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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35329

FusionGeneSummary for SNX7_SPATS2L

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX7_SPATS2L
Fusion gene ID: 35329
HgeneTgene
Gene symbol

SNX7

SPATS2L

Gene ID

51375

26010

Gene namesorting nexin 7spermatogenesis associated serine rich 2 like
Synonyms-DNAPTP6|SGNP
Cytomap

1p21.3

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-7SPATS2-like proteinDNA polymerase-transactivated protein 6stress granule and nucleolar protein
Modification date2018051920180523
UniProtAcc

Q9UNH6

Q9NUQ6

Ensembl transtripts involved in fusion geneENST00000370189, ENST00000529992, 
ENST00000306121, ENST00000473868, 
ENST00000409718, ENST00000358677, 
ENST00000409988, ENST00000409385, 
ENST00000451764, ENST00000360760, 
ENST00000409140, ENST00000409755, 
ENST00000409151, ENST00000460095, 
Fusion gene scores* DoF score3 X 3 X 2=187 X 7 X 3=147
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNX7 [Title/Abstract] AND SPATS2L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU615374SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000370189ENST00000409718SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000370189ENST00000358677SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000370189ENST00000409988SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000370189ENST00000409385SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000370189ENST00000451764SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000370189ENST00000360760SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000370189ENST00000409140SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000370189ENST00000409755SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000370189ENST00000409151SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-intronENST00000370189ENST00000460095SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000529992ENST00000409718SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000529992ENST00000358677SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000529992ENST00000409988SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000529992ENST00000409385SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000529992ENST00000451764SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000529992ENST00000360760SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000529992ENST00000409140SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000529992ENST00000409755SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000529992ENST00000409151SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-intronENST00000529992ENST00000460095SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000306121ENST00000409718SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000306121ENST00000358677SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000306121ENST00000409988SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000306121ENST00000409385SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000306121ENST00000451764SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000306121ENST00000360760SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000306121ENST00000409140SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000306121ENST00000409755SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000306121ENST00000409151SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-intronENST00000306121ENST00000460095SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000473868ENST00000409718SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000473868ENST00000358677SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-3CDSENST00000473868ENST00000409988SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000473868ENST00000409385SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000473868ENST00000451764SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000473868ENST00000360760SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000473868ENST00000409140SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000473868ENST00000409755SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-5UTRENST00000473868ENST00000409151SNX7chr1

99200682

-SPATS2Lchr2

201281113

+
intron-intronENST00000473868ENST00000460095SNX7chr1

99200682

-SPATS2Lchr2

201281113

+

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FusionProtFeatures for SNX7_SPATS2L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNX7

Q9UNH6

SPATS2L

Q9NUQ6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNX7_SPATS2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNX7_SPATS2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNX7_SPATS2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX7_SPATS2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSNX7C0023893Liver Cirrhosis, Experimental1CTD_human