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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35333

FusionGeneSummary for SNX9_DAP

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX9_DAP
Fusion gene ID: 35333
HgeneTgene
Gene symbol

SNX9

DAP

Gene ID

51429

23549

Gene namesorting nexin 9aspartyl aminopeptidase
SynonymsSDP1|SH3PX1|SH3PXD3A|WISPASPEP|DAP
Cytomap

6q25.3

2q35

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-9SH3 and PX domain-containing protein 1SH3 and PX domain-containing protein 3AWiskott-Aldrich syndrome protein (WASP) interactor proteinaspartyl aminopeptidase
Modification date2018052220180523
UniProtAcc

Q9Y5X1

P51397

Ensembl transtripts involved in fusion geneENST00000392185, ENST00000230895, 
ENST00000432074, ENST00000510546, 
Fusion gene scores* DoF score5 X 7 X 5=17510 X 6 X 6=360
# samples 710
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNX9 [Title/Abstract] AND DAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNX9

GO:0032461

positive regulation of protein oligomerization

15703209

HgeneSNX9

GO:0043547

positive regulation of GTPase activity

15703209

HgeneSNX9

GO:0045860

positive regulation of protein kinase activity

18388313

HgeneSNX9

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

18353773

HgeneSNX9

GO:0060988

lipid tube assembly

17948057

HgeneSNX9

GO:0097320

plasma membrane tubulation

18388313


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A09X-01ASNX9chr6

158323077

+DAPchr5

10683683

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000392185ENST00000230895SNX9chr6

158323077

+DAPchr5

10683683

-
5CDS-intronENST00000392185ENST00000432074SNX9chr6

158323077

+DAPchr5

10683683

-
5CDS-intronENST00000392185ENST00000510546SNX9chr6

158323077

+DAPchr5

10683683

-

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FusionProtFeatures for SNX9_DAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNX9

Q9Y5X1

DAP

P51397

Involved in endocytosis and intracellular vesicletrafficking, both during interphase and at the end of mitosis.Required for efficient progress through mitosis and cytokinesis.Required for normal formation of the cleavage furrow at the end ofmitosis. Plays a role in endocytosis via clathrin-coated pits, butalso clathrin-independent, actin-dependent fluid-phaseendocytosis. Plays a role in macropinocytosis. Promotesinternalization of TNFR. Promotes degradation of EGFR after EGFsignaling. Stimulates the GTPase activity of DNM1. Promotes DNM1oligomerization. Promotes activation of the Arp2/3 complex byWASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched inphosphatidylinositol 4,5-bisphosphate and promotes membranetubulation. Has lower affinity for membranes enriched inphosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118,ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209,ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057,ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313,ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. Negative regulator of autophagy. Involved in mediatinginterferon-gamma-induced cell death.{ECO:0000269|PubMed:20537536}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNX9chr6:158323077chr5:10683683ENST00000392185+6181_62206596DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNX9chr6:158323077chr5:10683683ENST00000392185+618250_361206596DomainPX
HgeneSNX9chr6:158323077chr5:10683683ENST00000392185+618392_595206596DomainNote=BAR
HgeneSNX9chr6:158323077chr5:10683683ENST00000392185+618201_213206596RegionNote=Critical for tubulation activity


