp2|Nesprin-2|SYNE-2|TROPH
Cytomap

2p14

14q23.2

Type of geneprotein-codingprotein-coding
Descriptionsprouty-related, EVH1 domain-containing protein 2sprouty protein with EVH-1 domain 2, related sequencenesprin-2KASH domain-containing protein 2nesprin 2nuclear envelope spectrin repeat protein 2nucleus and actin connecting element proteinpolytrophinspectrin repeat containing, nuclear envelope 2synaptic nuclear envelope protein 2synaptic nuclei exp
Modification date2018051920180523
UniProtAcc

Q7Z698

Q8WXH0

Ensembl transtripts involved in fusion geneENST00000356388, ENST00000443619, 
ENST00000474228, 
ENST00000357395, 
ENST00000358025, ENST00000344113, 
ENST00000341472, ENST00000356081, 
ENST00000554584, ENST00000555002, 
ENST00000394768, ENST00000556725, 
ENST00000553455, ENST00000555022, 
ENST00000554805, ENST00000458046, 
ENST00000441438, 
Fusion gene scores* DoF score5 X 3 X 5=754 X 6 X 2=48
# samples 66
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SPRED2 [Title/Abstract] AND SYNE2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYNE2

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA456989SPRED2chr2

65632964

-SYNE2chr14

64351333

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356388ENST00000357395SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000358025SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000344113SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000341472SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000356081SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000554584SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000555002SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000394768SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000556725SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000553455SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000555022SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000554805SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000458046SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000356388ENST00000441438SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000357395SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000358025SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000344113SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000341472SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000356081SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000554584SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000555002SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000394768SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000556725SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000553455SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000555022SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000554805SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000458046SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000443619ENST00000441438SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000357395SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000358025SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000344113SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000341472SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000356081SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000554584SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000555002SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000394768SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000556725SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000553455SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000555022SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000554805SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000458046SPRED2chr2

65632964

-SYNE2chr14

64351333

+
intron-intronENST00000474228ENST00000441438SPRED2chr2

65632964

-SYNE2chr14

64351333

+

Top

FusionProtFeatures for SPRED2_SYNE2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPRED2

Q7Z698

SYNE2

Q8WXH0

Negatively regulates Ras signaling pathways anddownstream activation of MAP kinases.{ECO:0000269|PubMed:15683364}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SPRED2_SYNE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SPRED2_SYNE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SPRED2_SYNE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SPRED2_SYNE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPRED2C0003873Rheumatoid Arthritis2CTD_human
TgeneSYNE2C0004238Atrial Fibrillation1CTD_human
TgeneSYNE2C0007134Renal Cell Carcinoma1CTD_human
TgeneSYNE2C2751805EMERY-DREIFUSS MUSCULAR DYSTROPHY 5, AUTOSOMAL DOMINANT1UNIPROT