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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35384

FusionGeneSummary for SORBS2_ARHGAP27

check button Fusion gene summary
Fusion gene informationFusion gene name: SORBS2_ARHGAP27
Fusion gene ID: 35384
HgeneTgene
Gene symbol

SORBS2

ARHGAP27

Gene ID

8470

201176

Gene namesorbin and SH3 domain containing 2Rho GTPase activating protein 27
SynonymsARGBP2|PRO0618CAMGAP1|PP905|SH3D20|SH3P20
Cytomap

4q35.1

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2rho GTPase-activating protein 27CIN85-associated multi-domain-containing Rho GTPase-activating protein 1SH3 domain containing 20SH3 domain-containing protein 20rho-type GTPase-activating protein 27
Modification date2018052320180523
UniProtAcc

O94875

Q6ZUM4

Ensembl transtripts involved in fusion geneENST00000448662, ENST00000431808, 
ENST00000284776, ENST00000437304, 
ENST00000319471, ENST00000449407, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000498125, 
ENST00000532038, ENST00000376922, 
ENST00000528384, ENST00000455881, 
ENST00000532891, ENST00000428638, 
ENST00000442348, ENST00000582826, 
ENST00000528273, ENST00000290470, 
Fusion gene scores* DoF score14 X 16 X 6=13443 X 3 X 2=18
# samples 182
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/18*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SORBS2 [Title/Abstract] AND ARHGAP27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7748-01ASORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000448662ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000448662ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000448662ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000448662ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000448662ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000448662ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000448662ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-5UTRENST00000448662ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000448662ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000448662ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000431808ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000431808ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000431808ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000431808ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000431808ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000431808ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000431808ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-5UTRENST00000431808ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000431808ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000431808ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000284776ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000284776ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000284776ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000284776ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000284776ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000284776ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000284776ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-5UTRENST00000284776ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-intronENST00000284776ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-intronENST00000284776ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000437304ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000437304ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000437304ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000437304ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000437304ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000437304ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000437304ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-5UTRENST00000437304ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000437304ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000437304ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000319471ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000319471ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000319471ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000319471ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000319471ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000319471ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000319471ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-5UTRENST00000319471ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000319471ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000319471ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000449407ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000449407ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000449407ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000449407ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000449407ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000449407ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000449407ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-5UTRENST00000449407ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000449407ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000449407ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000355634ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000355634ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000355634ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000355634ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000355634ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000355634ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-3CDSENST00000355634ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-5UTRENST00000355634ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-intronENST00000355634ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
5UTR-intronENST00000355634ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000393528ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000393528ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000393528ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000393528ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000393528ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000393528ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000393528ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-5UTRENST00000393528ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000393528ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000393528ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000418609ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000418609ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000418609ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000418609ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000418609ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000418609ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000418609ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-5UTRENST00000418609ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000418609ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000418609ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000498125ENST00000532038SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000498125ENST00000376922SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000498125ENST00000528384SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000498125ENST00000455881SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000498125ENST00000532891SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000498125ENST00000428638SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-3CDSENST00000498125ENST00000442348SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-5UTRENST00000498125ENST00000582826SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000498125ENST00000528273SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-
intron-intronENST00000498125ENST00000290470SORBS2chr4

186877350

-ARHGAP27chr17

43475413

-

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FusionProtFeatures for SORBS2_ARHGAP27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORBS2

O94875

ARHGAP27

Q6ZUM4

Rho GTPase-activating protein which may be involved inclathrin-mediated endocytosis. GTPase activators for the Rho-typeGTPases act by converting them to an inactive GDP-bound state. Hasactivity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SORBS2_ARHGAP27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SORBS2_ARHGAP27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SORBS2YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1ARHGAP27RAC1, CDC42, SH3KBP1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SORBS2_ARHGAP27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SORBS2_ARHGAP27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORBS2C0043094Weight Gain1CTD_human