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Fusion gene ID: 35515 |
FusionGeneSummary for SPAG1_STK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPAG1_STK3 | Fusion gene ID: 35515 | Hgene | Tgene | Gene symbol | SPAG1 | STK3 | Gene ID | 6674 | 8428 |
| Gene name | sperm associated antigen 1 | serine/threonine kinase 24 | |
| Synonyms | CILD28|CT140|HEL-S-268|HSD-3.8|SP75|TPIS | HEL-S-95|MST3|MST3B|STE20|STK3 | |
| Cytomap | 8q22.2 | 13q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sperm-associated antigen 1TPR-containing protein involved in spermatogenesisepididymis secretory protein Li 268infertility-related sperm protein Spag-1tetratricopeptide repeat-containing protein | serine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q07617 | Q13188 | |
| Ensembl transtripts involved in fusion gene | ENST00000520643, ENST00000251809, ENST00000520508, ENST00000388798, ENST00000523302, | ENST00000419617, ENST00000523601, ENST00000521768, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 6 X 5 X 4=120 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SPAG1 [Title/Abstract] AND STK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STK3 | GO:0006468 | protein phosphorylation | 19604147 |
| Tgene | STK3 | GO:0042542 | response to hydrogen peroxide | 22291017 |
| Tgene | STK3 | GO:0046777 | protein autophosphorylation | 17046825|17657516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-68-8250-01A | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000520643 | ENST00000419617 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| intron-3CDS | ENST00000520643 | ENST00000523601 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| intron-intron | ENST00000520643 | ENST00000521768 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| In-frame | ENST00000251809 | ENST00000419617 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| In-frame | ENST00000251809 | ENST00000523601 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| 5CDS-intron | ENST00000251809 | ENST00000521768 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| intron-3CDS | ENST00000520508 | ENST00000419617 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| intron-3CDS | ENST00000520508 | ENST00000523601 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| intron-intron | ENST00000520508 | ENST00000521768 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| In-frame | ENST00000388798 | ENST00000419617 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| In-frame | ENST00000388798 | ENST00000523601 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| 5CDS-intron | ENST00000388798 | ENST00000521768 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| intron-3CDS | ENST00000523302 | ENST00000419617 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| intron-3CDS | ENST00000523302 | ENST00000523601 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
| intron-intron | ENST00000523302 | ENST00000521768 | SPAG1 | chr8 | 101245765 | + | STK3 | chr8 | 99719539 | - |
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FusionProtFeatures for SPAG1_STK3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPAG1 | STK3 |
| May play a role in the cytoplasmic assembly of theciliary dynein arms (By similarity). May play a role infertilization. Binds GTP and has GTPase activity. {ECO:0000250,ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}. | Stress-activated, pro-apoptotic kinase which, followingcaspase-cleavage, enters the nucleus and induces chromatincondensation followed by internucleosomal DNA fragmentation. Keycomponent of the Hippo signaling pathway which plays a pivotalrole in organ size control and tumor suppression by restrictingproliferation and promoting apoptosis. The core of this pathway iscomposed of a kinase cascade wherein STK3/MST2 and STK4/MST1, incomplex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1,which in turn phosphorylates and inactivates YAP1 oncoprotein andWWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genesimportant for cell proliferation, cell death, and cell migration.STK3/MST2 and STK4/MST1 are required to repress proliferation ofmature hepatocytes, to prevent activation of facultative adultliver stem cells (oval cells), and to inhibit tumor formation.Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 andplays a role in centrosome disjunction by regulating thelocalization of NEK2 to centrosome, and its ability tophosphorylate CROCC and CEP250. In conjunction with SAV1,activates the transcriptional activity of ESR1 through themodulation of its phosphorylation. Positively regulates RAF1activation via suppression of the inhibitory phosphorylation ofRAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2.Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively withMOBKL1B to activate STK38. {ECO:0000250|UniProtKB:Q9JI10,ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133,ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890,ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043,ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395,ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:8566796,ECO:0000269|PubMed:8816758}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPAG1_STK3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SPAG1_ENST00000251809_chr8_101245765_+_STK3_ENST00000419617_chr8_99719539_-_1080aa MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEFCEKHLQALAPESRALRKDKPAATAASFTAE EWEKIDGDIKSWVSEIKKEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAYNNRAQAEIKLQNWNSAFQDCEKVLE LEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGHPGGGQGAENPAGLKS QGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEG NQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKLIEDEIATILKSTLK GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYA DIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEE EENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDF KNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNFX >In-frame_SPAG1_ENST00000251809_chr8_101245765_+_STK3_ENST00000523601_chr8_99719539_-_1080aa MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEFCEKHLQALAPESRALRKDKPAATAASFTAE EWEKIDGDIKSWVSEIKKEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAYNNRAQAEIKLQNWNSAFQDCEKVLE LEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGHPGGGQGAENPAGLKS QGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEG NQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKLIEDEIATILKSTLK GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYA DIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEE EENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDF KNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNFX >In-frame_SPAG1_ENST00000388798_chr8_101245765_+_STK3_ENST00000419617_chr8_99719539_-_1080aa MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEFCEKHLQALAPESRALRKDKPAATAASFTAE EWEKIDGDIKSWVSEIKKEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAYNNRAQAEIKLQNWNSAFQDCEKVLE LEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGHPGGGQGAENPAGLKS QGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEG NQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKLIEDEIATILKSTLK GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYA DIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEE EENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDF KNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNFX >In-frame_SPAG1_ENST00000388798_chr8_101245765_+_STK3_ENST00000523601_chr8_99719539_-_1080aa MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEFCEKHLQALAPESRALRKDKPAATAASFTAE EWEKIDGDIKSWVSEIKKEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAYNNRAQAEIKLQNWNSAFQDCEKVLE LEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGHPGGGQGAENPAGLKS QGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEG NQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKLIEDEIATILKSTLK GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYA DIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEE EENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDF KNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNFX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SPAG1_ENST00000251809_chr8_101245765_+_STK3_ENST00000419617_chr8_99719539_-_3240nt ATGACCACCAAAGATTATCCATCATTGTGGGGCTTTGGAACAACAAAAACATTCAAAATTCCCATTGAACATCTAGATTTCAAATACATT GAAAAATGTTCAGATGTTAAACATCTGGAAAAAATTCTTTGCGTGCTCAGATCTGGTGAGGAAGGATATTATCCTGAACTTACAGAATTT TGTGAAAAGCATCTTCAAGCCTTGGCCCCTGAAAGCAGAGCTTTGAGGAAAGATAAACCAGCAGCAACAGCAGCCAGTTTTACAGCTGAA GAATGGGAAAAAATTGATGGTGATATAAAGAGTTGGGTATCAGAAATTAAAAAAGAAGAAGATAAAATGCACTTTCATGAAACTGAGACA TTTCCAGCAATGAAAGATAATTTGCCTCCAGTTCGTGGTTCAAACAGCTGTCTTCATGTAGGCAAGGAAAAATATTCTAAAAGACCAACT AAAAAGAAAACTCCAAGGGATTACGCGGAATGGGATAAATTTGACGTGGAGAAGGAATGTTTAAAAATTGATGAAGATTACAAAGAAAAG ACGGTAATAGACAAGTCACACTTGTCTAAAATTGAGACAAGAATAGATACAGCAGGTCTAACTGAGAAAGAAAAGGATTTTCTTGCCACT CGTGAAAAGGAGAAAGGAAATGAAGCTTTCAACTCAGGAGATTATGAAGAAGCAGTGATGTATTATACCAGGAGCATATCAGCGCTTCCC ACTGTAGTTGCCTATAACAATCGAGCTCAAGCAGAAATCAAATTACAGAACTGGAATAGTGCTTTTCAGGATTGTGAAAAGGTCTTGGAG TTAGAACCTGGAAACGTAAAGGCTCTTCTGCGTCGTGCTACTACATATAAACATCAAAACAAGCTCCGGGAAGCTACAGAAGATTTGAGT AAAGTACTAGATGTTGAGCCTGATAATGATTTGGCCAAGAAAACCTTGTCAGAGGTTGAAAGAGATCTGAAAAATTCTGAAGCTGCATCT GAGACTCAAACCAAAGGGAAAAGGATGGTTATTCAGGAAATAGAAAACTCCGAAGATGAAGAAGGAAAAAGCGGAAGAAAACATGAAGAT GGCGGTGGAGATAAGAAGCCCGCGGAGCCGGCGGGAGCCGCGCGCGCCGCCCAGCCGTGCGTCATGGGCAACATCCAGAAGAAGCTGACT GGCAAAGCCGAAGGCGGCAAGCGGCCGGCAAGGGGCGCGCCGCAGCGGGGCCAGACCCCGGAGGCCGGCGCGGACAAGCGGAGCCCACGG CGGGCCTCTGCGGCGGCGGCGGCGGGCGGCGGCGCCACCGGGCATCCGGGCGGCGGGCAGGGCGCGGAGAACCCTGCCGGCCTGAAGAGC CAGGGCAACGAGCTGTTCCGAAGCGGGCAGTTCGCCGAGGCGGCCGGCAAGTACTCGGCGGCAATCGCGCTCCTGGAGCCAGCAGGAAGT GAAATTGCAGATGATCTAAGTATCTTATATTCAAATAGAGCAGCATGTTACCTAAAAGAAGGAAACTGCAGTGGCTGCATTCAAGATTGT AACAGGGCTCTGGAACTTCATCCATTCTCTATGAAACCTCTTCTGAGGCGGGCGATGGCCTATGAAACTCTAGAGCAGTATGGGAAAGCT TATGTGGATTATAAAACAGTGTTGCAGATAGACTGTGGACTCCAGCTAGCAAATGACAGTGTTAACAGGCTATCAAGAATTTTAATGGAG CTGGATGGACCAAATTGGCGGGAGAAGCTGTCACCTATTCCTGCTGTGCCTGCTTCTGTGCCACTGCAAGCTTGGCATCCGGCAAAAGAG ATGATCTCAAAACAAGCAGGAGACTCCAGCAGCCATCGCCAGCAGGGCATCACAGATGAAAAAACATTTAAAGCCCTTAAGGAAGAAGGA AATCAATGTGTAAATGACAAAAACTATAAAGACGCCCTCAGTAAATACAGCGAATGCTTAAAGATTAACAATAAGGAATGTGCCATATAT ACAAACAGAGCTCTCTGTTACTTGAAGCTGTGCCAGTTTGAAGAAGCAAAGCAGGACTGTGATCAGGCACTTCAGCTAGCTGATGGGAAC GTGAAAGCCTTCTATAGACGAGCTCTGGCTCATAAAGGACTCAAGTTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAA GGACTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTG GCAGATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTG ATTCAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCT GATATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACC GATTTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCAAGAATGCCAAA CCTGTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAATTGGAAGAGGAA GAAGAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACG ATGAGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACAGTGAGGATGAG GAAGAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATAAGCAAGACTTC AAGAATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCT CAAGATGGAGACTTTGACTTTTTGAAAAATCTAAGTTTAGAAGAACTACAGATGCGGTTAAAAGCACTGGACCCCATGATGGAACGGGAG ATAGAAGAACTTCGTCAGAGATACACTGCGAAAAGACAGCCCATTCTGGATGCGATGGATGCAAAGAAAAGAAGGCAGCAAAACTTTTGA >In-frame_SPAG1_ENST00000251809_chr8_101245765_+_STK3_ENST00000523601_chr8_99719539_-_3240nt ATGACCACCAAAGATTATCCATCATTGTGGGGCTTTGGAACAACAAAAACATTCAAAATTCCCATTGAACATCTAGATTTCAAATACATT GAAAAATGTTCAGATGTTAAACATCTGGAAAAAATTCTTTGCGTGCTCAGATCTGGTGAGGAAGGATATTATCCTGAACTTACAGAATTT TGTGAAAAGCATCTTCAAGCCTTGGCCCCTGAAAGCAGAGCTTTGAGGAAAGATAAACCAGCAGCAACAGCAGCCAGTTTTACAGCTGAA GAATGGGAAAAAATTGATGGTGATATAAAGAGTTGGGTATCAGAAATTAAAAAAGAAGAAGATAAAATGCACTTTCATGAAACTGAGACA TTTCCAGCAATGAAAGATAATTTGCCTCCAGTTCGTGGTTCAAACAGCTGTCTTCATGTAGGCAAGGAAAAATATTCTAAAAGACCAACT AAAAAGAAAACTCCAAGGGATTACGCGGAATGGGATAAATTTGACGTGGAGAAGGAATGTTTAAAAATTGATGAAGATTACAAAGAAAAG ACGGTAATAGACAAGTCACACTTGTCTAAAATTGAGACAAGAATAGATACAGCAGGTCTAACTGAGAAAGAAAAGGATTTTCTTGCCACT CGTGAAAAGGAGAAAGGAAATGAAGCTTTCAACTCAGGAGATTATGAAGAAGCAGTGATGTATTATACCAGGAGCATATCAGCGCTTCCC ACTGTAGTTGCCTATAACAATCGAGCTCAAGCAGAAATCAAATTACAGAACTGGAATAGTGCTTTTCAGGATTGTGAAAAGGTCTTGGAG TTAGAACCTGGAAACGTAAAGGCTCTTCTGCGTCGTGCTACTACATATAAACATCAAAACAAGCTCCGGGAAGCTACAGAAGATTTGAGT AAAGTACTAGATGTTGAGCCTGATAATGATTTGGCCAAGAAAACCTTGTCAGAGGTTGAAAGAGATCTGAAAAATTCTGAAGCTGCATCT GAGACTCAAACCAAAGGGAAAAGGATGGTTATTCAGGAAATAGAAAACTCCGAAGATGAAGAAGGAAAAAGCGGAAGAAAACATGAAGAT GGCGGTGGAGATAAGAAGCCCGCGGAGCCGGCGGGAGCCGCGCGCGCCGCCCAGCCGTGCGTCATGGGCAACATCCAGAAGAAGCTGACT GGCAAAGCCGAAGGCGGCAAGCGGCCGGCAAGGGGCGCGCCGCAGCGGGGCCAGACCCCGGAGGCCGGCGCGGACAAGCGGAGCCCACGG CGGGCCTCTGCGGCGGCGGCGGCGGGCGGCGGCGCCACCGGGCATCCGGGCGGCGGGCAGGGCGCGGAGAACCCTGCCGGCCTGAAGAGC CAGGGCAACGAGCTGTTCCGAAGCGGGCAGTTCGCCGAGGCGGCCGGCAAGTACTCGGCGGCAATCGCGCTCCTGGAGCCAGCAGGAAGT GAAATTGCAGATGATCTAAGTATCTTATATTCAAATAGAGCAGCATGTTACCTAAAAGAAGGAAACTGCAGTGGCTGCATTCAAGATTGT AACAGGGCTCTGGAACTTCATCCATTCTCTATGAAACCTCTTCTGAGGCGGGCGATGGCCTATGAAACTCTAGAGCAGTATGGGAAAGCT TATGTGGATTATAAAACAGTGTTGCAGATAGACTGTGGACTCCAGCTAGCAAATGACAGTGTTAACAGGCTATCAAGAATTTTAATGGAG CTGGATGGACCAAATTGGCGGGAGAAGCTGTCACCTATTCCTGCTGTGCCTGCTTCTGTGCCACTGCAAGCTTGGCATCCGGCAAAAGAG ATGATCTCAAAACAAGCAGGAGACTCCAGCAGCCATCGCCAGCAGGGCATCACAGATGAAAAAACATTTAAAGCCCTTAAGGAAGAAGGA AATCAATGTGTAAATGACAAAAACTATAAAGACGCCCTCAGTAAATACAGCGAATGCTTAAAGATTAACAATAAGGAATGTGCCATATAT ACAAACAGAGCTCTCTGTTACTTGAAGCTGTGCCAGTTTGAAGAAGCAAAGCAGGACTGTGATCAGGCACTTCAGCTAGCTGATGGGAAC GTGAAAGCCTTCTATAGACGAGCTCTGGCTCATAAAGGACTCAAGTTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAA GGACTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTG GCAGATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTG ATTCAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCT GATATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACC GATTTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCAAGAATGCCAAA CCTGTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAATTGGAAGAGGAA GAAGAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACG ATGAGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACAGTGAGGATGAG GAAGAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATAAGCAAGACTTC AAGAATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCT CAAGATGGAGACTTTGACTTTTTGAAAAATCTAAGTTTAGAAGAACTACAGATGCGGTTAAAAGCACTGGACCCCATGATGGAACGGGAG ATAGAAGAACTTCGTCAGAGATACACTGCGAAAAGACAGCCCATTCTGGATGCGATGGATGCAAAGAAAAGAAGGCAGCAAAACTTTTGA >In-frame_SPAG1_ENST00000388798_chr8_101245765_+_STK3_ENST00000419617_chr8_99719539_-_3240nt ATGACCACCAAAGATTATCCATCATTGTGGGGCTTTGGAACAACAAAAACATTCAAAATTCCCATTGAACATCTAGATTTCAAATACATT GAAAAATGTTCAGATGTTAAACATCTGGAAAAAATTCTTTGCGTGCTCAGATCTGGTGAGGAAGGATATTATCCTGAACTTACAGAATTT TGTGAAAAGCATCTTCAAGCCTTGGCCCCTGAAAGCAGAGCTTTGAGGAAAGATAAACCAGCAGCAACAGCAGCCAGTTTTACAGCTGAA GAATGGGAAAAAATTGATGGTGATATAAAGAGTTGGGTATCAGAAATTAAAAAAGAAGAAGATAAAATGCACTTTCATGAAACTGAGACA TTTCCAGCAATGAAAGATAATTTGCCTCCAGTTCGTGGTTCAAACAGCTGTCTTCATGTAGGCAAGGAAAAATATTCTAAAAGACCAACT AAAAAGAAAACTCCAAGGGATTACGCGGAATGGGATAAATTTGACGTGGAGAAGGAATGTTTAAAAATTGATGAAGATTACAAAGAAAAG ACGGTAATAGACAAGTCACACTTGTCTAAAATTGAGACAAGAATAGATACAGCAGGTCTAACTGAGAAAGAAAAGGATTTTCTTGCCACT CGTGAAAAGGAGAAAGGAAATGAAGCTTTCAACTCAGGAGATTATGAAGAAGCAGTGATGTATTATACCAGGAGCATATCAGCGCTTCCC ACTGTAGTTGCCTATAACAATCGAGCTCAAGCAGAAATCAAATTACAGAACTGGAATAGTGCTTTTCAGGATTGTGAAAAGGTCTTGGAG TTAGAACCTGGAAACGTAAAGGCTCTTCTGCGTCGTGCTACTACATATAAACATCAAAACAAGCTCCGGGAAGCTACAGAAGATTTGAGT AAAGTACTAGATGTTGAGCCTGATAATGATTTGGCCAAGAAAACCTTGTCAGAGGTTGAAAGAGATCTGAAAAATTCTGAAGCTGCATCT GAGACTCAAACCAAAGGGAAAAGGATGGTTATTCAGGAAATAGAAAACTCCGAAGATGAAGAAGGAAAAAGCGGAAGAAAACATGAAGAT GGCGGTGGAGATAAGAAGCCCGCGGAGCCGGCGGGAGCCGCGCGCGCCGCCCAGCCGTGCGTCATGGGCAACATCCAGAAGAAGCTGACT GGCAAAGCCGAAGGCGGCAAGCGGCCGGCAAGGGGCGCGCCGCAGCGGGGCCAGACCCCGGAGGCCGGCGCGGACAAGCGGAGCCCACGG CGGGCCTCTGCGGCGGCGGCGGCGGGCGGCGGCGCCACCGGGCATCCGGGCGGCGGGCAGGGCGCGGAGAACCCTGCCGGCCTGAAGAGC CAGGGCAACGAGCTGTTCCGAAGCGGGCAGTTCGCCGAGGCGGCCGGCAAGTACTCGGCGGCAATCGCGCTCCTGGAGCCAGCAGGAAGT GAAATTGCAGATGATCTAAGTATCTTATATTCAAATAGAGCAGCATGTTACCTAAAAGAAGGAAACTGCAGTGGCTGCATTCAAGATTGT AACAGGGCTCTGGAACTTCATCCATTCTCTATGAAACCTCTTCTGAGGCGGGCGATGGCCTATGAAACTCTAGAGCAGTATGGGAAAGCT TATGTGGATTATAAAACAGTGTTGCAGATAGACTGTGGACTCCAGCTAGCAAATGACAGTGTTAACAGGCTATCAAGAATTTTAATGGAG CTGGATGGACCAAATTGGCGGGAGAAGCTGTCACCTATTCCTGCTGTGCCTGCTTCTGTGCCACTGCAAGCTTGGCATCCGGCAAAAGAG ATGATCTCAAAACAAGCAGGAGACTCCAGCAGCCATCGCCAGCAGGGCATCACAGATGAAAAAACATTTAAAGCCCTTAAGGAAGAAGGA AATCAATGTGTAAATGACAAAAACTATAAAGACGCCCTCAGTAAATACAGCGAATGCTTAAAGATTAACAATAAGGAATGTGCCATATAT ACAAACAGAGCTCTCTGTTACTTGAAGCTGTGCCAGTTTGAAGAAGCAAAGCAGGACTGTGATCAGGCACTTCAGCTAGCTGATGGGAAC GTGAAAGCCTTCTATAGACGAGCTCTGGCTCATAAAGGACTCAAGTTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAA GGACTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTG GCAGATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTG ATTCAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCT GATATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACC GATTTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCAAGAATGCCAAA CCTGTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAATTGGAAGAGGAA GAAGAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACG ATGAGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACAGTGAGGATGAG GAAGAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATAAGCAAGACTTC AAGAATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCT CAAGATGGAGACTTTGACTTTTTGAAAAATCTAAGTTTAGAAGAACTACAGATGCGGTTAAAAGCACTGGACCCCATGATGGAACGGGAG ATAGAAGAACTTCGTCAGAGATACACTGCGAAAAGACAGCCCATTCTGGATGCGATGGATGCAAAGAAAAGAAGGCAGCAAAACTTTTGA >In-frame_SPAG1_ENST00000388798_chr8_101245765_+_STK3_ENST00000523601_chr8_99719539_-_3240nt ATGACCACCAAAGATTATCCATCATTGTGGGGCTTTGGAACAACAAAAACATTCAAAATTCCCATTGAACATCTAGATTTCAAATACATT GAAAAATGTTCAGATGTTAAACATCTGGAAAAAATTCTTTGCGTGCTCAGATCTGGTGAGGAAGGATATTATCCTGAACTTACAGAATTT TGTGAAAAGCATCTTCAAGCCTTGGCCCCTGAAAGCAGAGCTTTGAGGAAAGATAAACCAGCAGCAACAGCAGCCAGTTTTACAGCTGAA GAATGGGAAAAAATTGATGGTGATATAAAGAGTTGGGTATCAGAAATTAAAAAAGAAGAAGATAAAATGCACTTTCATGAAACTGAGACA TTTCCAGCAATGAAAGATAATTTGCCTCCAGTTCGTGGTTCAAACAGCTGTCTTCATGTAGGCAAGGAAAAATATTCTAAAAGACCAACT AAAAAGAAAACTCCAAGGGATTACGCGGAATGGGATAAATTTGACGTGGAGAAGGAATGTTTAAAAATTGATGAAGATTACAAAGAAAAG ACGGTAATAGACAAGTCACACTTGTCTAAAATTGAGACAAGAATAGATACAGCAGGTCTAACTGAGAAAGAAAAGGATTTTCTTGCCACT CGTGAAAAGGAGAAAGGAAATGAAGCTTTCAACTCAGGAGATTATGAAGAAGCAGTGATGTATTATACCAGGAGCATATCAGCGCTTCCC ACTGTAGTTGCCTATAACAATCGAGCTCAAGCAGAAATCAAATTACAGAACTGGAATAGTGCTTTTCAGGATTGTGAAAAGGTCTTGGAG TTAGAACCTGGAAACGTAAAGGCTCTTCTGCGTCGTGCTACTACATATAAACATCAAAACAAGCTCCGGGAAGCTACAGAAGATTTGAGT AAAGTACTAGATGTTGAGCCTGATAATGATTTGGCCAAGAAAACCTTGTCAGAGGTTGAAAGAGATCTGAAAAATTCTGAAGCTGCATCT GAGACTCAAACCAAAGGGAAAAGGATGGTTATTCAGGAAATAGAAAACTCCGAAGATGAAGAAGGAAAAAGCGGAAGAAAACATGAAGAT GGCGGTGGAGATAAGAAGCCCGCGGAGCCGGCGGGAGCCGCGCGCGCCGCCCAGCCGTGCGTCATGGGCAACATCCAGAAGAAGCTGACT GGCAAAGCCGAAGGCGGCAAGCGGCCGGCAAGGGGCGCGCCGCAGCGGGGCCAGACCCCGGAGGCCGGCGCGGACAAGCGGAGCCCACGG CGGGCCTCTGCGGCGGCGGCGGCGGGCGGCGGCGCCACCGGGCATCCGGGCGGCGGGCAGGGCGCGGAGAACCCTGCCGGCCTGAAGAGC CAGGGCAACGAGCTGTTCCGAAGCGGGCAGTTCGCCGAGGCGGCCGGCAAGTACTCGGCGGCAATCGCGCTCCTGGAGCCAGCAGGAAGT GAAATTGCAGATGATCTAAGTATCTTATATTCAAATAGAGCAGCATGTTACCTAAAAGAAGGAAACTGCAGTGGCTGCATTCAAGATTGT AACAGGGCTCTGGAACTTCATCCATTCTCTATGAAACCTCTTCTGAGGCGGGCGATGGCCTATGAAACTCTAGAGCAGTATGGGAAAGCT TATGTGGATTATAAAACAGTGTTGCAGATAGACTGTGGACTCCAGCTAGCAAATGACAGTGTTAACAGGCTATCAAGAATTTTAATGGAG CTGGATGGACCAAATTGGCGGGAGAAGCTGTCACCTATTCCTGCTGTGCCTGCTTCTGTGCCACTGCAAGCTTGGCATCCGGCAAAAGAG ATGATCTCAAAACAAGCAGGAGACTCCAGCAGCCATCGCCAGCAGGGCATCACAGATGAAAAAACATTTAAAGCCCTTAAGGAAGAAGGA AATCAATGTGTAAATGACAAAAACTATAAAGACGCCCTCAGTAAATACAGCGAATGCTTAAAGATTAACAATAAGGAATGTGCCATATAT ACAAACAGAGCTCTCTGTTACTTGAAGCTGTGCCAGTTTGAAGAAGCAAAGCAGGACTGTGATCAGGCACTTCAGCTAGCTGATGGGAAC GTGAAAGCCTTCTATAGACGAGCTCTGGCTCATAAAGGACTCAAGTTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAA GGACTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTG GCAGATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTG ATTCAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCT GATATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACC GATTTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCAAGAATGCCAAA CCTGTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAATTGGAAGAGGAA GAAGAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACG ATGAGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACAGTGAGGATGAG GAAGAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATAAGCAAGACTTC AAGAATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCT CAAGATGGAGACTTTGACTTTTTGAAAAATCTAAGTTTAGAAGAACTACAGATGCGGTTAAAAGCACTGGACCCCATGATGGAACGGGAG ATAGAAGAACTTCGTCAGAGATACACTGCGAAAAGACAGCCCATTCTGGATGCGATGGATGCAAAGAAAAGAAGGCAGCAAAACTTTTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SPAG1_ENST00000251809_chr8_101245765_+_STK3_ENST00000419617_chr8_99719539_-_4529nt GACGAGACCCTCCCTCAGCACCTGCAGTGCAGCCAGAGCCGGTGCGGCGGCCGCGACTTCCCCGACGCGGGGCGCTGAGAAGCACTATGA CCACCAAAGATTATCCATCATTGTGGGGCTTTGGAACAACAAAAACATTCAAAATTCCCATTGAACATCTAGATTTCAAATACATTGAAA AATGTTCAGATGTTAAACATCTGGAAAAAATTCTTTGCGTGCTCAGATCTGGTGAGGAAGGATATTATCCTGAACTTACAGAATTTTGTG AAAAGCATCTTCAAGCCTTGGCCCCTGAAAGCAGAGCTTTGAGGAAAGATAAACCAGCAGCAACAGCAGCCAGTTTTACAGCTGAAGAAT GGGAAAAAATTGATGGTGATATAAAGAGTTGGGTATCAGAAATTAAAAAAGAAGAAGATAAAATGCACTTTCATGAAACTGAGACATTTC CAGCAATGAAAGATAATTTGCCTCCAGTTCGTGGTTCAAACAGCTGTCTTCATGTAGGCAAGGAAAAATATTCTAAAAGACCAACTAAAA AGAAAACTCCAAGGGATTACGCGGAATGGGATAAATTTGACGTGGAGAAGGAATGTTTAAAAATTGATGAAGATTACAAAGAAAAGACGG TAATAGACAAGTCACACTTGTCTAAAATTGAGACAAGAATAGATACAGCAGGTCTAACTGAGAAAGAAAAGGATTTTCTTGCCACTCGTG AAAAGGAGAAAGGAAATGAAGCTTTCAACTCAGGAGATTATGAAGAAGCAGTGATGTATTATACCAGGAGCATATCAGCGCTTCCCACTG TAGTTGCCTATAACAATCGAGCTCAAGCAGAAATCAAATTACAGAACTGGAATAGTGCTTTTCAGGATTGTGAAAAGGTCTTGGAGTTAG AACCTGGAAACGTAAAGGCTCTTCTGCGTCGTGCTACTACATATAAACATCAAAACAAGCTCCGGGAAGCTACAGAAGATTTGAGTAAAG TACTAGATGTTGAGCCTGATAATGATTTGGCCAAGAAAACCTTGTCAGAGGTTGAAAGAGATCTGAAAAATTCTGAAGCTGCATCTGAGA CTCAAACCAAAGGGAAAAGGATGGTTATTCAGGAAATAGAAAACTCCGAAGATGAAGAAGGAAAAAGCGGAAGAAAACATGAAGATGGCG GTGGAGATAAGAAGCCCGCGGAGCCGGCGGGAGCCGCGCGCGCCGCCCAGCCGTGCGTCATGGGCAACATCCAGAAGAAGCTGACTGGCA AAGCCGAAGGCGGCAAGCGGCCGGCAAGGGGCGCGCCGCAGCGGGGCCAGACCCCGGAGGCCGGCGCGGACAAGCGGAGCCCACGGCGGG CCTCTGCGGCGGCGGCGGCGGGCGGCGGCGCCACCGGGCATCCGGGCGGCGGGCAGGGCGCGGAGAACCCTGCCGGCCTGAAGAGCCAGG GCAACGAGCTGTTCCGAAGCGGGCAGTTCGCCGAGGCGGCCGGCAAGTACTCGGCGGCAATCGCGCTCCTGGAGCCAGCAGGAAGTGAAA TTGCAGATGATCTAAGTATCTTATATTCAAATAGAGCAGCATGTTACCTAAAAGAAGGAAACTGCAGTGGCTGCATTCAAGATTGTAACA GGGCTCTGGAACTTCATCCATTCTCTATGAAACCTCTTCTGAGGCGGGCGATGGCCTATGAAACTCTAGAGCAGTATGGGAAAGCTTATG TGGATTATAAAACAGTGTTGCAGATAGACTGTGGACTCCAGCTAGCAAATGACAGTGTTAACAGGCTATCAAGAATTTTAATGGAGCTGG ATGGACCAAATTGGCGGGAGAAGCTGTCACCTATTCCTGCTGTGCCTGCTTCTGTGCCACTGCAAGCTTGGCATCCGGCAAAAGAGATGA TCTCAAAACAAGCAGGAGACTCCAGCAGCCATCGCCAGCAGGGCATCACAGATGAAAAAACATTTAAAGCCCTTAAGGAAGAAGGAAATC AATGTGTAAATGACAAAAACTATAAAGACGCCCTCAGTAAATACAGCGAATGCTTAAAGATTAACAATAAGGAATGTGCCATATATACAA ACAGAGCTCTCTGTTACTTGAAGCTGTGCCAGTTTGAAGAAGCAAAGCAGGACTGTGATCAGGCACTTCAGCTAGCTGATGGGAACGTGA AAGCCTTCTATAGACGAGCTCTGGCTCATAAAGGACTCAAGTTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGAC TAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCAG ATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATTC AAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGATA TACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACCGATT TTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCAAGAATGCCAAACCTG TATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAATTGGAAGAGGAAGAAG AAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACGATGA GTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACAGTGAGGATGAGGAAG AAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATAAGCAAGACTTCAAGA ATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCTCAAG ATGGAGACTTTGACTTTTTGAAAAATCTAAGTTTAGAAGAACTACAGATGCGGTTAAAAGCACTGGACCCCATGATGGAACGGGAGATAG AAGAACTTCGTCAGAGATACACTGCGAAAAGACAGCCCATTCTGGATGCGATGGATGCAAAGAAAAGAAGGCAGCAAAACTTTTGAGTCT AATTTCCTCTCTGTTTTTAACTATTCTGGAGACCAAGAAACCACTAGGAATTGAAGGAATATTTGGATATTTTTAATCCTAAGATTTTGC CCTACAATTAGGCAGAGGTCAAAAAGTGACAATGGTACATGCCCAGGTAAATTCCCAAAAGGCAGAATTGACAGTTGTATCTGCTGTGCA TTCACTCTAAGATGAGGAGAACAAAAGAAGTGTATTCTCTTGTTCTGTCAGCTGCATACCAGTAATAAAACTGTTATGAAATGGATTTTC AAGGTCTCTAAACCTTGAAAATCCAAAGCTATTGTTGCATTGTACAGCACTGAAGGGCTTTATGTTACAATATTCTTTATTCCTATCTAG TATACTAGGCTATTTATTGTATCCCCTTAGGTAAACTTATTTATTTATGCTATTTTGCTTTGTTTCATTTTTTAAGGACAAGATCAGGAT AGCTTTGGTGAAGGTAGGGTCATATTAATATGATGATAATGTGCAACCAATTTATACTTTCTGCAGGGAGCTATGGGGTACATTCCTTGA TTTCCAGGATAGTTTTTCAAATAGGAAAGCAATAATGGCAGTAGTTCTCAAATGGGCTAGGCCTTTTTTATATTGAAGCAATAATTCCAT TTTTACCCTTTGAAATTTTGTTTTTTTGATTTTTGATGTTTGGTACAAATAGAACTATATATATTTAGGTAAAATAGATCTATCGTGTTT AAAACCAAAGAAATCAATGGAACCCTTGCACAAAAAAGTGTGATAAATATTTTTAAATAAAAACTTAATACAAATGTAATTTGTTAATAT TGTTTCATGTTTTATGTGTAGATCTAATAGCTGAACTGATTCAAACTGTAATAAGCTCATCAATTTCATTTCTATGAAAATGTGCTCTGT TGTCACAGGATGTTTCTGTTGATTTTATTCATTTCCTGGGAATTGGTAAACATCATGTTCCTGATGATAACCCAGTAGCAAAAACATTTG TACTGAGTGGTACAAGCCTTGGGGACTGAAAAAAAAAAGATTAAAACCATTAAAAAGAAACTCATTTTTACGCTGAATGAACATTTATAT GATTGCATTGGGACCAGTCATTTCCTAAGCTACATATGGCCATCTTGACAGTGTTTTTTCTTTTGTGTGTTTAATTATTATGTGTAAATC >In-frame_SPAG1_ENST00000251809_chr8_101245765_+_STK3_ENST00000523601_chr8_99719539_-_4473nt GACGAGACCCTCCCTCAGCACCTGCAGTGCAGCCAGAGCCGGTGCGGCGGCCGCGACTTCCCCGACGCGGGGCGCTGAGAAGCACTATGA CCACCAAAGATTATCCATCATTGTGGGGCTTTGGAACAACAAAAACATTCAAAATTCCCATTGAACATCTAGATTTCAAATACATTGAAA AATGTTCAGATGTTAAACATCTGGAAAAAATTCTTTGCGTGCTCAGATCTGGTGAGGAAGGATATTATCCTGAACTTACAGAATTTTGTG AAAAGCATCTTCAAGCCTTGGCCCCTGAAAGCAGAGCTTTGAGGAAAGATAAACCAGCAGCAACAGCAGCCAGTTTTACAGCTGAAGAAT GGGAAAAAATTGATGGTGATATAAAGAGTTGGGTATCAGAAATTAAAAAAGAAGAAGATAAAATGCACTTTCATGAAACTGAGACATTTC CAGCAATGAAAGATAATTTGCCTCCAGTTCGTGGTTCAAACAGCTGTCTTCATGTAGGCAAGGAAAAATATTCTAAAAGACCAACTAAAA AGAAAACTCCAAGGGATTACGCGGAATGGGATAAATTTGACGTGGAGAAGGAATGTTTAAAAATTGATGAAGATTACAAAGAAAAGACGG TAATAGACAAGTCACACTTGTCTAAAATTGAGACAAGAATAGATACAGCAGGTCTAACTGAGAAAGAAAAGGATTTTCTTGCCACTCGTG AAAAGGAGAAAGGAAATGAAGCTTTCAACTCAGGAGATTATGAAGAAGCAGTGATGTATTATACCAGGAGCATATCAGCGCTTCCCACTG TAGTTGCCTATAACAATCGAGCTCAAGCAGAAATCAAATTACAGAACTGGAATAGTGCTTTTCAGGATTGTGAAAAGGTCTTGGAGTTAG AACCTGGAAACGTAAAGGCTCTTCTGCGTCGTGCTACTACATATAAACATCAAAACAAGCTCCGGGAAGCTACAGAAGATTTGAGTAAAG TACTAGATGTTGAGCCTGATAATGATTTGGCCAAGAAAACCTTGTCAGAGGTTGAAAGAGATCTGAAAAATTCTGAAGCTGCATCTGAGA CTCAAACCAAAGGGAAAAGGATGGTTATTCAGGAAATAGAAAACTCCGAAGATGAAGAAGGAAAAAGCGGAAGAAAACATGAAGATGGCG GTGGAGATAAGAAGCCCGCGGAGCCGGCGGGAGCCGCGCGCGCCGCCCAGCCGTGCGTCATGGGCAACATCCAGAAGAAGCTGACTGGCA AAGCCGAAGGCGGCAAGCGGCCGGCAAGGGGCGCGCCGCAGCGGGGCCAGACCCCGGAGGCCGGCGCGGACAAGCGGAGCCCACGGCGGG CCTCTGCGGCGGCGGCGGCGGGCGGCGGCGCCACCGGGCATCCGGGCGGCGGGCAGGGCGCGGAGAACCCTGCCGGCCTGAAGAGCCAGG GCAACGAGCTGTTCCGAAGCGGGCAGTTCGCCGAGGCGGCCGGCAAGTACTCGGCGGCAATCGCGCTCCTGGAGCCAGCAGGAAGTGAAA TTGCAGATGATCTAAGTATCTTATATTCAAATAGAGCAGCATGTTACCTAAAAGAAGGAAACTGCAGTGGCTGCATTCAAGATTGTAACA GGGCTCTGGAACTTCATCCATTCTCTATGAAACCTCTTCTGAGGCGGGCGATGGCCTATGAAACTCTAGAGCAGTATGGGAAAGCTTATG TGGATTATAAAACAGTGTTGCAGATAGACTGTGGACTCCAGCTAGCAAATGACAGTGTTAACAGGCTATCAAGAATTTTAATGGAGCTGG ATGGACCAAATTGGCGGGAGAAGCTGTCACCTATTCCTGCTGTGCCTGCTTCTGTGCCACTGCAAGCTTGGCATCCGGCAAAAGAGATGA TCTCAAAACAAGCAGGAGACTCCAGCAGCCATCGCCAGCAGGGCATCACAGATGAAAAAACATTTAAAGCCCTTAAGGAAGAAGGAAATC AATGTGTAAATGACAAAAACTATAAAGACGCCCTCAGTAAATACAGCGAATGCTTAAAGATTAACAATAAGGAATGTGCCATATATACAA ACAGAGCTCTCTGTTACTTGAAGCTGTGCCAGTTTGAAGAAGCAAAGCAGGACTGTGATCAGGCACTTCAGCTAGCTGATGGGAACGTGA AAGCCTTCTATAGACGAGCTCTGGCTCATAAAGGACTCAAGTTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGAC TAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCAG ATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATTC AAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGATA TACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACCGATT TTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCAAGAATGCCAAACCTG TATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAATTGGAAGAGGAAGAAG AAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACGATGA GTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACAGTGAGGATGAGGAAG AAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATAAGCAAGACTTCAAGA ATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCTCAAG ATGGAGACTTTGACTTTTTGAAAAATCTAAGTTTAGAAGAACTACAGATGCGGTTAAAAGCACTGGACCCCATGATGGAACGGGAGATAG AAGAACTTCGTCAGAGATACACTGCGAAAAGACAGCCCATTCTGGATGCGATGGATGCAAAGAAAAGAAGGCAGCAAAACTTTTGAGTCT AATTTCCTCTCTGTTTTTAACTATTCTGGAGACCAAGAAACCACTAGGAATTGAAGGAATATTTGGATATTTTTAATCCTAAGATTTTGC CCTACAATTAGGCAGAGGTCAAAAAGTGACAATGGTACATGCCCAGGTAAATTCCCAAAAGGCAGAATTGACAGTTGTATCTGCTGTGCA TTCACTCTAAGATGAGGAGAACAAAAGAAGTGTATTCTCTTGTTCTGTCAGCTGCATACCAGTAATAAAACTGTTATGAAATGGATTTTC AAGGTCTCTAAACCTTGAAAATCCAAAGCTATTGTTGCATTGTACAGCACTGAAGGGCTTTATGTTACAATATTCTTTATTCCTATCTAG TATACTAGGCTATTTATTGTATCCCCTTAGGTAAACTTATTTATTTATGCTATTTTGCTTTGTTTCATTTTTTAAGGACAAGATCAGGAT AGCTTTGGTGAAGGTAGGGTCATATTAATATGATGATAATGTGCAACCAATTTATACTTTCTGCAGGGAGCTATGGGGTACATTCCTTGA TTTCCAGGATAGTTTTTCAAATAGGAAAGCAATAATGGCAGTAGTTCTCAAATGGGCTAGGCCTTTTTTATATTGAAGCAATAATTCCAT TTTTACCCTTTGAAATTTTGTTTTTTTGATTTTTGATGTTTGGTACAAATAGAACTATATATATTTAGGTAAAATAGATCTATCGTGTTT AAAACCAAAGAAATCAATGGAACCCTTGCACAAAAAAGTGTGATAAATATTTTTAAATAAAAACTTAATACAAATGTAATTTGTTAATAT TGTTTCATGTTTTATGTGTAGATCTAATAGCTGAACTGATTCAAACTGTAATAAGCTCATCAATTTCATTTCTATGAAAATGTGCTCTGT TGTCACAGGATGTTTCTGTTGATTTTATTCATTTCCTGGGAATTGGTAAACATCATGTTCCTGATGATAACCCAGTAGCAAAAACATTTG TACTGAGTGGTACAAGCCTTGGGGACTGAAAAAAAAAAGATTAAAACCATTAAAAAGAAACTCATTTTTACGCTGAATGAACATTTATAT >In-frame_SPAG1_ENST00000388798_chr8_101245765_+_STK3_ENST00000419617_chr8_99719539_-_4634nt GGGGCTCCCCAGTCCCGGCAGGTCCTGGCGCCGCTGTACATAGAAACCGTTGCCACGGCGGGAGGATGCCGTTTCTTTTCGGTCTCCGAC