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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35218

FusionGeneSummary for SNRPN_TUBA1B

check button Fusion gene summary
Fusion gene informationFusion gene name: SNRPN_TUBA1B
Fusion gene ID: 35218
HgeneTgene
Gene symbol

SNRPN

TUBA1B

Gene ID

6638

10376

Gene namesmall nuclear ribonucleoprotein polypeptide Ntubulin alpha 1b
SynonymsHCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-NK-ALPHA-1
Cytomap

15q11.2

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionsmall nuclear ribonucleoprotein-associated protein NSM protein Nsm protein Dtissue-specific splicing proteintubulin alpha-1B chainalpha tubulinalpha-tubulin ubiquitoustubulin K-alpha-1tubulin alpha-ubiquitous chaintubulin, alpha, ubiquitous
Modification date2018052320180523
UniProtAcc

P63162

P68363

Ensembl transtripts involved in fusion geneENST00000400098, ENST00000400100, 
ENST00000400097, ENST00000553597, 
ENST00000390687, ENST00000346403, 
ENST00000554227, ENST00000577565, 
ENST00000444203, 
ENST00000336023, 
Fusion gene scores* DoF score10 X 13 X 2=2608 X 7 X 3=168
# samples 149
** MAII scorelog2(14/260*10)=-0.893084796083488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNRPN [Title/Abstract] AND TUBA1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA368267SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000400098ENST00000336023SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-
intron-3CDSENST00000400100ENST00000336023SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-
intron-3CDSENST00000400097ENST00000336023SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-
intron-3CDSENST00000553597ENST00000336023SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-
intron-3CDSENST00000390687ENST00000336023SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-
intron-3CDSENST00000346403ENST00000336023SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-
intron-3CDSENST00000554227ENST00000336023SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-
intron-3CDSENST00000577565ENST00000336023SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-
intron-3CDSENST00000444203ENST00000336023SNRPNchr15

25337026

+TUBA1Bchr12

49525178

-

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FusionProtFeatures for SNRPN_TUBA1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNRPN

P63162

TUBA1B

P68363

May be involved in tissue-specific alternative RNAprocessing events. Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNRPN_TUBA1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNRPN_TUBA1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNRPN_TUBA1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNRPN_TUBA1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTUBA1BC0029456Osteoporosis1CTD_human