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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35555

FusionGeneSummary for SPARC_FN1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPARC_FN1
Fusion gene ID: 35555
HgeneTgene
Gene symbol

SPARC

FN1

Gene ID

6678

2335

Gene namesecreted protein acidic and cysteine richfibronectin 1
SynonymsBM-40|OI17|ONCIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF
Cytomap

5q33.1

2q35

Type of geneprotein-codingprotein-coding
DescriptionSPARCbasement-membrane protein 40secreted protein, acidic, cysteine-rich (osteonectin)fibronectincold-insoluble globulinmigration-stimulating factor
Modification date2018052320180527
UniProtAcc

P09486

P02751

Ensembl transtripts involved in fusion geneENST00000231061, ENST00000537849, 
ENST00000421182, ENST00000357867, 
ENST00000323926, ENST00000336916, 
ENST00000354785, ENST00000357009, 
ENST00000346544, ENST00000345488, 
ENST00000359671, ENST00000446046, 
ENST00000443816, ENST00000432072, 
ENST00000356005, ENST00000490833, 
ENST00000426059, 
Fusion gene scores* DoF score12 X 16 X 5=96020 X 22 X 3=1320
# samples 1826
** MAII scorelog2(18/960*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/1320*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPARC [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPARC

GO:0001937

negative regulation of endothelial cell proliferation

12867428

HgeneSPARC

GO:0010595

positive regulation of endothelial cell migration

12867428

HgeneSPARC

GO:0016525

negative regulation of angiogenesis

12867428

HgeneSPARC

GO:0022604

regulation of cell morphogenesis

15389586

TgeneFN1

GO:0001932

regulation of protein phosphorylation

11792823

TgeneFN1

GO:0008284

positive regulation of cell proliferation

25834989

TgeneFN1

GO:0010628

positive regulation of gene expression

25834989

TgeneFN1

GO:0018149

peptide cross-linking

3997886

TgeneFN1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

TgeneFN1

GO:0035987

endodermal cell differentiation

23154389

TgeneFN1

GO:0048146

positive regulation of fibroblast proliferation

25834989

TgeneFN1

GO:0051702

interaction with symbiont

12167537|12421310|19429745

TgeneFN1

GO:0052047

interaction with other organism via secreted substance involved in symbiotic interaction

17849409

TgeneFN1

GO:0070372

regulation of ERK1 and ERK2 cascade

11792823

TgeneFN1

GO:1904237

positive regulation of substrate-dependent cell migration, cell attachment to substrate

25834989

TgeneFN1

GO:2001202

negative regulation of transforming growth factor-beta secretion

25834989


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ182246SPARCchr5

151042386

+FN1chr2

216238092

+
ChiTaRS3.1W48576SPARCchr5

151042969

-FN1chr2

216226765

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000231061ENST00000421182SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000357867SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000323926SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000336916SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000354785SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000357009SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000346544SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000345488SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000359671SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000446046SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000443816SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000432072SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000356005SPARCchr5

151042386

+FN1chr2

216238092

+
intron-intronENST00000231061ENST00000490833SPARCchr5

151042386

+FN1chr2

216238092

+
intron-intronENST00000231061ENST00000426059SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000421182SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000357867SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000323926SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000336916SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000354785SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000357009SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000346544SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000345488SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000359671SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000446046SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000443816SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000432072SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000537849ENST00000356005SPARCchr5

151042386

+FN1chr2

216238092

+
intron-intronENST00000537849ENST00000490833SPARCchr5

151042386

+FN1chr2

216238092

+
intron-intronENST00000537849ENST00000426059SPARCchr5

151042386

+FN1chr2

216238092

+
intron-3CDSENST00000231061ENST00000421182SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3CDSENST00000231061ENST00000357867SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3CDSENST00000231061ENST00000323926SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3CDSENST00000231061ENST00000336916SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3CDSENST00000231061ENST00000354785SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000231061ENST00000357009SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000231061ENST00000346544SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000231061ENST00000345488SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000231061ENST00000359671SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000231061ENST00000446046SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000231061ENST00000443816SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000231061ENST00000432072SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000231061ENST00000356005SPARCchr5

151042969

-FN1chr2

216226765

-
intron-intronENST00000231061ENST00000490833SPARCchr5

151042969

-FN1chr2

216226765

-
intron-intronENST00000231061ENST00000426059SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3CDSENST00000537849ENST00000421182SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3CDSENST00000537849ENST00000357867SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3CDSENST00000537849ENST00000323926SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3CDSENST00000537849ENST00000336916SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3CDSENST00000537849ENST00000354785SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000537849ENST00000357009SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000537849ENST00000346544SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000537849ENST00000345488SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000537849ENST00000359671SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000537849ENST00000446046SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000537849ENST00000443816SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000537849ENST00000432072SPARCchr5

151042969

-FN1chr2

216226765

-
intron-3UTRENST00000537849ENST00000356005SPARCchr5

151042969

-FN1chr2

216226765

-
intron-intronENST00000537849ENST00000490833SPARCchr5

151042969

-FN1chr2

216226765

-
intron-intronENST00000537849ENST00000426059SPARCchr5

151042969

-FN1chr2

216226765

-

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FusionProtFeatures for SPARC_FN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPARC

P09486

FN1

P02751

Appears to regulate cell growth through interactionswith the extracellular matrix and cytokines. Binds calcium andcopper, several types of collagen, albumin, thrombospondin, PDGFand cell membranes. There are two calcium binding sites; an acidicdomain that binds 5 to 8 Ca(2+) with a low affinity and an EF-handloop that binds a Ca(2+) ion with a high affinity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPARC_FN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPARC_FN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPARC_FN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSPARCP09486DB11093Calcium CitrateSPARCsmall moleculeapproved
HgeneSPARCP09486DB11348Calcium PhosphateSPARCsmall moleculeapproved
TgeneFN1P02751DB08888OcriplasminFibronectinbiotechapproved
TgeneFN1P02751DB01593ZincFibronectinsmall moleculeapproved|investigational

Top

RelatedDiseases for SPARC_FN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPARCC0023893Liver Cirrhosis, Experimental2CTD_human
HgeneSPARCC0009375Colonic Neoplasms1CTD_human
HgeneSPARCC0009404Colorectal Neoplasms1CTD_human
HgeneSPARCC0019158Hepatitis1CTD_human
HgeneSPARCC0020429Hyperalgesia1CTD_human
HgeneSPARCC0022658Kidney Diseases1CTD_human
HgeneSPARCC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneSPARCC0023890Liver Cirrhosis1CTD_human
HgeneSPARCC0024031Low Back Pain1CTD_human
HgeneSPARCC0026764Multiple Myeloma1CTD_human
HgeneSPARCC0027540Necrosis1CTD_human
HgeneSPARCC0027659Neoplasms, Experimental1CTD_human
HgeneSPARCC0029434Osteogenesis Imperfecta1CTD_human
HgeneSPARCC0041948Uremia1CTD_human
HgeneSPARCC0043094Weight Gain1CTD_human
HgeneSPARCC0151744Myocardial Ischemia1CTD_human
HgeneSPARCC0158266Intervertebral Disc Degeneration1CTD_human
HgeneSPARCC0206686Adrenocortical carcinoma1CTD_human
HgeneSPARCC0919267ovarian neoplasm1CTD_human
HgeneSPARCC4225301OSTEOGENESIS IMPERFECTA, TYPE XVII1UNIPROT
TgeneFN1C0020538Hypertensive disease2CTD_human;HPO
TgeneFN1C0000786Spontaneous abortion1CTD_human
TgeneFN1C0003504Aortic Valve Insufficiency1CTD_human
TgeneFN1C0007621Neoplastic Cell Transformation1CTD_human
TgeneFN1C0010346Crohn Disease1CTD_human
TgeneFN1C0011849Diabetes Mellitus1CTD_human
TgeneFN1C0011881Diabetic Nephropathy1CTD_human
TgeneFN1C0017636Glioblastoma1CTD_human
TgeneFN1C0017668Focal glomerulosclerosis1CTD_human
TgeneFN1C0024667Animal Mammary Neoplasms1CTD_human
TgeneFN1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneFN1C0027626Neoplasm Invasiveness1CTD_human
TgeneFN1C0034069Pulmonary Fibrosis1CTD_human
TgeneFN1C0036341Schizophrenia1PSYGENET
TgeneFN1C0085762Alcohol abuse1PSYGENET
TgeneFN1C0149721Left Ventricular Hypertrophy1CTD_human
TgeneFN1C0345967Malignant mesothelioma1CTD_human
TgeneFN1C1458155Mammary Neoplasms1CTD_human
TgeneFN1C1866075GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)1UNIPROT