FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 35765

FusionGeneSummary for SPOP_VMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPOP_VMP1
Fusion gene ID: 35765
HgeneTgene
Gene symbol

SPOP

VMP1

Gene ID

8405

81671

Gene namespeckle type BTB/POZ proteinvacuole membrane protein 1
SynonymsBTBD32|TEF2EPG3|TANGO5|TMEM49
Cytomap

17q21.33

17q23.1

Type of geneprotein-codingprotein-coding
Descriptionspeckle-type POZ proteinHIB homolog 1roadkill homolog 1vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2018052320180523
UniProtAcc

O43791

Q96GC9

Ensembl transtripts involved in fusion geneENST00000393328, ENST00000393331, 
ENST00000347630, ENST00000504102, 
ENST00000503676, ENST00000513080, 
ENST00000262291, ENST00000537567, 
ENST00000539763, ENST00000536180, 
ENST00000545362, ENST00000588617, 
Fusion gene scores* DoF score20 X 8 X 13=208024 X 11 X 12=3168
# samples 2227
** MAII scorelog2(22/2080*10)=-3.24100809950379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/3168*10)=-3.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPOP [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0DD-01ASPOPchr17

47679227

-VMP1chr17

57808782

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000393328ENST00000262291SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000393328ENST00000537567SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000393328ENST00000539763SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000393328ENST00000536180SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000393328ENST00000545362SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-intronENST00000393328ENST00000588617SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000393331ENST00000262291SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000393331ENST00000537567SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000393331ENST00000539763SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000393331ENST00000536180SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000393331ENST00000545362SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-intronENST00000393331ENST00000588617SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000347630ENST00000262291SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000347630ENST00000537567SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000347630ENST00000539763SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000347630ENST00000536180SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000347630ENST00000545362SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-intronENST00000347630ENST00000588617SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000504102ENST00000262291SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000504102ENST00000537567SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000504102ENST00000539763SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000504102ENST00000536180SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000504102ENST00000545362SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-intronENST00000504102ENST00000588617SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000503676ENST00000262291SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000503676ENST00000537567SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000503676ENST00000539763SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000503676ENST00000536180SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-5UTRENST00000503676ENST00000545362SPOPchr17

47679227

-VMP1chr17

57808782

+
5CDS-intronENST00000503676ENST00000588617SPOPchr17

47679227

-VMP1chr17

57808782

+
intron-5UTRENST00000513080ENST00000262291SPOPchr17

47679227

-VMP1chr17

57808782

+
intron-5UTRENST00000513080ENST00000537567SPOPchr17

47679227

-VMP1chr17

57808782

+
intron-5UTRENST00000513080ENST00000539763SPOPchr17

47679227

-VMP1chr17

57808782

+
intron-5UTRENST00000513080ENST00000536180SPOPchr17

47679227

-VMP1chr17

57808782

+
intron-5UTRENST00000513080ENST00000545362SPOPchr17

47679227

-VMP1chr17

57808782

+
intron-intronENST00000513080ENST00000588617SPOPchr17

47679227

-VMP1chr17

57808782

+

Top

FusionProtFeatures for SPOP_VMP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPOP

O43791

VMP1

Q96GC9

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex that mediates the ubiquitinationof target proteins, leading most often to their proteasomaldegradation. In complex with CUL3, involved in ubiquitination andproteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.In complex with CUL3, involved in ubiquitination of H2AFY andBMI1; this does not lead to their proteasomal degradation.Inhibits transcriptional activation of PDX1/IPF1 targets, such asinsulin, by promoting PDX1/IPF1 degradation. The cullin-RING-basedBCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containinghomodimeric SPOP has higher ubiquitin ligase activity than thecomplex that contains the heterodimer formed by SPOP and SPOPL.{ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469,ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708,ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}. Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SPOP_VMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SPOP_VMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPOPZBTB16, DPPA2, RXRB, DDIT3, RTN3, MYD88, SIRT2, DOK2, KPNA6, GDI1, PIP5K1B, TRAF1, TRAF6, AR, BMI1, NCOA3, CUL3, ESR1, DAXX, SPOP, PIP4K2B, UBE2E3, FADD, PIAS1, GIT2, SRRM1, ATM, GLI2, DEK, BRMS1, NUP50, RTN4, GCC1, ERG, ERF, PGR, GLI3, UBE2D1, UBE2D2, NANOG, PTEN, DUSP7, EGLN2, RFWD2, SOST, ARIH1, MSRB3, BRD4, BRD3, BRD2VMP1HGS, ELAVL1, TJP1, KLK11, LPAR6, ERGIC3, FAF2, KRAS, TCTN2, TCTN3, TMEM216, DPEP1, CDH13, MAS1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SPOP_VMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SPOP_VMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPOPC0014170Endometrial Neoplasms1CTD_human
HgeneSPOPC0033578Prostatic Neoplasms1CTD_human