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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35224

FusionGeneSummary for SNTB1_ZNF250

check button Fusion gene summary
Fusion gene informationFusion gene name: SNTB1_ZNF250
Fusion gene ID: 35224
HgeneTgene
Gene symbol

SNTB1

ZNF250

Gene ID

6641

58500

Gene namesyntrophin beta 1zinc finger protein 250
Synonyms59-DAP|A1B|BSYN2|DAPA1B|SNT2|SNT2B1|TIP-43ZFP647|ZNF647
Cytomap

8q24.12

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionbeta-1-syntrophin59 kDa dystrophin-associated protein A1 basic component 1dystrophin-associated protein A1, 59kD, basic component 1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)syntrophin-2tax interaction protein 43zinc finger protein 250zinc finger protein (clone 647)zinc finger protein 647
Modification date2018052220180522
UniProtAcc

Q13884

P15622

Ensembl transtripts involved in fusion geneENST00000395601, ENST00000517992, 
ENST00000519177, 
ENST00000543949, 
ENST00000342660, ENST00000292579, 
ENST00000417550, 
Fusion gene scores* DoF score4 X 4 X 4=641 X 1 X 1=1
# samples 41
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: SNTB1 [Title/Abstract] AND ZNF250 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GC-A4ZW-01ASNTB1chr8

121561002

-ZNF250chr8

146115788

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000395601ENST00000543949SNTB1chr8

121561002

-ZNF250chr8

146115788

-
5CDS-5UTRENST00000395601ENST00000342660SNTB1chr8

121561002

-ZNF250chr8

146115788

-
5CDS-5UTRENST00000395601ENST00000292579SNTB1chr8

121561002

-ZNF250chr8

146115788

-
5CDS-5UTRENST00000395601ENST00000417550SNTB1chr8

121561002

-ZNF250chr8

146115788

-
5CDS-5UTRENST00000517992ENST00000543949SNTB1chr8

121561002

-ZNF250chr8

146115788

-
5CDS-5UTRENST00000517992ENST00000342660SNTB1chr8

121561002

-ZNF250chr8

146115788

-
5CDS-5UTRENST00000517992ENST00000292579SNTB1chr8

121561002

-ZNF250chr8

146115788

-
5CDS-5UTRENST00000517992ENST00000417550SNTB1chr8

121561002

-ZNF250chr8

146115788

-
intron-5UTRENST00000519177ENST00000543949SNTB1chr8

121561002

-ZNF250chr8

146115788

-
intron-5UTRENST00000519177ENST00000342660SNTB1chr8

121561002

-ZNF250chr8

146115788

-
intron-5UTRENST00000519177ENST00000292579SNTB1chr8

121561002

-ZNF250chr8

146115788

-
intron-5UTRENST00000519177ENST00000417550SNTB1chr8

121561002

-ZNF250chr8

146115788

-

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FusionProtFeatures for SNTB1_ZNF250


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNTB1

Q13884

ZNF250

P15622

Adapter protein that binds to and probably organizes thesubcellular localization of a variety of membrane proteins. Maylink various receptors to the actin cytoskeleton and thedystrophin glycoprotein complex. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNTB1_ZNF250


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNTB1_ZNF250


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SNTB1KCNJ12, DGKZ, DMD, SCN5A, SIRT3, BAI1, ADRA1D, SAV1, MORC3, TNS1, TNS3, SNTG2, HMG20A, NDEL1, TENC1ZNF250CCDC85B, DPPA2, KRTAP4-12, GOLGA2, BEGAIN, HOOK1, LDOC1, HOOK2, CEP44, NINL, DVL2, TRIM23, ZNF165, ZBTB8A, TNNT1, TRIM27, TFF1, ZNF175, TMCC2, ZNF460, MID2, MTUS2, TENC1, ZNF473, PRPF31, MAGOHB, CDCA7L, ZC4H2, TRIM54, ZNF250, CARD9, GMCL1, CCDC136, GNPTAB, PLEKHF2, CCDC102B, LZTS2, TRIM41, SSX2IP, KRT40, CCDC155, SYNE4, FAM124A, KRTAP10-7, KRTAP10-3, LTF, TPM2, SPINT1, HEXIM2, TRAF1, TRIM28


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNTB1_ZNF250


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNTB1_ZNF250


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource