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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35800

FusionGeneSummary for SPRED2_G2E3

check button Fusion gene summary
Fusion gene informationFusion gene name: SPRED2_G2E3
Fusion gene ID: 35800
HgeneTgene
Gene symbol

SPRED2

G2E3

Gene ID

200734

55632

Gene namesprouty related EVH1 domain containing 2G2/M-phase specific E3 ubiquitin protein ligase
SynonymsSpred-2KIAA1333|PHF7B
Cytomap

2p14

14q12

Type of geneprotein-codingprotein-coding
Descriptionsprouty-related, EVH1 domain-containing protein 2sprouty protein with EVH-1 domain 2, related sequenceG2/M phase-specific E3 ubiquitin-protein ligaseG2/M phase-specific HECT-type E3 ubiquitin transferaseG2/M-phase specific E3 ubiquitin ligasePHD finger protein 7B
Modification date2018051920180519
UniProtAcc

Q7Z698

Q7L622

Ensembl transtripts involved in fusion geneENST00000356388, ENST00000443619, 
ENST00000474228, 
ENST00000206595, 
ENST00000544007, ENST00000438909, 
ENST00000553504, 
Fusion gene scores* DoF score5 X 3 X 5=751 X 1 X 1=1
# samples 61
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: SPRED2 [Title/Abstract] AND G2E3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-28-2514-01ASPRED2chr2

65659096

-G2E3chr14

31050282

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000356388ENST00000206595SPRED2chr2

65659096

-G2E3chr14

31050282

+
5CDS-intronENST00000356388ENST00000544007SPRED2chr2

65659096

-G2E3chr14

31050282

+
5CDS-intronENST00000356388ENST00000438909SPRED2chr2

65659096

-G2E3chr14

31050282

+
5CDS-intronENST00000356388ENST00000553504SPRED2chr2

65659096

-G2E3chr14

31050282

+
intron-5UTRENST00000443619ENST00000206595SPRED2chr2

65659096

-G2E3chr14

31050282

+
intron-intronENST00000443619ENST00000544007SPRED2chr2

65659096

-G2E3chr14

31050282

+
intron-intronENST00000443619ENST00000438909SPRED2chr2

65659096

-G2E3chr14

31050282

+
intron-intronENST00000443619ENST00000553504SPRED2chr2

65659096

-G2E3chr14

31050282

+
intron-5UTRENST00000474228ENST00000206595SPRED2chr2

65659096

-G2E3chr14

31050282

+
intron-intronENST00000474228ENST00000544007SPRED2chr2

65659096

-G2E3chr14

31050282

+
intron-intronENST00000474228ENST00000438909SPRED2chr2

65659096

-G2E3chr14

31050282

+
intron-intronENST00000474228ENST00000553504SPRED2chr2

65659096

-G2E3chr14

31050282

+

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FusionProtFeatures for SPRED2_G2E3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPRED2

Q7Z698

G2E3

Q7L622

Negatively regulates Ras signaling pathways anddownstream activation of MAP kinases.{ECO:0000269|PubMed:15683364}. E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.Essential in early embryonic development to prevent apoptoticdeath. {ECO:0000269|PubMed:18511420}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPRED2_G2E3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPRED2_G2E3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPRED2TESK1, ELAVL1, NBR1, SQSTM1, TOP3B, SPG21, ZDHHC17, PDP1, DPP9, PRTFDC1, RPS6KA3, GNG5, RPS6KA2, STOM, GNAQG2E3WDR6, HSP90AA1, RPS15, SPECC1L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPRED2_G2E3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPRED2_G2E3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPRED2C0003873Rheumatoid Arthritis2CTD_human