TGCAGGGGGCGGTCGGCCCTGTGGATGCAGGAAAGAGGGTGCCTCGGTGGGAGAGACCCAGCTTTTCGCGTTAGTAGGCCCGAGCAGTTT GAACTGGAGCTATGACCACCAAAGATTATCCATCATTGTGGGGCTTTGGAACAACAAAAACATTCAAAATTCCCATTGAACATCTAGATT TCAAATACATTGAAAAATGTTCAGATGTTAAACATCTGGAAAAAATTCTTTGCGTGCTCAGATCTGGTGAGGAAGGATATTATCCTGAAC TTACAGAATTTTGTGAAAAGCATCTTCAAGCCTTGGCCCCTGAAAGCAGAGCTTTGAGGAAAGATAAACCAGCAGCAACAGCAGCCAGTT TTACAGCTGAAGAATGGGAAAAAATTGATGGTGATATAAAGAGTTGGGTATCAGAAATTAAAAAAGAAGAAGATAAAATGCACTTTCATG AAACTGAGACATTTCCAGCAATGAAAGATAATTTGCCTCCAGTTCGTGGTTCAAACAGCTGTCTTCATGTAGGCAAGGAAAAATATTCTA AAAGACCAACTAAAAAGAAAACTCCAAGGGATTACGCGGAATGGGATAAATTTGACGTGGAGAAGGAATGTTTAAAAATTGATGAAGATT ACAAAGAAAAGACGGTAATAGACAAGTCACACTTGTCTAAAATTGAGACAAGAATAGATACAGCAGGTCTAACTGAGAAAGAAAAGGATT TTCTTGCCACTCGTGAAAAGGAGAAAGGAAATGAAGCTTTCAACTCAGGAGATTATGAAGAAGCAGTGATGTATTATACCAGGAGCATAT CAGCGCTTCCCACTGTAGTTGCCTATAACAATCGAGCTCAAGCAGAAATCAAATTACAGAACTGGAATAGTGCTTTTCAGGATTGTGAAA AGGTCTTGGAGTTAGAACCTGGAAACGTAAAGGCTCTTCTGCGTCGTGCTACTACATATAAACATCAAAACAAGCTCCGGGAAGCTACAG AAGATTTGAGTAAAGTACTAGATGTTGAGCCTGATAATGATTTGGCCAAGAAAACCTTGTCAGAGGTTGAAAGAGATCTGAAAAATTCTG AAGCTGCATCTGAGACTCAAACCAAAGGGAAAAGGATGGTTATTCAGGAAATAGAAAACTCCGAAGATGAAGAAGGAAAAAGCGGAAGAA AACATGAAGATGGCGGTGGAGATAAGAAGCCCGCGGAGCCGGCGGGAGCCGCGCGCGCCGCCCAGCCGTGCGTCATGGGCAACATCCAGA AGAAGCTGACTGGCAAAGCCGAAGGCGGCAAGCGGCCGGCAAGGGGCGCGCCGCAGCGGGGCCAGACCCCGGAGGCCGGCGCGGACAAGC GGAGCCCACGGCGGGCCTCTGCGGCGGCGGCGGCGGGCGGCGGCGCCACCGGGCATCCGGGCGGCGGGCAGGGCGCGGAGAACCCTGCCG GCCTGAAGAGCCAGGGCAACGAGCTGTTCCGAAGCGGGCAGTTCGCCGAGGCGGCCGGCAAGTACTCGGCGGCAATCGCGCTCCTGGAGC CAGCAGGAAGTGAAATTGCAGATGATCTAAGTATCTTATATTCAAATAGAGCAGCATGTTACCTAAAAGAAGGAAACTGCAGTGGCTGCA TTCAAGATTGTAACAGGGCTCTGGAACTTCATCCATTCTCTATGAAACCTCTTCTGAGGCGGGCGATGGCCTATGAAACTCTAGAGCAGT ATGGGAAAGCTTATGTGGATTATAAAACAGTGTTGCAGATAGACTGTGGACTCCAGCTAGCAAATGACAGTGTTAACAGGCTATCAAGAA TTTTAATGGAGCTGGATGGACCAAATTGGCGGGAGAAGCTGTCACCTATTCCTGCTGTGCCTGCTTCTGTGCCACTGCAAGCTTGGCATC CGGCAAAAGAGATGATCTCAAAACAAGCAGGAGACTCCAGCAGCCATCGCCAGCAGGGCATCACAGATGAAAAAACATTTAAAGCCCTTA AGGAAGAAGGAAATCAATGTGTAAATGACAAAAACTATAAAGACGCCCTCAGTAAATACAGCGAATGCTTAAAGATTAACAATAAGGAAT GTGCCATATATACAAACAGAGCTCTCTGTTACTTGAAGCTGTGCCAGTTTGAAGAAGCAAAGCAGGACTGTGATCAGGCACTTCAGCTAG CTGATGGGAACGTGAAAGCCTTCTATAGACGAGCTCTGGCTCATAAAGGACTCAAGTTAATAGAAGATGAAATTGCAACCATTCTTAAAT CTACATTGAAAGGACTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGAC ATGCAAAATTGGCAGATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGG CTCCTGAGGTGATTCAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAAC CTCCTTATGCTGATATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCG ATGATTTCACCGATTTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCA AGAATGCCAAACCTGTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAAT TGGAAGAGGAAGAAGAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGG CCACAAGCACGATGAGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACA GTGAGGATGAGGAAGAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATA AGCAAGACTTCAAGAATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACT GGAAAGTTCCTCAAGATGGAGACTTTGACTTTTTGAAAAATCTAAGTTTAGAAGAACTACAGATGCGGTTAAAAGCACTGGACCCCATGA TGGAACGGGAGATAGAAGAACTTCGTCAGAGATACACTGCGAAAAGACAGCCCATTCTGGATGCGATGGATGCAAAGAAAAGAAGGCAGC AAAACTTTTGAGTCTAATTTCCTCTCTGTTTTTAACTATTCTGGAGACCAAGAAACCACTAGGAATTGAAGGAATATTTGGATATTTTTA ATCCTAAGATTTTGCCCTACAATTAGGCAGAGGTCAAAAAGTGACAATGGTACATGCCCAGGTAAATTCCCAAAAGGCAGAATTGACAGT TGTATCTGCTGTGCATTCACTCTAAGATGAGGAGAACAAAAGAAGTGTATTCTCTTGTTCTGTCAGCTGCATACCAGTAATAAAACTGTT ATGAAATGGATTTTCAAGGTCTCTAAACCTTGAAAATCCAAAGCTATTGTTGCATTGTACAGCACTGAAGGGCTTTATGTTACAATATTC TTTATTCCTATCTAGTATACTAGGCTATTTATTGTATCCCCTTAGGTAAACTTATTTATTTATGCTATTTTGCTTTGTTTCATTTTTTAA GGACAAGATCAGGATAGCTTTGGTGAAGGTAGGGTCATATTAATATGATGATAATGTGCAACCAATTTATACTTTCTGCAGGGAGCTATG GGGTACATTCCTTGATTTCCAGGATAGTTTTTCAAATAGGAAAGCAATAATGGCAGTAGTTCTCAAATGGGCTAGGCCTTTTTTATATTG AAGCAATAATTCCATTTTTACCCTTTGAAATTTTGTTTTTTTGATTTTTGATGTTTGGTACAAATAGAACTATATATATTTAGGTAAAAT AGATCTATCGTGTTTAAAACCAAAGAAATCAATGGAACCCTTGCACAAAAAAGTGTGATAAATATTTTTAAATAAAAACTTAATACAAAT GTAATTTGTTAATATTGTTTCATGTTTTATGTGTAGATCTAATAGCTGAACTGATTCAAACTGTAATAAGCTCATCAATTTCATTTCTAT GAAAATGTGCTCTGTTGTCACAGGATGTTTCTGTTGATTTTATTCATTTCCTGGGAATTGGTAAACATCATGTTCCTGATGATAACCCAG TAGCAAAAACATTTGTACTGAGTGGTACAAGCCTTGGGGACTGAAAAAAAAAAGATTAAAACCATTAAAAAGAAACTCATTTTTACGCTG AATGAACATTTATATGATTGCATTGGGACCAGTCATTTCCTAAGCTACATATGGCCATCTTGACAGTGTTTTTTCTTTTGTGTGTTTAAT >In-frame_SPAG1_ENST00000388798_chr8_101245765_+_STK3_ENST00000523601_chr8_99719539_-_4578nt GGGGCTCCCCAGTCCCGGCAGGTCCTGGCGCCGCTGTACATAGAAACCGTTGCCACGGCGGGAGGATGCCGTTTCTTTTCGGTCTCCGAC TGCAGGGGGCGGTCGGCCCTGTGGATGCAGGAAAGAGGGTGCCTCGGTGGGAGAGACCCAGCTTTTCGCGTTAGTAGGCCCGAGCAGTTT GAACTGGAGCTATGACCACCAAAGATTATCCATCATTGTGGGGCTTTGGAACAACAAAAACATTCAAAATTCCCATTGAACATCTAGATT TCAAATACATTGAAAAATGTTCAGATGTTAAACATCTGGAAAAAATTCTTTGCGTGCTCAGATCTGGTGAGGAAGGATATTATCCTGAAC TTACAGAATTTTGTGAAAAGCATCTTCAAGCCTTGGCCCCTGAAAGCAGAGCTTTGAGGAAAGATAAACCAGCAGCAACAGCAGCCAGTT TTACAGCTGAAGAATGGGAAAAAATTGATGGTGATATAAAGAGTTGGGTATCAGAAATTAAAAAAGAAGAAGATAAAATGCACTTTCATG AAACTGAGACATTTCCAGCAATGAAAGATAATTTGCCTCCAGTTCGTGGTTCAAACAGCTGTCTTCATGTAGGCAAGGAAAAATATTCTA AAAGACCAACTAAAAAGAAAACTCCAAGGGATTACGCGGAATGGGATAAATTTGACGTGGAGAAGGAATGTTTAAAAATTGATGAAGATT ACAAAGAAAAGACGGTAATAGACAAGTCACACTTGTCTAAAATTGAGACAAGAATAGATACAGCAGGTCTAACTGAGAAAGAAAAGGATT TTCTTGCCACTCGTGAAAAGGAGAAAGGAAATGAAGCTTTCAACTCAGGAGATTATGAAGAAGCAGTGATGTATTATACCAGGAGCATAT CAGCGCTTCCCACTGTAGTTGCCTATAACAATCGAGCTCAAGCAGAAATCAAATTACAGAACTGGAATAGTGCTTTTCAGGATTGTGAAA AGGTCTTGGAGTTAGAACCTGGAAACGTAAAGGCTCTTCTGCGTCGTGCTACTACATATAAACATCAAAACAAGCTCCGGGAAGCTACAG AAGATTTGAGTAAAGTACTAGATGTTGAGCCTGATAATGATTTGGCCAAGAAAACCTTGTCAGAGGTTGAAAGAGATCTGAAAAATTCTG AAGCTGCATCTGAGACTCAAACCAAAGGGAAAAGGATGGTTATTCAGGAAATAGAAAACTCCGAAGATGAAGAAGGAAAAAGCGGAAGAA AACATGAAGATGGCGGTGGAGATAAGAAGCCCGCGGAGCCGGCGGGAGCCGCGCGCGCCGCCCAGCCGTGCGTCATGGGCAACATCCAGA AGAAGCTGACTGGCAAAGCCGAAGGCGGCAAGCGGCCGGCAAGGGGCGCGCCGCAGCGGGGCCAGACCCCGGAGGCCGGCGCGGACAAGC GGAGCCCACGGCGGGCCTCTGCGGCGGCGGCGGCGGGCGGCGGCGCCACCGGGCATCCGGGCGGCGGGCAGGGCGCGGAGAACCCTGCCG GCCTGAAGAGCCAGGGCAACGAGCTGTTCCGAAGCGGGCAGTTCGCCGAGGCGGCCGGCAAGTACTCGGCGGCAATCGCGCTCCTGGAGC CAGCAGGAAGTGAAATTGCAGATGATCTAAGTATCTTATATTCAAATAGAGCAGCATGTTACCTAAAAGAAGGAAACTGCAGTGGCTGCA TTCAAGATTGTAACAGGGCTCTGGAACTTCATCCATTCTCTATGAAACCTCTTCTGAGGCGGGCGATGGCCTATGAAACTCTAGAGCAGT ATGGGAAAGCTTATGTGGATTATAAAACAGTGTTGCAGATAGACTGTGGACTCCAGCTAGCAAATGACAGTGTTAACAGGCTATCAAGAA TTTTAATGGAGCTGGATGGACCAAATTGGCGGGAGAAGCTGTCACCTATTCCTGCTGTGCCTGCTTCTGTGCCACTGCAAGCTTGGCATC CGGCAAAAGAGATGATCTCAAAACAAGCAGGAGACTCCAGCAGCCATCGCCAGCAGGGCATCACAGATGAAAAAACATTTAAAGCCCTTA AGGAAGAAGGAAATCAATGTGTAAATGACAAAAACTATAAAGACGCCCTCAGTAAATACAGCGAATGCTTAAAGATTAACAATAAGGAAT GTGCCATATATACAAACAGAGCTCTCTGTTACTTGAAGCTGTGCCAGTTTGAAGAAGCAAAGCAGGACTGTGATCAGGCACTTCAGCTAG CTGATGGGAACGTGAAAGCCTTCTATAGACGAGCTCTGGCTCATAAAGGACTCAAGTTAATAGAAGATGAAATTGCAACCATTCTTAAAT CTACATTGAAAGGACTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGAC ATGCAAAATTGGCAGATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGG CTCCTGAGGTGATTCAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAAC CTCCTTATGCTGATATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCG ATGATTTCACCGATTTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCA AGAATGCCAAACCTGTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAAT TGGAAGAGGAAGAAGAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGG CCACAAGCACGATGAGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACA GTGAGGATGAGGAAGAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATA AGCAAGACTTCAAGAATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACT GGAAAGTTCCTCAAGATGGAGACTTTGACTTTTTGAAAAATCTAAGTTTAGAAGAACTACAGATGCGGTTAAAAGCACTGGACCCCATGA TGGAACGGGAGATAGAAGAACTTCGTCAGAGATACACTGCGAAAAGACAGCCCATTCTGGATGCGATGGATGCAAAGAAAAGAAGGCAGC AAAACTTTTGAGTCTAATTTCCTCTCTGTTTTTAACTATTCTGGAGACCAAGAAACCACTAGGAATTGAAGGAATATTTGGATATTTTTA ATCCTAAGATTTTGCCCTACAATTAGGCAGAGGTCAAAAAGTGACAATGGTACATGCCCAGGTAAATTCCCAAAAGGCAGAATTGACAGT TGTATCTGCTGTGCATTCACTCTAAGATGAGGAGAACAAAAGAAGTGTATTCTCTTGTTCTGTCAGCTGCATACCAGTAATAAAACTGTT ATGAAATGGATTTTCAAGGTCTCTAAACCTTGAAAATCCAAAGCTATTGTTGCATTGTACAGCACTGAAGGGCTTTATGTTACAATATTC TTTATTCCTATCTAGTATACTAGGCTATTTATTGTATCCCCTTAGGTAAACTTATTTATTTATGCTATTTTGCTTTGTTTCATTTTTTAA GGACAAGATCAGGATAGCTTTGGTGAAGGTAGGGTCATATTAATATGATGATAATGTGCAACCAATTTATACTTTCTGCAGGGAGCTATG GGGTACATTCCTTGATTTCCAGGATAGTTTTTCAAATAGGAAAGCAATAATGGCAGTAGTTCTCAAATGGGCTAGGCCTTTTTTATATTG AAGCAATAATTCCATTTTTACCCTTTGAAATTTTGTTTTTTTGATTTTTGATGTTTGGTACAAATAGAACTATATATATTTAGGTAAAAT AGATCTATCGTGTTTAAAACCAAAGAAATCAATGGAACCCTTGCACAAAAAAGTGTGATAAATATTTTTAAATAAAAACTTAATACAAAT GTAATTTGTTAATATTGTTTCATGTTTTATGTGTAGATCTAATAGCTGAACTGATTCAAACTGTAATAAGCTCATCAATTTCATTTCTAT GAAAATGTGCTCTGTTGTCACAGGATGTTTCTGTTGATTTTATTCATTTCCTGGGAATTGGTAAACATCATGTTCCTGATGATAACCCAG TAGCAAAAACATTTGTACTGAGTGGTACAAGCCTTGGGGACTGAAAAAAAAAAGATTAAAACCATTAAAAAGAAACTCATTTTTACGCTG |
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FusionGenePPI for SPAG1_STK3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SPAG1 | PCNA, GNB1, UBC, MAGEA1, PRKCA, ATL3, LDHD, CDH1, BBX, C12orf45, PRPF38A, WDR92 | STK3 | CNKSR1, MAP1LC3A, MAP1LC3B, RASSF5, STK4, SAV1, ATG4B, PLK1, CACYBP, RASSF2, FREM1, KHSRP, DDAH2, PHAX, QARS, MPP1, GBP2, LATS1, RASSF6, MOB4, NRD1, MOB1A, RASSF1, RAF1, MBP, MOB1B, LATS2, PTPN14, LRRK2, EIF4EBP1, TAZ, STK3, AKT1, ORM2, CPNE1, PEX19, ZC3H7A, HSPE1, SULT2A1, SLMAP, CTTNBP2NL, RASSF3, AURKB, ERLIN2, STRIP1, FGFR1OP2, KIF2C, MAP1S, PRKRIR, RAE1, RASSF4, RUNDC3B, STRN, STRN3, STRN4, TSPYL1, YWHAB, CSNK1E, NEB, MAP1B, CDK3, DST, ACACA, VAPA, FBXW11, GAD1, TRAF1, TFPT, GMCL1, FAM9B, BTRC, ADCYAP1, MRPL40, NSUN5, IFI16, FGFR1OP, CEP128, XPO1, C21orf59, CENPO, CASP3, MTMR7, KIF2B, ZNF133, VAPB, ZIM2, ZNF420, ZNF695, SKP2, KIF3B, CDK1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPAG1_STK3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPAG1_STK3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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