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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35428

FusionGeneSummary for SOS2_NRXN3

check button Fusion gene summary
Fusion gene informationFusion gene name: SOS2_NRXN3
Fusion gene ID: 35428
HgeneTgene
Gene symbol

SOS2

NRXN3

Gene ID

6655

9369

Gene nameSOS Ras/Rho guanine nucleotide exchange factor 2neurexin 3
SynonymsNS9|SOS-2C14orf60
Cytomap

14q21.3

14q24.3-q31.1

Type of geneprotein-codingprotein-coding
Descriptionson of sevenless homolog 2guanine nucleotide releasing factorneurexin 3neurexin IIIneurexin-3-alpha
Modification date2018052220180519
UniProtAcc

Q07890

Q9Y4C0

Ensembl transtripts involved in fusion geneENST00000216373, ENST00000543680, 
ENST00000555794, 		ENST00000554719, 
ENST00000335750, ENST00000557594, 
ENST00000281127, ENST00000428277, 
ENST00000556003, 
Fusion gene scores* DoF score5 X 5 X 4=1004 X 4 X 2=32
# samples 64
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SOS2 [Title/Abstract] AND NRXN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D9-A4Z5-01ASOS2chr14

50600841

-NRXN3chr14

79423585

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000216373ENST00000554719SOS2chr14

50600841

-NRXN3chr14

79423585

+
Frame-shiftENST00000216373ENST00000335750SOS2chr14

50600841

-NRXN3chr14

79423585

+
5CDS-intronENST00000216373ENST00000557594SOS2chr14

50600841

-NRXN3chr14

79423585

+
5CDS-intronENST00000216373ENST00000281127SOS2chr14

50600841

-NRXN3chr14

79423585

+
5CDS-intronENST00000216373ENST00000428277SOS2chr14

50600841

-NRXN3chr14

79423585

+
5CDS-intronENST00000216373ENST00000556003SOS2chr14

50600841

-NRXN3chr14

79423585

+
Frame-shiftENST00000543680ENST00000554719SOS2chr14

50600841

-NRXN3chr14

79423585

+
Frame-shiftENST00000543680ENST00000335750SOS2chr14

50600841

-NRXN3chr14

79423585

+
5CDS-intronENST00000543680ENST00000557594SOS2chr14

50600841

-NRXN3chr14

79423585

+
5CDS-intronENST00000543680ENST00000281127SOS2chr14

50600841

-NRXN3chr14

79423585

+
5CDS-intronENST00000543680ENST00000428277SOS2chr14

50600841

-NRXN3chr14

79423585

+
5CDS-intronENST00000543680ENST00000556003SOS2chr14

50600841

-NRXN3chr14

79423585

+
intron-3CDSENST00000555794ENST00000554719SOS2chr14

50600841

-NRXN3chr14

79423585

+
intron-3CDSENST00000555794ENST00000335750SOS2chr14

50600841

-NRXN3chr14

79423585

+
intron-intronENST00000555794ENST00000557594SOS2chr14

50600841

-NRXN3chr14

79423585

+
intron-intronENST00000555794ENST00000281127SOS2chr14

50600841

-NRXN3chr14

79423585

+
intron-intronENST00000555794ENST00000428277SOS2chr14

50600841

-NRXN3chr14

79423585

+
intron-intronENST00000555794ENST00000556003SOS2chr14

50600841

-NRXN3chr14

79423585

+

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FusionProtFeatures for SOS2_NRXN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SOS2

Q07890

NRXN3

Q9Y4C0

Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000250|UniProtKB:Q62245}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SOS2_NRXN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SOS2_NRXN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SOS2GRAP2, SHC1, EGFR, PLCG1, GRB2, ESR1, ITSN2, LRRK1, CRK, BIN1, NTRK1NRXN3NLGN1, NLGN2, NLGN3, MLLT4, MYC, GPR183, PIP5K1A, FAM19A4, CAMKV, CBLN4, FAM19A1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SOS2_NRXN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SOS2_NRXN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSOS2C4225282NOONAN SYNDROME 91UNIPROT
TgeneNRXN3C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNRXN3C0036341Schizophrenia1PSYGENET
TgeneNRXN3C0236969Substance-Related Disorders1CTD_human
TgeneNRXN3C0853193Bipolar I disorder1PSYGENET