FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 35217

FusionGeneSummary for SNRPN_SUGP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SNRPN_SUGP1
Fusion gene ID: 35217
HgeneTgene
Gene symbol

SNRPN

SUGP1

Gene ID

6638

57794

Gene namesmall nuclear ribonucleoprotein polypeptide NSURP and G-patch domain containing 1
SynonymsHCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-NF23858|RBP|SF4
Cytomap

15q11.2

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionsmall nuclear ribonucleoprotein-associated protein NSM protein Nsm protein Dtissue-specific splicing proteinSURP and G-patch domain-containing protein 1RNA-binding protein RBPsplicing factor 4
Modification date2018052320180519
UniProtAcc

P63162

Q8IWZ8

Ensembl transtripts involved in fusion geneENST00000400098, ENST00000400100, 
ENST00000400097, ENST00000553597, 
ENST00000390687, ENST00000346403, 
ENST00000554227, ENST00000577565, 
ENST00000444203, 
ENST00000247001, 
ENST00000585763, ENST00000334782, 
Fusion gene scores* DoF score10 X 13 X 2=2603 X 3 X 2=18
# samples 143
** MAII scorelog2(14/260*10)=-0.893084796083488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SNRPN [Title/Abstract] AND SUGP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI207554SNRPNchr15

25229060

-SUGP1chr19

19387436

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000400098ENST00000247001SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000400098ENST00000585763SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000400098ENST00000334782SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-3UTRENST00000400100ENST00000247001SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000400100ENST00000585763SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000400100ENST00000334782SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-3UTRENST00000400097ENST00000247001SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000400097ENST00000585763SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000400097ENST00000334782SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-3UTRENST00000553597ENST00000247001SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000553597ENST00000585763SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000553597ENST00000334782SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-3UTRENST00000390687ENST00000247001SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000390687ENST00000585763SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000390687ENST00000334782SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-3UTRENST00000346403ENST00000247001SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000346403ENST00000585763SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000346403ENST00000334782SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-3UTRENST00000554227ENST00000247001SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000554227ENST00000585763SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000554227ENST00000334782SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-3UTRENST00000577565ENST00000247001SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000577565ENST00000585763SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000577565ENST00000334782SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-3UTRENST00000444203ENST00000247001SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000444203ENST00000585763SNRPNchr15

25229060

-SUGP1chr19

19387436

-
intron-intronENST00000444203ENST00000334782SNRPNchr15

25229060

-SUGP1chr19

19387436

-

Top

FusionProtFeatures for SNRPN_SUGP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNRPN

P63162

SUGP1

Q8IWZ8

May be involved in tissue-specific alternative RNAprocessing events. Plays a role in pre-mRNA splicing.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SNRPN_SUGP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SNRPN_SUGP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SNRPN_SUGP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SNRPN_SUGP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource