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Fusion gene ID: 35585 |
FusionGeneSummary for SPATA6_MAD2L2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPATA6_MAD2L2 | Fusion gene ID: 35585 | Hgene | Tgene | Gene symbol | SPATA6 | MAD2L2 | Gene ID | 54558 | 10459 |
| Gene name | spermatogenesis associated 6 | mitotic arrest deficient 2 like 2 | |
| Synonyms | HASH|SRF-1|SRF1 | FANCV|MAD2B|POLZ2|REV7 | |
| Cytomap | 1p33 | 1p36.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | spermatogenesis-associated protein 6spermatogenesis-related factor-1testicular tissue protein Li 178 | mitotic spindle assembly checkpoint protein MAD2BMAD2 (mitotic arrest deficient, yeast, homolog)-like 2MAD2 mitotic arrest deficient-like 2MAD2-like protein 2REV7 homologhREV7mitotic arrest deficient 2-like protein 2mitotic arrest deficient homolog | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9NWH7 | Q9UI95 | |
| Ensembl transtripts involved in fusion gene | ENST00000371847, ENST00000371843, ENST00000396199, ENST00000463938, | ENST00000235310, ENST00000376692, ENST00000376672, ENST00000376669, ENST00000376667, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SPATA6 [Title/Abstract] AND MAD2L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAD2L2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 19443654 |
| Tgene | MAD2L2 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 17296730 |
| Tgene | MAD2L2 | GO:0042177 | negative regulation of protein catabolic process | 11459826 |
| Tgene | MAD2L2 | GO:0042772 | DNA damage response, signal transduction resulting in transcription | 17296730 |
| Tgene | MAD2L2 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 19443654 |
| Tgene | MAD2L2 | GO:1904667 | negative regulation of ubiquitin protein ligase activity | 11459826 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E9-A22A-01A | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000371847 | ENST00000235310 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| Frame-shift | ENST00000371847 | ENST00000376692 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| Frame-shift | ENST00000371847 | ENST00000376672 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| Frame-shift | ENST00000371847 | ENST00000376669 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| Frame-shift | ENST00000371847 | ENST00000376667 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| Frame-shift | ENST00000371843 | ENST00000235310 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| Frame-shift | ENST00000371843 | ENST00000376692 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| Frame-shift | ENST00000371843 | ENST00000376672 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| Frame-shift | ENST00000371843 | ENST00000376669 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| Frame-shift | ENST00000371843 | ENST00000376667 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| In-frame | ENST00000396199 | ENST00000235310 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| In-frame | ENST00000396199 | ENST00000376692 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| In-frame | ENST00000396199 | ENST00000376672 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| In-frame | ENST00000396199 | ENST00000376669 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| In-frame | ENST00000396199 | ENST00000376667 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| intron-3CDS | ENST00000463938 | ENST00000235310 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| intron-3CDS | ENST00000463938 | ENST00000376692 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| intron-3CDS | ENST00000463938 | ENST00000376672 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| intron-3CDS | ENST00000463938 | ENST00000376669 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
| intron-3CDS | ENST00000463938 | ENST00000376667 | SPATA6 | chr1 | 48917224 | - | MAD2L2 | chr1 | 11737005 | - |
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FusionProtFeatures for SPATA6_MAD2L2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPATA6 | MAD2L2 |
| Required for formation of the sperm connecting pieceduring spermiogenesis. Sperm connecting piece is essential forlinking the developing flagellum to the head during latespermiogenesis. May be involved in myosin-based microfilamenttransport through interaction with myosin subunits.{ECO:0000250|UniProtKB:Q3U6K5}. | Adapter protein able to interact with different proteinsand involved in different biological processes (PubMed:11459825,PubMed:11459826, PubMed:17719540, PubMed:17296730,PubMed:19443654, PubMed:29656893). Mediates the interactionbetween the error-prone DNA polymerase zeta catalytic subunitREV3L and the inserter polymerase REV1, thereby mediating thesecond polymerase switching in translesion DNA synthesis(PubMed:20164194). Translesion DNA synthesis releases thereplication blockade of replicative polymerases, stalled inpresence of DNA lesions (PubMed:20164194). Component of theshieldin complex, which plays an important role in repair of DNAdouble-stranded breaks (DSBs) (PubMed:29656893). During G1 and Sphase of the cell cycle, the complex functions downstream ofTP53BP1 to promote non-homologous end joining (NHEJ) and suppressDNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switchrecombination, and fusion of unprotected telomeres(PubMed:29656893). May also regulate another aspect of cellularresponse to DNA damage through regulation of the JNK-mediatedphosphorylation and activation of the transcriptional activatorELK1 (PubMed:17296730). Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC therebyregulating progression through the cell cycle (PubMed:11459825,PubMed:17719540). Regulates TCF7L2-mediated gene transcription andmay play a role in epithelial-mesenchymal transdifferentiation(PubMed:19443654). {ECO:0000269|PubMed:11459825,ECO:0000269|PubMed:11459826, ECO:0000269|PubMed:17296730,ECO:0000269|PubMed:17719540, ECO:0000269|PubMed:19443654,ECO:0000269|PubMed:20164194, ECO:0000269|PubMed:29656893}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPATA6_MAD2L2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000235310_chr1_11737005_-_156aa MVFEKVFPDAVDPGDVVTQLEXXCGESGGGDFGXRAPPSGEIRLXDHPASTAVHQLRLAVVSCGAAAPGLHPEDQRVRCRPGPQPPRLYL >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376692_chr1_11737005_-_156aa MVFEKVFPDAVDPGDVVTQLEXXCGESGGGDFGXRAPPSGEIRLXDHPASTAVHQLRLAVVSCGAAAPGLHPEDQRVRCRPGPQPPRLYL >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376672_chr1_11737005_-_169aa MVFEKVFPDAVDPGDVVTQLEXXCGESGGGDFGXRAPPSGEIRLXDHPASTAVHQVGCPCPSPTSWHQLRLAVVSCGAAAPGLHPEDQRV >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376669_chr1_11737005_-_169aa MVFEKVFPDAVDPGDVVTQLEXXCGESGGGDFGXRAPPSGEIRLXDHPASTAVHQVGCPCPSPTSWHQLRLAVVSCGAAAPGLHPEDQRV >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376667_chr1_11737005_-_156aa MVFEKVFPDAVDPGDVVTQLEXXCGESGGGDFGXRAPPSGEIRLXDHPASTAVHQLRLAVVSCGAAAPGLHPEDQRVRCRPGPQPPRLYL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000235310_chr1_11737005_-_469nt ATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGGAGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGT GATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCTTTGAGATCACCCAGCCTCCACTGCTGTCCATCAGCTCAGACTCGCTGTT GTCTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGATCAGCGTGTGCGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTT CACAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACATGGAGAAGATCCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGA GCAGGATGTCCACATGCATGACCCCCGGCTGATACCACTAAAAACCATGACGTCGGACATTTTAAAGATGCAGCTTTACGTGGAAGAGCG >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376692_chr1_11737005_-_469nt ATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGGAGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGT GATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCTTTGAGATCACCCAGCCTCCACTGCTGTCCATCAGCTCAGACTCGCTGTT GTCTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGATCAGCGTGTGCGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTT CACAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACATGGAGAAGATCCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGA GCAGGATGTCCACATGCATGACCCCCGGCTGATACCACTAAAAACCATGACGTCGGACATTTTAAAGATGCAGCTTTACGTGGAAGAGCG >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376672_chr1_11737005_-_508nt ATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGGAGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGT GATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCTTTGAGATCACCCAGCCTCCACTGCTGTCCATCAGGTGGGCTGCCCCTGC CCCTCGCCCACTAGCTGGCATCAGCTCAGACTCGCTGTTGTCTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGATCAGCGTGTG CGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTTCACAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACATGGAGAAGAT CCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGAGCAGGATGTCCACATGCATGACCCCCGGCTGATACCACTAAAAACCATGAC >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376669_chr1_11737005_-_508nt ATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGGAGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGT GATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCTTTGAGATCACCCAGCCTCCACTGCTGTCCATCAGGTGGGCTGCCCCTGC CCCTCGCCCACTAGCTGGCATCAGCTCAGACTCGCTGTTGTCTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGATCAGCGTGTG CGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTTCACAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACATGGAGAAGAT CCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGAGCAGGATGTCCACATGCATGACCCCCGGCTGATACCACTAAAAACCATGAC >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376667_chr1_11737005_-_469nt ATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGGAGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGT GATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCTTTGAGATCACCCAGCCTCCACTGCTGTCCATCAGCTCAGACTCGCTGTT GTCTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGATCAGCGTGTGCGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTT CACAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACATGGAGAAGATCCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGA GCAGGATGTCCACATGCATGACCCCCGGCTGATACCACTAAAAACCATGACGTCGGACATTTTAAAGATGCAGCTTTACGTGGAAGAGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000235310_chr1_11737005_-_1083nt GCTGGACCGCGGGCCCCGGCCTGGGGGCCACTGCTGCCACCGCCGCCGCCACCTCGTCTCCTCCCCGTCCCCGCCCAGCCCCAGGTCTCC CCGCCTCACTCGGGCCCGTGGCCGGGGTCACTCCCCGCCGCCCCTCCCCGCACGGATGCCGAAGGTGAAGGCGCTGCAGTGCGCCCTGGC GCTGGAGATCAGCTCAGTAACTTGCCCAGGAGTCGTGCTTAAAGACAAAGAGGACATCTATCTTAGCATCTGTGTGTTTGGCCAATACAA AAAGACACAATGTGTCCCAGCCACTTTTCCCCTGGTCTTCAATGCCAGAATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGG AGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGTGATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCT TTGAGATCACCCAGCCTCCACTGCTGTCCATCAGCTCAGACTCGCTGTTGTCTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGA TCAGCGTGTGCGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTTCACAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACA TGGAGAAGATCCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGAGCAGGATGTCCACATGCATGACCCCCGGCTGATACCACTAA AAACCATGACGTCGGACATTTTAAAGATGCAGCTTTACGTGGAAGAGCGCGCTCATAAAGGCAGCTGAGGGGGCACCTGCCACCCCACTG ATGCCCAAACTGTCAGACTTTGGGGGATCCCCGCCTAGGGCAGTGCTGCATGGCTGCCCTGATTCCAAGTGCTCTTATCGCCTCTGTGTG TGGATCGCCCGCCCCAGCCCGGGGCCGCTCAGGTCTGCTTGGAGGATGCCTCCCCCAGGAGGGCAGTGAGGGATGCCGCAACCTCGACTT CTCAGCCTCCTGGGGTTCCGCCGGCCAACACTGTCTGTCTCAAATACTGTGCTGTGAGTTGTTTCAATAAAGGGGCCCCAAGGGCTGGGC >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376692_chr1_11737005_-_1082nt GCTGGACCGCGGGCCCCGGCCTGGGGGCCACTGCTGCCACCGCCGCCGCCACCTCGTCTCCTCCCCGTCCCCGCCCAGCCCCAGGTCTCC CCGCCTCACTCGGGCCCGTGGCCGGGGTCACTCCCCGCCGCCCCTCCCCGCACGGATGCCGAAGGTGAAGGCGCTGCAGTGCGCCCTGGC GCTGGAGATCAGCTCAGTAACTTGCCCAGGAGTCGTGCTTAAAGACAAAGAGGACATCTATCTTAGCATCTGTGTGTTTGGCCAATACAA AAAGACACAATGTGTCCCAGCCACTTTTCCCCTGGTCTTCAATGCCAGAATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGG AGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGTGATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCT TTGAGATCACCCAGCCTCCACTGCTGTCCATCAGCTCAGACTCGCTGTTGTCTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGA TCAGCGTGTGCGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTTCACAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACA TGGAGAAGATCCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGAGCAGGATGTCCACATGCATGACCCCCGGCTGATACCACTAA AAACCATGACGTCGGACATTTTAAAGATGCAGCTTTACGTGGAAGAGCGCGCTCATAAAGGCAGCTGAGGGGGCACCTGCCACCCCACTG ATGCCCAAACTGTCAGACTTTGGGGGATCCCCGCCTAGGGCAGTGCTGCATGGCTGCCCTGATTCCAAGTGCTCTTATCGCCTCTGTGTG