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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 35562

FusionGeneSummary for SPAST_MEMO1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPAST_MEMO1
Fusion gene ID: 35562
HgeneTgene
Gene symbol

SPAST

MEMO1

Gene ID

6683

51072

Gene namespastinmediator of cell motility 1
SynonymsADPSP|FSP2|SPG4C2orf4|CGI-27|MEMO|NS5ATP7
Cytomap

2p22.3

2p22.3

Type of geneprotein-codingprotein-coding
Descriptionspastinspastic paraplegia 4 (autosomal dominant; spastin)spastic paraplegia 4 proteinprotein MEMO1C21orf19-like proteinHCV NS5A-transactivated protein 7hepatitis C virus NS5A-transactivated protein 7mediator of ErbB2-driven cell motility 1
Modification date2018052320180523
UniProtAcc

Q9UBP0

Q9Y316

Ensembl transtripts involved in fusion geneENST00000345662, ENST00000315285, 
ENST00000295065, ENST00000379383, 
ENST00000404530, ENST00000490459, 
ENST00000426310, ENST00000407893, 
Fusion gene scores* DoF score2 X 1 X 2=46 X 6 X 2=72
# samples 26
** MAII scorelog2(2/4*10)=2.32192809488736log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPAST [Title/Abstract] AND MEMO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPAST

GO:0001578

microtubule bundle formation

16219033

HgeneSPAST

GO:0034214

protein hexamerization

17389232

HgeneSPAST

GO:0051013

microtubule severing

15716377|16219033|17389232|23745751|26875866

HgeneSPAST

GO:0051260

protein homooligomerization

17389232


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-HU-A4GF-01ASPASTchr2

32289315

+MEMO1chr2

32168452

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000345662ENST00000295065SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000345662ENST00000379383SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000345662ENST00000404530SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000345662ENST00000490459SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000345662ENST00000426310SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000345662ENST00000407893SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000315285ENST00000295065SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000315285ENST00000379383SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000315285ENST00000404530SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000315285ENST00000490459SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000315285ENST00000426310SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000315285ENST00000407893SPASTchr2

32289315

+MEMO1chr2

32168452

-

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FusionProtFeatures for SPAST_MEMO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPAST

Q9UBP0

MEMO1

Q9Y316

ATP-dependent microtubule severing protein thatspecifically recognizes and cuts microtubules that arepolyglutamylated (PubMed:11809724, PubMed:15716377,PubMed:16219033, PubMed:17389232, PubMed:20530212,PubMed:22637577, PubMed:26875866). Preferentially recognizes andacts on microtubules decorated with short polyglutamate tails:severing activity increases as the number of glutamates pertubulin rises from one to eight, but decreases beyond thisglutamylation threshold (PubMed:26875866). Severing activity isnot dependent on tubulin acetylation or detyrosination(PubMed:26875866). Microtubule severing promotes reorganization ofcellular microtubule arrays and the release of microtubules fromthe centrosome following nucleation. It is critical for thebiogenesis and maintenance of complex microtubule arrays in axons,spindles and cilia. SPAST is involved in abscission step ofcytokinesis and nuclear envelope reassembly during anaphase incooperation with the ESCRT-III complex (PubMed:19000169,PubMed:21310966, PubMed:26040712). Recruited at the midbody,probably by IST1, and participates in membrane fission duringabscission together with the ESCRT-III complex (PubMed:21310966).Recruited to the nuclear membrane by IST1 and mediates microtubulesevering, promoting nuclear envelope sealing and mitotic spindledisassembly during late anaphase (PubMed:26040712). Required formembrane traffic from the endoplasmic reticulum (ER) to the Golgiand endosome recycling (PubMed:23897888). Recruited by IST1 toendosomes and regulates early endosomal tubulation and recyclingby mediating microtubule severing (PubMed:23897888). Probablyplays a role in axon growth and the formation of axonal branches(PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021,ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377,ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232,ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212,ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577,ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712,ECO:0000269|PubMed:26875866}. Isoform 1: Involved in lipid metabolism by regulatingthe size and distribution of lipid droplets.{ECO:0000269|PubMed:25875445}. May control cell migration by relaying extracellularchemotactic signals to the microtubule cytoskeleton. Mediator ofERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays animportant role in ERBB2-dependent stabilization of microtubules atthe cell cortex. It controls the localization of APC and CLASP2 tothe cell membrane, via the regulation of GSK3B activity. In turn,membrane-bound APC allows the localization of the MACF1 to thecell membrane, which is required for microtubule capture andstabilization. Is required for breast carcinoma cell migration.{ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+11757_77138617IntramembraneHelical
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+11657_77138585IntramembraneHelical
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+1174_11138617MotifNuclear localization signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+11759_67138617MotifNuclear export signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+1164_11138585MotifNuclear localization signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+11659_67138585MotifNuclear export signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+1171_50138617RegionRequired for nuclear localization
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+1161_50138585RegionRequired for nuclear localization
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+1171_56138617Topological domainCytoplasmic
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+1161_56138585Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+117120_195138617DomainMIT
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+116120_195138585DomainMIT
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+117309_312138617MotifNuclear localization signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+116309_312138585MotifNuclear localization signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+117382_389138617Nucleotide bindingATP
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+116382_389138585Nucleotide bindingATP
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+1171_194138617RegionRequired for midbody localization
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+117228_616138617RegionSufficient for microtubule severing
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+1161_194138585RegionRequired for midbody localization
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+116228_616138585RegionSufficient for microtubule severing
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+11778_616138617Topological domainCytoplasmic
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+11678_616138585Topological domainCytoplasmic


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FusionGeneSequence for SPAST_MEMO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SPAST_ENST00000345662_chr2_32289315_+_MEMO1_ENST00000295065_chr2_32168452_-_416aa
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

>In-frame_SPAST_ENST00000345662_chr2_32289315_+_MEMO1_ENST00000379383_chr2_32168452_-_416aa
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

>In-frame_SPAST_ENST00000345662_chr2_32289315_+_MEMO1_ENST00000404530_chr2_32168452_-_416aa
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

>In-frame_SPAST_ENST00000315285_chr2_32289315_+_MEMO1_ENST00000295065_chr2_32168452_-_416aa
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

>In-frame_SPAST_ENST00000315285_chr2_32289315_+_MEMO1_ENST00000379383_chr2_32168452_-_416aa
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

>In-frame_SPAST_ENST00000315285_chr2_32289315_+_MEMO1_ENST00000404530_chr2_32168452_-_416aa
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SPAST_ENST00000345662_chr2_32289315_+_MEMO1_ENST00000295065_chr2_32168452_-_1248nt
ATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCC
CCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGC
TTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAG
AGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCAC
AAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTT
TCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCT
TATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGT
GTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATG
TCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACC
ATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAAT
CTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCC
ATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACT
ATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAAT

>In-frame_SPAST_ENST00000345662_chr2_32289315_+_MEMO1_ENST00000379383_chr2_32168452_-_1248nt
ATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCC
CCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGC
TTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAG
AGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCAC
AAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTT
TCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCT
TATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGT
GTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATG
TCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACC
ATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAAT
CTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCC
ATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACT
ATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAAT

>In-frame_SPAST_ENST00000345662_chr2_32289315_+_MEMO1_ENST00000404530_chr2_32168452_-_1248nt
ATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCC
CCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGC
TTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAG
AGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCAC
AAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTT
TCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCT
TATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGT
GTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATG
TCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACC
ATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAAT
CTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCC
ATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACT
ATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAAT

>In-frame_SPAST_ENST00000315285_chr2_32289315_+_MEMO1_ENST00000295065_chr2_32168452_-_1248nt
ATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCC
CCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGC
TTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAG
AGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCAC
AAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTT
TCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCT
TATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGT
GTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATG
TCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACC
ATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAAT
CTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCC
ATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACT
ATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAAT

>In-frame_SPAST_ENST00000315285_chr2_32289315_+_MEMO1_ENST00000379383_chr2_32168452_-_1248nt
ATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCC
CCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGC
TTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAG
AGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCAC
AAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTT
TCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCT
TATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGT
GTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATG
TCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACC
ATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAAT
CTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCC
ATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACT
ATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAAT

>In-frame_SPAST_ENST00000315285_chr2_32289315_+_MEMO1_ENST00000404530_chr2_32168452_-_1248nt
ATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCC
CCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGC
TTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAG
AGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCAC
AAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTT
TCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCT
TATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGT
GTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATG
TCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACC
ATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAAT
CTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCC
ATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACT
ATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SPAST_ENST00000345662_chr2_32289315_+_MEMO1_ENST00000295065_chr2_32168452_-_4770nt
GGCCCGAGCCACCGACTGCAGGAGGAGAAGGGGTTGTGCTCCTGGCCGAGGAAGGAGAAAGGGGCGGGGCCGGCGGGCAGCGTGCGGCAG
TGCGGAGCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTG
CGGGAGGCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCA
GCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATA
AGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGT
GGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGC
CGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATG
AGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCC
ATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGC
CTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGA
TTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTT
ATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAAT
TCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTT
ACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACC
CTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGC
TCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTT
ATGCAGCTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCT
AGCCTTTACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAG
TCCTTCCTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGA
TGACAATGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGA
CTTGTGCACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCA
TTTATAAATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTT
GCTAATAAAGGGCTACACAACTCAAAATAGTCTGATTTAAACTTATTGCTCTGTGGTATATATGAAAATTGTTTTTTATTAATTCCATCT
CAGAATTTTTGTTAAAAATGGTAAACCTCAGCTCTTATGTAAAAATATATTAGGATGTATTTTATATTTTATATATTTGTATGATTTTTT
TAAATCAGAAATTAGAATCATATGATCTTAAAGTTAACTTTTTAAATTACATGCAGTTTGCCTTTTTGTCTGTGACATCCCTTTGTGTCA
TTACTATATTGTAACAGAATATATATTCAAGATTGGTAAAAGAACGTAGATGTAATCCTTGACTTCAAAGATCATGTTTGATAGTCTGCA
AATGAGGAAACATTGAAGAGTGTTCTTAGTGTTTTTCAAATCATTGCAGACCTTACACTGCTGTGCTTTTTTAATGCTTTAAGCAGTTTG
ACTCTTTTACTTGAATTTTTAGCCAGAGATCATTAACATCATCAACAACAACAAGCCACTGGATTTTCTTATGGTTACACAATTTTTTTT
GTCATGATTTTTGGTGCGGCTCTTCCAACTAAAATAATGGTATGATGTTGTATTTCTTTCTTTCTTTAGCATAGACCAATTCTAGTCACT
TTCGCCAAAAAAAAAAAAAAAAAAAAAAAAAAGATATAATTTAGTTAATAATTCAGTTACCATGTATGTACTGCATTATACCTATTTTAA
CCTAACAGTGTCTACATTATATTAGAGAGTGTTTATATCTCCAGTGTTATGCCAGAGTAGCACAATTTTTAGATGCCTTGCACCAATTTT
ATTTAAAGATTTATGTTTCTTATTTATTAAATATCAACTTTCTATACTCGAGTGAAATAAAATAATGTTACCTTTTAGATTCAAAGTCGC
CCACCTATGTATGTGTGGAAATTATATTCTTACACATTAGTGATTTATTTTCCGTAATTTAGATACACTTTTTAGTACTATTAATATTTA
TTTCTTGTTTAATATGAACTATAAAATTTTAAAATGGACAACAGTGAATTTTTAAAATAATGTTTTCTGAGTATAAGACTAATACATGAT
TATTTTAGAAAATTTGAAAATTACTGAAAAGTTATAAAGAGAAAAAATTATCTGCAATCTCACTACCCAGAGATAACCCTGTTAATATTT
TTCTGTATTTCTTTTCAGTCTTTGTCTGTGCTATTTCTATGTATGAGTGTGTATACATGTGTTTGTGTGTGTGTGTAATAACAAACTTGA
GATTATACTGACCATATAGTTATGTACCCTGTTTTTTATAACCTAACTTCATACATATTTACCCATGTCTATGAAAATGTGACTTTTAAA
AATGGCTGCCTAATATTCTATTGTATGAATATGCCACAATTTAACTACTTCTCTCTTTGGATATTAGGTTGTTCTAATCTTTCACCATTA
TAAATAATAGTGGGATAGACATCCTTGTTTGTAAAATTTCATCTCTATATTAGACTCTTTAGGATATACTCATGTACATGGAATAAGTGG
TTTAGACAGTGAGAACTTTTTAGGCTCTTTAAAATATTTCCAAGTTATAACCCTTTAGAAAGATTGTACTAAATTAACAATGTATGAGTA
CCCATCATTCTGCCCCTTCACCAGTATCATTATTTTTTTAATCTTTGACAGTTGGTTAACATAACAATCGGTTGTTTCTTTGACCATTCT
AATAAGAGTTGCTTTATAATGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTC
AGGAGATCGAGACCATCCCGGCTAAAACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGGCGGGCGCCTGT
AGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGTGGCGGAGCCTGCAGTGAGCCGAGATCCCGCCACTGCACTC
CAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAGTTGCTTTATAATTAATTATTTTTGTCTTT
CTATAATTTTATAGTTGATTGATTTTTAAAAAGACAAGAGGGTTGCCTAAGTTGGGTGGACTATAGTACAAGTATGGTTCTTGCACTTTT
AAAACTGTAGAAGCTGGACACGATGGTATGCACCTGTAGTCCCAGCTACTTTGACTGTGGAGGCAGGAGGATCACTTGACAGTTTGAGAC
CAGCCTGGGCAATGTAGTGAGCCCCCCAAAACCCTCTAAACAAACAAACAAATCTGCAGAATATTTCAGCATCACTCTACACTTTCCTAG
AATATCAACATACCTGATAATGAAGTAGAAAGAGTTCCAAATTGATGATTGAGTGTTGGGTTCTAGTTCTATTTCTGCCACTAATTAGTT
CTCTGAACTTAAGTGTTTCATGTCATATTGAAACTTTCTCATTTGTAAAATGTGGAGGGGATCTCTTAAGTGCTTTCTAGTTTCAAAGTA
CTTTGATACTGTGACTTTATTTTGTAGAGGTTCTGGTGTCATTTATTTTTAATAGCTACATGAATAATGTAGAGATACTATCTTTTGATT
TCAACTTCACATACATGGAAATGAAAGTCTTGTTATTTAACACAAAAGGAAATTTAATTTGCATTATTTAATGCAGTTAATATTACCTAA
AATGTTGAACTTAAGCTTTTCTACTTTAAGTGCCTTTAAAAGTTTTGTATTTGGAATCTAAAATATAAAGGAAATTCTTATGTAGCTCTA

