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Fusion gene ID: 3555 |
FusionGeneSummary for ATXN10_APPL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATXN10_APPL1 | Fusion gene ID: 3555 | Hgene | Tgene | Gene symbol | ATXN10 | APPL1 | Gene ID | 25814 | 26060 |
| Gene name | ataxin 10 | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | |
| Synonyms | E46L|HUMEEP|SCA10 | APPL|DIP13alpha|MODY14 | |
| Cytomap | 22q13.31 | 3p14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ataxin-10brain protein E46 homologspinocerebellar ataxia type 10 protein | DCC-interacting protein 13-alphaAKT2 interactoradapter protein containing PH domain, PTB domain and leucine zipper motif 1adaptor protein containing pH domain, PTB domain and leucine zipper motif 1adaptor protein, phosphotyrosine interaction, PH domai | |
| Modification date | 20180522 | 20180528 | |
| UniProtAcc | Q9UBB4 | Q9UKG1 | |
| Ensembl transtripts involved in fusion gene | ENST00000381061, ENST00000252934, ENST00000498009, ENST00000402380, | ENST00000288266, | |
| Fusion gene scores | * DoF score | 10 X 4 X 9=360 | 3 X 3 X 2=18 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ATXN10 [Title/Abstract] AND APPL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATXN10 | GO:0031175 | neuron projection development | 16498633 |
| Tgene | APPL1 | GO:0008283 | cell proliferation | 15016378 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0H7-01A | ATXN10 | chr22 | 46136418 | + | APPL1 | chr3 | 57280104 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000381061 | ENST00000288266 | ATXN10 | chr22 | 46136418 | + | APPL1 | chr3 | 57280104 | + |
| In-frame | ENST00000252934 | ENST00000288266 | ATXN10 | chr22 | 46136418 | + | APPL1 | chr3 | 57280104 | + |
| intron-3CDS | ENST00000498009 | ENST00000288266 | ATXN10 | chr22 | 46136418 | + | APPL1 | chr3 | 57280104 | + |
| intron-3CDS | ENST00000402380 | ENST00000288266 | ATXN10 | chr22 | 46136418 | + | APPL1 | chr3 | 57280104 | + |
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FusionProtFeatures for ATXN10_APPL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATXN10 | APPL1 |
| Necessary for the survival of cerebellar neurons.Induces neuritogenesis by activating the Ras-MAP kinase pathway.May play a role in the maintenance of a critical intracellularglycosylation level and homeostasis. {ECO:0000250}. | Adapter protein that interacts with proteins involved indifferent cellular signaling pathways. Required for the regulationof cell proliferation in response to extracellular signals from anearly endosomal compartment. Links Rab5 to nuclear signaltransduction. Involved in the regulation of the insulin receptorsignaling pathway. {ECO:0000269|PubMed:10490823,ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:26073777}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >APPL1 | chr22:46136418 | chr3:57280104 | ENST00000288266 | + | 6 | 22 | 215_259 | 158 | 710 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >APPL1 | chr22:46136418 | chr3:57280104 | ENST00000288266 | + | 6 | 22 | 621_673 | 158 | 710 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >APPL1 | chr22:46136418 | chr3:57280104 | ENST00000288266 | + | 6 | 22 | 277_375 | 158 | 710 | Domain | PH |
| Tgene | >APPL1 | chr22:46136418 | chr3:57280104 | ENST00000288266 | + | 6 | 22 | 496_656 | 158 | 710 | Domain | PID |
| Tgene | >APPL1 | chr22:46136418 | chr3:57280104 | ENST00000288266 | + | 6 | 22 | 403_414 | 158 | 710 | Motif | Note=F%26H |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | APPL1 | chr22:46136418 | chr3:57280104 | ENST00000288266 | + | 6 | 22 | 1_428 | 158 | 710 | Region | Note=Required for RAB5A binding |
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FusionGeneSequence for ATXN10_APPL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ATXN10_ENST00000381061_chr22_46136418_+_APPL1_ENST00000288266_chr3_57280104_+_879aa MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVW VHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERV TLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVI DLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYK KKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKA GYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTIN NISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPV CEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDC LKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKE >In-frame_ATXN10_ENST00000252934_chr22_46136418_+_APPL1_ENST00000288266_chr3_57280104_+_943aa MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRN ACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMI LFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLR HAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAE GDISNVANGFKSHLIRLIGNLCYKNKDNQDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSEN LNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGG NLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEA VTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGG STKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATH QENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ATXN10_ENST00000381061_chr22_46136418_+_APPL1_ENST00000288266_chr3_57280104_+_2637nt ATGGCGGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACG GCGCTCTTCAAAGAGCAGCGGAACCGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAA CAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGG GTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCC CTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAA TGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTT ACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTG ATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATT AGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATT GATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCC AATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTGAAGTAT GAAGTAACAGAAGATGTGTACACATCCAGAAAGAAACAACACCAGACCATGATGCATTATTTTTGTGCATTAAATACTCTTCAGTACAAG AAGAAAATAGCATTGTTAGAACCTCTACTTGGGTACATGCAAGCTCAGATAAGTTTCTTTAAGATGGGTTCTGAAAATCTTAATGAACAA CTGGAAGAATTTTTAGCTAATATTGGAACAAGCGTTCAGAATGTTCGCAGGGAAATGGACAGTGATATAGAGACCATGCAACAGACAATA GAGGATTTGGAAGTAGCCAGTGATCCCTTATATGTGCCTGACCCAGACCCCACCAAATTTCCTGTTAATCGAAATTTAACCCGAAAGGCT GGATACCTTAATGCTAGGAATAAAACAGGCTTGGTGTCATCTACCTGGGACAGACAGTTTTACTTCACGCAGGGTGGAAATTTAATGAGT CAGGCCCGTGGGGATGTAGCAGGAGGCCTGGCCATGGACATAGACAACTGTTCAGTGATGGCTGTGGACTGTGAAGACAGACGATATTGT TTTCAGATCACCTCTTTCGATGGAAAAAAATCTTCAATTTTGCAAGCAGAGAGTAAAAAAGATCATGAAGAGTGGATCTGTACAATAAAC AACATATCTAAACAAATATACTTAAGTGAAAATCCAGAGGAAACTGCTGCACGAGTAAATCAATCAGCTCTGGAAGCTGTCACTCCTTCC CCATCTTTCCAGCAGAGGCACGAGAGCCTGCGGCCAGCAGCAGGACAATCTCGGCCACCGACAGCTCGAACCAGCAGTTCAGGATCCTTA GGATCTGAGTCTACAAATTTGGCTGCCCTCTCTCTAGATTCTCTTGTTGCCCCAGACACCCCAATACAGTTTGACATAATTTCTCCTGTG TGTGAAGATCAGCCTGGCCAGGCAAAAGCCTTTGGCCAGGGAGGCAGGCGTACAAATCCATTTGGAGAATCTGGAGGAAGTACAAAATCT GAAACTGAAGATTCTATTCTTCATCAGTTATTTATTGTCCGATTCCTTGGTTCAATGGAGGTGAAATCAGATGACCATCCAGATGTTGTT TATGAAACTATGCGCCAAATCTTAGCTGCCCGGGCCATCCATAACATCTTTCGTATGACAGAATCGCATTTATTAGTCACTTGTGACTGT TTAAAGTTAATTGATCCACAGACACAAGTTACAAGGCTCACGTTTCCATTACCTTGTGTAGTTTTGTATGCTACACACCAGGAAAATAAG CGCCTTTTTGGATTTGTTCTTCGGACATCAAGCGGGAGAAGTGAAAGTAATCTGTCATCAGTCTGCTATATATTTGAGTCAAACAATGAG GGGGAAAAGATATGTGATTCTGTTGGACTGGCAAAACAGATAGCTTTGCATGCTGAACTGGATCGTAGGGCATCAGAAAAACAAAAAGAA ATAGAGAGAGTAAAAGAGAAGCAACAGAAAGAACTCAATAAACAAAAACAGATTGAAAAGGACTTGGAAGAACAAAGTCGGTTGATAGCT GCTTCCAGTAGACCAAACCAAGCCAGTAGTGAGGGGCAGTTTGTTGTCCTTAGCAGTAGCCAGTCAGAAGAGAGTGATTTGGGAGAAGGA >In-frame_ATXN10_ENST00000252934_chr22_46136418_+_APPL1_ENST00000288266_chr3_57280104_+_2829nt ATGGCGGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACG GCGCTCTTCAAAGAGCAGCGGAACCGAGAAACAGCACCCAGGACTATCTTCCAAAGAGTTCTGGATATCCTAAAGAAATCTTCTCATGCT GTTGAGCTTGCCTGCAGAGATCCATCCCAAGTGGAAAACCTGGCTTCCAGTCTGCAGTTAATAACAGAATGCTTCAGGTGTCTTCGCAAT GCTTGCATAGAGTGTTCTGTGAACCAGAATTCAATCAGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAA CTGCGAGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAG TCTATTGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATT TTGTTTACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACAT CCTGAATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAAT CAAGAAAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGG CATGCTGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCA CTGGCTACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTG GAAAGAGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAA GGTGACATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGAC AAGGTGAAGTATGAAGTAACAGAAGATGTGTACACATCCAGAAAGAAACAACACCAGACCATGATGCATTATTTTTGTGCATTAAATACT CTTCAGTACAAGAAGAAAATAGCATTGTTAGAACCTCTACTTGGGTACATGCAAGCTCAGATAAGTTTCTTTAAGATGGGTTCTGAAAAT CTTAATGAACAACTGGAAGAATTTTTAGCTAATATTGGAACAAGCGTTCAGAATGTTCGCAGGGAAATGGACAGTGATATAGAGACCATG CAACAGACAATAGAGGATTTGGAAGTAGCCAGTGATCCCTTATATGTGCCTGACCCAGACCCCACCAAATTTCCTGTTAATCGAAATTTA ACCCGAAAGGCTGGATACCTTAATGCTAGGAATAAAACAGGCTTGGTGTCATCTACCTGGGACAGACAGTTTTACTTCACGCAGGGTGGA AATTTAATGAGTCAGGCCCGTGGGGATGTAGCAGGAGGCCTGGCCATGGACATAGACAACTGTTCAGTGATGGCTGTGGACTGTGAAGAC AGACGATATTGTTTTCAGATCACCTCTTTCGATGGAAAAAAATCTTCAATTTTGCAAGCAGAGAGTAAAAAAGATCATGAAGAGTGGATC