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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35210

FusionGeneSummary for SNRPN_ARPC2

check button Fusion gene summary
Fusion gene informationFusion gene name: SNRPN_ARPC2
Fusion gene ID: 35210
HgeneTgene
Gene symbol

SNRPN

ARPC2

Gene ID

6638

10109

Gene namesmall nuclear ribonucleoprotein polypeptide Nactin related protein 2/3 complex subunit 2
SynonymsHCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-NARC34|PNAS-139|PRO2446|p34-Arc
Cytomap

15q11.2

2q35

Type of geneprotein-codingprotein-coding
Descriptionsmall nuclear ribonucleoprotein-associated protein NSM protein Nsm protein Dtissue-specific splicing proteinactin-related protein 2/3 complex subunit 2ARP2/3 protein complex subunit 34actin related protein 2/3 complex, subunit 2, 34kDaarp2/3 complex 34 kDa subunittestis tissue sperm-binding protein Li 53e
Modification date2018052320180523
UniProtAcc

P63162

O15144

Ensembl transtripts involved in fusion geneENST00000400098, ENST00000400100, 
ENST00000400097, ENST00000553597, 
ENST00000390687, ENST00000346403, 
ENST00000554227, ENST00000577565, 
ENST00000444203, 
ENST00000315717, 
ENST00000295685, ENST00000477992, 
Fusion gene scores* DoF score10 X 13 X 2=2609 X 10 X 4=360
# samples 1411
** MAII scorelog2(14/260*10)=-0.893084796083488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNRPN [Title/Abstract] AND ARPC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARPC2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI174735SNRPNchr15

25584243

+ARPC2chr2

219114631

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000400098ENST00000315717SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000400098ENST00000295685SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3UTRENST00000400098ENST00000477992SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000400100ENST00000315717SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000400100ENST00000295685SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3UTRENST00000400100ENST00000477992SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000400097ENST00000315717SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000400097ENST00000295685SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3UTRENST00000400097ENST00000477992SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000553597ENST00000315717SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000553597ENST00000295685SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3UTRENST00000553597ENST00000477992SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000390687ENST00000315717SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000390687ENST00000295685SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3UTRENST00000390687ENST00000477992SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000346403ENST00000315717SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000346403ENST00000295685SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3UTRENST00000346403ENST00000477992SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000554227ENST00000315717SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000554227ENST00000295685SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3UTRENST00000554227ENST00000477992SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000577565ENST00000315717SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000577565ENST00000295685SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3UTRENST00000577565ENST00000477992SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000444203ENST00000315717SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3CDSENST00000444203ENST00000295685SNRPNchr15

25584243

+ARPC2chr2

219114631

-
intron-3UTRENST00000444203ENST00000477992SNRPNchr15

25584243

+ARPC2chr2

219114631

-

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FusionProtFeatures for SNRPN_ARPC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNRPN

P63162

ARPC2

O15144

May be involved in tissue-specific alternative RNAprocessing events. Functions as actin-binding component of the Arp2/3complex which is involved in regulation of actin polymerizationand together with an activating nucleation-promoting factor (NPF)mediates the formation of branched actin networks. Seems tocontact the mother actin filament.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNRPN_ARPC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNRPN_ARPC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNRPN_ARPC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNRPN_ARPC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARPC2C0009324Ulcerative Colitis1CTD_human