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Fusion gene ID: 35345 |
FusionGeneSummary for SOCS5_ADCY2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SOCS5_ADCY2 | Fusion gene ID: 35345 | Hgene | Tgene | Gene symbol | SOCS5 | ADCY2 | Gene ID | 9655 | 108 |
Gene name | suppressor of cytokine signaling 5 | adenylate cyclase 2 | |
Synonyms | CIS6|CISH6|Cish5|SOCS-5 | AC2|HBAC2 | |
Cytomap | 2p21 | 5p15.31 | |
Type of gene | protein-coding | protein-coding | |
Description | suppressor of cytokine signaling 5CIS-6cytokine-inducible SH2 protein 6cytokine-inducible SH2-containing protein 5 | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O75159 | Q08462 | |
Ensembl transtripts involved in fusion gene | ENST00000306503, ENST00000394861, | ENST00000338316, ENST00000537121, ENST00000513693, | |
Fusion gene scores | * DoF score | 3 X 1 X 3=9 | 13 X 12 X 5=780 |
# samples | 3 | 13 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/780*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SOCS5 [Title/Abstract] AND ADCY2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SOCS5 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity | 15590694 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PCPG | TCGA-W2-A7HC-01A | SOCS5 | chr2 | 46926588 | + | ADCY2 | chr5 | 7520851 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000306503 | ENST00000338316 | SOCS5 | chr2 | 46926588 | + | ADCY2 | chr5 | 7520851 | + |
intron-intron | ENST00000306503 | ENST00000537121 | SOCS5 | chr2 | 46926588 | + | ADCY2 | chr5 | 7520851 | + |
intron-intron | ENST00000306503 | ENST00000513693 | SOCS5 | chr2 | 46926588 | + | ADCY2 | chr5 | 7520851 | + |
5UTR-3CDS | ENST00000394861 | ENST00000338316 | SOCS5 | chr2 | 46926588 | + | ADCY2 | chr5 | 7520851 | + |
5UTR-intron | ENST00000394861 | ENST00000537121 | SOCS5 | chr2 | 46926588 | + | ADCY2 | chr5 | 7520851 | + |
5UTR-intron | ENST00000394861 | ENST00000513693 | SOCS5 | chr2 | 46926588 | + | ADCY2 | chr5 | 7520851 | + |
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FusionProtFeatures for SOCS5_ADCY2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SOCS5 | ADCY2 |
SOCS family proteins form part of a classical negativefeedback system that regulates cytokine signal transduction. Maybe a substrate-recognition component of a SCF-like ECS (ElonginBC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. Inhibits for instance EGFsignaling by mediating the degradation of the EGF receptor/EGFR.Involved in the regulation of T-helper cell differentiation byinhibiting of the IL4 signaling pathway which promotesdifferentiation into the Th2 phenotype. Can also partially inhibitIL6 and LIF signaling. {ECO:0000269|PubMed:15590694}. | Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling (PubMed:15385642). Down-streamsignaling cascades mediate changes in gene expression patterns andlead to increased IL6 production. Functions in signaling cascadesdownstream of the muscarinic acetylcholine receptors (Bysimilarity). {ECO:0000250|UniProtKB:P26769,ECO:0000269|PubMed:15385642}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SOCS5_ADCY2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SOCS5_ADCY2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SOCS5 | ALK, DCUN1D1, IL4R, APP, UBC, TMBIM1, CASP3, EGFR, CUL5, TRIM25 | ADCY2 | ADCY5, GNAS |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SOCS5_ADCY2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ADCY2 | Q08462 | DB09121 | Aurothioglucose | Adenylate cyclase type 2 | small molecule | approved|withdrawn |
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RelatedDiseases for SOCS5_ADCY2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ADCY2 | C0004096 | Asthma | 1 | CTD_human |
Tgene | ADCY2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |