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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35365

FusionGeneSummary for SOGA1_RALY

check button Fusion gene summary
Fusion gene informationFusion gene name: SOGA1_RALY
Fusion gene ID: 35365
HgeneTgene
Gene symbol

SOGA1

RALY

Gene ID

140710

22913

Gene namesuppressor of glucose, autophagy associated 1RALY heterogeneous nuclear ribonucleoprotein
SynonymsC20orf117|KIAA0889|SOGAHNRPCL2|P542
Cytomap

20q11.23

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionprotein SOGA1SOGA family member 1suppressor of glucose by autophagysuppressor of glucose from autophagysuppressor of glucose, autophagy-associated protein 1RNA-binding protein RalyRNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog)RNA-binding protein (autoantigenic)RNA-binding protein (autoantigenic, hnRNP-associated with lethal yellow)autoantigen p542heterogeneous nuclear r
Modification date2018052320180523
UniProtAcc

O94964

Q9UKM9

Ensembl transtripts involved in fusion geneENST00000237536, ENST00000279034, 
ENST00000456801, ENST00000357779, 
ENST00000375114, ENST00000246194, 
ENST00000493399, 
Fusion gene scores* DoF score5 X 4 X 5=10015 X 7 X 8=840
# samples 620
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/840*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SOGA1 [Title/Abstract] AND RALY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-FS-A1ZE-06ASOGA1chr20

35491061

-RALYchr20

32619328

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000237536ENST00000375114SOGA1chr20

35491061

-RALYchr20

32619328

+
5CDS-5UTRENST00000237536ENST00000246194SOGA1chr20

35491061

-RALYchr20

32619328

+
5CDS-intronENST00000237536ENST00000493399SOGA1chr20

35491061

-RALYchr20

32619328

+
intron-5UTRENST00000279034ENST00000375114SOGA1chr20

35491061

-RALYchr20

32619328

+
intron-5UTRENST00000279034ENST00000246194SOGA1chr20

35491061

-RALYchr20

32619328

+
intron-intronENST00000279034ENST00000493399SOGA1chr20

35491061

-RALYchr20

32619328

+
intron-5UTRENST00000456801ENST00000375114SOGA1chr20

35491061

-RALYchr20

32619328

+
intron-5UTRENST00000456801ENST00000246194SOGA1chr20

35491061

-RALYchr20

32619328

+
intron-intronENST00000456801ENST00000493399SOGA1chr20

35491061

-RALYchr20

32619328

+
intron-5UTRENST00000357779ENST00000375114SOGA1chr20

35491061

-RALYchr20

32619328

+
intron-5UTRENST00000357779ENST00000246194SOGA1chr20

35491061

-RALYchr20

32619328

+
intron-intronENST00000357779ENST00000493399SOGA1chr20

35491061

-RALYchr20

32619328

+

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FusionProtFeatures for SOGA1_RALY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SOGA1

O94964

RALY

Q9UKM9

Regulates autophagy by playing a role in the reductionof glucose production in an adiponectin- and insulin-dependentmanner. {ECO:0000250}. RNA-binding protein that acts as a transcriptionalcofactor for cholesterol biosynthetic genes in the liver. Bindsthe lipid-responsive non-coding RNA LeXis and is required forLeXis-mediated effect on cholesterogenesis (By similarity). May bea heterogeneous nuclear ribonucleoprotein (hnRNP)(PubMed:9376072). {ECO:0000250|UniProtKB:Q64012,ECO:0000269|PubMed:9376072}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SOGA1_RALY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SOGA1_RALY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SOGA1PLEKHA5, MARK4, SIRT7, CCDC8, ZNF219, TSNAX, NTRK1, ANKRA2, RFXANK, HERC2, MARK2, PPP2R1A, DYNLL1, RNF41, NOP56, SAMHD1, LDHD, ZNF785, ZNF169, LZTS2, ZNF263, TRIM25RALYSPG7, WDR62, USP45, TADA2A, YWHAQ, CAND1, PCBP1, RBMX, PABPC1, HNRNPM, HNRNPU, HNRNPH1, SYNCRIP, HNRNPR, SNRNP40, HNRNPC, RBM39, RNPS1, DHX9, HNRNPA0, MED16, HSP90AB2P, HNRNPD, MED1, ERLIN1, RPS20, FMNL1, FN1, VCAM1, HNRNPK, QKI, KHDRBS1, CELF1, SOX2, TARDBP, PARK2, RPA3, RPA2, RPA1, LIN28A, LIN28B, SHMT2, MOV10, NXF1, PHF6, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, PSME3, RPL6, RALYL, HNRNPA1, ILF2, NTRK1, HNRNPUL2, PRPF8, RANGAP1, RANBP2, SPICE1, HIST1H3E, MATR3, TEAD2, FOXA3, FOXB1, FOXD4, FOXE1, FOXL1, FOXP3, FOXS1, SNW1, CDC5L, U2AF2, ELAVL2, STRBP, APOBEC3D, C11orf57, ZC3H18, STAU1, DGCR8, FBXW11, ZFC3H1, SNRNP70, SNIP1, RPL7, COX15, HSD17B10, FOXA1, TRIM25, BRCA1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SOGA1_RALY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SOGA1_RALY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRALYC0236733Amphetamine-Related Disorders1CTD_human