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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35213

FusionGeneSummary for SNRPN_LENG8

check button Fusion gene summary
Fusion gene informationFusion gene name: SNRPN_LENG8
Fusion gene ID: 35213
HgeneTgene
Gene symbol

SNRPN

LENG8

Gene ID

6638

114823

Gene namesmall nuclear ribonucleoprotein polypeptide Nleukocyte receptor cluster member 8
SynonymsHCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-Npp13842
Cytomap

15q11.2

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionsmall nuclear ribonucleoprotein-associated protein NSM protein Nsm protein Dtissue-specific splicing proteinleukocyte receptor cluster member 8leukocyte receptor cluster (LRC) member 8
Modification date2018052320180519
UniProtAcc

P63162

Q96PV6

Ensembl transtripts involved in fusion geneENST00000400098, ENST00000400100, 
ENST00000400097, ENST00000553597, 
ENST00000390687, ENST00000346403, 
ENST00000554227, ENST00000577565, 
ENST00000444203, 
ENST00000326764, 
ENST00000376514, 
Fusion gene scores* DoF score10 X 13 X 2=2603 X 5 X 1=15
# samples 146
** MAII scorelog2(14/260*10)=-0.893084796083488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/15*10)=2
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SNRPN [Title/Abstract] AND LENG8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI034781SNRPNchr15

25425043

+LENG8chr19

54972911

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000400098ENST00000326764SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-intronENST00000400098ENST00000376514SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-3UTRENST00000400100ENST00000326764SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-intronENST00000400100ENST00000376514SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-3UTRENST00000400097ENST00000326764SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-intronENST00000400097ENST00000376514SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-3UTRENST00000553597ENST00000326764SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-intronENST00000553597ENST00000376514SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-3UTRENST00000390687ENST00000326764SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-intronENST00000390687ENST00000376514SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-3UTRENST00000346403ENST00000326764SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-intronENST00000346403ENST00000376514SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-3UTRENST00000554227ENST00000326764SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-intronENST00000554227ENST00000376514SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-3UTRENST00000577565ENST00000326764SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-intronENST00000577565ENST00000376514SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-3UTRENST00000444203ENST00000326764SNRPNchr15

25425043

+LENG8chr19

54972911

-
intron-intronENST00000444203ENST00000376514SNRPNchr15

25425043

+LENG8chr19

54972911

-

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FusionProtFeatures for SNRPN_LENG8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNRPN

P63162

LENG8

Q96PV6

May be involved in tissue-specific alternative RNAprocessing events.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNRPN_LENG8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNRPN_LENG8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNRPN_LENG8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNRPN_LENG8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource