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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 3550

FusionGeneSummary for ATRX_ZNF304

check button Fusion gene summary
Fusion gene informationFusion gene name: ATRX_ZNF304
Fusion gene ID: 3550
HgeneTgene
Gene symbol

ATRX

ZNF304

Gene ID

546

57343

Gene nameATRX, chromatin remodelerzinc finger protein 304
SynonymsJMS|MRX52|RAD54|RAD54L|XH2|XNP|ZNF-HX-
Cytomap

Xq21.1

19q13.43

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ATRXATP-dependent helicase ATRXX-linked helicase IIX-linked nuclear proteinalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)zinc finger protein 304KRAB-containing zinc finger protein
Modification date2018051920180522
UniProtAcc

P46100

Q9HCX3

Ensembl transtripts involved in fusion geneENST00000373344, ENST00000395603, 
ENST00000480283, ENST00000373341, 
ENST00000391705, ENST00000598744, 
ENST00000443917, ENST00000282286, 
Fusion gene scores* DoF score9 X 4 X 6=2161 X 1 X 1=1
# samples 91
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: ATRX [Title/Abstract] AND ZNF304 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATRX

GO:0006334

nucleosome assembly

20651253

HgeneATRX

GO:0006338

chromatin remodeling

20651253

TgeneZNF304

GO:0045944

positive regulation of transcription by RNA polymerase II

26081979


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-CS-6290-01AATRXchrX

77041468

-ZNF304chr19

57865093

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373344ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000373344ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000373344ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000373344ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57865093

+
In-frameENST00000395603ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000395603ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000395603ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000395603ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57865093

+
5UTR-3CDSENST00000480283ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57865093

+
5UTR-5UTRENST00000480283ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57865093

+
5UTR-5UTRENST00000480283ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57865093

+
5UTR-5UTRENST00000480283ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57865093

+
intron-3CDSENST00000373341ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57865093

+
intron-5UTRENST00000373341ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57865093

+
intron-5UTRENST00000373341ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57865093

+
intron-5UTRENST00000373341ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57865093

+

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FusionProtFeatures for ATRX_ZNF304


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATRX

P46100

ZNF304

Q9HCX3

Acts as transcriptional regulator and plays a role ingene silencing (PubMed:24623306, PubMed:26081979). Probably formsa corepressor complex required for activated KRAS-mediatedpromoter hypermethylation and transcriptional silencing of severaltumor suppressor genes (TSGs) or other tumor-related genes incolorectal cancer (CRC) cells (PubMed:24623306). Also required tomaintain a transcriptionally repressive state of genes inundifferentiated embryonic stem cells (ESCs) by inducingtrimethylation of 'Lys-27' of histone H3 (H3K27me3)(PubMed:24623306) in a Polycomb group (PcG) complexes-dependentmanner. Associates at promoter regions of TSGs and mediates therecruitment of the corepressor complex containing the scaffoldingprotein TRIM28, methyltransferase DNMT1 and histonemethyltransferase SETDB1 and/or the PcG complexes at those sites(PubMed:24623306). Transcription factor involved in the metastaticcascade process by inducing cell migration and proliferation andgain resistance to anoikis of ovarian carcinoma (OC) cells viaintegrin-mediated signaling pathways (PubMed:26081979). Associateswith the ITGB1 promoter and positively regulates beta-1 integrintranscription expression (PubMed:26081979). Promotes angiogenesis(PubMed:26081979). Promotes tumor growth (PubMed:24623306,PubMed:26081979). {ECO:0000269|PubMed:24623306,ECO:0000269|PubMed:26081979}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+0314_8811660DomainKRAB
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+1414_8811660DomainKRAB
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03115_13911660Zinc fingerC2H2-type 2
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03251_27311660Zinc fingerC2H2-type 3
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03279_30111660Zinc fingerC2H2-type 4
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03307_32911660Zinc fingerC2H2-type 5
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03335_35711660Zinc fingerC2H2-type 6
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03363_38511660Zinc fingerC2H2-type 7
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03391_41311660Zinc fingerC2H2-type 8
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03419_44111660Zinc fingerC2H2-type 9
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03447_46911660Zinc fingerC2H2-type 10
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03475_49711660Zinc fingerC2H2-type 11
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03503_52511660Zinc fingerC2H2-type 12
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03531_55311660Zinc fingerC2H2-type 13
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03559_58111660Zinc fingerC2H2-type 14
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03587_60911660Zinc fingerC2H2-type 15
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+03615_63711660Zinc fingerC2H2-type 16
TgeneZNF304chrX:77041468chr19:57865093ENST00000282286+0389_11111660Zinc fingerC2H2-type 1
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14115_13911660Zinc fingerC2H2-type 2
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14251_27311660Zinc fingerC2H2-type 3
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14279_30111660Zinc fingerC2H2-type 4
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14307_32911660Zinc fingerC2H2-type 5
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14335_35711660Zinc fingerC2H2-type 6
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14363_38511660Zinc fingerC2H2-type 7
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14391_41311660Zinc fingerC2H2-type 8
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14419_44111660Zinc fingerC2H2-type 9
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14447_46911660Zinc fingerC2H2-type 10
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14475_49711660Zinc fingerC2H2-type 11
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14503_52511660Zinc fingerC2H2-type 12
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14531_55311660Zinc fingerC2H2-type 13
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14559_58111660Zinc fingerC2H2-type 14
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14587_60911660Zinc fingerC2H2-type 15
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+14615_63711660Zinc fingerC2H2-type 16
TgeneZNF304chrX:77041468chr19:57865093ENST00000391705+1489_11111660Zinc fingerC2H2-type 1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351151_115662493Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351166_116962493Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351202_120662493Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351259_126662493Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351443_146662493Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351499_150262493Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351929_193962493Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351941_194862493Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352222_222562493Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352262_226562493Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352420_242562493Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135745_75062493Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341151_115662455Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341166_116962455Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341202_120662455Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341259_126662455Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341443_146662455Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341499_150262455Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341929_193962455Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341941_194862455Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342222_222562455Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342262_226562455Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342420_242562455Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134745_75062455Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351581_176862493DomainHelicase ATP-binding
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135159_29662493DomainADD
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352025_220562493DomainHelicase C-terminal
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341581_176862455DomainHelicase ATP-binding
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134159_29662455DomainADD
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342025_220562455DomainHelicase C-terminal
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351719_172262493MotifNote=DEGH box
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135581_59462493MotifNote=PxVxL motif
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341719_172262455MotifNote=DEGH box
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134581_59462455MotifNote=PxVxL motif
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351594_160162493Nucleotide bindingATP
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341594_160162455Nucleotide bindingATP
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135170_20662493Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135217_27262493Zinc fingerPHD-type%3B atypical
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134170_20662455Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134217_27262455Zinc fingerPHD-type%3B atypical


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FusionGeneSequence for ATRX_ZNF304


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ZNF304_ENST00000391705_chr19_57865093_+_655aa
MTAEPMRVVXPSRMCSCTSLGRSGNSLRRHRDSCTVMXCWRTLHLWLHXVFGVKQNMRHLLSRAFLXKECHRSGLLSQVFSRKHTHVRCV
THSXKTFCTWLNTRDHTLHRNCAHVGCVGEDSRSVQTFTSTRSNIMERIASEGMMEGPHLXRAVQSTCXGDPLRAGRKGWTYQIALAFSS
TRPLTIGXVHAEGLNAWSLSHTAPVSGNTKETMMDRCFSVAVMKGKPSWTPLLFLTARXLMLRXDPSDAYHVEMCSRRNQLLLITEKSTV
EKYLMCVRSVEKPSFTCTTXKCTRNFTLEKDTIHAVNVGRPSAARTHLFSIREFTLEKDLMTAVNVEKPTAEAPTLFSTREFTQEKGLIS
ATNVGKPLAVKTHLFSTRDFILEKGLMSAVNVENSLAKAPTLLSTGEFIPGQGPMNAXNVENSLAITLASLNIGESTQEQDPTCAANVGR
PLAAKTHLFSTRXFTLEQGLMSAVNVGRPSAVKTHLCNTKKSTLEKGLMSVVNVVNSSAIAPTLLYTREFTLEQSLMSAMNVGNALATTP
ASFCTREFTQEQGLMCAVNVGRLTLVAPTLFNTRKFTLEQDLMSAVNVGNSLAATLASFCTRGFTLEKSLTYAANVGKPIAEAPILFVTR

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ZNF304_ENST00000391705_chr19_57865093_+_655aa
MTAEPMRVVXPSRMCSCTSLGRSGNSLRRHRDSCTVMXCWRTLHLWLHXVFGVKQNMRHLLSRAFLXKECHRSGLLSQVFSRKHTHVRCV
THSXKTFCTWLNTRDHTLHRNCAHVGCVGEDSRSVQTFTSTRSNIMERIASEGMMEGPHLXRAVQSTCXGDPLRAGRKGWTYQIALAFSS
TRPLTIGXVHAEGLNAWSLSHTAPVSGNTKETMMDRCFSVAVMKGKPSWTPLLFLTARXLMLRXDPSDAYHVEMCSRRNQLLLITEKSTV
EKYLMCVRSVEKPSFTCTTXKCTRNFTLEKDTIHAVNVGRPSAARTHLFSIREFTLEKDLMTAVNVEKPTAEAPTLFSTREFTQEKGLIS
ATNVGKPLAVKTHLFSTRDFILEKGLMSAVNVENSLAKAPTLLSTGEFIPGQGPMNAXNVENSLAITLASLNIGESTQEQDPTCAANVGR
PLAAKTHLFSTRXFTLEQGLMSAVNVGRPSAVKTHLCNTKKSTLEKGLMSVVNVVNSSAIAPTLLYTREFTLEQSLMSAMNVGNALATTP
ASFCTREFTQEQGLMCAVNVGRLTLVAPTLFNTRKFTLEQDLMSAVNVGNSLAATLASFCTRGFTLEKSLTYAANVGKPIAEAPILFVTR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ZNF304_ENST00000391705_chr19_57865093_+_1967nt
ATGACCGCTGAGCCCATGAGAGTTGTGTGACCTTCGAGGATGTGTTCGTGTACTTCTCTCGGGAGGAGTGGGAACTCCTTGAGGAGGCAC
AGAGATTCCTGTACCGTGATGTGATGCTGGAGAACTTTGCACTTGTGGCTACACTAGGTTTTTGGTGTGAAGCAGAACATGAGGCACCTT
CTGAGCAGAGCGTTTCTGTAGAAGGAGTGTCACAGGTCAGGACTGCTGAGTCAGGTCTTTTCCAGAAAGCACACCCATGTGAGATGTGTG
ACCCACTCTTGAAAGACATTTTGCACCTGGCTGAACACCAGGGATCACACCTTACACAGAAACTGTGCACACGTGGGCTGTGTAGGAGAA
GATTCTCGTTCAGTGCAAACTTTTACCAGCACCAGAAGCAACATAATGGAGAGAATTGCTTCAGAGGGGATGATGGAGGGGCCTCATTTG
TGAAGAGCTGTACAGTCCACATGTTAGGGAGATCCTTTACGTGCAGGGAGGAAGGGATGGACTTACCAGATAGCTCTGGCCTTTTCCAGC
ACCAGACCACTTACAATAGGGTGAGTCCATGCAGAAGGACTGAATGCATGGAGTCTTTCCCACACAGCTCCAGTCTCAGGCAACACCAAG
GAGACTATGATGGACAGATGCTTTTCAGTTGCGGTGATGAAGGGAAAGCCTTCCTGGACACCTTTACTCTTCTTGACAGCCAGATGACTC
ATGCTGAGGTGAGACCCTTCAGATGCCTACCATGTGGAAATGTGTTCAAGGAGAAATCAGCTCTTATTAATCACAGAAAAATCCACAGTG
GAGAAATATCTCATGTGTGTAAGGAGTGTGGAAAAGCCTTCATTCACTTGCACCACCTAAAAATGCACCAGAAATTTCACACTGGAAAAA
GACACTATACATGCAGTGAATGTGGGAAGGCCTTCAGCCGCAAGGACACACTTGTTCAGCATCAGAGAGTTCACACTGGAGAAAGATCTT
ATGACTGCAGTGAATGTGGAAAAGCCTACAGCAGAAGCTCCCACCTTGTTCAGCACCAGAGAATTCACACAGGAGAAAGGCCTTATAAGT
GCAACAAATGTGGGAAAGCCTTTAGCCGTAAAGACACACTTGTTCAGCACCAGAGATTTCATACTGGAGAAAGGCCTTATGAGTGCAGTG
AATGTGGAAAATTCTTTAGCCAAAGCTCCCACCTTATTGAGCACTGGAGAATTCATACCGGGGCAAGGCCCTATGAATGCATAGAATGTG
GAAAATTCTTTAGCCATAACTCTAGCCTCATTAAACATCGGAGAGTCCACACAGGAGCAAGATCCTACGTGTGCAGCAAATGTGGGAAGG
CCTTTGGCTGCAAAGACACACTTGTTCAGCACCAGATAATTCACACTGGAGCAAGGCCTTATGAGTGCAGTGAATGTGGGAAGGCCTTCA
GCCGTAAAGACACACTTGTGCAACACCAAAAAATCCACACTGGAGAAAGGCCTTATGAGTGTGGTGAATGTGGTAAATTCTTCAGCCATA
GCTCCAACCTTATTGTACACCAGAGAATTCACACTGGAGCAAAGCCTTATGAGTGCAATGAATGTGGGAAATGCTTTAGCCACAACTCCA
GCCTCATTTTGCACCAGAGAGTTCACACAGGAGCAAGGCCTTATGTGTGCAGTGAATGTGGGAAGGCTTACATTAGTAGCTCCCACCTTG
TTCAACACAAGAAAGTTCACACTGGAGCAAGACCTTATGAGTGCAGTGAATGTGGGAAATTCTTTAGCCGCAACTCTGGCCTCATTCTGC
ACCAGAGGGTTCACACTGGAGAAAAGCCTTACGTATGCAGCGAATGTGGGAAAGCCTATAGCAGAAGCTCCCATCTTGTTCGTCACCAGA