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FusionGeneSequence for SNX9_DAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SNX9_ENST00000392185_chr6_158323077_+_DAP_ENST00000230895_chr5_10683683_-_259aa
MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEILPSDGKDQFSCGNSVADQAFLDSLSASTAQA
SSSAASNNHQVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SNX9_ENST00000392185_chr6_158323077_+_DAP_ENST00000230895_chr5_10683683_-_777nt
ATGGCCACCAAGGCTCGGGTTATGTATGATTTTGCTGCTGAACCTGGAAATAATGAACTGACGGTTAATGAAGGAGAAATCATCACAATC
ACAAATCCGGATGTAGGTGGAGGATGGCTGGAAGGAAGAAACATCAAAGGAGAACGAGGGCTGGTTCCCACAGACTACGTTGAAATTTTA
CCCAGTGATGGAAAAGATCAATTTTCTTGTGGAAATTCAGTGGCTGACCAAGCCTTCCTTGATTCTCTCTCAGCCAGCACAGCTCAGGCC
AGTTCGTCGGCTGCCAGCAACAATCACCAGGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGAGTGCCTCCAAATCTGGGAACTGGGAA
AGCTCAGAAGGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCAACAACTGGGACACTGCCTTCGGCCAC
CCCCAGGCCTACCAAGGACCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGGATGGGCCCAAATCCTCTTCCTACTTTAAGGAT
TCAGAGTCAGCTGATGCAGGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCATCCATGAAAATTCCCCTTAACAATCCACCTAAA
CCCACTGTGTTCATCTCTGGGGTCATCGCCCGGGGTGACAAAGATTTCCCCCCGGCGGCTGCGCAGGTGGCTCACCAGAAGCCGCATGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SNX9_ENST00000392185_chr6_158323077_+_DAP_ENST00000230895_chr5_10683683_-_2774nt
AGCGGCTGGGCCTGAGCGTCGAGACTCGGGGCCGAGGCGGAGGAGCGGCCGCCGCGCCGGGGCCCAGCCGGAGCCGCCGCCCTCGCCCTT
GCCTTTGCCTGCGCGGCTCAGAATCACCATCCGCGGCGCGGGAGACGAGCCGGCCGTCCCGGGCCGGGGGACCCGCCCGCCATGGCCACC
AAGGCTCGGGTTATGTATGATTTTGCTGCTGAACCTGGAAATAATGAACTGACGGTTAATGAAGGAGAAATCATCACAATCACAAATCCG
GATGTAGGTGGAGGATGGCTGGAAGGAAGAAACATCAAAGGAGAACGAGGGCTGGTTCCCACAGACTACGTTGAAATTTTACCCAGTGAT
GGAAAAGATCAATTTTCTTGTGGAAATTCAGTGGCTGACCAAGCCTTCCTTGATTCTCTCTCAGCCAGCACAGCTCAGGCCAGTTCGTCG
GCTGCCAGCAACAATCACCAGGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGAGTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAA
GGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCAACAACTGGGACACTGCCTTCGGCCACCCCCAGGCC
TACCAAGGACCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGGATGGGCCCAAATCCTCTTCCTACTTTAAGGATTCAGAGTCA
GCTGATGCAGGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCATCCATGAAAATTCCCCTTAACAATCCACCTAAACCCACTGTG
TTCATCTCTGGGGTCATCGCCCGGGGTGACAAAGATTTCCCCCCGGCGGCTGCGCAGGTGGCTCACCAGAAGCCGCATGCCTCCATGGAC
AAGCATCCTTCCCCAAGAACCCAGCACATCCAGCAGCCACGCAAGTGAGCCTGGAGTCCACCAGCCTGCCCCATGGCCCCGGCTCTGCTG
CACTTGGTATTTCCCTGACAGAGAGAACCAGCAGTTTCGCCCAAATCCTACTCTGCTGGGAAATCTAAGGCAAAACCAAGTGCTCTGTCC
TTTGCCTTACATTTCCATATTTAAAACTAGAAACAGCTCCAGCCCAAACCTTGTTTATGGGGAGTCTGGTTGGATGTCATTTGAGGATCA
TTGTGCCCCTAGAGGTGCCATTAGCAGAATTTGCCAAGATCCGAGAAAAATTTTAGCTTTAGTTCTATTTCAGCAGTCACCTGACGTCCT
TGTCTATGGTCTTAAAAACAAGAAGGCACACATTTGAGAAGATGAGATTAAGGTTAGGAGAAAACCTCAGTCATTGCATGCTTTTTAGTA
TGGGCCAATAAAATCTCAACACCTGTGGGAGAGTAAGAACTAAGGGAATGAGTTTGGGCGGCCCCTCATAAAGGACCTTAGAGGCAGGGA
ACAGCAATGCCAAATTTCCCTCTCTCGTGAGATGGGGGATCCTGTGCAGGCTGATGAGGCACCCATGAGAAAAGCCGAAAAAGCATGCAT
CTTAGAAATAGCCCCTCAATTCCAGGAGTCAACATGCCAAAGAATGAGGCTGGAGACAGGTAGCTCCGAGGGAGGACTTCTGGCATGAGA
TCTCGGCACGGCAAGCCCAGCATCGCCTCAGCCCAGACAGGCTCCACCAGGAGATCAAGCAAGGGCTGCCTTTCAGGAGTCACCTCCTGA
GCCACTTCAGAGTTCTGGAAGTGACCACGGACCAGGGTGGAGGAATAGACTTCTAGTTCATTCTGGGACACTTGAGCCAGAGAGTTGAAA
GCTTGGAAAGACCAGATAAGAAACCTGCCCTTTGTCTCCCTAGGGACATGAGACACCACATTCCATTTGTGCTAGAAAAACCTATCCACT
GATGAGTCTAACTGTTCCAAACGCCTCCCACCTGGTGTGCACAGCTGCCTGGGTCCATTGTCACTTGGGTGCATCAGGTTGTCCTCCGAT
TTTTAGATGAGTTTCCTGTCTAGAGATGTCCTAGTCTGCTCACTGGCTGGTGGCAGTAGGGTACCCTGCGTCCTCGAAAAGCCAGAGGGT
TCACCTAGTCAGACGAAACTCCAGAACAGTGCTTGTGGAGGGCCTGACTGTCCTGCTCACCCACAGCCGATCTGCTGCAGGTCAGCAACT
GTGTCGTGAGCAGCTGCCAACCACCAGCCTTTCTGGTGCTGTTCTCCAGTTCACGTCTGCCAGCTGGTGAGGGCAGAGGCAGACCTGGTC
AGACCCAGCGCCCCTCCTCCCTGAGGGAGCATGGCACAGCCTCACACTTGAAAGACGGTGTTTGGTTTCCCATCTAATCAACTTAAGGGA
AGCCGGCATGTACCCTTCAAGGCCCTGTCACCACCTATTTCCTGATCAGTTGGTATAAACTGAGGGTGGCTTTTAGAGACCCAGACTTGG
TTGGCAGCGCTGCCATGGAACACCCCAGCAAGCACCTCCCAGCCTGCCTTTCGGAGCAGCACCCAGGAGGGGATGCCGCGCTCCAGCAAC
ACCAGGTCAGGCCTGTGCAGACCCCTGCCCTGCCGCTGCAGAAATCCAGAAGCATCCTTAATGCTTCTCAGTCTTCAGCCAGAGGGAGGG
CTGTTATTTCCAGAGGTGCGCTTTTTATGTACTTTTAGCTAGATGTGGCATGCATCTGTGAGCTTTAGATCATTAAATCCAAAATGTTTG


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FusionGenePPI for SNX9_DAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SNX9ADAM15, MPP6, DNM2, CLTC, ADAM9, ITCH, SIRT7, KHDRBS1, SNX33, CUL3, COPS5, TNK2, FASLG, SNX9, MED28, CFTR, DNM1, WASL, OBSL1, EGFR, DPPA4, AURKA, NTRK1, FBF1, NPHP1, HDAC1, GTSE1, NAF1, FOXG1, FOXK2, MCM2, CDH1, SYNJ1, DNM3, AP2A1, FCHSD1, MLYCD, AP2M1, AP2A2, AP1B1, HNRNPK, AP2B1, CPNE5, RNGTT, OCRL, BRCA1, TESDAPSETDB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNX9_DAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX9_DAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDAPC0009324Ulcerative Colitis1CTD_human