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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 3543

FusionGeneSummary for ATRX_ARHGEF9

check button Fusion gene summary
Fusion gene informationFusion gene name: ATRX_ARHGEF9
Fusion gene ID: 3543
HgeneTgene
Gene symbol

ATRX

ARHGEF9

Gene ID

546

23229

Gene nameATRX, chromatin remodelerCdc42 guanine nucleotide exchange factor 9
SynonymsJMS|MRX52|RAD54|RAD54L|XH2|XNP|ZNF-HXCOLLYBISTIN|EIEE8|HPEM-2|PEM-2|PEM2
Cytomap

Xq21.1

Xq11.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ATRXATP-dependent helicase ATRXX-linked helicase IIX-linked nuclear proteinalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)rho guanine nucleotide exchange factor 9Cdc42 guanine nucleotide exchange factor (GEF) 9PEM-2 homologhPEM-2 collybistinrac/Cdc42 guanine nucleotide exchange factor 9
Modification date2018051920180519
UniProtAcc

P46100

O43307

Ensembl transtripts involved in fusion geneENST00000373344, ENST00000395603, 
ENST00000480283, ENST00000373341, 
ENST00000253401, ENST00000374878, 
ENST00000374870, ENST00000437457, 
ENST00000495564, ENST00000374872, 
ENST00000433323, 
Fusion gene scores* DoF score9 X 4 X 6=2161 X 1 X 1=1
# samples 91
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ATRX [Title/Abstract] AND ARHGEF9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATRX

GO:0006334

nucleosome assembly

20651253

HgeneATRX

GO:0006338

chromatin remodeling

20651253


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-MQ-A4LP-01AATRXchrX

77041468

-ARHGEF9chrX

62875617

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373344ENST00000253401ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
In-frameENST00000373344ENST00000374878ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
In-frameENST00000373344ENST00000374870ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
In-frameENST00000373344ENST00000437457ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5CDS-5UTRENST00000373344ENST00000495564ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5CDS-5UTRENST00000373344ENST00000374872ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5CDS-5UTRENST00000373344ENST00000433323ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
In-frameENST00000395603ENST00000253401ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
In-frameENST00000395603ENST00000374878ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
In-frameENST00000395603ENST00000374870ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
In-frameENST00000395603ENST00000437457ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5CDS-5UTRENST00000395603ENST00000495564ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5CDS-5UTRENST00000395603ENST00000374872ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5CDS-5UTRENST00000395603ENST00000433323ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5UTR-3CDSENST00000480283ENST00000253401ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5UTR-3CDSENST00000480283ENST00000374878ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5UTR-3CDSENST00000480283ENST00000374870ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5UTR-3CDSENST00000480283ENST00000437457ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5UTR-5UTRENST00000480283ENST00000495564ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5UTR-5UTRENST00000480283ENST00000374872ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
5UTR-5UTRENST00000480283ENST00000433323ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
intron-3CDSENST00000373341ENST00000253401ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
intron-3CDSENST00000373341ENST00000374878ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
intron-3CDSENST00000373341ENST00000374870ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
intron-3CDSENST00000373341ENST00000437457ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
intron-5UTRENST00000373341ENST00000495564ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
intron-5UTRENST00000373341ENST00000374872ATRXchrX

77041468

-ARHGEF9chrX

62875617

-
intron-5UTRENST00000373341ENST00000433323ATRXchrX

77041468

-ARHGEF9chrX

62875617

-

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FusionProtFeatures for ATRX_ARHGEF9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATRX

P46100

ARHGEF9

O43307

Acts as guanine nucleotide exchange factor (GEF) forCDC42. Promotes formation of GPHN clusters.{ECO:0000269|PubMed:10559246}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000374870-59318_425250415DomainPH
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000437457-59318_425299464DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351151_115662493Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351166_116962493Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351202_120662493Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351259_126662493Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351443_146662493Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351499_150262493Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351929_193962493Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351941_194862493Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1352222_222562493Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1352262_226562493Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1352420_242562493Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-135745_75062493Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341151_115662455Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341166_116962455Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341202_120662455Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341259_126662455Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341443_146662455Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341499_150262455Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341929_193962455Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341941_194862455Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1342222_222562455Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1342262_226562455Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1342420_242562455Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-134745_75062455Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351581_176862493DomainHelicase ATP-binding
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-135159_29662493DomainADD
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1352025_220562493DomainHelicase C-terminal
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341581_176862455DomainHelicase ATP-binding
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-134159_29662455DomainADD
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1342025_220562455DomainHelicase C-terminal
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351719_172262493MotifNote=DEGH box
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-135581_59462493MotifNote=PxVxL motif
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341719_172262455MotifNote=DEGH box
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-134581_59462455MotifNote=PxVxL motif
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351594_160162493Nucleotide bindingATP
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341594_160162455Nucleotide bindingATP
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-135170_20662493Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-135217_27262493Zinc fingerPHD-type%3B atypical
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-134170_20662455Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-134217_27262455Zinc fingerPHD-type%3B atypical
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000253401-610103_287352517DomainDH
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000253401-610318_425352517DomainPH
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000253401-6108_67352517DomainSH3
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000374870-59103_287250415DomainDH
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000374870-598_67250415DomainSH3
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000437457-59103_287299464DomainDH
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000437457-598_67299464DomainSH3


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FusionGeneSequence for ATRX_ARHGEF9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000253401_chrX_62875617_-_171aa
MTAEPMRTXSGETSCTTKAALTWINMRXLTLRMAEMMTSMSAXRMPLSFTTRRLRRYICSLPRSWRKKYAGSGLSEKRGKWYRKMKKLAL

>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000374878_chrX_62875617_-_135aa
MTAEPMRTXSGETSCTTKAALTWINMRXLTLRMAEMMTSMSAXRMPLSFTTRRLRRYICSLPRSWRKKYAGSGLSEKRGKWYRKMKKLAL

>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000374870_chrX_62875617_-_171aa
MTAEPMRTXSGETSCTTKAALTWINMRXLTLRMAEMMTSMSAXRMPLSFTTRRLRRYICSLPRSWRKKYAGSGLSEKRGKWYRKMKKLAL

>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000437457_chrX_62875617_-_171aa
MTAEPMRTXSGETSCTTKAALTWINMRXLTLRMAEMMTSMSAXRMPLSFTTRRLRRYICSLPRSWRKKYAGSGLSEKRGKWYRKMKKLAL

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000253401_chrX_62875617_-_171aa
MTAEPMRTXSGETSCTTKAALTWINMRXLTLRMAEMMTSMSAXRMPLSFTTRRLRRYICSLPRSWRKKYAGSGLSEKRGKWYRKMKKLAL

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000374878_chrX_62875617_-_135aa
MTAEPMRTXSGETSCTTKAALTWINMRXLTLRMAEMMTSMSAXRMPLSFTTRRLRRYICSLPRSWRKKYAGSGLSEKRGKWYRKMKKLAL

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000374870_chrX_62875617_-_171aa
MTAEPMRTXSGETSCTTKAALTWINMRXLTLRMAEMMTSMSAXRMPLSFTTRRLRRYICSLPRSWRKKYAGSGLSEKRGKWYRKMKKLAL

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000437457_chrX_62875617_-_171aa
MTAEPMRTXSGETSCTTKAALTWINMRXLTLRMAEMMTSMSAXRMPLSFTTRRLRRYICSLPRSWRKKYAGSGLSEKRGKWYRKMKKLAL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000253401_chrX_62875617_-_515nt
ATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGGCCGCATTGACATGGATAAATATGAGGTAGTTGACA
TTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCTTCACAACAAGGAGACTGAGGAGATACATCTGTTCT
TTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAGGAAAATGGTACAGGAAGATGAAAAAATTGGCTTTG
AAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAAGCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTC
CTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGACGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCG

>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000374878_chrX_62875617_-_407nt
ATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGGCCGCATTGACATGGATAAATATGAGGTAGTTGACA
TTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCTTCACAACAAGGAGACTGAGGAGATACATCTGTTCT
TTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAGGAAAATGGTACAGGAAGATGAAAAAATTGGCTTTG
AAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAACTCCCTTTTCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAA

>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000374870_chrX_62875617_-_515nt
ATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGGCCGCATTGACATGGATAAATATGAGGTAGTTGACA
TTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCTTCACAACAAGGAGACTGAGGAGATACATCTGTTCT
TTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAGGAAAATGGTACAGGAAGATGAAAAAATTGGCTTTG
AAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAAGCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTC
CTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGACGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCG

>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000437457_chrX_62875617_-_515nt
ATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGGCCGCATTGACATGGATAAATATGAGGTAGTTGACA
TTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCTTCACAACAAGGAGACTGAGGAGATACATCTGTTCT
TTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAGGAAAATGGTACAGGAAGATGAAAAAATTGGCTTTG
AAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAAGCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTC
CTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGACGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCG

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000253401_chrX_62875617_-_515nt
ATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGGCCGCATTGACATGGATAAATATGAGGTAGTTGACA
TTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCTTCACAACAAGGAGACTGAGGAGATACATCTGTTCT
TTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAGGAAAATGGTACAGGAAGATGAAAAAATTGGCTTTG
AAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAAGCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTC
CTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGACGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCG

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000374878_chrX_62875617_-_407nt
ATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGGCCGCATTGACATGGATAAATATGAGGTAGTTGACA
TTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCTTCACAACAAGGAGACTGAGGAGATACATCTGTTCT
TTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAGGAAAATGGTACAGGAAGATGAAAAAATTGGCTTTG
AAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAACTCCCTTTTCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAA

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000374870_chrX_62875617_-_515nt
ATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGGCCGCATTGACATGGATAAATATGAGGTAGTTGACA
TTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCTTCACAACAAGGAGACTGAGGAGATACATCTGTTCT
TTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAGGAAAATGGTACAGGAAGATGAAAAAATTGGCTTTG
AAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAAGCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTC
CTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGACGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCG

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000437457_chrX_62875617_-_515nt
ATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGGCCGCATTGACATGGATAAATATGAGGTAGTTGACA
TTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCTTCACAACAAGGAGACTGAGGAGATACATCTGTTCT
TTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAGGAAAATGGTACAGGAAGATGAAAAAATTGGCTTTG
AAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAAGCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTC
CTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGACGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000253401_chrX_62875617_-_3791nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGG
CCGCATTGACATGGATAAATATGAGGTAGTTGACATTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCT
TCACAACAAGGAGACTGAGGAGATACATCTGTTCTTTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAG
GAAAATGGTACAGGAAGATGAAAAAATTGGCTTTGAAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAA
GCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTCCTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGA
CGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCGAACCCAAGCGCAGCCAGTCACCATTCTGGCAAAACTTCAGCAGGTTAACCCCCTT
CAAAAAATGATACCTACAGGGAGGCAGATAATTTTAAAATAAAGTAAATAAAATTATATTTATAGATGGACCTTTTTTCGGAGAAGCACT
GTTGAAATTTATACACACACACACACACAGAGACCCTTGAGTACACATACACACACACACACACAGACACACACACACACACACACACAC
ACACACACACAGAGAGATAAGGAACAAAAGTGTTTTCTGTTGTTTTGGGGAAGTGAAATATGTGGTTGGTAGGAAGAGGTACCAATGACT
TCCAAACATGTGATTCCGTCTTAAAAGTTTTCCATTTTTACCCTGTCCCCCTTCCCTTTGCTTTCAGAAGTTGACATTTCTATTCATTGC
TTTTCTTGTTAAGATAATCTCTTTACTCCCCTGTGAGTGATTCACTGCCTTGTCATTATTACGATAGATGTGTTTGTATTGTTTTTTTTC
TGATGATACTGATGTTGATGAATTTTTAATTTTATTTGATGTGGTAGAGTTGGGAGGTTTCAGGGTTTTTTCCCCTCTTTTACTTTCCAT
TGAGGAAGGGAATGAGCTCCTTTCTCCTCTCCTTCAGCCAATCATTATCAAATGTTCCTTCAGCCCTGCAGTTGCCCCAAATAACCTTTT
TTCAGCATCCTCTGTCCTCAGTCATGCCAGTCTGGACATGCTCTGTTGTGCCCTGTGACAAAACTGCTCAGTATTCCTATTGCTTTTACT
GTGTTTTAGGTACTGTGAAGGGATCAAAAAACCAAACAGAAGCAAGGGAGTATCAGACTATGATGATGCTGGAGTGGACTTCTGTTCAGG
GAACATTTTGCATTCAGGCTGTTTCTTCTATCACTGGGGTTTCCCATGTTGCAGCACTTCTGGGTCGTTGCAATTTTGCATCTAGGAGTT
AGTTTGATCGAGTTATTCTCTTTTTTCAAGTCACTTTTGTTATAGGTCTCCCCCTAGGCCTGTCTCTCCCTTAGCCCAAAAGATCTGAAC
TGGAAGCAGAGGTTGAGATTCTGCCTCCCAGGAGAGGGATTTACCTGCCCCCTAGTACCAGATAGGTTTAGGGCAGTGATCTCTACAGCA
ATCAGTTCAGTGTCCTGGTTGTCCCTGCTCCCATTTACAGATGTTTGGGCAGCATTGATAGAAGTATGGAGGGGTTCAAGACAGAGCCCA
CCTGATCAAGATCATCAGCTACCTTCAAATTATTGACCTGGACAGGGTCCAAGTCTGATAGTAACCTTTTACAAGAAAGAACAGGGATGG
GAATGGAAAGAGATAGCCTTGATCCACAGTATTGTACCTGCATTTTCTACCACCCTAAAATTGTGTGAGACTTCTCCCATTGTTAACAGA
TTGCATGGACAATCTTCCCTGGCTTCTTTCTTTCCCTCTCTCTTTCTTCTTTCTCCTGCCATCCTAGCACAGGAGGATTTTTGGTATTGA
TATAGTTAAAGCTGTTCTGGCACTCAAAGAAGGCCGTGTTTCCAACATCCTCTCATCCCAGGACATTTGGGGCAAGTGAGTTAGGGGCCC
AGGGGCAATTTTCCCTCTGAATAACGTGTCTGAGGCAGGGATGCTACCCTCAGGCTCGCTTTTGGCCAGCTTTTTGCTTGGGAAAATCTA
ACTTCTTTCACAAGGAGGCAGGCTTCCTATGGATGTTGGAGTACCTGTTTTTCCTCCACACATAGCCCTTTTCATGGATAGACCTTGAAC
AACAAAAAGGGTATAAGGGAATAAGGATGAACTCTGCTGTGAAGAGCAAGCCACTGTAGTGAGGAATGTGGAGACTGGGAGTCTGTCCTA
AACCCCATGGGAGAAGACTTCATCATGACAGGACTTCAGCTTACCAAGCAGCAGCCATAGCTGTGTGGAGGCTTCAGCATAGCTAGCATG
TTTACTGCTCTATGCCTCCTGATCCAGACCAGGCATTGCCCAGCCTGGGAATCTTTTCTTTGTGGGAATCAAATTACAAGCTATTTAAGT
TTATATTCCATCACAACCAAGTCAGACTTGTATTATAAGTCAAGGATGAGCCTGATCTGGGGAGAGGGCCGGGGCTCGGGACTGGCCACC
ACTGTTCAGCACATGACCTAACTACGTAAGCCTCTTTGGCAAGGGTCCTGGTGCCCAGCACCCAGGCTAAAATATCCTGTCTGGCAGAGT
GTTTTGGTAGCTATGCAGGCCTCCCTTCAGTGTACCTCTTTTTCCAACTTCTCACTCCTCCTTACTAGGCTTGGCCTTGACATGCTTCTT
CGAGGGTTGGCAGCACACCGGGAGGGGATGCTTGGACAAGTTTCTGGGCCTACATTTCTTGACTAGGCCCTCTCATTTCCTCCCTCCTTG
GGGCTTCTGCCCAGGGCTCCAGGATCAGGGATATTACTTCTCAACCCGCACTTCTCCTCTACTGAACCCACTGGCATCACCTGATGCCAC
TAATTTGTGAACAACAAGAAATCATTTCCCCATTGGTTGGAGTATTCCCTCAGCCTATAGCATCAAAGCAGACCAGTGGCCAACAGCCCC
AAGGGGAGCCCAATTAAATACCTGGGTTCAGTATCCTAACCTGTTATGTCCTGACAGCAATGGTAACCCCAGTAATTCTGTAATGTTGTA
ATTTCCGCATGGCCCTGAGCTCCCTTTTCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAAAAGGCTTTGCTAGTGTGTTCAATGGGAC
CTGCTGTGGGGAGTCCTAAGACAGACATCTAATTATTCTCTCTTTTTCCCCCCCTCTCTATGTGTATATTTCTAATGGATCTATAAGAAC
AGCAACAAGAGAGTTCTAACAATTCTAGTGTGAAGCCAAATAGTGATCTTTTAGTGCTTTGGGGATGGGGTGGGCTGGGGTGGATGGATG
GGCAACAGTGACTTTGATTACCCTTGCTGCTCTGCATTTGCCAGTTTATTCTTTTGTTTCTTTTATCTGACTGACTCTGTCAAACAAGTG
TCAAAGTTGTGTGTTAAAAAATGTTTAACAAAAAAAATGTTGTAATGACACAAAGCCTTATGAAAATATTTATGGAGTTCAATAAAAGAA

>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000374878_chrX_62875617_-_974nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGG
CCGCATTGACATGGATAAATATGAGGTAGTTGACATTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCT
TCACAACAAGGAGACTGAGGAGATACATCTGTTCTTTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAG
GAAAATGGTACAGGAAGATGAAAAAATTGGCTTTGAAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAACTCCCTTT
TCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAAAAGGCTTTGCTAGTGTGTTCAATGGGACCTGCTGTGGGGAGTCCTAAGACAGACA
TCTAATTATTCTCTCTTTTTCCCCCCCTCTCTATGTGTATATTTCTAATGGATCTATAAGAACAGCAACAAGAGAGTTCTAACAATTCTA
GTGTGAAGCCAAATAGTGATCTTTTAGTGCTTTGGGGATGGGGTGGGCTGGGGTGGATGGATGGGCAACAGTGACTTTGATTACCCTTGC
TGCTCTGCATTTGCCAGTTTATTCTTTTGTTTCTTTTATCTGACTGACTCTGTCAAACAAGTGTCAAAGTTGTGTGTTAAAAAATGTTTA

>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000374870_chrX_62875617_-_3782nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGG
CCGCATTGACATGGATAAATATGAGGTAGTTGACATTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCT
TCACAACAAGGAGACTGAGGAGATACATCTGTTCTTTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAG
GAAAATGGTACAGGAAGATGAAAAAATTGGCTTTGAAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAA
GCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTCCTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGA
CGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCGAACCCAAGCGCAGCCAGTCACCATTCTGGCAAAACTTCAGCAGGTTAACCCCCTT
CAAAAAATGATACCTACAGGGAGGCAGATAATTTTAAAATAAAGTAAATAAAATTATATTTATAGATGGACCTTTTTTCGGAGAAGCACT
GTTGAAATTTATACACACACACACACACAGAGACCCTTGAGTACACATACACACACACACACACAGACACACACACACACACACACACAC
ACACACACACAGAGAGATAAGGAACAAAAGTGTTTTCTGTTGTTTTGGGGAAGTGAAATATGTGGTTGGTAGGAAGAGGTACCAATGACT
TCCAAACATGTGATTCCGTCTTAAAAGTTTTCCATTTTTACCCTGTCCCCCTTCCCTTTGCTTTCAGAAGTTGACATTTCTATTCATTGC
TTTTCTTGTTAAGATAATCTCTTTACTCCCCTGTGAGTGATTCACTGCCTTGTCATTATTACGATAGATGTGTTTGTATTGTTTTTTTTC
TGATGATACTGATGTTGATGAATTTTTAATTTTATTTGATGTGGTAGAGTTGGGAGGTTTCAGGGTTTTTTCCCCTCTTTTACTTTCCAT
TGAGGAAGGGAATGAGCTCCTTTCTCCTCTCCTTCAGCCAATCATTATCAAATGTTCCTTCAGCCCTGCAGTTGCCCCAAATAACCTTTT
TTCAGCATCCTCTGTCCTCAGTCATGCCAGTCTGGACATGCTCTGTTGTGCCCTGTGACAAAACTGCTCAGTATTCCTATTGCTTTTACT
GTGTTTTAGGTACTGTGAAGGGATCAAAAAACCAAACAGAAGCAAGGGAGTATCAGACTATGATGATGCTGGAGTGGACTTCTGTTCAGG
GAACATTTTGCATTCAGGCTGTTTCTTCTATCACTGGGGTTTCCCATGTTGCAGCACTTCTGGGTCGTTGCAATTTTGCATCTAGGAGTT
AGTTTGATCGAGTTATTCTCTTTTTTCAAGTCACTTTTGTTATAGGTCTCCCCCTAGGCCTGTCTCTCCCTTAGCCCAAAAGATCTGAAC
TGGAAGCAGAGGTTGAGATTCTGCCTCCCAGGAGAGGGATTTACCTGCCCCCTAGTACCAGATAGGTTTAGGGCAGTGATCTCTACAGCA
ATCAGTTCAGTGTCCTGGTTGTCCCTGCTCCCATTTACAGATGTTTGGGCAGCATTGATAGAAGTATGGAGGGGTTCAAGACAGAGCCCA
CCTGATCAAGATCATCAGCTACCTTCAAATTATTGACCTGGACAGGGTCCAAGTCTGATAGTAACCTTTTACAAGAAAGAACAGGGATGG
GAATGGAAAGAGATAGCCTTGATCCACAGTATTGTACCTGCATTTTCTACCACCCTAAAATTGTGTGAGACTTCTCCCATTGTTAACAGA
TTGCATGGACAATCTTCCCTGGCTTCTTTCTTTCCCTCTCTCTTTCTTCTTTCTCCTGCCATCCTAGCACAGGAGGATTTTTGGTATTGA
TATAGTTAAAGCTGTTCTGGCACTCAAAGAAGGCCGTGTTTCCAACATCCTCTCATCCCAGGACATTTGGGGCAAGTGAGTTAGGGGCCC
AGGGGCAATTTTCCCTCTGAATAACGTGTCTGAGGCAGGGATGCTACCCTCAGGCTCGCTTTTGGCCAGCTTTTTGCTTGGGAAAATCTA
ACTTCTTTCACAAGGAGGCAGGCTTCCTATGGATGTTGGAGTACCTGTTTTTCCTCCACACATAGCCCTTTTCATGGATAGACCTTGAAC
AACAAAAAGGGTATAAGGGAATAAGGATGAACTCTGCTGTGAAGAGCAAGCCACTGTAGTGAGGAATGTGGAGACTGGGAGTCTGTCCTA
AACCCCATGGGAGAAGACTTCATCATGACAGGACTTCAGCTTACCAAGCAGCAGCCATAGCTGTGTGGAGGCTTCAGCATAGCTAGCATG
TTTACTGCTCTATGCCTCCTGATCCAGACCAGGCATTGCCCAGCCTGGGAATCTTTTCTTTGTGGGAATCAAATTACAAGCTATTTAAGT
TTATATTCCATCACAACCAAGTCAGACTTGTATTATAAGTCAAGGATGAGCCTGATCTGGGGAGAGGGCCGGGGCTCGGGACTGGCCACC
ACTGTTCAGCACATGACCTAACTACGTAAGCCTCTTTGGCAAGGGTCCTGGTGCCCAGCACCCAGGCTAAAATATCCTGTCTGGCAGAGT
GTTTTGGTAGCTATGCAGGCCTCCCTTCAGTGTACCTCTTTTTCCAACTTCTCACTCCTCCTTACTAGGCTTGGCCTTGACATGCTTCTT
CGAGGGTTGGCAGCACACCGGGAGGGGATGCTTGGACAAGTTTCTGGGCCTACATTTCTTGACTAGGCCCTCTCATTTCCTCCCTCCTTG
GGGCTTCTGCCCAGGGCTCCAGGATCAGGGATATTACTTCTCAACCCGCACTTCTCCTCTACTGAACCCACTGGCATCACCTGATGCCAC
TAATTTGTGAACAACAAGAAATCATTTCCCCATTGGTTGGAGTATTCCCTCAGCCTATAGCATCAAAGCAGACCAGTGGCCAACAGCCCC
AAGGGGAGCCCAATTAAATACCTGGGTTCAGTATCCTAACCTGTTATGTCCTGACAGCAATGGTAACCCCAGTAATTCTGTAATGTTGTA
ATTTCCGCATGGCCCTGAGCTCCCTTTTCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAAAAGGCTTTGCTAGTGTGTTCAATGGGAC
CTGCTGTGGGGAGTCCTAAGACAGACATCTAATTATTCTCTCTTTTTCCCCCCCTCTCTATGTGTATATTTCTAATGGATCTATAAGAAC
AGCAACAAGAGAGTTCTAACAATTCTAGTGTGAAGCCAAATAGTGATCTTTTAGTGCTTTGGGGATGGGGTGGGCTGGGGTGGATGGATG
GGCAACAGTGACTTTGATTACCCTTGCTGCTCTGCATTTGCCAGTTTATTCTTTTGTTTCTTTTATCTGACTGACTCTGTCAAACAAGTG
TCAAAGTTGTGTGTTAAAAAATGTTTAACAAAAAAAATGTTGTAATGACACAAAGCCTTATGAAAATATTTATGGAGTTCAATAAAAGAA

>In-frame_ATRX_ENST00000373344_chrX_77041468_-_ARHGEF9_ENST00000437457_chrX_62875617_-_3782nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGG
CCGCATTGACATGGATAAATATGAGGTAGTTGACATTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCT
TCACAACAAGGAGACTGAGGAGATACATCTGTTCTTTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAG
GAAAATGGTACAGGAAGATGAAAAAATTGGCTTTGAAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAA
GCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTCCTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGA
CGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCGAACCCAAGCGCAGCCAGTCACCATTCTGGCAAAACTTCAGCAGGTTAACCCCCTT
CAAAAAATGATACCTACAGGGAGGCAGATAATTTTAAAATAAAGTAAATAAAATTATATTTATAGATGGACCTTTTTTCGGAGAAGCACT
GTTGAAATTTATACACACACACACACACAGAGACCCTTGAGTACACATACACACACACACACACAGACACACACACACACACACACACAC
ACACACACACAGAGAGATAAGGAACAAAAGTGTTTTCTGTTGTTTTGGGGAAGTGAAATATGTGGTTGGTAGGAAGAGGTACCAATGACT
TCCAAACATGTGATTCCGTCTTAAAAGTTTTCCATTTTTACCCTGTCCCCCTTCCCTTTGCTTTCAGAAGTTGACATTTCTATTCATTGC
TTTTCTTGTTAAGATAATCTCTTTACTCCCCTGTGAGTGATTCACTGCCTTGTCATTATTACGATAGATGTGTTTGTATTGTTTTTTTTC
TGATGATACTGATGTTGATGAATTTTTAATTTTATTTGATGTGGTAGAGTTGGGAGGTTTCAGGGTTTTTTCCCCTCTTTTACTTTCCAT
TGAGGAAGGGAATGAGCTCCTTTCTCCTCTCCTTCAGCCAATCATTATCAAATGTTCCTTCAGCCCTGCAGTTGCCCCAAATAACCTTTT
TTCAGCATCCTCTGTCCTCAGTCATGCCAGTCTGGACATGCTCTGTTGTGCCCTGTGACAAAACTGCTCAGTATTCCTATTGCTTTTACT
GTGTTTTAGGTACTGTGAAGGGATCAAAAAACCAAACAGAAGCAAGGGAGTATCAGACTATGATGATGCTGGAGTGGACTTCTGTTCAGG
GAACATTTTGCATTCAGGCTGTTTCTTCTATCACTGGGGTTTCCCATGTTGCAGCACTTCTGGGTCGTTGCAATTTTGCATCTAGGAGTT
AGTTTGATCGAGTTATTCTCTTTTTTCAAGTCACTTTTGTTATAGGTCTCCCCCTAGGCCTGTCTCTCCCTTAGCCCAAAAGATCTGAAC
TGGAAGCAGAGGTTGAGATTCTGCCTCCCAGGAGAGGGATTTACCTGCCCCCTAGTACCAGATAGGTTTAGGGCAGTGATCTCTACAGCA
ATCAGTTCAGTGTCCTGGTTGTCCCTGCTCCCATTTACAGATGTTTGGGCAGCATTGATAGAAGTATGGAGGGGTTCAAGACAGAGCCCA
CCTGATCAAGATCATCAGCTACCTTCAAATTATTGACCTGGACAGGGTCCAAGTCTGATAGTAACCTTTTACAAGAAAGAACAGGGATGG
GAATGGAAAGAGATAGCCTTGATCCACAGTATTGTACCTGCATTTTCTACCACCCTAAAATTGTGTGAGACTTCTCCCATTGTTAACAGA
TTGCATGGACAATCTTCCCTGGCTTCTTTCTTTCCCTCTCTCTTTCTTCTTTCTCCTGCCATCCTAGCACAGGAGGATTTTTGGTATTGA
TATAGTTAAAGCTGTTCTGGCACTCAAAGAAGGCCGTGTTTCCAACATCCTCTCATCCCAGGACATTTGGGGCAAGTGAGTTAGGGGCCC
AGGGGCAATTTTCCCTCTGAATAACGTGTCTGAGGCAGGGATGCTACCCTCAGGCTCGCTTTTGGCCAGCTTTTTGCTTGGGAAAATCTA
ACTTCTTTCACAAGGAGGCAGGCTTCCTATGGATGTTGGAGTACCTGTTTTTCCTCCACACATAGCCCTTTTCATGGATAGACCTTGAAC
AACAAAAAGGGTATAAGGGAATAAGGATGAACTCTGCTGTGAAGAGCAAGCCACTGTAGTGAGGAATGTGGAGACTGGGAGTCTGTCCTA
AACCCCATGGGAGAAGACTTCATCATGACAGGACTTCAGCTTACCAAGCAGCAGCCATAGCTGTGTGGAGGCTTCAGCATAGCTAGCATG
TTTACTGCTCTATGCCTCCTGATCCAGACCAGGCATTGCCCAGCCTGGGAATCTTTTCTTTGTGGGAATCAAATTACAAGCTATTTAAGT
TTATATTCCATCACAACCAAGTCAGACTTGTATTATAAGTCAAGGATGAGCCTGATCTGGGGAGAGGGCCGGGGCTCGGGACTGGCCACC
ACTGTTCAGCACATGACCTAACTACGTAAGCCTCTTTGGCAAGGGTCCTGGTGCCCAGCACCCAGGCTAAAATATCCTGTCTGGCAGAGT
GTTTTGGTAGCTATGCAGGCCTCCCTTCAGTGTACCTCTTTTTCCAACTTCTCACTCCTCCTTACTAGGCTTGGCCTTGACATGCTTCTT
CGAGGGTTGGCAGCACACCGGGAGGGGATGCTTGGACAAGTTTCTGGGCCTACATTTCTTGACTAGGCCCTCTCATTTCCTCCCTCCTTG
GGGCTTCTGCCCAGGGCTCCAGGATCAGGGATATTACTTCTCAACCCGCACTTCTCCTCTACTGAACCCACTGGCATCACCTGATGCCAC
TAATTTGTGAACAACAAGAAATCATTTCCCCATTGGTTGGAGTATTCCCTCAGCCTATAGCATCAAAGCAGACCAGTGGCCAACAGCCCC
AAGGGGAGCCCAATTAAATACCTGGGTTCAGTATCCTAACCTGTTATGTCCTGACAGCAATGGTAACCCCAGTAATTCTGTAATGTTGTA
ATTTCCGCATGGCCCTGAGCTCCCTTTTCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAAAAGGCTTTGCTAGTGTGTTCAATGGGAC
CTGCTGTGGGGAGTCCTAAGACAGACATCTAATTATTCTCTCTTTTTCCCCCCCTCTCTATGTGTATATTTCTAATGGATCTATAAGAAC
AGCAACAAGAGAGTTCTAACAATTCTAGTGTGAAGCCAAATAGTGATCTTTTAGTGCTTTGGGGATGGGGTGGGCTGGGGTGGATGGATG
GGCAACAGTGACTTTGATTACCCTTGCTGCTCTGCATTTGCCAGTTTATTCTTTTGTTTCTTTTATCTGACTGACTCTGTCAAACAAGTG
TCAAAGTTGTGTGTTAAAAAATGTTTAACAAAAAAAATGTTGTAATGACACAAAGCCTTATGAAAATATTTATGGAGTTCAATAAAAGAA

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000253401_chrX_62875617_-_3791nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGG
CCGCATTGACATGGATAAATATGAGGTAGTTGACATTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCT
TCACAACAAGGAGACTGAGGAGATACATCTGTTCTTTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAG
GAAAATGGTACAGGAAGATGAAAAAATTGGCTTTGAAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAA
GCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTCCTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGA
CGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCGAACCCAAGCGCAGCCAGTCACCATTCTGGCAAAACTTCAGCAGGTTAACCCCCTT
CAAAAAATGATACCTACAGGGAGGCAGATAATTTTAAAATAAAGTAAATAAAATTATATTTATAGATGGACCTTTTTTCGGAGAAGCACT
GTTGAAATTTATACACACACACACACACAGAGACCCTTGAGTACACATACACACACACACACACAGACACACACACACACACACACACAC
ACACACACACAGAGAGATAAGGAACAAAAGTGTTTTCTGTTGTTTTGGGGAAGTGAAATATGTGGTTGGTAGGAAGAGGTACCAATGACT
TCCAAACATGTGATTCCGTCTTAAAAGTTTTCCATTTTTACCCTGTCCCCCTTCCCTTTGCTTTCAGAAGTTGACATTTCTATTCATTGC
TTTTCTTGTTAAGATAATCTCTTTACTCCCCTGTGAGTGATTCACTGCCTTGTCATTATTACGATAGATGTGTTTGTATTGTTTTTTTTC
TGATGATACTGATGTTGATGAATTTTTAATTTTATTTGATGTGGTAGAGTTGGGAGGTTTCAGGGTTTTTTCCCCTCTTTTACTTTCCAT
TGAGGAAGGGAATGAGCTCCTTTCTCCTCTCCTTCAGCCAATCATTATCAAATGTTCCTTCAGCCCTGCAGTTGCCCCAAATAACCTTTT
TTCAGCATCCTCTGTCCTCAGTCATGCCAGTCTGGACATGCTCTGTTGTGCCCTGTGACAAAACTGCTCAGTATTCCTATTGCTTTTACT
GTGTTTTAGGTACTGTGAAGGGATCAAAAAACCAAACAGAAGCAAGGGAGTATCAGACTATGATGATGCTGGAGTGGACTTCTGTTCAGG
GAACATTTTGCATTCAGGCTGTTTCTTCTATCACTGGGGTTTCCCATGTTGCAGCACTTCTGGGTCGTTGCAATTTTGCATCTAGGAGTT
AGTTTGATCGAGTTATTCTCTTTTTTCAAGTCACTTTTGTTATAGGTCTCCCCCTAGGCCTGTCTCTCCCTTAGCCCAAAAGATCTGAAC
TGGAAGCAGAGGTTGAGATTCTGCCTCCCAGGAGAGGGATTTACCTGCCCCCTAGTACCAGATAGGTTTAGGGCAGTGATCTCTACAGCA
ATCAGTTCAGTGTCCTGGTTGTCCCTGCTCCCATTTACAGATGTTTGGGCAGCATTGATAGAAGTATGGAGGGGTTCAAGACAGAGCCCA
CCTGATCAAGATCATCAGCTACCTTCAAATTATTGACCTGGACAGGGTCCAAGTCTGATAGTAACCTTTTACAAGAAAGAACAGGGATGG
GAATGGAAAGAGATAGCCTTGATCCACAGTATTGTACCTGCATTTTCTACCACCCTAAAATTGTGTGAGACTTCTCCCATTGTTAACAGA
TTGCATGGACAATCTTCCCTGGCTTCTTTCTTTCCCTCTCTCTTTCTTCTTTCTCCTGCCATCCTAGCACAGGAGGATTTTTGGTATTGA
TATAGTTAAAGCTGTTCTGGCACTCAAAGAAGGCCGTGTTTCCAACATCCTCTCATCCCAGGACATTTGGGGCAAGTGAGTTAGGGGCCC
AGGGGCAATTTTCCCTCTGAATAACGTGTCTGAGGCAGGGATGCTACCCTCAGGCTCGCTTTTGGCCAGCTTTTTGCTTGGGAAAATCTA
ACTTCTTTCACAAGGAGGCAGGCTTCCTATGGATGTTGGAGTACCTGTTTTTCCTCCACACATAGCCCTTTTCATGGATAGACCTTGAAC
AACAAAAAGGGTATAAGGGAATAAGGATGAACTCTGCTGTGAAGAGCAAGCCACTGTAGTGAGGAATGTGGAGACTGGGAGTCTGTCCTA
AACCCCATGGGAGAAGACTTCATCATGACAGGACTTCAGCTTACCAAGCAGCAGCCATAGCTGTGTGGAGGCTTCAGCATAGCTAGCATG
TTTACTGCTCTATGCCTCCTGATCCAGACCAGGCATTGCCCAGCCTGGGAATCTTTTCTTTGTGGGAATCAAATTACAAGCTATTTAAGT
TTATATTCCATCACAACCAAGTCAGACTTGTATTATAAGTCAAGGATGAGCCTGATCTGGGGAGAGGGCCGGGGCTCGGGACTGGCCACC
ACTGTTCAGCACATGACCTAACTACGTAAGCCTCTTTGGCAAGGGTCCTGGTGCCCAGCACCCAGGCTAAAATATCCTGTCTGGCAGAGT
GTTTTGGTAGCTATGCAGGCCTCCCTTCAGTGTACCTCTTTTTCCAACTTCTCACTCCTCCTTACTAGGCTTGGCCTTGACATGCTTCTT
CGAGGGTTGGCAGCACACCGGGAGGGGATGCTTGGACAAGTTTCTGGGCCTACATTTCTTGACTAGGCCCTCTCATTTCCTCCCTCCTTG
GGGCTTCTGCCCAGGGCTCCAGGATCAGGGATATTACTTCTCAACCCGCACTTCTCCTCTACTGAACCCACTGGCATCACCTGATGCCAC
TAATTTGTGAACAACAAGAAATCATTTCCCCATTGGTTGGAGTATTCCCTCAGCCTATAGCATCAAAGCAGACCAGTGGCCAACAGCCCC
AAGGGGAGCCCAATTAAATACCTGGGTTCAGTATCCTAACCTGTTATGTCCTGACAGCAATGGTAACCCCAGTAATTCTGTAATGTTGTA
ATTTCCGCATGGCCCTGAGCTCCCTTTTCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAAAAGGCTTTGCTAGTGTGTTCAATGGGAC
CTGCTGTGGGGAGTCCTAAGACAGACATCTAATTATTCTCTCTTTTTCCCCCCCTCTCTATGTGTATATTTCTAATGGATCTATAAGAAC
AGCAACAAGAGAGTTCTAACAATTCTAGTGTGAAGCCAAATAGTGATCTTTTAGTGCTTTGGGGATGGGGTGGGCTGGGGTGGATGGATG
GGCAACAGTGACTTTGATTACCCTTGCTGCTCTGCATTTGCCAGTTTATTCTTTTGTTTCTTTTATCTGACTGACTCTGTCAAACAAGTG
TCAAAGTTGTGTGTTAAAAAATGTTTAACAAAAAAAATGTTGTAATGACACAAAGCCTTATGAAAATATTTATGGAGTTCAATAAAAGAA

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000374878_chrX_62875617_-_974nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGG
CCGCATTGACATGGATAAATATGAGGTAGTTGACATTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCT
TCACAACAAGGAGACTGAGGAGATACATCTGTTCTTTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAG
GAAAATGGTACAGGAAGATGAAAAAATTGGCTTTGAAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAACTCCCTTT
TCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAAAAGGCTTTGCTAGTGTGTTCAATGGGACCTGCTGTGGGGAGTCCTAAGACAGACA
TCTAATTATTCTCTCTTTTTCCCCCCCTCTCTATGTGTATATTTCTAATGGATCTATAAGAACAGCAACAAGAGAGTTCTAACAATTCTA
GTGTGAAGCCAAATAGTGATCTTTTAGTGCTTTGGGGATGGGGTGGGCTGGGGTGGATGGATGGGCAACAGTGACTTTGATTACCCTTGC
TGCTCTGCATTTGCCAGTTTATTCTTTTGTTTCTTTTATCTGACTGACTCTGTCAAACAAGTGTCAAAGTTGTGTGTTAAAAAATGTTTA

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000374870_chrX_62875617_-_3782nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGG
CCGCATTGACATGGATAAATATGAGGTAGTTGACATTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCT
TCACAACAAGGAGACTGAGGAGATACATCTGTTCTTTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAG
GAAAATGGTACAGGAAGATGAAAAAATTGGCTTTGAAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAA
GCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTCCTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGA
CGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCGAACCCAAGCGCAGCCAGTCACCATTCTGGCAAAACTTCAGCAGGTTAACCCCCTT
CAAAAAATGATACCTACAGGGAGGCAGATAATTTTAAAATAAAGTAAATAAAATTATATTTATAGATGGACCTTTTTTCGGAGAAGCACT
GTTGAAATTTATACACACACACACACACAGAGACCCTTGAGTACACATACACACACACACACACAGACACACACACACACACACACACAC
ACACACACACAGAGAGATAAGGAACAAAAGTGTTTTCTGTTGTTTTGGGGAAGTGAAATATGTGGTTGGTAGGAAGAGGTACCAATGACT
TCCAAACATGTGATTCCGTCTTAAAAGTTTTCCATTTTTACCCTGTCCCCCTTCCCTTTGCTTTCAGAAGTTGACATTTCTATTCATTGC
TTTTCTTGTTAAGATAATCTCTTTACTCCCCTGTGAGTGATTCACTGCCTTGTCATTATTACGATAGATGTGTTTGTATTGTTTTTTTTC
TGATGATACTGATGTTGATGAATTTTTAATTTTATTTGATGTGGTAGAGTTGGGAGGTTTCAGGGTTTTTTCCCCTCTTTTACTTTCCAT
TGAGGAAGGGAATGAGCTCCTTTCTCCTCTCCTTCAGCCAATCATTATCAAATGTTCCTTCAGCCCTGCAGTTGCCCCAAATAACCTTTT
TTCAGCATCCTCTGTCCTCAGTCATGCCAGTCTGGACATGCTCTGTTGTGCCCTGTGACAAAACTGCTCAGTATTCCTATTGCTTTTACT
GTGTTTTAGGTACTGTGAAGGGATCAAAAAACCAAACAGAAGCAAGGGAGTATCAGACTATGATGATGCTGGAGTGGACTTCTGTTCAGG
GAACATTTTGCATTCAGGCTGTTTCTTCTATCACTGGGGTTTCCCATGTTGCAGCACTTCTGGGTCGTTGCAATTTTGCATCTAGGAGTT
AGTTTGATCGAGTTATTCTCTTTTTTCAAGTCACTTTTGTTATAGGTCTCCCCCTAGGCCTGTCTCTCCCTTAGCCCAAAAGATCTGAAC
TGGAAGCAGAGGTTGAGATTCTGCCTCCCAGGAGAGGGATTTACCTGCCCCCTAGTACCAGATAGGTTTAGGGCAGTGATCTCTACAGCA
ATCAGTTCAGTGTCCTGGTTGTCCCTGCTCCCATTTACAGATGTTTGGGCAGCATTGATAGAAGTATGGAGGGGTTCAAGACAGAGCCCA
CCTGATCAAGATCATCAGCTACCTTCAAATTATTGACCTGGACAGGGTCCAAGTCTGATAGTAACCTTTTACAAGAAAGAACAGGGATGG
GAATGGAAAGAGATAGCCTTGATCCACAGTATTGTACCTGCATTTTCTACCACCCTAAAATTGTGTGAGACTTCTCCCATTGTTAACAGA
TTGCATGGACAATCTTCCCTGGCTTCTTTCTTTCCCTCTCTCTTTCTTCTTTCTCCTGCCATCCTAGCACAGGAGGATTTTTGGTATTGA
TATAGTTAAAGCTGTTCTGGCACTCAAAGAAGGCCGTGTTTCCAACATCCTCTCATCCCAGGACATTTGGGGCAAGTGAGTTAGGGGCCC
AGGGGCAATTTTCCCTCTGAATAACGTGTCTGAGGCAGGGATGCTACCCTCAGGCTCGCTTTTGGCCAGCTTTTTGCTTGGGAAAATCTA
ACTTCTTTCACAAGGAGGCAGGCTTCCTATGGATGTTGGAGTACCTGTTTTTCCTCCACACATAGCCCTTTTCATGGATAGACCTTGAAC
AACAAAAAGGGTATAAGGGAATAAGGATGAACTCTGCTGTGAAGAGCAAGCCACTGTAGTGAGGAATGTGGAGACTGGGAGTCTGTCCTA
AACCCCATGGGAGAAGACTTCATCATGACAGGACTTCAGCTTACCAAGCAGCAGCCATAGCTGTGTGGAGGCTTCAGCATAGCTAGCATG
TTTACTGCTCTATGCCTCCTGATCCAGACCAGGCATTGCCCAGCCTGGGAATCTTTTCTTTGTGGGAATCAAATTACAAGCTATTTAAGT
TTATATTCCATCACAACCAAGTCAGACTTGTATTATAAGTCAAGGATGAGCCTGATCTGGGGAGAGGGCCGGGGCTCGGGACTGGCCACC
ACTGTTCAGCACATGACCTAACTACGTAAGCCTCTTTGGCAAGGGTCCTGGTGCCCAGCACCCAGGCTAAAATATCCTGTCTGGCAGAGT
GTTTTGGTAGCTATGCAGGCCTCCCTTCAGTGTACCTCTTTTTCCAACTTCTCACTCCTCCTTACTAGGCTTGGCCTTGACATGCTTCTT
CGAGGGTTGGCAGCACACCGGGAGGGGATGCTTGGACAAGTTTCTGGGCCTACATTTCTTGACTAGGCCCTCTCATTTCCTCCCTCCTTG
GGGCTTCTGCCCAGGGCTCCAGGATCAGGGATATTACTTCTCAACCCGCACTTCTCCTCTACTGAACCCACTGGCATCACCTGATGCCAC
TAATTTGTGAACAACAAGAAATCATTTCCCCATTGGTTGGAGTATTCCCTCAGCCTATAGCATCAAAGCAGACCAGTGGCCAACAGCCCC
AAGGGGAGCCCAATTAAATACCTGGGTTCAGTATCCTAACCTGTTATGTCCTGACAGCAATGGTAACCCCAGTAATTCTGTAATGTTGTA
ATTTCCGCATGGCCCTGAGCTCCCTTTTCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAAAAGGCTTTGCTAGTGTGTTCAATGGGAC
CTGCTGTGGGGAGTCCTAAGACAGACATCTAATTATTCTCTCTTTTTCCCCCCCTCTCTATGTGTATATTTCTAATGGATCTATAAGAAC
AGCAACAAGAGAGTTCTAACAATTCTAGTGTGAAGCCAAATAGTGATCTTTTAGTGCTTTGGGGATGGGGTGGGCTGGGGTGGATGGATG
GGCAACAGTGACTTTGATTACCCTTGCTGCTCTGCATTTGCCAGTTTATTCTTTTGTTTCTTTTATCTGACTGACTCTGTCAAACAAGTG
TCAAAGTTGTGTGTTAAAAAATGTTTAACAAAAAAAATGTTGTAATGACACAAAGCCTTATGAAAATATTTATGGAGTTCAATAAAAGAA

>In-frame_ATRX_ENST00000395603_chrX_77041468_-_ARHGEF9_ENST00000437457_chrX_62875617_-_3782nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGACCTAATCCGGAGAGACATCCTGTACTACAAAGG
CCGCATTGACATGGATAAATATGAGGTAGTTGACATTGAGGATGGCAGAGATGATGACTTCAATGTCAGCATGAAGAATGCCTTTAAGCT
TCACAACAAGGAGACTGAGGAGATACATCTGTTCTTTGCCAAGAAGCTGGAGGAAAAAATACGCTGGCTCAGGGCTTTCAGAGAAGAGAG
GAAAATGGTACAGGAAGATGAAAAAATTGGCTTTGAAATTTCTGAAAACCAGAAGAGGCAGGCTGCAATGACTGTGAGAAAAGTCCCTAA
GCAAAAAGGTGTCAACTCTGCCCGCTCAGTTCCTCCTTCCTACCCACCACCGCAGGACCCGTTAAACCACGGCCAGTACCTGGTCCCCGA
CGGCATCGCTCAGTCGCAGGTCTTTGAGTTCACCGAACCCAAGCGCAGCCAGTCACCATTCTGGCAAAACTTCAGCAGGTTAACCCCCTT
CAAAAAATGATACCTACAGGGAGGCAGATAATTTTAAAATAAAGTAAATAAAATTATATTTATAGATGGACCTTTTTTCGGAGAAGCACT
GTTGAAATTTATACACACACACACACACAGAGACCCTTGAGTACACATACACACACACACACACAGACACACACACACACACACACACAC
ACACACACACAGAGAGATAAGGAACAAAAGTGTTTTCTGTTGTTTTGGGGAAGTGAAATATGTGGTTGGTAGGAAGAGGTACCAATGACT
TCCAAACATGTGATTCCGTCTTAAAAGTTTTCCATTTTTACCCTGTCCCCCTTCCCTTTGCTTTCAGAAGTTGACATTTCTATTCATTGC
TTTTCTTGTTAAGATAATCTCTTTACTCCCCTGTGAGTGATTCACTGCCTTGTCATTATTACGATAGATGTGTTTGTATTGTTTTTTTTC
TGATGATACTGATGTTGATGAATTTTTAATTTTATTTGATGTGGTAGAGTTGGGAGGTTTCAGGGTTTTTTCCCCTCTTTTACTTTCCAT
TGAGGAAGGGAATGAGCTCCTTTCTCCTCTCCTTCAGCCAATCATTATCAAATGTTCCTTCAGCCCTGCAGTTGCCCCAAATAACCTTTT
TTCAGCATCCTCTGTCCTCAGTCATGCCAGTCTGGACATGCTCTGTTGTGCCCTGTGACAAAACTGCTCAGTATTCCTATTGCTTTTACT
GTGTTTTAGGTACTGTGAAGGGATCAAAAAACCAAACAGAAGCAAGGGAGTATCAGACTATGATGATGCTGGAGTGGACTTCTGTTCAGG
GAACATTTTGCATTCAGGCTGTTTCTTCTATCACTGGGGTTTCCCATGTTGCAGCACTTCTGGGTCGTTGCAATTTTGCATCTAGGAGTT
AGTTTGATCGAGTTATTCTCTTTTTTCAAGTCACTTTTGTTATAGGTCTCCCCCTAGGCCTGTCTCTCCCTTAGCCCAAAAGATCTGAAC
TGGAAGCAGAGGTTGAGATTCTGCCTCCCAGGAGAGGGATTTACCTGCCCCCTAGTACCAGATAGGTTTAGGGCAGTGATCTCTACAGCA
ATCAGTTCAGTGTCCTGGTTGTCCCTGCTCCCATTTACAGATGTTTGGGCAGCATTGATAGAAGTATGGAGGGGTTCAAGACAGAGCCCA
CCTGATCAAGATCATCAGCTACCTTCAAATTATTGACCTGGACAGGGTCCAAGTCTGATAGTAACCTTTTACAAGAAAGAACAGGGATGG
GAATGGAAAGAGATAGCCTTGATCCACAGTATTGTACCTGCATTTTCTACCACCCTAAAATTGTGTGAGACTTCTCCCATTGTTAACAGA
TTGCATGGACAATCTTCCCTGGCTTCTTTCTTTCCCTCTCTCTTTCTTCTTTCTCCTGCCATCCTAGCACAGGAGGATTTTTGGTATTGA
TATAGTTAAAGCTGTTCTGGCACTCAAAGAAGGCCGTGTTTCCAACATCCTCTCATCCCAGGACATTTGGGGCAAGTGAGTTAGGGGCCC
AGGGGCAATTTTCCCTCTGAATAACGTGTCTGAGGCAGGGATGCTACCCTCAGGCTCGCTTTTGGCCAGCTTTTTGCTTGGGAAAATCTA
ACTTCTTTCACAAGGAGGCAGGCTTCCTATGGATGTTGGAGTACCTGTTTTTCCTCCACACATAGCCCTTTTCATGGATAGACCTTGAAC
AACAAAAAGGGTATAAGGGAATAAGGATGAACTCTGCTGTGAAGAGCAAGCCACTGTAGTGAGGAATGTGGAGACTGGGAGTCTGTCCTA
AACCCCATGGGAGAAGACTTCATCATGACAGGACTTCAGCTTACCAAGCAGCAGCCATAGCTGTGTGGAGGCTTCAGCATAGCTAGCATG
TTTACTGCTCTATGCCTCCTGATCCAGACCAGGCATTGCCCAGCCTGGGAATCTTTTCTTTGTGGGAATCAAATTACAAGCTATTTAAGT
TTATATTCCATCACAACCAAGTCAGACTTGTATTATAAGTCAAGGATGAGCCTGATCTGGGGAGAGGGCCGGGGCTCGGGACTGGCCACC
ACTGTTCAGCACATGACCTAACTACGTAAGCCTCTTTGGCAAGGGTCCTGGTGCCCAGCACCCAGGCTAAAATATCCTGTCTGGCAGAGT
GTTTTGGTAGCTATGCAGGCCTCCCTTCAGTGTACCTCTTTTTCCAACTTCTCACTCCTCCTTACTAGGCTTGGCCTTGACATGCTTCTT
CGAGGGTTGGCAGCACACCGGGAGGGGATGCTTGGACAAGTTTCTGGGCCTACATTTCTTGACTAGGCCCTCTCATTTCCTCCCTCCTTG
GGGCTTCTGCCCAGGGCTCCAGGATCAGGGATATTACTTCTCAACCCGCACTTCTCCTCTACTGAACCCACTGGCATCACCTGATGCCAC
TAATTTGTGAACAACAAGAAATCATTTCCCCATTGGTTGGAGTATTCCCTCAGCCTATAGCATCAAAGCAGACCAGTGGCCAACAGCCCC
AAGGGGAGCCCAATTAAATACCTGGGTTCAGTATCCTAACCTGTTATGTCCTGACAGCAATGGTAACCCCAGTAATTCTGTAATGTTGTA
ATTTCCGCATGGCCCTGAGCTCCCTTTTCCTCAACTCAGTGAGGCCAGGATTTGCTCTCCAAAAGGCTTTGCTAGTGTGTTCAATGGGAC
CTGCTGTGGGGAGTCCTAAGACAGACATCTAATTATTCTCTCTTTTTCCCCCCCTCTCTATGTGTATATTTCTAATGGATCTATAAGAAC
AGCAACAAGAGAGTTCTAACAATTCTAGTGTGAAGCCAAATAGTGATCTTTTAGTGCTTTGGGGATGGGGTGGGCTGGGGTGGATGGATG
GGCAACAGTGACTTTGATTACCCTTGCTGCTCTGCATTTGCCAGTTTATTCTTTTGTTTCTTTTATCTGACTGACTCTGTCAAACAAGTG
TCAAAGTTGTGTGTTAAAAAATGTTTAACAAAAAAAATGTTGTAATGACACAAAGCCTTATGAAAATATTTATGGAGTTCAATAAAAGAA


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FusionGenePPI for ATRX_ARHGEF9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATRXEIF4A2, EZH2, CCSER2, KIAA1377, LUC7L2, PTN, PTPN4, RAD51, SMC1A, CBX5, H3F3A, H3F3B, DAXX, HDAC4, HIST1H3A, WRN, CALM1, SVIL, ZBED1, HIST2H3C, BLM, NEK1, ZNF512B, PRKDC, RAD50, XRCC5, MRE11A, XRCC6, SUPT16H, NBN, SSRP1, HIST1H4J, HIST2H2BE, RPA1, TP53, HIST1H1C, RAD9A, HIST1H2BL, HIST1H2AB, RAD1, PML, NSD1, SUMO2, TMPO, CNOT1, LRRK2, H2AFY, SNW1, ZNF274, TRIM28, SETDB1, BMI1, AURKA, HIST1H4A, WDR1, EAF1, DDX20, NAF1, EIF2AK1, AP3B1, POLD1, RBM14, MFAP1ARHGEF9GPHN, SMURF1, PLEKHA5, KHDRBS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1351189_132662493DAXX
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1341189_132662455DAXX
HgeneATRXchrX:77041468chrX:62875617ENST00000373344-1352010_228062493MECP2
HgeneATRXchrX:77041468chrX:62875617ENST00000395603-1342010_228062455MECP2
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000253401-610100_110352517GPHN
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000374870-59100_110250415GPHN
TgeneARHGEF9chrX:77041468chrX:62875617ENST00000437457-59100_110299464GPHN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATRX_ARHGEF9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATRX_ARHGEF9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATRXC1845055ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED11CTD_human;ORPHANET;UNIPROT
HgeneATRXC0796003Juberg-Marsidi syndrome5CTD_human;ORPHANET;UNIPROT
HgeneATRXC0017638Glioma2CTD_human
HgeneATRXC0027819Neuroblastoma2CTD_human
HgeneATRXC0010417Cryptorchidism1CTD_human;HPO
HgeneATRXC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneATRXC0018273Growth Disorders1CTD_human
HgeneATRXC0030297Pancreatic Neoplasm1CTD_human
HgeneATRXC0030846Penile Diseases1CTD_human
HgeneATRXC0039978Thoracic Diseases1CTD_human
HgeneATRXC0206754Neuroendocrine Tumors1CTD_human
HgeneATRXC0376634Craniofacial Abnormalities1CTD_human
HgeneATRXC1136249Mental Retardation, X-Linked1CTD_human
HgeneATRXC3463824MYELODYSPLASTIC SYNDROME1CTD_human;HPO
TgeneARHGEF9C1845102Hyperekplexia and Epilepsy2CTD_human;ORPHANET;UNIPROT
TgeneARHGEF9C1136249Mental Retardation, X-Linked1CTD_human