>In-frame_SPAST_ENST00000345662_chr2_32289315_+_MEMO1_ENST00000379383_chr2_32168452_-_2007nt
GGCCCGAGCCACCGACTGCAGGAGGAGAAGGGGTTGTGCTCCTGGCCGAGGAAGGAGAAAGGGGCGGGGCCGGCGGGCAGCGTGCGGCAG
TGCGGAGCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTG
CGGGAGGCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCA
GCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATA
AGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGT
GGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGC
CGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATG
AGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCC
ATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGC
CTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGA
TTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTT
ATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAAT
TCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTT
ACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACC
CTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGC
TCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTT
ATGCAGCTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCT
AGCCTTTACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAG
TCCTTCCTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGA
TGACAATGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGA
CTTGTGCACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCA
TTTATAAATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTT

>In-frame_SPAST_ENST00000345662_chr2_32289315_+_MEMO1_ENST00000404530_chr2_32168452_-_2007nt
GGCCCGAGCCACCGACTGCAGGAGGAGAAGGGGTTGTGCTCCTGGCCGAGGAAGGAGAAAGGGGCGGGGCCGGCGGGCAGCGTGCGGCAG
TGCGGAGCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTG
CGGGAGGCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCA
GCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATA
AGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGT
GGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGC
CGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATG
AGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCC
ATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGC
CTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGA
TTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTT
ATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAAT
TCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTT
ACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACC
CTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGC
TCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTT
ATGCAGCTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCT
AGCCTTTACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAG
TCCTTCCTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGA
TGACAATGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGA
CTTGTGCACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCA
TTTATAAATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTT

>In-frame_SPAST_ENST00000315285_chr2_32289315_+_MEMO1_ENST00000295065_chr2_32168452_-_4674nt
GCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTGCGGGAG
GCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACC
CGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGA
ACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCT
GCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGC
CGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAG
GACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAG
GATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTC
ATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACG
GAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAG
CTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAA
AACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTT
ACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTAT
CTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGA
AGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAG
CTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTT
TACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTC
CTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAA
TGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTG
CACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATA
AATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAAT
AAAGGGCTACACAACTCAAAATAGTCTGATTTAAACTTATTGCTCTGTGGTATATATGAAAATTGTTTTTTATTAATTCCATCTCAGAAT
TTTTGTTAAAAATGGTAAACCTCAGCTCTTATGTAAAAATATATTAGGATGTATTTTATATTTTATATATTTGTATGATTTTTTTAAATC
AGAAATTAGAATCATATGATCTTAAAGTTAACTTTTTAAATTACATGCAGTTTGCCTTTTTGTCTGTGACATCCCTTTGTGTCATTACTA
TATTGTAACAGAATATATATTCAAGATTGGTAAAAGAACGTAGATGTAATCCTTGACTTCAAAGATCATGTTTGATAGTCTGCAAATGAG
GAAACATTGAAGAGTGTTCTTAGTGTTTTTCAAATCATTGCAGACCTTACACTGCTGTGCTTTTTTAATGCTTTAAGCAGTTTGACTCTT
TTACTTGAATTTTTAGCCAGAGATCATTAACATCATCAACAACAACAAGCCACTGGATTTTCTTATGGTTACACAATTTTTTTTGTCATG
ATTTTTGGTGCGGCTCTTCCAACTAAAATAATGGTATGATGTTGTATTTCTTTCTTTCTTTAGCATAGACCAATTCTAGTCACTTTCGCC
AAAAAAAAAAAAAAAAAAAAAAAAAAGATATAATTTAGTTAATAATTCAGTTACCATGTATGTACTGCATTATACCTATTTTAACCTAAC
AGTGTCTACATTATATTAGAGAGTGTTTATATCTCCAGTGTTATGCCAGAGTAGCACAATTTTTAGATGCCTTGCACCAATTTTATTTAA
AGATTTATGTTTCTTATTTATTAAATATCAACTTTCTATACTCGAGTGAAATAAAATAATGTTACCTTTTAGATTCAAAGTCGCCCACCT
ATGTATGTGTGGAAATTATATTCTTACACATTAGTGATTTATTTTCCGTAATTTAGATACACTTTTTAGTACTATTAATATTTATTTCTT
GTTTAATATGAACTATAAAATTTTAAAATGGACAACAGTGAATTTTTAAAATAATGTTTTCTGAGTATAAGACTAATACATGATTATTTT
AGAAAATTTGAAAATTACTGAAAAGTTATAAAGAGAAAAAATTATCTGCAATCTCACTACCCAGAGATAACCCTGTTAATATTTTTCTGT
ATTTCTTTTCAGTCTTTGTCTGTGCTATTTCTATGTATGAGTGTGTATACATGTGTTTGTGTGTGTGTGTAATAACAAACTTGAGATTAT
ACTGACCATATAGTTATGTACCCTGTTTTTTATAACCTAACTTCATACATATTTACCCATGTCTATGAAAATGTGACTTTTAAAAATGGC
TGCCTAATATTCTATTGTATGAATATGCCACAATTTAACTACTTCTCTCTTTGGATATTAGGTTGTTCTAATCTTTCACCATTATAAATA
ATAGTGGGATAGACATCCTTGTTTGTAAAATTTCATCTCTATATTAGACTCTTTAGGATATACTCATGTACATGGAATAAGTGGTTTAGA
CAGTGAGAACTTTTTAGGCTCTTTAAAATATTTCCAAGTTATAACCCTTTAGAAAGATTGTACTAAATTAACAATGTATGAGTACCCATC
ATTCTGCCCCTTCACCAGTATCATTATTTTTTTAATCTTTGACAGTTGGTTAACATAACAATCGGTTGTTTCTTTGACCATTCTAATAAG
AGTTGCTTTATAATGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGA
TCGAGACCATCCCGGCTAAAACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGGCGGGCGCCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGTGGCGGAGCCTGCAGTGAGCCGAGATCCCGCCACTGCACTCCAGCCT
GGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAGTTGCTTTATAATTAATTATTTTTGTCTTTCTATAA
TTTTATAGTTGATTGATTTTTAAAAAGACAAGAGGGTTGCCTAAGTTGGGTGGACTATAGTACAAGTATGGTTCTTGCACTTTTAAAACT
GTAGAAGCTGGACACGATGGTATGCACCTGTAGTCCCAGCTACTTTGACTGTGGAGGCAGGAGGATCACTTGACAGTTTGAGACCAGCCT
GGGCAATGTAGTGAGCCCCCCAAAACCCTCTAAACAAACAAACAAATCTGCAGAATATTTCAGCATCACTCTACACTTTCCTAGAATATC
AACATACCTGATAATGAAGTAGAAAGAGTTCCAAATTGATGATTGAGTGTTGGGTTCTAGTTCTATTTCTGCCACTAATTAGTTCTCTGA
ACTTAAGTGTTTCATGTCATATTGAAACTTTCTCATTTGTAAAATGTGGAGGGGATCTCTTAAGTGCTTTCTAGTTTCAAAGTACTTTGA
TACTGTGACTTTATTTTGTAGAGGTTCTGGTGTCATTTATTTTTAATAGCTACATGAATAATGTAGAGATACTATCTTTTGATTTCAACT
TCACATACATGGAAATGAAAGTCTTGTTATTTAACACAAAAGGAAATTTAATTTGCATTATTTAATGCAGTTAATATTACCTAAAATGTT