TGTACAATAAACAACATATCTAAACAAATATACTTAAGTGAAAATCCAGAGGAAACTGCTGCACGAGTAAATCAATCAGCTCTGGAAGCT GTCACTCCTTCCCCATCTTTCCAGCAGAGGCACGAGAGCCTGCGGCCAGCAGCAGGACAATCTCGGCCACCGACAGCTCGAACCAGCAGT TCAGGATCCTTAGGATCTGAGTCTACAAATTTGGCTGCCCTCTCTCTAGATTCTCTTGTTGCCCCAGACACCCCAATACAGTTTGACATA ATTTCTCCTGTGTGTGAAGATCAGCCTGGCCAGGCAAAAGCCTTTGGCCAGGGAGGCAGGCGTACAAATCCATTTGGAGAATCTGGAGGA AGTACAAAATCTGAAACTGAAGATTCTATTCTTCATCAGTTATTTATTGTCCGATTCCTTGGTTCAATGGAGGTGAAATCAGATGACCAT CCAGATGTTGTTTATGAAACTATGCGCCAAATCTTAGCTGCCCGGGCCATCCATAACATCTTTCGTATGACAGAATCGCATTTATTAGTC ACTTGTGACTGTTTAAAGTTAATTGATCCACAGACACAAGTTACAAGGCTCACGTTTCCATTACCTTGTGTAGTTTTGTATGCTACACAC CAGGAAAATAAGCGCCTTTTTGGATTTGTTCTTCGGACATCAAGCGGGAGAAGTGAAAGTAATCTGTCATCAGTCTGCTATATATTTGAG TCAAACAATGAGGGGGAAAAGATATGTGATTCTGTTGGACTGGCAAAACAGATAGCTTTGCATGCTGAACTGGATCGTAGGGCATCAGAA AAACAAAAAGAAATAGAGAGAGTAAAAGAGAAGCAACAGAAAGAACTCAATAAACAAAAACAGATTGAAAAGGACTTGGAAGAACAAAGT CGGTTGATAGCTGCTTCCAGTAGACCAAACCAAGCCAGTAGTGAGGGGCAGTTTGTTGTCCTTAGCAGTAGCCAGTCAGAAGAGAGTGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ATXN10_ENST00000381061_chr22_46136418_+_APPL1_ENST00000288266_chr3_57280104_+_6684nt AGGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGG CGGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATC CTACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGG CGGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGC TCTTCAAAGAGCAGCGGAACCGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAACAGG AATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTGC ATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCCCTTA ATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGC CGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTTACAC TGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTGATTG CAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATTAGGC TTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATTGATC TTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCCAATG TGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTGAAGTATGAAG TAACAGAAGATGTGTACACATCCAGAAAGAAACAACACCAGACCATGATGCATTATTTTTGTGCATTAAATACTCTTCAGTACAAGAAGA AAATAGCATTGTTAGAACCTCTACTTGGGTACATGCAAGCTCAGATAAGTTTCTTTAAGATGGGTTCTGAAAATCTTAATGAACAACTGG AAGAATTTTTAGCTAATATTGGAACAAGCGTTCAGAATGTTCGCAGGGAAATGGACAGTGATATAGAGACCATGCAACAGACAATAGAGG ATTTGGAAGTAGCCAGTGATCCCTTATATGTGCCTGACCCAGACCCCACCAAATTTCCTGTTAATCGAAATTTAACCCGAAAGGCTGGAT ACCTTAATGCTAGGAATAAAACAGGCTTGGTGTCATCTACCTGGGACAGACAGTTTTACTTCACGCAGGGTGGAAATTTAATGAGTCAGG CCCGTGGGGATGTAGCAGGAGGCCTGGCCATGGACATAGACAACTGTTCAGTGATGGCTGTGGACTGTGAAGACAGACGATATTGTTTTC AGATCACCTCTTTCGATGGAAAAAAATCTTCAATTTTGCAAGCAGAGAGTAAAAAAGATCATGAAGAGTGGATCTGTACAATAAACAACA TATCTAAACAAATATACTTAAGTGAAAATCCAGAGGAAACTGCTGCACGAGTAAATCAATCAGCTCTGGAAGCTGTCACTCCTTCCCCAT CTTTCCAGCAGAGGCACGAGAGCCTGCGGCCAGCAGCAGGACAATCTCGGCCACCGACAGCTCGAACCAGCAGTTCAGGATCCTTAGGAT CTGAGTCTACAAATTTGGCTGCCCTCTCTCTAGATTCTCTTGTTGCCCCAGACACCCCAATACAGTTTGACATAATTTCTCCTGTGTGTG AAGATCAGCCTGGCCAGGCAAAAGCCTTTGGCCAGGGAGGCAGGCGTACAAATCCATTTGGAGAATCTGGAGGAAGTACAAAATCTGAAA CTGAAGATTCTATTCTTCATCAGTTATTTATTGTCCGATTCCTTGGTTCAATGGAGGTGAAATCAGATGACCATCCAGATGTTGTTTATG AAACTATGCGCCAAATCTTAGCTGCCCGGGCCATCCATAACATCTTTCGTATGACAGAATCGCATTTATTAGTCACTTGTGACTGTTTAA AGTTAATTGATCCACAGACACAAGTTACAAGGCTCACGTTTCCATTACCTTGTGTAGTTTTGTATGCTACACACCAGGAAAATAAGCGCC TTTTTGGATTTGTTCTTCGGACATCAAGCGGGAGAAGTGAAAGTAATCTGTCATCAGTCTGCTATATATTTGAGTCAAACAATGAGGGGG AAAAGATATGTGATTCTGTTGGACTGGCAAAACAGATAGCTTTGCATGCTGAACTGGATCGTAGGGCATCAGAAAAACAAAAAGAAATAG AGAGAGTAAAAGAGAAGCAACAGAAAGAACTCAATAAACAAAAACAGATTGAAAAGGACTTGGAAGAACAAAGTCGGTTGATAGCTGCTT CCAGTAGACCAAACCAAGCCAGTAGTGAGGGGCAGTTTGTTGTCCTTAGCAGTAGCCAGTCAGAAGAGAGTGATTTGGGAGAAGGAGGAA AGAAGAGAGAATCAGAAGCATAAGCTTATACTTTTGGTAGATATTCCCCCTTGGAATTTGACAGTTTCTATGGTGAAATGGCAGAAGGTA ACAACTATGTTGAAATATCAAGGAGGAGATTAAGCTTTATATTTGCTTATTTGTTGTAGCTACATTTTAAAAAAAAGATTGAACTTGATG ACTTAGGTTTGCATTGATCTTTTTTCCCCCTTAAACATAATGTACTATGTATTAACATCTAAAGGAAACCTGCTCATCTCCCTGAAGCAG ACTGCTGAGGAATTACATTTGCTCAAGAATTTTTTCCGTCAAATTGTGAACTTTTAATTCTTGCATTGTAATTGGCTGTGTCCATAAGAA ATCATTTATTCTTCAGGCTTAGACATTCATGGATATGCTTTTCTTTCATTAGGAACATTTTGCTGGTGATGAGGAAGCATTTAGCTGAAT AAGTTTAAAGCCCTTTATACAGAGAATTCTACAAGTTTGCAAATATTTTAACAATATTAAATGTGCAATAGAACTTTTATAAAATAATTA GAACAGAGATTTTACAGTTAAGGTTTCAAATTGTGGCAGGTGGTACTGTTGATCTCAGGGTACTTTCTGGGATTGCTCACATTTCTCTAA TGTACTGCACTTGATGCCAGTAGGAAAGAAGCTTAAGTGTCTTCAGTTCAAGATTGATAGAGCCCTTGGCATTTTATTATCACATTCTTA GTTCTCAGGTTGGGACTTCAATTACTGCTGCAGAGCAGTAGTGGTTAAAAATAAGATATTGGAATTTATTAAAAGATTTTTGTTCAATAC ATTTTAGATTAGGATTGACAAGTAAAGATACTGCTATGGAATGATACATTGTATTTTCTGCATTGTGTGAAATAGTTTTTATTGAAAGTC AAGTGACATTTCAAAAGAAGTTCTATAACAATTATGTTTCATGCTTAAAGTAAAAATTCCCAGAGTTTAGTTTAGAAAATGTAATCTTTT AAATTTCAGACTGATATATTCCCAGTATTTTCATAATGCCATGTTTTGATAAAGTACTGAATCACCACTTTATATCCACAAAGGCAAATA ACTAATGTATGATAATAGAATAATTTGCACTAATTATTGTAAATATGTCTACTCTTCAAATGAGTAAAAGGTCCAATTTTGTGAAAGATT GAAAATGAATTGAATGCCTAGTAGAGTATAGGAGAAGTTGACCAAGGAAGGATTTAACCTGGTGCCAAGGTTAAAATAACATTTCTCTAC TGCCTATTGTTTATGTTAAACCTTAATTTTTTTTCTGTAATCACTTTTAACACTGCTAATAGAAATTATGTTTTCATGTGTTTCACATGA AAAAGTATATATATACAAAGTTAATATAGTGGGTAAAATACTTTACATAGTCACACATTTACAAATTTTTCAAGAGGTTAGCCACTAAGA CTTTAATAATTTTACAAGGGAAAAAGCCTTTTTTTTTCTTTGATATACAGTTTTTTCTTCTTAGTTCTGCATTAGAAATGGCATCTGTTT TAGGTCTCAAAATATAACTCAGCTGTTTCACACTGTATATGTACATTGTTTTCTGTAGGAATAGGATAATGATATATAGGATCATGATAT TCCTTCTATCCATGTGCCAAATGGGTGTAATGTTTATTTACTGATGCTTTATGTTACCAAAACATACAGTAAAAAAGTAGAAATTTATGA AATACTTTTGATAAAAAGTTTATTTTGTGCTTACCAAAAGGAATGCTTTCACAATAGTGTATCAGTTCTTTTGTTTTGTTAAAGTTGGAA TTTATTCTGTTGCCAGCATTTAAGTAGTCATGGCAAGTCCTGTTTTTAAGACCTTTTGGAGACTGGAGCTTTCTGTTCCATTAAGTCTTT TGTTTATACTACAAATTGTCACCTCACTTAGTTCAGATGAAATCTGTTACTCTACAAGGAAGGTGTTCATCATTAGGAGGCAGCTTTACT AAGCTGGTGCTTTGCATGGTAGCAAGTGCTGCCCTTTATCAGCACCCTGGGTCATAGTGTAGGCTAGAGTTAAGGCACTGGCAGACTTAG GGATGCTGGACAGACCTGTAGTTCGTTTTAAGTCATGTTCACAGGAATTTCTACAATAATAAACCCATCATCTCCATAGGTCAGATCGAA GTGCATTCCAATGCTAAATAGAAGTTATGAGTGGGTTTAACAATTTTAGATGATTCAGCTTTTGTTCCATTACTGTTGAACTATATGAAC TATTCCATTACTGCAGAGATTTAAGTATCTGTTTTAATAAGCTCTTTTTGTTATTTAAAGGCTGCCCATGGGTTTCTGCCTAGTGGTAAA GCTGATTGTTACCCTCCTTTGAAATCCCTTCTAGTTCTGAGATGCTTTGAGGGTAACTGGATTCGATTTTGGGATATCTTTTCTCACATT CAGACTTACACTTAATGGTGTTAGAAATCAACAAAACTCCTTTTTAAAAAGAAAAGATATTAAGCCTGCCTACTTCTACAATGCATTCTG TTACCTATTTGAACAGTATGTTTGTAACTATGGCAATGAAGTCAGTAGATAGGAAACCAGTTATTCCTTCTACCTTTAAAAATTTTGAGA ACTTGCCAACCAGGGATTAAAGCTATTATCTTGAACAGAGTCCCTAAAGCTAGTCTAGTTTTTGCCACATCTGCAATGATTATTGTTTAA TTTCAAAAGAATCCTCAGGCTCTACAATCTAGGGGTGGTAAATGTGTTTCCACTATACTTGGGAAAAGGTCAGTAGGATGTGCATCCTAG GGAAGATAAAATCGTATATGGTAAAGGCATTTGAGTTAATTTTGCATTATATCTAGGAACCATATTATTTAAAATTTGAATCCTATTAAT GCTGAGAGATCCTAAGAGCTAGTATGTTGTAAAACCTGCCACCTGAATAAAATGAAAAAAAAAGTGTTTTTTTGAGACAGAGTCTTGCTC TGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGGTCACTGCAAACTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCC GAGTAGCTGGGACCACAGGGGCCCACCACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGAT GTTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCCTAAAA TGAAATTATTAATGTTGGTTCTGAAACAGCCTCTTAGCATTCAGATTGTATTTTAAATACTTAAACACACCAATTGTAGAAAGCAACCCT TTATTTTTAGCAAGTTTGGTTTACTCTTCTCCCATGAGATTTTGTCTTTCTACATTAACTAGTAAGACATAAAGATTTGAAACTGGAACT ATATTATACTTTTTAACCAATCTCTGTGGCTTCACTCATGAAATTTACTTCAGTTAATATGAGACTGGGGGTTAAGTTGTAACTAATATG CAAAATTGCTTTGTATATTTGGTGATTTTGTAATGTAAGTGAATTGATTCTTATTTCACTGATACTATTAATCATGCAGTGTACAATTCA AAATCATGCAATGTTTCACTTTAGAATTGGATTTGAAGAACTCGACTTTATGTGATCATGGTATTGGTATACATGTGGGGTGGAGAACTT ATTTTTTCATTTTGTCACAATAGGTATATACTGACAAGGCTTCAGGAAAAAAGTTGTTAGAAGATTTTTTAATGTATAATAAAGTCCATG >In-frame_ATXN10_ENST00000252934_chr22_46136418_+_APPL1_ENST00000288266_chr3_57280104_+_6875nt GGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGGC GGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATCC TACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGGC GGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGCT CTTCAAAGAGCAGCGGAACCGAGAAACAGCACCCAGGACTATCTTCCAAAGAGTTCTGGATATCCTAAAGAAATCTTCTCATGCTGTTGA GCTTGCCTGCAGAGATCCATCCCAAGTGGAAAACCTGGCTTCCAGTCTGCAGTTAATAACAGAATGCTTCAGGTGTCTTCGCAATGCTTG CATAGAGTGTTCTGTGAACCAGAATTCAATCAGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCG AGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTAT TGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTT TACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGA ATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGA AAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGC TGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGC TACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAG AGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGA CATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGT GAAGTATGAAGTAACAGAAGATGTGTACACATCCAGAAAGAAACAACACCAGACCATGATGCATTATTTTTGTGCATTAAATACTCTTCA GTACAAGAAGAAAATAGCATTGTTAGAACCTCTACTTGGGTACATGCAAGCTCAGATAAGTTTCTTTAAGATGGGTTCTGAAAATCTTAA TGAACAACTGGAAGAATTTTTAGCTAATATTGGAACAAGCGTTCAGAATGTTCGCAGGGAAATGGACAGTGATATAGAGACCATGCAACA GACAATAGAGGATTTGGAAGTAGCCAGTGATCCCTTATATGTGCCTGACCCAGACCCCACCAAATTTCCTGTTAATCGAAATTTAACCCG AAAGGCTGGATACCTTAATGCTAGGAATAAAACAGGCTTGGTGTCATCTACCTGGGACAGACAGTTTTACTTCACGCAGGGTGGAAATTT AATGAGTCAGGCCCGTGGGGATGTAGCAGGAGGCCTGGCCATGGACATAGACAACTGTTCAGTGATGGCTGTGGACTGTGAAGACAGACG ATATTGTTTTCAGATCACCTCTTTCGATGGAAAAAAATCTTCAATTTTGCAAGCAGAGAGTAAAAAAGATCATGAAGAGTGGATCTGTAC AATAAACAACATATCTAAACAAATATACTTAAGTGAAAATCCAGAGGAAACTGCTGCACGAGTAAATCAATCAGCTCTGGAAGCTGTCAC TCCTTCCCCATCTTTCCAGCAGAGGCACGAGAGCCTGCGGCCAGCAGCAGGACAATCTCGGCCACCGACAGCTCGAACCAGCAGTTCAGG ATCCTTAGGATCTGAGTCTACAAATTTGGCTGCCCTCTCTCTAGATTCTCTTGTTGCCCCAGACACCCCAATACAGTTTGACATAATTTC TCCTGTGTGTGAAGATCAGCCTGGCCAGGCAAAAGCCTTTGGCCAGGGAGGCAGGCGTACAAATCCATTTGGAGAATCTGGAGGAAGTAC AAAATCTGAAACTGAAGATTCTATTCTTCATCAGTTATTTATTGTCCGATTCCTTGGTTCAATGGAGGTGAAATCAGATGACCATCCAGA TGTTGTTTATGAAACTATGCGCCAAATCTTAGCTGCCCGGGCCATCCATAACATCTTTCGTATGACAGAATCGCATTTATTAGTCACTTG TGACTGTTTAAAGTTAATTGATCCACAGACACAAGTTACAAGGCTCACGTTTCCATTACCTTGTGTAGTTTTGTATGCTACACACCAGGA AAATAAGCGCCTTTTTGGATTTGTTCTTCGGACATCAAGCGGGAGAAGTGAAAGTAATCTGTCATCAGTCTGCTATATATTTGAGTCAAA CAATGAGGGGGAAAAGATATGTGATTCTGTTGGACTGGCAAAACAGATAGCTTTGCATGCTGAACTGGATCGTAGGGCATCAGAAAAACA AAAAGAAATAGAGAGAGTAAAAGAGAAGCAACAGAAAGAACTCAATAAACAAAAACAGATTGAAAAGGACTTGGAAGAACAAAGTCGGTT GATAGCTGCTTCCAGTAGACCAAACCAAGCCAGTAGTGAGGGGCAGTTTGTTGTCCTTAGCAGTAGCCAGTCAGAAGAGAGTGATTTGGG AGAAGGAGGAAAGAAGAGAGAATCAGAAGCATAAGCTTATACTTTTGGTAGATATTCCCCCTTGGAATTTGACAGTTTCTATGGTGAAAT GGCAGAAGGTAACAACTATGTTGAAATATCAAGGAGGAGATTAAGCTTTATATTTGCTTATTTGTTGTAGCTACATTTTAAAAAAAAGAT TGAACTTGATGACTTAGGTTTGCATTGATCTTTTTTCCCCCTTAAACATAATGTACTATGTATTAACATCTAAAGGAAACCTGCTCATCT CCCTGAAGCAGACTGCTGAGGAATTACATTTGCTCAAGAATTTTTTCCGTCAAATTGTGAACTTTTAATTCTTGCATTGTAATTGGCTGT GTCCATAAGAAATCATTTATTCTTCAGGCTTAGACATTCATGGATATGCTTTTCTTTCATTAGGAACATTTTGCTGGTGATGAGGAAGCA TTTAGCTGAATAAGTTTAAAGCCCTTTATACAGAGAATTCTACAAGTTTGCAAATATTTTAACAATATTAAATGTGCAATAGAACTTTTA TAAAATAATTAGAACAGAGATTTTACAGTTAAGGTTTCAAATTGTGGCAGGTGGTACTGTTGATCTCAGGGTACTTTCTGGGATTGCTCA CATTTCTCTAATGTACTGCACTTGATGCCAGTAGGAAAGAAGCTTAAGTGTCTTCAGTTCAAGATTGATAGAGCCCTTGGCATTTTATTA TCACATTCTTAGTTCTCAGGTTGGGACTTCAATTACTGCTGCAGAGCAGTAGTGGTTAAAAATAAGATATTGGAATTTATTAAAAGATTT TTGTTCAATACATTTTAGATTAGGATTGACAAGTAAAGATACTGCTATGGAATGATACATTGTATTTTCTGCATTGTGTGAAATAGTTTT TATTGAAAGTCAAGTGACATTTCAAAAGAAGTTCTATAACAATTATGTTTCATGCTTAAAGTAAAAATTCCCAGAGTTTAGTTTAGAAAA TGTAATCTTTTAAATTTCAGACTGATATATTCCCAGTATTTTCATAATGCCATGTTTTGATAAAGTACTGAATCACCACTTTATATCCAC AAAGGCAAATAACTAATGTATGATAATAGAATAATTTGCACTAATTATTGTAAATATGTCTACTCTTCAAATGAGTAAAAGGTCCAATTT TGTGAAAGATTGAAAATGAATTGAATGCCTAGTAGAGTATAGGAGAAGTTGACCAAGGAAGGATTTAACCTGGTGCCAAGGTTAAAATAA CATTTCTCTACTGCCTATTGTTTATGTTAAACCTTAATTTTTTTTCTGTAATCACTTTTAACACTGCTAATAGAAATTATGTTTTCATGT GTTTCACATGAAAAAGTATATATATACAAAGTTAATATAGTGGGTAAAATACTTTACATAGTCACACATTTACAAATTTTTCAAGAGGTT AGCCACTAAGACTTTAATAATTTTACAAGGGAAAAAGCCTTTTTTTTTCTTTGATATACAGTTTTTTCTTCTTAGTTCTGCATTAGAAAT GGCATCTGTTTTAGGTCTCAAAATATAACTCAGCTGTTTCACACTGTATATGTACATTGTTTTCTGTAGGAATAGGATAATGATATATAG GATCATGATATTCCTTCTATCCATGTGCCAAATGGGTGTAATGTTTATTTACTGATGCTTTATGTTACCAAAACATACAGTAAAAAAGTA GAAATTTATGAAATACTTTTGATAAAAAGTTTATTTTGTGCTTACCAAAAGGAATGCTTTCACAATAGTGTATCAGTTCTTTTGTTTTGT TAAAGTTGGAATTTATTCTGTTGCCAGCATTTAAGTAGTCATGGCAAGTCCTGTTTTTAAGACCTTTTGGAGACTGGAGCTTTCTGTTCC ATTAAGTCTTTTGTTTATACTACAAATTGTCACCTCACTTAGTTCAGATGAAATCTGTTACTCTACAAGGAAGGTGTTCATCATTAGGAG GCAGCTTTACTAAGCTGGTGCTTTGCATGGTAGCAAGTGCTGCCCTTTATCAGCACCCTGGGTCATAGTGTAGGCTAGAGTTAAGGCACT GGCAGACTTAGGGATGCTGGACAGACCTGTAGTTCGTTTTAAGTCATGTTCACAGGAATTTCTACAATAATAAACCCATCATCTCCATAG GTCAGATCGAAGTGCATTCCAATGCTAAATAGAAGTTATGAGTGGGTTTAACAATTTTAGATGATTCAGCTTTTGTTCCATTACTGTTGA ACTATATGAACTATTCCATTACTGCAGAGATTTAAGTATCTGTTTTAATAAGCTCTTTTTGTTATTTAAAGGCTGCCCATGGGTTTCTGC CTAGTGGTAAAGCTGATTGTTACCCTCCTTTGAAATCCCTTCTAGTTCTGAGATGCTTTGAGGGTAACTGGATTCGATTTTGGGATATCT TTTCTCACATTCAGACTTACACTTAATGGTGTTAGAAATCAACAAAACTCCTTTTTAAAAAGAAAAGATATTAAGCCTGCCTACTTCTAC AATGCATTCTGTTACCTATTTGAACAGTATGTTTGTAACTATGGCAATGAAGTCAGTAGATAGGAAACCAGTTATTCCTTCTACCTTTAA AAATTTTGAGAACTTGCCAACCAGGGATTAAAGCTATTATCTTGAACAGAGTCCCTAAAGCTAGTCTAGTTTTTGCCACATCTGCAATGA TTATTGTTTAATTTCAAAAGAATCCTCAGGCTCTACAATCTAGGGGTGGTAAATGTGTTTCCACTATACTTGGGAAAAGGTCAGTAGGAT GTGCATCCTAGGGAAGATAAAATCGTATATGGTAAAGGCATTTGAGTTAATTTTGCATTATATCTAGGAACCATATTATTTAAAATTTGA ATCCTATTAATGCTGAGAGATCCTAAGAGCTAGTATGTTGTAAAACCTGCCACCTGAATAAAATGAAAAAAAAAGTGTTTTTTTGAGACA GAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGGTCACTGCAAACTCCGCCTCCCAGGTTCACGCCATTCTCCTGC CTCAGCCTCCCGAGTAGCTGGGACCACAGGGGCCCACCACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTG TTAGCCAGGATGTTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCC CGGCCCTAAAATGAAATTATTAATGTTGGTTCTGAAACAGCCTCTTAGCATTCAGATTGTATTTTAAATACTTAAACACACCAATTGTAG AAAGCAACCCTTTATTTTTAGCAAGTTTGGTTTACTCTTCTCCCATGAGATTTTGTCTTTCTACATTAACTAGTAAGACATAAAGATTTG AAACTGGAACTATATTATACTTTTTAACCAATCTCTGTGGCTTCACTCATGAAATTTACTTCAGTTAATATGAGACTGGGGGTTAAGTTG TAACTAATATGCAAAATTGCTTTGTATATTTGGTGATTTTGTAATGTAAGTGAATTGATTCTTATTTCACTGATACTATTAATCATGCAG TGTACAATTCAAAATCATGCAATGTTTCACTTTAGAATTGGATTTGAAGAACTCGACTTTATGTGATCATGGTATTGGTATACATGTGGG GTGGAGAACTTATTTTTTCATTTTGTCACAATAGGTATATACTGACAAGGCTTCAGGAAAAAAGTTGTTAGAAGATTTTTTAATGTATAA |
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FusionGenePPI for ATXN10_APPL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ATXN10 | BSG, STYXL1, MAGED1, GSTK1, CUL3, PPP1R12A, GNB1, GNB2, FN1, MRPS16, GLS, GOLGA1, ABCA1, CA9, VCP, EGFR, SERPINH1, HSPA1A, HSPA8, CCDC8, ABCE1, HTR6, HSPB1, CEP162, CEP152, CEP128, SCLT1, CENPJ, LAMB3, MYC, UBE2A, TUBA1C, MTMR14, DUSP22, PTPRN, STOM, DLD | APPL1 | AKT2, APPL2, TRAF2, DCC, MTA2, HDAC1, HDAC2, RBBP4, RBBP7, RUVBL2, RAB5A, ELAVL1, FSHR, ADIPOR1, ADIPOR2, APPL1, RAB21, VCP, EGFR, PLEKHF2, PIK3R1, AKT1, AR, HDAC3, HDAC5, TRAF6, DPYSL5, KXD1, CMTM4, CLUH, KIAA1468, TTC4, MAGEA9, MEOX1, FARS2, UBE2O, RHEBL1, MAP3K1, GIPC2, C16orf70, NTRK1, BATF3, BRWD1, RTCB, DOK3, DOK7, INO80E, KLF15, MAGEC3, ZNF829, CBL, CBLB, DOK2, ID1, SH2D2A, SOCS6, SCAPER, PIK3R2, TP53, TMEM17, PIK3CA, TGFBR1, PRKCZ, TUBB3, ZNF830, TPCN2, FAM167A, KLHL2, OCRL, CLTA, CLTB, EIF3CL |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATXN10_APPL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATXN10_APPL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | APPL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | APPL1 | C4225299 | MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 14 | 1 | UNIPROT |
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