TGGATCGCCCGCCCCAGCCCGGGGCCGCTCAGGTCTGCTTGGAGGATGCCTCCCCCAGGAGGGCAGTGAGGGATGCCGCAACCTCGACTT CTCAGCCTCCTGGGGTTCCGCCGGCCAACACTGTCTGTCTCAAATACTGTGCTGTGAGTTGTTTCAATAAAGGGGCCCCAAGGGCTGGGC >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376672_chr1_11737005_-_1077nt GCTGGACCGCGGGCCCCGGCCTGGGGGCCACTGCTGCCACCGCCGCCGCCACCTCGTCTCCTCCCCGTCCCCGCCCAGCCCCAGGTCTCC CCGCCTCACTCGGGCCCGTGGCCGGGGTCACTCCCCGCCGCCCCTCCCCGCACGGATGCCGAAGGTGAAGGCGCTGCAGTGCGCCCTGGC GCTGGAGATCAGCTCAGTAACTTGCCCAGGAGTCGTGCTTAAAGACAAAGAGGACATCTATCTTAGCATCTGTGTGTTTGGCCAATACAA AAAGACACAATGTGTCCCAGCCACTTTTCCCCTGGTCTTCAATGCCAGAATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGG AGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGTGATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCT TTGAGATCACCCAGCCTCCACTGCTGTCCATCAGGTGGGCTGCCCCTGCCCCTCGCCCACTAGCTGGCATCAGCTCAGACTCGCTGTTGT CTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGATCAGCGTGTGCGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTTCA CAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACATGGAGAAGATCCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGAGC AGGATGTCCACATGCATGACCCCCGGCTGATACCACTAAAAACCATGACGTCGGACATTTTAAAGATGCAGCTTTACGTGGAAGAGCGCG CTCATAAAGGCAGCTGAGGGGGCACCTGCCACCCCACTGATGCCCAAACTGTCAGACTTTGGGGGATCCCCGCCTAGGGCAGTGCTGCAT GGCTGCCCTGATTCCAAGTGCTCTTATCGCCTCTGTGTGTGGATCGCCCGCCCCAGCCCGGGGCCGCTCAGGTCTGCTTGGAGGATGCCT >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376669_chr1_11737005_-_924nt GCTGGACCGCGGGCCCCGGCCTGGGGGCCACTGCTGCCACCGCCGCCGCCACCTCGTCTCCTCCCCGTCCCCGCCCAGCCCCAGGTCTCC CCGCCTCACTCGGGCCCGTGGCCGGGGTCACTCCCCGCCGCCCCTCCCCGCACGGATGCCGAAGGTGAAGGCGCTGCAGTGCGCCCTGGC GCTGGAGATCAGCTCAGTAACTTGCCCAGGAGTCGTGCTTAAAGACAAAGAGGACATCTATCTTAGCATCTGTGTGTTTGGCCAATACAA AAAGACACAATGTGTCCCAGCCACTTTTCCCCTGGTCTTCAATGCCAGAATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGG AGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGTGATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCT TTGAGATCACCCAGCCTCCACTGCTGTCCATCAGGTGGGCTGCCCCTGCCCCTCGCCCACTAGCTGGCATCAGCTCAGACTCGCTGTTGT CTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGATCAGCGTGTGCGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTTCA CAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACATGGAGAAGATCCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGAGC AGGATGTCCACATGCATGACCCCCGGCTGATACCACTAAAAACCATGACGTCGGACATTTTAAAGATGCAGCTTTACGTGGAAGAGCGCG CTCATAAAGGCAGCTGAGGGGGCACCTGCCACCCCACTGATGCCCAAACTGTCAGACTTTGGGGGATCCCCGCCTAGGGCAGTGCTGCAT >In-frame_SPATA6_ENST00000396199_chr1_48917224_-_MAD2L2_ENST00000376667_chr1_11737005_-_815nt GCTGGACCGCGGGCCCCGGCCTGGGGGCCACTGCTGCCACCGCCGCCGCCACCTCGTCTCCTCCCCGTCCCCGCCCAGCCCCAGGTCTCC CCGCCTCACTCGGGCCCGTGGCCGGGGTCACTCCCCGCCGCCCCTCCCCGCACGGATGCCGAAGGTGAAGGCGCTGCAGTGCGCCCTGGC GCTGGAGATCAGCTCAGTAACTTGCCCAGGAGTCGTGCTTAAAGACAAAGAGGACATCTATCTTAGCATCTGTGTGTTTGGCCAATACAA AAAGACACAATGTGTCCCAGCCACTTTTCCCCTGGTCTTCAATGCCAGAATGGTGTTTGAAAAGGTGTTCCCGGACGCAGTAGATCCTGG AGATGTGGTTACACAGCTTGAATAATGATGTGGAGAAAGTGGTGGTGGTGATTTTGGATAAAGAGCACCGCCCAGTGGAGAAATTCGTCT TTGAGATCACCCAGCCTCCACTGCTGTCCATCAGCTCAGACTCGCTGTTGTCTCATGTGGAGCAGCTGCTCCGGGCCTTCATCCTGAAGA TCAGCGTGTGCGATGCCGTCCTGGACCACAACCCCCCAGGCTGTACCTTCACAGTCCTGGTGCACACGAGAGAAGCCGCCACTCGCAACA TGGAGAAGATCCAGGTCATCAAGGATTTCCCCTGGATCCTGGCGGATGAGCAGGATGTCCACATGCATGACCCCCGGCTGATACCACTAA AAACCATGACGTCGGACATTTTAAAGATGCAGCTTTACGTGGAAGAGCGCGCTCATAAAGGCAGCTGAGGGGGCACCTGCCACCCCACTG |
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FusionGenePPI for SPATA6_MAD2L2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SPATA6 | FUS, NEDD8-MDP1, DDB2 | MAD2L2 | PRRC2A, CDC20, ADAM15, ADAM9, REV3L, MAD2L1, REV1, MAD2L2, FZR1, POLDIP2, RBBP6, TCF7L2, PRCC, RAN, CLTA, YY1AP1, ELK1, CDC27, TRIP13, POLD3, CAMK2B, REL, TRIM27, TCF4, SFI1, IKZF1, KCTD9, MOV10, NXF1, POGZ, CBX3, CHAMP1, GTF2I, CBX5, SRPRB, ICAM2, SPACA1, HLA-C, SLAMF1, HEPACAM2, ATP5O, SSR4, DCTN3, DICER1, IFNGR1, FAM78B, GYPB, GRPR, PMEL, LAMP3, FAM174A, TSPYL6, LRFN4, CHST12, TFR2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPATA6_MAD2L2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPATA6_MAD2L2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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