FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 35753

FusionGeneSummary for SPOP_FAM117A

check button Fusion gene summary
Fusion gene informationFusion gene name: SPOP_FAM117A
Fusion gene ID: 35753
HgeneTgene
Gene symbol

SPOP

FAM117A

Gene ID

8405

81558

Gene namespeckle type BTB/POZ proteinfamily with sequence similarity 117 member A
SynonymsBTBD32|TEF2-
Cytomap

17q21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionspeckle-type POZ proteinHIB homolog 1roadkill homolog 1protein FAM117AC/EBP-induced protein
Modification date2018052320180523
UniProtAcc

O43791

Q9C073

Ensembl transtripts involved in fusion geneENST00000393328, ENST00000393331, 
ENST00000347630, ENST00000504102, 
ENST00000503676, ENST00000513080, 
ENST00000240364, ENST00000513602, 
ENST00000514018, 
Fusion gene scores* DoF score20 X 8 X 13=20806 X 3 X 4=72
# samples 228
** MAII scorelog2(22/2080*10)=-3.24100809950379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/72*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SPOP [Title/Abstract] AND FAM117A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-B0-4713-01ASPOPchr17

47755295

-FAM117Achr17

47799956

-
TCGARVOVTCGA-13-A5FT-01ASPOPchr17

47745389

-FAM117Achr17

47810082

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000393328ENST00000240364SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000393328ENST00000513602SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000393328ENST00000514018SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-3CDSENST00000393331ENST00000240364SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000393331ENST00000513602SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000393331ENST00000514018SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-3CDSENST00000347630ENST00000240364SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000347630ENST00000513602SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000347630ENST00000514018SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-3CDSENST00000504102ENST00000240364SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000504102ENST00000513602SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000504102ENST00000514018SPOPchr17

47755295

-FAM117Achr17

47799956

-
intron-3CDSENST00000503676ENST00000240364SPOPchr17

47755295

-FAM117Achr17

47799956

-
intron-5UTRENST00000503676ENST00000513602SPOPchr17

47755295

-FAM117Achr17

47799956

-
intron-5UTRENST00000503676ENST00000514018SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-3CDSENST00000513080ENST00000240364SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000513080ENST00000513602SPOPchr17

47755295

-FAM117Achr17

47799956

-
5UTR-5UTRENST00000513080ENST00000514018SPOPchr17

47755295

-FAM117Achr17

47799956

-
intron-3CDSENST00000393328ENST00000240364SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000393328ENST00000513602SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000393328ENST00000514018SPOPchr17

47745389

-FAM117Achr17

47810082

-
5UTR-3CDSENST00000393331ENST00000240364SPOPchr17

47745389

-FAM117Achr17

47810082

-
5UTR-5UTRENST00000393331ENST00000513602SPOPchr17

47745389

-FAM117Achr17

47810082

-
5UTR-5UTRENST00000393331ENST00000514018SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-3CDSENST00000347630ENST00000240364SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000347630ENST00000513602SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000347630ENST00000514018SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-3CDSENST00000504102ENST00000240364SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000504102ENST00000513602SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000504102ENST00000514018SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-3CDSENST00000503676ENST00000240364SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000503676ENST00000513602SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000503676ENST00000514018SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-3CDSENST00000513080ENST00000240364SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000513080ENST00000513602SPOPchr17

47745389

-FAM117Achr17

47810082

-
intron-5UTRENST00000513080ENST00000514018SPOPchr17

47745389

-FAM117Achr17

47810082

-

Top

FusionProtFeatures for SPOP_FAM117A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPOP

O43791

FAM117A

Q9C073

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex that mediates the ubiquitinationof target proteins, leading most often to their proteasomaldegradation. In complex with CUL3, involved in ubiquitination andproteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.In complex with CUL3, involved in ubiquitination of H2AFY andBMI1; this does not lead to their proteasomal degradation.Inhibits transcriptional activation of PDX1/IPF1 targets, such asinsulin, by promoting PDX1/IPF1 degradation. The cullin-RING-basedBCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containinghomodimeric SPOP has higher ubiquitin ligase activity than thecomplex that contains the heterodimer formed by SPOP and SPOPL.{ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469,ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708,ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SPOP_FAM117A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SPOP_FAM117A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPOPZBTB16, DPPA2, RXRB, DDIT3, RTN3, MYD88, SIRT2, DOK2, KPNA6, GDI1, PIP5K1B, TRAF1, TRAF6, AR, BMI1, NCOA3, CUL3, ESR1, DAXX, SPOP, PIP4K2B, UBE2E3, FADD, PIAS1, GIT2, SRRM1, ATM, GLI2, DEK, BRMS1, NUP50, RTN4, GCC1, ERG, ERF, PGR, GLI3, UBE2D1, UBE2D2, NANOG, PTEN, DUSP7, EGLN2, RFWD2, SOST, ARIH1, MSRB3, BRD4, BRD3, BRD2FAM117ADYRK1B, DYRK1A, PICK1, HMBOX1, COBLL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SPOP_FAM117A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SPOP_FAM117A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPOPC0014170Endometrial Neoplasms1CTD_human
HgeneSPOPC0033578Prostatic Neoplasms1CTD_human