FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 35727

FusionGeneSummary for SPO11_GSTA1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPO11_GSTA1
Fusion gene ID: 35727
HgeneTgene
Gene symbol

SPO11

GSTA1

Gene ID

23626

2938

Gene nameSPO11, initiator of meiotic double stranded breaksglutathione S-transferase alpha 1
SynonymsCT35|SPATA43|TOPVIAGST-epsilon|GST2|GSTA1-1|GTH1
Cytomap

20q13.31

6p12.2

Type of geneprotein-codingprotein-coding
Descriptionmeiotic recombination protein SPO11SPO11 meiotic protein covalently bound to DSB homologcancer/testis antigen 35spermatogenesis associated 43glutathione S-transferase A1GST HA subunit 1GST class-alpha member 1S-(hydroxyalkyl)glutathione lyase A1glutathione S-alkyltransferase A1glutathione S-aryltransferase A1glutathione S-transferase 2glutathione S-transferase Ha subunit 1testicular ti
Modification date2018052320180519
UniProtAcc

Q9Y5K1

P08263

Ensembl transtripts involved in fusion geneENST00000371263, ENST00000345868, 
ENST00000371260, 
ENST00000493331, 
ENST00000334575, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: SPO11 [Title/Abstract] AND GSTA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGSTA1

GO:0006749

glutathione metabolic process

11851347|20606271

TgeneGSTA1

GO:0043651

linoleic acid metabolic process

16624487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-3C-AALJ-01ASPO11chr20

55910963

+GSTA1chr6

52657785

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000371263ENST00000493331SPO11chr20

55910963

+GSTA1chr6

52657785

-
5CDS-5UTRENST00000371263ENST00000334575SPO11chr20

55910963

+GSTA1chr6

52657785

-
5CDS-5UTRENST00000345868ENST00000493331SPO11chr20

55910963

+GSTA1chr6

52657785

-
5CDS-5UTRENST00000345868ENST00000334575SPO11chr20

55910963

+GSTA1chr6

52657785

-
5CDS-5UTRENST00000371260ENST00000493331SPO11chr20

55910963

+GSTA1chr6

52657785

-
5CDS-5UTRENST00000371260ENST00000334575SPO11chr20

55910963

+GSTA1chr6

52657785

-

Top

FusionProtFeatures for SPO11_GSTA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPO11

Q9Y5K1

GSTA1

P08263

Component of a topoisomerase 6 complex specificallyrequired for meiotic recombination. Together with TOP6BL, mediatesDNA cleavage that forms the double-strand breaks (DSB) thatinitiate meiotic recombination. The complex promotes relaxation ofnegative and positive supercoiled DNA and DNA decatenation throughcleavage and ligation cycles. Essential for the phosphorylation ofSMC3, HORMAD1 and HORMAD2. {ECO:0000250|UniProtKB:Q9WTK8}. Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles.{ECO:0000269|PubMed:20606271}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SPO11_GSTA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SPO11_GSTA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPO11GSTA1GSTA1, APP, BAG3, LSM3, PPP2CB, ST3GAL1, YWHAE, RPAIN, GSTA3, ZBTB21, SPDL1, ACOX1, GSTA4, GAR1, GGTLC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SPO11_GSTA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSTA1P08263DB00143GlutathioneGlutathione S-transferase A1small moleculeapproved|investigational|nutraceutical

Top

RelatedDiseases for SPO11_GSTA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGSTA1C0036341Schizophrenia2PSYGENET
TgeneGSTA1C0033578Prostatic Neoplasms1CTD_human
TgeneGSTA1C0033975Psychotic Disorders1PSYGENET
TgeneGSTA1C0151744Myocardial Ischemia1CTD_human
TgeneGSTA1C0400966Non-alcoholic Fatty Liver Disease1CTD_human