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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35481

FusionGeneSummary for SP140_DGKI

check button Fusion gene summary
Fusion gene informationFusion gene name: SP140_DGKI
Fusion gene ID: 35481
HgeneTgene
Gene symbol

SP140

DGKI

Gene ID

11262

9162

Gene nameSP140 nuclear body proteindiacylglycerol kinase iota
SynonymsLYSP100|LYSP100-A|LYSP100-BDGK-IOTA
Cytomap

2q37.1

7q33

Type of geneprotein-codingprotein-coding
Descriptionnuclear body protein SP140lymphoid-restricted homolog of Sp100lymphoid-specific SP100 homolognuclear autoantigen Sp-140speckled 140 kDadiacylglycerol kinase iotaDAG kinase iotadiglyceride kinase iota
Modification date2018052220180519
UniProtAcc

Q13342

O75912

Ensembl transtripts involved in fusion geneENST00000486687, ENST00000350136, 
ENST00000392045, ENST00000417495, 
ENST00000343805, ENST00000420434, 
ENST00000373645, ENST00000544128, 
ENST00000453654, ENST00000288490, 
ENST00000424189, ENST00000446122, 
ENST00000494390, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 3=48
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SP140 [Title/Abstract] AND DGKI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDGKI

GO:0046834

lipid phosphorylation

9830018


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF357704SP140chr2

231118475

-DGKIchr7

137498017

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000486687ENST00000453654SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000486687ENST00000288490SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000486687ENST00000424189SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000486687ENST00000446122SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000486687ENST00000494390SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000350136ENST00000453654SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000350136ENST00000288490SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000350136ENST00000424189SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000350136ENST00000446122SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000350136ENST00000494390SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000392045ENST00000453654SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000392045ENST00000288490SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000392045ENST00000424189SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000392045ENST00000446122SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000392045ENST00000494390SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000417495ENST00000453654SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000417495ENST00000288490SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000417495ENST00000424189SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000417495ENST00000446122SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000417495ENST00000494390SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000343805ENST00000453654SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000343805ENST00000288490SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000343805ENST00000424189SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000343805ENST00000446122SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000343805ENST00000494390SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000420434ENST00000453654SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000420434ENST00000288490SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000420434ENST00000424189SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000420434ENST00000446122SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000420434ENST00000494390SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000373645ENST00000453654SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000373645ENST00000288490SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000373645ENST00000424189SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000373645ENST00000446122SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000373645ENST00000494390SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000544128ENST00000453654SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000544128ENST00000288490SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000544128ENST00000424189SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000544128ENST00000446122SP140chr2

231118475

-DGKIchr7

137498017

+
intron-intronENST00000544128ENST00000494390SP140chr2

231118475

-DGKIchr7

137498017

+

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FusionProtFeatures for SP140_DGKI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SP140

Q13342

DGKI

O75912


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SP140_DGKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SP140_DGKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SP140_DGKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SP140_DGKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSP140C0023434Chronic Lymphocytic Leukemia1CTD_human
HgeneSP140C0023893Liver Cirrhosis, Experimental1CTD_human