>In-frame_SPAST_ENST00000315285_chr2_32289315_+_MEMO1_ENST00000379383_chr2_32168452_-_1911nt
GCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTGCGGGAG
GCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACC
CGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGA
ACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCT
GCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGC
CGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAG
GACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAG
GATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTC
ATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACG
GAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAG
CTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAA
AACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTT
ACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTAT
CTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGA
AGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAG
CTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTT
TACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTC
CTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAA
TGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTG
CACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATA
AATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAAT

>In-frame_SPAST_ENST00000315285_chr2_32289315_+_MEMO1_ENST00000404530_chr2_32168452_-_1911nt
GCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTGCGGGAG
GCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACC
CGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGA
ACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCT
GCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGC
CGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAG
GACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAG
GATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTC
ATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACG
GAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAG
CTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAA
AACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTT
ACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTAT
CTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGA
AGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAG
CTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTT
TACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTC
CTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAA
TGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTG
CACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATA
AATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAAT


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FusionGenePPI for SPAST_MEMO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPASTELAVL1, CHMP1B, IST1, VCP, ALB, HECW2, KRAS, FOSL2, NLRP3, CHMP4B, NUP98, NUP107, WDR45, NUP43, NUP133, CHMP2A, HIST2H2AB, VTA1, NUP85, RNF111MEMO1DISC1, ITGA4, REL, TRIM27, TACC1, TCF4, TRIP6, LZTS2, LNX1, RBM45, UBE3D, UPF1, ANKFY1, DICER1, DNAAF2, HMBOX1, WDR54, TARBP2, CFL2, AKR1A1, AKR1B1, APOA1BP, BPNT1, DSTN, GALK2, KYNU, NEDD8, RFK, SELENBP1, YKT6, CUL3, COPRS, CD93


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPAST_MEMO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPAST_MEMO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPASTC1866855Spastic paraplegia 4, autosomal dominant32CTD_human;ORPHANET;UNIPROT