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ZNF304_ENST00000391705_chr19_57865093_+_1967nt
ATGACCGCTGAGCCCATGAGAGTTGTGTGACCTTCGAGGATGTGTTCGTGTACTTCTCTCGGGAGGAGTGGGAACTCCTTGAGGAGGCAC
AGAGATTCCTGTACCGTGATGTGATGCTGGAGAACTTTGCACTTGTGGCTACACTAGGTTTTTGGTGTGAAGCAGAACATGAGGCACCTT
CTGAGCAGAGCGTTTCTGTAGAAGGAGTGTCACAGGTCAGGACTGCTGAGTCAGGTCTTTTCCAGAAAGCACACCCATGTGAGATGTGTG
ACCCACTCTTGAAAGACATTTTGCACCTGGCTGAACACCAGGGATCACACCTTACACAGAAACTGTGCACACGTGGGCTGTGTAGGAGAA
GATTCTCGTTCAGTGCAAACTTTTACCAGCACCAGAAGCAACATAATGGAGAGAATTGCTTCAGAGGGGATGATGGAGGGGCCTCATTTG
TGAAGAGCTGTACAGTCCACATGTTAGGGAGATCCTTTACGTGCAGGGAGGAAGGGATGGACTTACCAGATAGCTCTGGCCTTTTCCAGC
ACCAGACCACTTACAATAGGGTGAGTCCATGCAGAAGGACTGAATGCATGGAGTCTTTCCCACACAGCTCCAGTCTCAGGCAACACCAAG
GAGACTATGATGGACAGATGCTTTTCAGTTGCGGTGATGAAGGGAAAGCCTTCCTGGACACCTTTACTCTTCTTGACAGCCAGATGACTC
ATGCTGAGGTGAGACCCTTCAGATGCCTACCATGTGGAAATGTGTTCAAGGAGAAATCAGCTCTTATTAATCACAGAAAAATCCACAGTG
GAGAAATATCTCATGTGTGTAAGGAGTGTGGAAAAGCCTTCATTCACTTGCACCACCTAAAAATGCACCAGAAATTTCACACTGGAAAAA
GACACTATACATGCAGTGAATGTGGGAAGGCCTTCAGCCGCAAGGACACACTTGTTCAGCATCAGAGAGTTCACACTGGAGAAAGATCTT
ATGACTGCAGTGAATGTGGAAAAGCCTACAGCAGAAGCTCCCACCTTGTTCAGCACCAGAGAATTCACACAGGAGAAAGGCCTTATAAGT
GCAACAAATGTGGGAAAGCCTTTAGCCGTAAAGACACACTTGTTCAGCACCAGAGATTTCATACTGGAGAAAGGCCTTATGAGTGCAGTG
AATGTGGAAAATTCTTTAGCCAAAGCTCCCACCTTATTGAGCACTGGAGAATTCATACCGGGGCAAGGCCCTATGAATGCATAGAATGTG
GAAAATTCTTTAGCCATAACTCTAGCCTCATTAAACATCGGAGAGTCCACACAGGAGCAAGATCCTACGTGTGCAGCAAATGTGGGAAGG
CCTTTGGCTGCAAAGACACACTTGTTCAGCACCAGATAATTCACACTGGAGCAAGGCCTTATGAGTGCAGTGAATGTGGGAAGGCCTTCA
GCCGTAAAGACACACTTGTGCAACACCAAAAAATCCACACTGGAGAAAGGCCTTATGAGTGTGGTGAATGTGGTAAATTCTTCAGCCATA
GCTCCAACCTTATTGTACACCAGAGAATTCACACTGGAGCAAAGCCTTATGAGTGCAATGAATGTGGGAAATGCTTTAGCCACAACTCCA
GCCTCATTTTGCACCAGAGAGTTCACACAGGAGCAAGGCCTTATGTGTGCAGTGAATGTGGGAAGGCTTACATTAGTAGCTCCCACCTTG
TTCAACACAAGAAAGTTCACACTGGAGCAAGACCTTATGAGTGCAGTGAATGTGGGAAATTCTTTAGCCGCAACTCTGGCCTCATTCTGC
ACCAGAGGGTTCACACTGGAGAAAAGCCTTACGTATGCAGCGAATGTGGGAAAGCCTATAGCAGAAGCTCCCATCTTGTTCGTCACCAGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ZNF304_ENST00000391705_chr19_57865093_+_4231nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGAGTTGTGTGACCTTCGAGGATGTGTTCGTGTACTT
CTCTCGGGAGGAGTGGGAACTCCTTGAGGAGGCACAGAGATTCCTGTACCGTGATGTGATGCTGGAGAACTTTGCACTTGTGGCTACACT
AGGTTTTTGGTGTGAAGCAGAACATGAGGCACCTTCTGAGCAGAGCGTTTCTGTAGAAGGAGTGTCACAGGTCAGGACTGCTGAGTCAGG
TCTTTTCCAGAAAGCACACCCATGTGAGATGTGTGACCCACTCTTGAAAGACATTTTGCACCTGGCTGAACACCAGGGATCACACCTTAC
ACAGAAACTGTGCACACGTGGGCTGTGTAGGAGAAGATTCTCGTTCAGTGCAAACTTTTACCAGCACCAGAAGCAACATAATGGAGAGAA
TTGCTTCAGAGGGGATGATGGAGGGGCCTCATTTGTGAAGAGCTGTACAGTCCACATGTTAGGGAGATCCTTTACGTGCAGGGAGGAAGG
GATGGACTTACCAGATAGCTCTGGCCTTTTCCAGCACCAGACCACTTACAATAGGGTGAGTCCATGCAGAAGGACTGAATGCATGGAGTC
TTTCCCACACAGCTCCAGTCTCAGGCAACACCAAGGAGACTATGATGGACAGATGCTTTTCAGTTGCGGTGATGAAGGGAAAGCCTTCCT
GGACACCTTTACTCTTCTTGACAGCCAGATGACTCATGCTGAGGTGAGACCCTTCAGATGCCTACCATGTGGAAATGTGTTCAAGGAGAA
ATCAGCTCTTATTAATCACAGAAAAATCCACAGTGGAGAAATATCTCATGTGTGTAAGGAGTGTGGAAAAGCCTTCATTCACTTGCACCA
CCTAAAAATGCACCAGAAATTTCACACTGGAAAAAGACACTATACATGCAGTGAATGTGGGAAGGCCTTCAGCCGCAAGGACACACTTGT
TCAGCATCAGAGAGTTCACACTGGAGAAAGATCTTATGACTGCAGTGAATGTGGAAAAGCCTACAGCAGAAGCTCCCACCTTGTTCAGCA
CCAGAGAATTCACACAGGAGAAAGGCCTTATAAGTGCAACAAATGTGGGAAAGCCTTTAGCCGTAAAGACACACTTGTTCAGCACCAGAG
ATTTCATACTGGAGAAAGGCCTTATGAGTGCAGTGAATGTGGAAAATTCTTTAGCCAAAGCTCCCACCTTATTGAGCACTGGAGAATTCA
TACCGGGGCAAGGCCCTATGAATGCATAGAATGTGGAAAATTCTTTAGCCATAACTCTAGCCTCATTAAACATCGGAGAGTCCACACAGG
AGCAAGATCCTACGTGTGCAGCAAATGTGGGAAGGCCTTTGGCTGCAAAGACACACTTGTTCAGCACCAGATAATTCACACTGGAGCAAG
GCCTTATGAGTGCAGTGAATGTGGGAAGGCCTTCAGCCGTAAAGACACACTTGTGCAACACCAAAAAATCCACACTGGAGAAAGGCCTTA
TGAGTGTGGTGAATGTGGTAAATTCTTCAGCCATAGCTCCAACCTTATTGTACACCAGAGAATTCACACTGGAGCAAAGCCTTATGAGTG
CAATGAATGTGGGAAATGCTTTAGCCACAACTCCAGCCTCATTTTGCACCAGAGAGTTCACACAGGAGCAAGGCCTTATGTGTGCAGTGA
ATGTGGGAAGGCTTACATTAGTAGCTCCCACCTTGTTCAACACAAGAAAGTTCACACTGGAGCAAGACCTTATGAGTGCAGTGAATGTGG
GAAATTCTTTAGCCGCAACTCTGGCCTCATTCTGCACCAGAGGGTTCACACTGGAGAAAAGCCTTACGTATGCAGCGAATGTGGGAAAGC
CTATAGCAGAAGCTCCCATCTTGTTCGTCACCAGAAAGCTCACACTGGAGAAAGAGCTCACGAGTGCAACAGTTTTGGTGGCCCTTTAGC
TGCATCTCTTAAACTTGTTTAACACCAGAAAATTCACACAAGAGAAAGGCCTTATGAATGCAGAAAATATGTCATCTTGTTCATCCTCAT
AGGACTCACACCAGAGCAATGCTCTGTGAGTACCCTTTGTGAGGGAACCATCAGCTAGCAGATGAGCACCGTATATTCATTCCACCCTGG
GGAGATTCCTGATAAGCACCACATATGTGGGAGGCTTTCATGAGGTGTGTTGCACTTTGTAACTGTCTAGAGCTCTTGATGGAATTATAT
CACTGCCAGTGCCTGTGGCGGAAGCCATCTTATTGCTACCAGCTGTGTGTGTCAATCACTCCATTTTGCTCAGGGAAGGCAGACTTCTGT
GCTTTCTTTCCTGTTCCCTACAGGTAATCATGAATATTTTCAAGGACTTCCCCCCCCCCCCACTTCACCCCCTACCATTGAGGGTCCTCA
TCTTTTCCCTCATGATTAGGTTCTGAGCAAACATGATCTAGCTCTCACCAAAAGGACCTGAGCTAGGGTCTGCTGGGATTTCCTGACACG
ATTTTCCATCTTCATGGACAATGTTAACTGTAAACGTGATAGCTGTGACTTACTTGTCTTACTGCCAAATCGCCCAAATTTGGAACTGCT
TGTCCCATGCTGCTCTGATTTATACAGTGATAAGGGCCTATTGTGGCAGTCTTTACTCTTGGGGATTTTGTTACTGTGTAGAGTGGATTG
AGAAAAGAATTGGGTTCTGTCATGAAGGGAGTAGCACCTTTTGTGGGCACCACCTTTATGTGCCTCAGAGGGGACCAAAGGATGGCAGAA
AACTGTTCTCAGTCTAGTTTGACCTAATTTACACTATTGCCCTAGGCTTGCTAGGAAAGACTGAAAAAATTTTTGTGCCTAACTTTGTGG
CCTGGCTGCCAGGATTTCCTGTGAGCCCAGTGAGGAGGGCATAGTTGGTGCGAAAATCTCCTGTGCTTGTGGAAGCAACATAAGTTGGGT
CCCTTAACTGTCACGTACTCCCCAGCACTGTTGAGGGATTGCTGTCTTCTGTACCTGTACAGGATCAAGTCCCTGATATCCAGAACCCCA
TAGGCAAGTAACATTGACTGTAAGACCTCTGTAGGGCAATGTGAAAATCATGATTGCTACAGAAGCACTGAGATAATGGAGTGGGGATGA
CTGTGGCAAACAAAAGGAGATTCGAACATTCTAGAGGGGCATCCACAAGTCTCGGTGCAGTTATGATGGTGTGGGATGGGAGTGCATAGA
AATTCTCAGGACCTTCAGACATCTGTATCTCCTGTGGCCAAGGCCACTGTCAGAGGAAATAATCTAAATGTTTGTGGATTCCTGTGTCTC
CCTGGGCAGTTGACCTGCACAGACAGGAACCTCAGCAGTGACAGAAGAGAGATCCAGGGATGGGTCTTCTCTGACCCAGCCAGCATTCCG
AGTGACTGAGGTGGATGTGGACATCATTGCTTACCAATTTTTACCAACATTGAGGCAGGGCTCACTCTCCTAAATTGTAGGGAGAGGAAT
ATGGTAAAGCCAAAATAGTTGACAGATCTAACTTTCCTAGTGGAACAGTATATATAGATTTTAATGAGGAACATTTATTTAATAGCTTTA
TGGAGGTATGATTAACATGCAATAAACTGCAAATATGTAAAGTGTAAAATGTGCTGTTTCAGCATGTGTGTACACCTATGAAACCACCAC
AGTCAAGATATCCAACACAACAAAAGATTGTCCCTTTATAATCCTCAATTTTTCCTTATCTTGTTTTCCACAATTCACAAGCAACAGCAA
GCATTTTCTATAATTTTATAAATGAAACCATATGGTGTGTACTTTTTAGGGGGTGGGGCTCTGGCTTTTTCAGTAAACATAACTATTTTA
AGGTTAATCCATTATCTTGTTGCATGAATCAATTGTTTGCTCATTTGTATTGCTGCGTAGTATTTCAGTATTTCATTGTATACCACAATT
TTTCTTCTTTGTCAACTTAATTGTTATGGATGTTTGGGTAACTTTCAGTTTTTGGCTATTACAAATAAACCTCTGAAGATTTGTGTGCAA

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ZNF304_ENST00000391705_chr19_57865093_+_4231nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGAGTTGTGTGACCTTCGAGGATGTGTTCGTGTACTT
CTCTCGGGAGGAGTGGGAACTCCTTGAGGAGGCACAGAGATTCCTGTACCGTGATGTGATGCTGGAGAACTTTGCACTTGTGGCTACACT
AGGTTTTTGGTGTGAAGCAGAACATGAGGCACCTTCTGAGCAGAGCGTTTCTGTAGAAGGAGTGTCACAGGTCAGGACTGCTGAGTCAGG
TCTTTTCCAGAAAGCACACCCATGTGAGATGTGTGACCCACTCTTGAAAGACATTTTGCACCTGGCTGAACACCAGGGATCACACCTTAC
ACAGAAACTGTGCACACGTGGGCTGTGTAGGAGAAGATTCTCGTTCAGTGCAAACTTTTACCAGCACCAGAAGCAACATAATGGAGAGAA
TTGCTTCAGAGGGGATGATGGAGGGGCCTCATTTGTGAAGAGCTGTACAGTCCACATGTTAGGGAGATCCTTTACGTGCAGGGAGGAAGG
GATGGACTTACCAGATAGCTCTGGCCTTTTCCAGCACCAGACCACTTACAATAGGGTGAGTCCATGCAGAAGGACTGAATGCATGGAGTC
TTTCCCACACAGCTCCAGTCTCAGGCAACACCAAGGAGACTATGATGGACAGATGCTTTTCAGTTGCGGTGATGAAGGGAAAGCCTTCCT
GGACACCTTTACTCTTCTTGACAGCCAGATGACTCATGCTGAGGTGAGACCCTTCAGATGCCTACCATGTGGAAATGTGTTCAAGGAGAA
ATCAGCTCTTATTAATCACAGAAAAATCCACAGTGGAGAAATATCTCATGTGTGTAAGGAGTGTGGAAAAGCCTTCATTCACTTGCACCA
CCTAAAAATGCACCAGAAATTTCACACTGGAAAAAGACACTATACATGCAGTGAATGTGGGAAGGCCTTCAGCCGCAAGGACACACTTGT
TCAGCATCAGAGAGTTCACACTGGAGAAAGATCTTATGACTGCAGTGAATGTGGAAAAGCCTACAGCAGAAGCTCCCACCTTGTTCAGCA
CCAGAGAATTCACACAGGAGAAAGGCCTTATAAGTGCAACAAATGTGGGAAAGCCTTTAGCCGTAAAGACACACTTGTTCAGCACCAGAG
ATTTCATACTGGAGAAAGGCCTTATGAGTGCAGTGAATGTGGAAAATTCTTTAGCCAAAGCTCCCACCTTATTGAGCACTGGAGAATTCA
TACCGGGGCAAGGCCCTATGAATGCATAGAATGTGGAAAATTCTTTAGCCATAACTCTAGCCTCATTAAACATCGGAGAGTCCACACAGG
AGCAAGATCCTACGTGTGCAGCAAATGTGGGAAGGCCTTTGGCTGCAAAGACACACTTGTTCAGCACCAGATAATTCACACTGGAGCAAG
GCCTTATGAGTGCAGTGAATGTGGGAAGGCCTTCAGCCGTAAAGACACACTTGTGCAACACCAAAAAATCCACACTGGAGAAAGGCCTTA
TGAGTGTGGTGAATGTGGTAAATTCTTCAGCCATAGCTCCAACCTTATTGTACACCAGAGAATTCACACTGGAGCAAAGCCTTATGAGTG
CAATGAATGTGGGAAATGCTTTAGCCACAACTCCAGCCTCATTTTGCACCAGAGAGTTCACACAGGAGCAAGGCCTTATGTGTGCAGTGA
ATGTGGGAAGGCTTACATTAGTAGCTCCCACCTTGTTCAACACAAGAAAGTTCACACTGGAGCAAGACCTTATGAGTGCAGTGAATGTGG
GAAATTCTTTAGCCGCAACTCTGGCCTCATTCTGCACCAGAGGGTTCACACTGGAGAAAAGCCTTACGTATGCAGCGAATGTGGGAAAGC
CTATAGCAGAAGCTCCCATCTTGTTCGTCACCAGAAAGCTCACACTGGAGAAAGAGCTCACGAGTGCAACAGTTTTGGTGGCCCTTTAGC
TGCATCTCTTAAACTTGTTTAACACCAGAAAATTCACACAAGAGAAAGGCCTTATGAATGCAGAAAATATGTCATCTTGTTCATCCTCAT
AGGACTCACACCAGAGCAATGCTCTGTGAGTACCCTTTGTGAGGGAACCATCAGCTAGCAGATGAGCACCGTATATTCATTCCACCCTGG
GGAGATTCCTGATAAGCACCACATATGTGGGAGGCTTTCATGAGGTGTGTTGCACTTTGTAACTGTCTAGAGCTCTTGATGGAATTATAT
CACTGCCAGTGCCTGTGGCGGAAGCCATCTTATTGCTACCAGCTGTGTGTGTCAATCACTCCATTTTGCTCAGGGAAGGCAGACTTCTGT
GCTTTCTTTCCTGTTCCCTACAGGTAATCATGAATATTTTCAAGGACTTCCCCCCCCCCCCACTTCACCCCCTACCATTGAGGGTCCTCA
TCTTTTCCCTCATGATTAGGTTCTGAGCAAACATGATCTAGCTCTCACCAAAAGGACCTGAGCTAGGGTCTGCTGGGATTTCCTGACACG
ATTTTCCATCTTCATGGACAATGTTAACTGTAAACGTGATAGCTGTGACTTACTTGTCTTACTGCCAAATCGCCCAAATTTGGAACTGCT
TGTCCCATGCTGCTCTGATTTATACAGTGATAAGGGCCTATTGTGGCAGTCTTTACTCTTGGGGATTTTGTTACTGTGTAGAGTGGATTG
AGAAAAGAATTGGGTTCTGTCATGAAGGGAGTAGCACCTTTTGTGGGCACCACCTTTATGTGCCTCAGAGGGGACCAAAGGATGGCAGAA
AACTGTTCTCAGTCTAGTTTGACCTAATTTACACTATTGCCCTAGGCTTGCTAGGAAAGACTGAAAAAATTTTTGTGCCTAACTTTGTGG
CCTGGCTGCCAGGATTTCCTGTGAGCCCAGTGAGGAGGGCATAGTTGGTGCGAAAATCTCCTGTGCTTGTGGAAGCAACATAAGTTGGGT
CCCTTAACTGTCACGTACTCCCCAGCACTGTTGAGGGATTGCTGTCTTCTGTACCTGTACAGGATCAAGTCCCTGATATCCAGAACCCCA
TAGGCAAGTAACATTGACTGTAAGACCTCTGTAGGGCAATGTGAAAATCATGATTGCTACAGAAGCACTGAGATAATGGAGTGGGGATGA
CTGTGGCAAACAAAAGGAGATTCGAACATTCTAGAGGGGCATCCACAAGTCTCGGTGCAGTTATGATGGTGTGGGATGGGAGTGCATAGA
AATTCTCAGGACCTTCAGACATCTGTATCTCCTGTGGCCAAGGCCACTGTCAGAGGAAATAATCTAAATGTTTGTGGATTCCTGTGTCTC
CCTGGGCAGTTGACCTGCACAGACAGGAACCTCAGCAGTGACAGAAGAGAGATCCAGGGATGGGTCTTCTCTGACCCAGCCAGCATTCCG
AGTGACTGAGGTGGATGTGGACATCATTGCTTACCAATTTTTACCAACATTGAGGCAGGGCTCACTCTCCTAAATTGTAGGGAGAGGAAT
ATGGTAAAGCCAAAATAGTTGACAGATCTAACTTTCCTAGTGGAACAGTATATATAGATTTTAATGAGGAACATTTATTTAATAGCTTTA
TGGAGGTATGATTAACATGCAATAAACTGCAAATATGTAAAGTGTAAAATGTGCTGTTTCAGCATGTGTGTACACCTATGAAACCACCAC
AGTCAAGATATCCAACACAACAAAAGATTGTCCCTTTATAATCCTCAATTTTTCCTTATCTTGTTTTCCACAATTCACAAGCAACAGCAA
GCATTTTCTATAATTTTATAAATGAAACCATATGGTGTGTACTTTTTAGGGGGTGGGGCTCTGGCTTTTTCAGTAAACATAACTATTTTA
AGGTTAATCCATTATCTTGTTGCATGAATCAATTGTTTGCTCATTTGTATTGCTGCGTAGTATTTCAGTATTTCATTGTATACCACAATT
TTTCTTCTTTGTCAACTTAATTGTTATGGATGTTTGGGTAACTTTCAGTTTTTGGCTATTACAAATAAACCTCTGAAGATTTGTGTGCAA


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FusionGenePPI for ATRX_ZNF304


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATRXEIF4A2, EZH2, CCSER2, KIAA1377, LUC7L2, PTN, PTPN4, RAD51, SMC1A, CBX5, H3F3A, H3F3B, DAXX, HDAC4, HIST1H3A, WRN, CALM1, SVIL, ZBED1, HIST2H3C, BLM, NEK1, ZNF512B, PRKDC, RAD50, XRCC5, MRE11A, XRCC6, SUPT16H, NBN, SSRP1, HIST1H4J, HIST2H2BE, RPA1, TP53, HIST1H1C, RAD9A, HIST1H2BL, HIST1H2AB, RAD1, PML, NSD1, SUMO2, TMPO, CNOT1, LRRK2, H2AFY, SNW1, ZNF274, TRIM28, SETDB1, BMI1, AURKA, HIST1H4A, WDR1, EAF1, DDX20, NAF1, EIF2AK1, AP3B1, POLD1, RBM14, MFAP1ZNF304USP28


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351189_132662493DAXX
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341189_132662455DAXX
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352010_228062493MECP2
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342010_228062455MECP2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATRX_ZNF304


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATRX_ZNF304


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATRXC1845055ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED11CTD_human;ORPHANET;UNIPROT
HgeneATRXC0796003Juberg-Marsidi syndrome5CTD_human;ORPHANET;UNIPROT
HgeneATRXC0017638Glioma2CTD_human
HgeneATRXC0027819Neuroblastoma2CTD_human
HgeneATRXC0010417Cryptorchidism1CTD_human;HPO
HgeneATRXC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneATRXC0018273Growth Disorders1CTD_human
HgeneATRXC0030297Pancreatic Neoplasm1CTD_human
HgeneATRXC0030846Penile Diseases1CTD_human
HgeneATRXC0039978Thoracic Diseases1CTD_human
HgeneATRXC0206754Neuroendocrine Tumors1CTD_human
HgeneATRXC0376634Craniofacial Abnormalities1CTD_human
HgeneATRXC1136249Mental Retardation, X-Linked1CTD_human
HgeneATRXC3463824MYELODYSPLASTIC SYNDROME1CTD_human;HPO