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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35381

FusionGeneSummary for SORBS1_SPOP

check button Fusion gene summary
Fusion gene informationFusion gene name: SORBS1_SPOP
Fusion gene ID: 35381
HgeneTgene
Gene symbol

SORBS1

SPOP

Gene ID

10580

8405

Gene namesorbin and SH3 domain containing 1speckle type BTB/POZ protein
SynonymsCAP|FLAF2|R85FL|SH3D5|SH3P12|SORB1BTBD32|TEF2
Cytomap

10q24.1

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionsorbin and SH3 domain-containing protein 1Fas-ligand associated factor 2SH3 domain protein 5c-Cbl associated proteinponsinspeckle-type POZ proteinHIB homolog 1roadkill homolog 1
Modification date2018051920180523
UniProtAcc

Q9BX66

O43791

Ensembl transtripts involved in fusion geneENST00000371227, ENST00000371249, 
ENST00000306402, ENST00000353505, 
ENST00000371246, ENST00000347291, 
ENST00000393949, ENST00000371247, 
ENST00000607232, ENST00000371245, 
ENST00000361941, ENST00000277982, 
ENST00000354106, ENST00000371239, 
ENST00000371241, ENST00000474353, 
ENST00000393328, ENST00000393331, 
ENST00000347630, ENST00000504102, 
ENST00000503676, ENST00000513080, 
Fusion gene scores* DoF score7 X 8 X 3=1689 X 4 X 5=180
# samples 88
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORBS1 [Title/Abstract] AND SPOP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB256869SORBS1chr10

97321076

-SPOPchr17

47700240

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000371227ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371227ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371227ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371227ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371227ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371227ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371249ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371249ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371249ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371249ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371249ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371249ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000306402ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000306402ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000306402ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000306402ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000306402ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000306402ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000353505ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000353505ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000353505ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000353505ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000353505ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000353505ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371246ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371246ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371246ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371246ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371246ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371246ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000347291ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000347291ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000347291ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000347291ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000347291ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000347291ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000393949ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000393949ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000393949ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000393949ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000393949ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000393949ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371247ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371247ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371247ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371247ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371247ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000371247ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000607232ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000607232ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000607232ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000607232ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000607232ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000607232ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371245ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371245ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371245ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371245ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371245ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371245ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000361941ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000361941ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000361941ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000361941ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000361941ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000361941ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000277982ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000277982ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000277982ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000277982ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000277982ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000277982ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000354106ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000354106ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000354106ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000354106ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000354106ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000354106ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371239ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371239ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371239ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371239ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371239ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371239ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371241ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371241ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371241ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371241ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371241ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
intron-5UTRENST00000371241ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000474353ENST00000393328SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000474353ENST00000393331SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000474353ENST00000347630SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000474353ENST00000504102SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000474353ENST00000503676SORBS1chr10

97321076

-SPOPchr17

47700240

-
5UTR-5UTRENST00000474353ENST00000513080SORBS1chr10

97321076

-SPOPchr17

47700240

-

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FusionProtFeatures for SORBS1_SPOP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORBS1

Q9BX66

SPOP

O43791

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex that mediates the ubiquitinationof target proteins, leading most often to their proteasomaldegradation. In complex with CUL3, involved in ubiquitination andproteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.In complex with CUL3, involved in ubiquitination of H2AFY andBMI1; this does not lead to their proteasomal degradation.Inhibits transcriptional activation of PDX1/IPF1 targets, such asinsulin, by promoting PDX1/IPF1 degradation. The cullin-RING-basedBCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containinghomodimeric SPOP has higher ubiquitin ligase activity than thecomplex that contains the heterodimer formed by SPOP and SPOPL.{ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469,ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708,ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SORBS1_SPOP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SORBS1_SPOP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SORBS1INSM1, INPPL1, EIF6, CBL, FLOT1, MLLT4, VCL, INSR, ABL1, MAP4K3, SEMA6A, KHDRBS1, CASP8, NTRK1, SH2B2, SOS1, SRC, FRS2, TENM1, CDK6, SLC10A3, RPL4, PILRA, LATS2, YWHAB, EFNB1, NCK2, CEP128, CNTRL, FBF1, CDK4, TGS1, CDH1, G3BP1SPOPZBTB16, DPPA2, RXRB, DDIT3, RTN3, MYD88, SIRT2, DOK2, KPNA6, GDI1, PIP5K1B, TRAF1, TRAF6, AR, BMI1, NCOA3, CUL3, ESR1, DAXX, SPOP, PIP4K2B, UBE2E3, FADD, PIAS1, GIT2, SRRM1, ATM, GLI2, DEK, BRMS1, NUP50, RTN4, GCC1, ERG, ERF, PGR, GLI3, UBE2D1, UBE2D2, NANOG, PTEN, DUSP7, EGLN2, RFWD2, SOST, ARIH1, MSRB3, BRD4, BRD3, BRD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SORBS1_SPOP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SORBS1_SPOP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSPOPC0014170Endometrial Neoplasms1CTD_human
TgeneSPOPC0033578Prostatic Neoplasms1CTD_human