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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35247

FusionGeneSummary for SNX13_PHF14

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX13_PHF14
Fusion gene ID: 35247
HgeneTgene
Gene symbol

SNX13

PHF14

Gene ID

23161

9678

Gene namesorting nexin 13PHD finger protein 14
SynonymsRGS-PX1-
Cytomap

7p21.1

7p21.3

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-13rgs domain- and phox domain-containing proteinPHD finger protein 14
Modification date2018051920180519
UniProtAcc

Q9Y5W8

O94880

Ensembl transtripts involved in fusion geneENST00000428135, ENST00000409389, 
ENST00000409604, ENST00000496855, 
ENST00000403050, ENST00000445996, 
ENST00000469407, 
Fusion gene scores* DoF score5 X 2 X 4=407 X 5 X 6=210
# samples 57
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNX13 [Title/Abstract] AND PHF14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNX13

GO:0043547

positive regulation of GTPase activity

11729322


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-A6-6653-01ASNX13chr7

17979907

-PHF14chr7

11150977

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000428135ENST00000403050SNX13chr7

17979907

-PHF14chr7

11150977

+
5CDS-intronENST00000428135ENST00000445996SNX13chr7

17979907

-PHF14chr7

11150977

+
5CDS-3UTRENST00000428135ENST00000469407SNX13chr7

17979907

-PHF14chr7

11150977

+
5CDS-intronENST00000409389ENST00000403050SNX13chr7

17979907

-PHF14chr7

11150977

+
5CDS-intronENST00000409389ENST00000445996SNX13chr7

17979907

-PHF14chr7

11150977

+
5CDS-3UTRENST00000409389ENST00000469407SNX13chr7

17979907

-PHF14chr7

11150977

+
5CDS-intronENST00000409604ENST00000403050SNX13chr7

17979907

-PHF14chr7

11150977

+
5CDS-intronENST00000409604ENST00000445996SNX13chr7

17979907

-PHF14chr7

11150977

+
5CDS-3UTRENST00000409604ENST00000469407SNX13chr7

17979907

-PHF14chr7

11150977

+
intron-intronENST00000496855ENST00000403050SNX13chr7

17979907

-PHF14chr7

11150977

+
intron-intronENST00000496855ENST00000445996SNX13chr7

17979907

-PHF14chr7

11150977

+
intron-3UTRENST00000496855ENST00000469407SNX13chr7

17979907

-PHF14chr7

11150977

+

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FusionProtFeatures for SNX13_PHF14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNX13

Q9Y5W8

PHF14

O94880

May be involved in several stages of intracellulartrafficking. May play a role in endosome homeostasis (Bysimilarity). Acts as a GAP for Galphas. {ECO:0000250,ECO:0000269|PubMed:11729322}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNX13_PHF14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNX13_PHF14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SNX13GNAS, TDP2, G6PC, NR1I3, KLF15, TSPAN2, IPPK, TPRA1, TRIM25PHF14H2AFY, PCBD2, MOV10, HIST1H2BA, IFI16, DAXX, HDAC1, HNRNPU, TCF20, KAT6A, CDK2AP1, TM9SF4, HMG20A, NLRP3, CEP170P1, H2AFX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNX13_PHF14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX13_PHF14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource