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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35676

FusionGeneSummary for SPIDR_DNAJC5B

check button Fusion gene summary
Fusion gene informationFusion gene name: SPIDR_DNAJC5B
Fusion gene ID: 35676
HgeneTgene
Gene symbol

SPIDR

DNAJC5B

Gene ID

23514

85479

Gene namescaffold protein involved in DNA repairDnaJ heat shock protein family (Hsp40) member C5 beta
SynonymsKIAA0146CSP-beta
Cytomap

8q11.21

8q13.1

Type of geneprotein-codingprotein-coding
DescriptionDNA repair-scaffolding proteinscaffolding protein involved in DNA repairdnaJ homolog subfamily C member 5BDnaJ (Hsp40) homolog, subfamily C, member 5 betabeta cysteine string proteinbeta-CSPcysteine string protein betadnaJ homolog subfamily C member Xtesticular tissue protein Li 55
Modification date2018052320180519
UniProtAcc

Q14159

Q9UF47

Ensembl transtripts involved in fusion geneENST00000297423, ENST00000518074, 
ENST00000541342, ENST00000521214, 
ENST00000517693, ENST00000518060, 
ENST00000276570, ENST00000519330, 
Fusion gene scores* DoF score16 X 11 X 13=22886 X 5 X 4=120
# samples 216
** MAII scorelog2(21/2288*10)=-3.44562581911227
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPIDR [Title/Abstract] AND DNAJC5B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPIDR

GO:0006974

cellular response to DNA damage stimulus

23509288

HgeneSPIDR

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

HgeneSPIDR

GO:0031334

positive regulation of protein complex assembly

23509288

HgeneSPIDR

GO:0070202

regulation of establishment of protein localization to chromosome

23509288

HgeneSPIDR

GO:0071479

cellular response to ionizing radiation

23509288|23754376

HgeneSPIDR

GO:0072711

cellular response to hydroxyurea

23509288

HgeneSPIDR

GO:0072757

cellular response to camptothecin

23509288


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-VS-A94W-01ASPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000297423ENST00000276570SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
5CDS-3UTRENST00000297423ENST00000519330SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
5CDS-5UTRENST00000518074ENST00000276570SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
5CDS-3UTRENST00000518074ENST00000519330SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
5CDS-5UTRENST00000541342ENST00000276570SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
5CDS-3UTRENST00000541342ENST00000519330SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
3UTR-5UTRENST00000521214ENST00000276570SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
3UTR-3UTRENST00000521214ENST00000519330SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
intron-5UTRENST00000517693ENST00000276570SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
intron-3UTRENST00000517693ENST00000519330SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
intron-5UTRENST00000518060ENST00000276570SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+
intron-3UTRENST00000518060ENST00000519330SPIDRchr8

48206619

+DNAJC5Bchr8

66955723

+

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FusionProtFeatures for SPIDR_DNAJC5B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPIDR

Q14159

DNAJC5B

Q9UF47

Plays a role in DNA double-strand break (DBS) repair viahomologous recombination (HR). Serves as a scaffolding proteinthat helps to promote the recruitment of DNA-processing enzymeslike the helicase BLM and recombinase RAD51 to site of DNA damage,and hence contributes to maintain genomic integrity.{ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPIDR_DNAJC5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPIDR_DNAJC5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPIDRFOXL1, PLA2G10, TRIM25DNAJC5BTFCP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPIDR_DNAJC5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPIDR_DNAJC5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource